12-Substituted 2,3-dimethoxy-8,9-methylenedioxybenzo[i]phenanthridines as novel topoisomerase I-targeting antitumor agents

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 7, 2009, Pages 2877-2885

  Feng, Wei ^a   Satyanarayana, Mavurapu ^a   Tsai, Yuan Chin ^b   Liu, Angela A ^b   Liu, Leroy F ^b,c   LaVoie, Edmond J ^a,c  

^a RUTGERS UNIVERSITY   (United States)

^b RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^c RUTGERS CANCER INSTITUTE OF NEW JERSEY   (United States)

Author keywords

Benzo i phenanthridines; Cytotoxicity; Structure activity; Topoisomerase I

Indexed keywords

12 (2 AMINOETHYL) 2,3 DIMETHOXY 8,9 METHYLENEDIOXYBENZO[I]PHENANTHRIDINE; 12 (2 DIMETHYLAMINO)ETHYL 2,3 DIMETHOXY 8,9 METHYLENEDIOXYBENZO[I]PHENANTHRIDINE; 12 (2 N,N DIMETHYLAMINOETHYL)AMINOMETHYL 2,3 DIMETHOXY 8,9 METHYLENEDIOXYBENZO[I]PHENANTHRIDINE; 12 (2 NITROETHYL) 2,3 DIMETHOXY 8,9 METHYLENEDIOXYBENZO[I]PHENANTHRIDINE; 12 (2 NITROVINYL) 2,3 DIMETHOXY 8,9 METHYLENEDIOXYBENZO[I]PHENANTHRIDINE; 12 (3 DIMETHYLAMINO)PROPYL 2,3 DIMETHOXY 8,9 METHYLENEDIOXYBENZO[I]PHENANTHRIDINE; 12 (4 DIMETHYLAMINO)BUT 1 ENYL 2,3 DIMETHOXY 8,9 METHYLENEDIOXYBENZO[I]PHENANTHRIDINE; 12 (4 DIMETHYLAMINO)BUTYL 2,3 DIMETHOXY 8,9 METHYLENEDIOXYBENZO[I]PHENANTHRIDINE; 12 (N AMINOCARBONYL) 2,3 DIMETHOXY 8,9 METHYLENEDIOXYBENZO[I]PHENANTHRIDINE; 12 (N METHYLAMINOCARBONYL) 2,3 DIMETHOXY 8,9 METHYLENEDIOXYBENZO[I]PHENANTHRIDINE; 12 (N,N DIMETHYLAMINOCARBONYL) 2,3 DIMETHOXY 8,9 METHYLENEDIOXYBENZO[I]PHENANTHRIDINE; 12 DIMETHYLAMINOMETHYL 2,3 DIMETHOXY 8,9 METHYLENEDIOXYBENZO[I]PHENANTHRIDINE; 12 FORMYL 2,3 DIMETHOXY 8,9 METHYLENEDIOXYBENZO[I]PHENANTHRIDINE; 12 HYDROXYMETHYL 2,3 DIMETHOXY 8,9 METHYLENEDIOXYBENZO[I]PHENANTHRIDINE; ANTINEOPLASTIC AGENT; DNA TOPOISOMERASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG SYNTHESIS; DRUG TARGETING; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; TUMOR GROWTH;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DNA TOPOISOMERASES, TYPE I, EUKARYOTIC; HUMANS; PHENANTHRIDINES;

EID: 62949117616     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.02.023     Document Type: Article

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