Synthesis and evaluation of 9-benzylideneamino derivatives of homocamptothecin as potent inhibitors of DNA topoisomerase I

European Journal of Medicinal Chemistry

Volumn 45, Issue 6, 2010, Pages 2223-2228

  Guo, Wei ^a   Miao, Zhenyuan ^a   Sheng, Chunquan ^a   Yao, Jianzhong ^a   Feng, Hao ^a   Zhang, Wannian ^a   Zhu, Lingjian ^a   Liu, Wenfeng ^a   Cheng, Pengfei ^a   Zhang, Jing ^a   Che, Xiaoying ^a   Wang, Wenya ^a   Luo, Chuan ^a   Xu, Yulan ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

9 Benzylideneamino; Antitumor activity; Homocamptothecin; Synthesis

Indexed keywords

7 METHYL 9 ACETAMINOHOMOCAMPTOTHECIN; 7 METHYL 9 AMINOHOMOCAMPTOTHECIN; 9 (2 BROMOBENZYLIDENEAMINO) 7 METHYLHOMOCAMPTOTHECIN; 9 (2 METHOXYBENZYLIDENEAMINO) 7 METHYLHOMOCAMPTOTHECIN; 9 (2 METHYLBENZYLIDENEAMINO) 7 METHYLHOMOCAMPTOTHECIN; 9 (2,4 DICHLOROBENZYLIDENEAMINO) 7 METHYLHOMOCAMPTOTHECIN; 9 (2,4 DIMETHYLBENZYLIDENEAMINO) 7 METHYLHOMOCAMPTOTHECIN; 9 (3 METHYLBENZYLIDENEAMINO) 7 METHYLHOMOCAMPTOTHECIN; 9 (3 NITROBENZYLIDENEAMINO) 7 METHYLHOMOCAMPTOTHECIN; 9 (3,5 DIMETHYLBENZYLIDENEAMINO) 7 METHYLHOMOCAMPTOTHECIN; 9 (4 CHLOROBENZYLIDENEAMINO) 7 METHYLHOMOCAMPTOTHECIN; 9 (4 METHYLBENZYLIDENEAMINO) 7 METHYLHOMOCAMPTOTHECIN; 9 (4 NITROBENZYLIDENEAMINO) 7 METHYLHOMOCAMPTOTHECIN; 9 (4 TERT BUTYLBENZYLIDENEAMINO) 7 METHYLHOMOCAMPTOTHECIN; 9 [4 (N,N DIMETHYLAMINO)BENZYLIDENEAMINO] 7 METHYLHOMOCAMPTOTHECIN; CAMPTOTHECIN DERIVATIVE; DNA TOPOISOMERASE; TOPOTECAN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER INHIBITION; COLON CANCER; CONTROLLED STUDY; CYCLIZATION; CYTOTOXICITY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; LUNG CANCER;

ANTINEOPLASTIC AGENTS; BENZYLIDENE COMPOUNDS; CAMPTOTHECIN; CELL LINE, TUMOR; DNA; DNA TOPOISOMERASES, TYPE I; ENZYME INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77950859671     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.01.063     Document Type: Article

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