Ubiquitin/26s proteasome-mediated degradation of topoisomerase I as a resistance mechanism to camptothecin in tumor cells

Cancer Research

Volumn 61, Issue 15, 2001, Pages 5926-5932

  Desai, Shyamal D ^a   Li, Tsai Kun ^a   Rodriguez Bauman, Alexandra ^a   Liu, Leroy F ^a   Rubin, Eric H ^b  

^a RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^b ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CAMPTOTHECIN; PROTEASOME; UBIQUITIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER RESISTANCE; CELL TRANSFORMATION; COLORECTAL CANCER; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; DRUG MECHANISM; ENZYME DEGRADATION; GENETIC HETEROGENEITY; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; BREAST NEOPLASMS; CAMPTOTHECIN; CELL LINE; CHO CELLS; COLONIC NEOPLASMS; CRICETINAE; DNA TOPOISOMERASES, TYPE I; DOWN-REGULATION; DRUG RESISTANCE, NEOPLASM; FIBROBLASTS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; KB CELLS; PEPTIDE HYDROLASES; PROTEASOME ENDOPEPTIDASE COMPLEX; UBIQUITINS;

EID: 0035422206     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. DNA topoisomerase I-targeted chemotherapy of human colon cancer in xenografts
2. Treatment of malignant melanoma with CPT (NSC-100880)
3. DNA topoisomerases: Essential enzymes and lethal targets
4. DNA topoisomerases
5. Identification of mammalian DNA topoisomerase I as an intracellular target of the anticancer drug CPT
6. CPT induces protein-linked DNA breaks via mammalian DNA topoisomerase I
7. Involvement of nucleic acid synthesis in cell killing mechanisms of topoisomerase poisons
8. Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by CPT
9. Topoisomerase I-related parameters and CPT activity in the colon carcinoma cell lines from the National Cancer Institute Anticancer screen
10. Induction of neuronal apoptosis by CPT, an inhibitor of DNA topoisomerase-I: Evidence for cell cycle-independent toxicity
11. Complex response of breast epithelial cell lines to topoisomerase inhibitors
12. Tumor cell death induced by topoisomerase-targeting drugs
13. SUMO-1 conjugation to human DNA topoisomerase II isozymes
14. SUMO-1 conjugation to topoisomerase I: A possible repair response to topoisomerase-mediated DNA damage
15. Ubiquitin-dependent destruction of topoisomerase I is stimulated by the antitumor drug CPT
16. CPT induction of a time- and concentration-dependent decrease of topoisomerase 1 and its implication in CPT activity
17. Effect of prolonged topotecan infusion on topoisomerase 1 levels: A phase I and pharmacodynamic study
18. Trials of 9-amino-20(S)-camptothecin in Boston
19. A phase I and pharmacokinetic study of a new camptothecin derivative, 9-amino-camptothecin
20. CPT resistance related to drug-induced down-regulation of topoisomerase I and to steps occurring after the formation of protein- linked DNA breaks
21. Mechanism of resistance of camptothecins
22. Plasmid linking number change induced by topoisomerase I-mediated DNA damage
23. SUMO, ubiquitin's mysterious cousin
24. SUMO-1: Wrestling with a new ubiquitin-related modifier
25. Yeast gene for a Tyr-DNA phosphodiesterase that repairs topoisomerase I complexes