5H-Dibenzo[c,h]1,6-naphthyridin-6-ones: Novel topoisomerase I-targeting anticancer agents with potent cytotoxic activity

Bioorganic and Medicinal Chemistry

Volumn 11, Issue 9, 2003, Pages 2061-2073

  Ruchelman, Alexander L ^a   Singh, Sudhir K ^a   Ray, Abhijit ^a   Wu, Xiao Hua ^b   Yang, Jin Ming ^b   Li, Tsai Kun ^c   Liu, Angela ^c   Liu, Leroy F ^b,c   LaVoie, Edmond J ^a,c,d  

^a RUTGERS UNIVERSITY   (United States)

^b RUTGERS CANCER INSTITUTE OF NEW JERSEY   (United States)

^c RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^d RUTGERS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5H 8,9 DIMETHOXY 2,3 METHYLENEDIOXYDIBENZO[C,H] 1,6 NAPHTHYRIDINE; 8,9 DIMETHOXY 2,3 METHYLENEDIOXY 5 (2 TETRAHYDROFURANYL)METHYL 5H DIBENZO[C,H] 1,6 NAPHTHYRIDIN 6 ONE; 8,9 DIMETHOXY 2,3 METHYLENEDIOXY 5 (2,3 DIHYDROXYPROPYL) 5H DIBENZO[C,H] 1,6 NAPHTHYRIDIN 6 ONE; 8,9 DIMETHOXY 2,3 METHYLENEDIOXY 5 (BUTYL) 5H DIBENZO[C,H] 1,6 NAPHTHYRIDIN 6 ONE; 8,9 DIMETHOXY 2,3 METHYLENEDIOXY 5 [2 (2 HYDROXYETHOXY)ETHYL] 5H DIBENZO[C,H] 1,6 NAPHTHYRIDIN 6 ONE; 8,9 DIMETHOXY 2,3 METHYLENEDIOXY 5 [2 (4 METHYLPIPERAZIN 1 YL)ETHYL] 5H DIBENZO[C,H] 1,6 NAPHTHYRIDIN 6 ONE; 8,9 DIMETHOXY 2,3 METHYLENEDIOXY 5 [2 (HYDROXY)ETHYL] 5H DIBENZO[C,H] 1,6 NAPHTHYRIDIN 6 ONE; 8,9 DIMETHOXY 2,3 METHYLENEDIOXY 5 [2 (N,N DIMETHYLAMINO) 1 METHYLETHYL] 5,6 DIHYDRODIBENZO[C,H] 1,6 NAPHTHYRIDINE; 8,9 DIMETHOXY 2,3 METHYLENEDIOXY 5 [2 (N,N DIMETHYLAMINO) 1 METHYLETHYL] 5H DIBENZO[C,H] 1,6 NAPHTHYRIDIN 6 ONE; 8,9 DIMETHOXY 2,3 METHYLENEDIOXY 5 [2 (N,N DIMETHYLAMINO)ETHYL] 5,6 DIHYDRODIBENZO[C,H] 1,6 NAPHTHYRIDINE; 8,9 DIMETHOXY 2,3 METHYLENEDIOXY 5 [2 (N,N DIMETHYLAMINO)ETHYL] 5H DIBENZO[C,H] 1,6 NAPHTHYRIDIN 6 ONE; 8,9 DIMETHOXY 2,3 METHYLENEDIOXY 5 [2 (PYRROLIDIN 1 YL)ETHYL] 5H DIBENZO[C,H] 1,6 NAPHTHYRIDIN 6 ONE; 8,9 DIMETHOXY 2,3 METHYLENEDIOXY 5 [2 N,N DIMETHYLAMINO 1 (HYDROXYMETHYL)ETHYL] 5H DIBENZO[C,H] 1,6 NAPHTHYRIDIN 6 ONE; 8,9 DIMETHOXY 2,3 METHYLENEDIOXY 5 [3 (N,N DIMETHYLAMINO)PROPYL] 5H DIBENZO[C,H] 1,6 NAPHTHYRIDIN 6 ONE; 8,9 DIMETHOXY 2,3 METHYLENEDIOXY 5 [[2,2 DIMETHYL[1,3]DIOXOLAN 4 YL]METHYL] 5H DIBENZO[C,H] 1,6 NAPHTHYRIDIN 6 ONE; ALKYL GROUP; ANTINEOPLASTIC AGENT; DIMETHYLAMINE; DNA TOPOISOMERASE; FUNCTIONAL GROUP; GAMMA LACTONE DERIVATIVE; METHYL GROUP; NAPHTHYRIDINE DERIVATIVE; PROPANE; UNCLASSIFIED DRUG;

ALKYLATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST TUMOR; CANCER GRAFT; CANCER INHIBITION; CONTROLLED STUDY; DERIVATIZATION; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG SCREENING; DRUG TARGETING; HUMAN; HUMAN CELL; HUMAN TISSUE; MOUSE; NONHUMAN; NUDE MOUSE; SUBSTITUTION REACTION; TREATMENT OUTCOME; TUMOR CELL LINE; XENOGRAFT;

MUS MUSCULUS; STAPHYLOCOCCUS PHAGE 3A;

EID: 0037401629     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(03)00051-8     Document Type: Article

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