Design, synthesis, and evaluation of dibenzo[ c,h ][1,6]naphthyridines as topoisomerase i inhibitors and potential anticancer agents

Journal of Medicinal Chemistry

Volumn 53, Issue 24, 2010, Pages 8716-8726

  Kiselev, Evgeny ^a   Dexheimer, Thomas S ^b   Pommier, Yves ^b   Cushman, Mark ^a  

^a PURDUE UNIVERSITY   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; DIBENZO[C,H][1,6]NAPHTHYRIDINE DERIVATIVE; DNA TOPOISOMERASE INHIBITOR; HETEROCYCLIC COMPOUND; INDENOISOQUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; CYTOTOXICITY; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL;

CELL LINE, TUMOR; DNA CLEAVAGE; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MODELS, MOLECULAR; NAPHTHYRIDINES; STEREOISOMERISM; TOPOISOMERASE I INHIBITORS;

EID: 78650395550     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm101048k     Document Type: Article

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