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Volumn 50, Issue 5, 1996, Pages 1095-1102

Mechanisms of cell killing by drugs that trap covalent complexes between DNA topoisomerases and DNA

Author keywords

[No Author keywords available]

Indexed keywords

AMSACRINE; ANTINEOPLASTIC AGENT; CAMPTOTHECIN; DNA TOPOISOMERASE; DNA TOPOISOMERASE (ATP HYDROLYSING); ETOPOSIDE; FUNGAL DNA; GYRASE INHIBITOR; NOCODAZOLE; TENIPOSIDE;

EID: 0029847080     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (133)

References (39)
  • 1
    • 0029144134 scopus 로고
    • Topoisomerase poisons: Harnessing the dark side of enzyme mechanism
    • Froelich-Ammon, S. J., and N. Osheroff. Topoisomerase poisons: harnessing the dark side of enzyme mechanism. J. Biol. Chem. 270:21429-21432 (1995).
    • (1995) J. Biol. Chem. , vol.270 , pp. 21429-21432
    • Froelich-Ammon, S.J.1    Osheroff, N.2
  • 3
    • 0028174984 scopus 로고
    • DNA topoisomerases: Essential enzymes and lethal targets
    • Chen, A. Y., and L. F. Liu. DNA topoisomerases: essential enzymes and lethal targets. Annu. Rev. Pharmacol. Toxicol. 34:191-218 (1994).
    • (1994) Annu. Rev. Pharmacol. Toxicol. , vol.34 , pp. 191-218
    • Chen, A.Y.1    Liu, L.F.2
  • 4
    • 0024278459 scopus 로고
    • Inhibitors of DNA topoisomerases
    • Drlica, K., and R. J. Franco. Inhibitors of DNA topoisomerases. Biochemistry 27:2253-2259 (1988).
    • (1988) Biochemistry , vol.27 , pp. 2253-2259
    • Drlica, K.1    Franco, R.J.2
  • 5
    • 0028719174 scopus 로고
    • DNA topoisomerases as targets of therapeutics: An overview
    • Wang, J. C. DNA topoisomerases as targets of therapeutics: an overview. Adv. Pharmacol 29:1-19 (1994).
    • (1994) Adv. Pharmacol , vol.29 , pp. 1-19
    • Wang, J.C.1
  • 6
    • 0027092752 scopus 로고
    • Camptothecin inhibits both the cleavage and religation reactions of eukaryotic DNA topoisomerase I
    • Kjeldsen, E., J. Q. Svejstrup, I.I. Gromova, J. Alsner, and O. Westergaard. Camptothecin inhibits both the cleavage and religation reactions of eukaryotic DNA topoisomerase I. J. Mol. Biol. 228:1025-1030 (1992).
    • (1992) J. Mol. Biol. , vol.228 , pp. 1025-1030
    • Kjeldsen, E.1    Svejstrup, J.Q.2    Gromova, I.I.3    Alsner, J.4    Westergaard, O.5
  • 7
    • 0025305782 scopus 로고
    • Stabilization of the topoisomerase II-DNA cleavage complex by antineoplastic drugs: Inhibition of enzymemediated DNA religation by 4′-(9-acridinylamino)methanesulfon-manisidide
    • Robinson, M. J., and N. Osheroff. Stabilization of the topoisomerase II-DNA cleavage complex by antineoplastic drugs: inhibition of enzymemediated DNA religation by 4′-(9-acridinylamino)methanesulfon-manisidide. Biochemistry 29:2511-2515 (1990).
    • (1990) Biochemistry , vol.29 , pp. 2511-2515
    • Robinson, M.J.1    Osheroff, N.2
  • 8
    • 0025165637 scopus 로고
    • Saintopin, a new antitumor antibiotic with topoisomerase II dependent DNA cleavage activity, from Paecilomyces
    • Yamashita, Y., Y. Saitoh, K. Ando, K. Takahashi, H. Ohno, and H. Nakano. Saintopin, a new antitumor antibiotic with topoisomerase II dependent DNA cleavage activity, from Paecilomyces [Letter). J. Antibiot. (Tokyo) 43:1344-1346 (1990).
    • (1990) J. Antibiot. (Tokyo) , vol.43 , pp. 1344-1346
    • Yamashita, Y.1    Saitoh, Y.2    Ando, K.3    Takahashi, K.4    Ohno, H.5    Nakano, H.6
  • 10
    • 0029046736 scopus 로고
    • DNA topoisomerase II is the molecular target of bisdioxopiperazine derivatives ICRF-159 and ICRF-193 in Saccharomyces cerevisiae
    • Ishida, R., M. Hamatake, R. A. Wasserman, J. L. Nitiss, J. C. Wang, and T. Andoh. DNA topoisomerase II is the molecular target of bisdioxopiperazine derivatives ICRF-159 and ICRF-193 in Saccharomyces cerevisiae. Cancer Res. 55:2299-2303 (1995).
    • (1995) Cancer Res. , vol.55 , pp. 2299-2303
    • Ishida, R.1    Hamatake, M.2    Wasserman, R.A.3    Nitiss, J.L.4    Wang, J.C.5    Andoh, T.6
  • 12
    • 0028697603 scopus 로고
    • Roles of DNA topoisomerases in chromosomal replication and segregation
    • Nitiss, J. L. Roles of DNA topoisomerases in chromosomal replication and segregation. Adv. Pharmacol. 29:103-134 (1994).
    • (1994) Adv. Pharmacol. , vol.29 , pp. 103-134
    • Nitiss, J.L.1
  • 13
    • 0022588813 scopus 로고
    • Novobiocin precipitates histones at concentrations normally used to inhibit eukaryotic type II topoisomerase
    • Cotten, M., D. Bresnahan, S. Thompson, L. Sealy, and R. Chalkley. Novobiocin precipitates histones at concentrations normally used to inhibit eukaryotic type II topoisomerase. Nucleic Acids Res. 14:3671-3686 (1986).
    • (1986) Nucleic Acids Res. , vol.14 , pp. 3671-3686
    • Cotten, M.1    Bresnahan, D.2    Thompson, S.3    Sealy, L.4    Chalkley, R.5
  • 14
    • 0023002286 scopus 로고
    • Topoisomerase inhibitors can selectively interfere with different stages of simian virus 40 DNA replication
    • Snapka, R. M. Topoisomerase inhibitors can selectively interfere with different stages of simian virus 40 DNA replication. Mol. Cell. Biol. 6:4221-4227 (1986).
    • (1986) Mol. Cell. Biol. , vol.6 , pp. 4221-4227
    • Snapka, R.M.1
  • 15
    • 0025133118 scopus 로고
    • Involvement of nucleic acid synthesis in cell killing mechanisms of topoisomerase poisons
    • D'Arpa, P., C. Beardmore, and L. F. Liu. Involvement of nucleic acid synthesis in cell killing mechanisms of topoisomerase poisons. Cancer Res. 60:6919-6924 (1990).
    • (1990) Cancer Res. , vol.60 , pp. 6919-6924
    • D'Arpa, P.1    Beardmore, C.2    Liu, L.F.3
  • 16
    • 0023807621 scopus 로고
    • Camptothecin, a specific inhibitor of type I DNA topoisomerase, induces DNA breakage at replication forks
    • Avemann, K., R. Knippers, T. Koller, and J. M. Sogo. Camptothecin, a specific inhibitor of type I DNA topoisomerase, induces DNA breakage at replication forks. Mol. Cell. Biol. 8:3026-3034 (1988).
    • (1988) Mol. Cell. Biol. , vol.8 , pp. 3026-3034
    • Avemann, K.1    Knippers, R.2    Koller, T.3    Sogo, J.M.4
  • 17
    • 0024420685 scopus 로고
    • Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin
    • Hsiang, Y. H., M. G. Lihou, and L. F. Liu. Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin. Cancer Res. 49:5077-5082 (1989).
    • (1989) Cancer Res. , vol.49 , pp. 5077-5082
    • Hsiang, Y.H.1    Lihou, M.G.2    Liu, L.F.3
  • 18
    • 0024316466 scopus 로고
    • DNA topoisomerase poisons as antitumor drugs
    • Liu, L. F. DNA topoisomerase poisons as antitumor drugs. Annu. Rev. Biochem. 58:351-375 (1989).
    • (1989) Annu. Rev. Biochem. , vol.58 , pp. 351-375
    • Liu, L.F.1
  • 19
    • 0028308298 scopus 로고
    • Caffeine attenuates the action of amsacrine and etoposide in U-937 cells by mechanisms which involve inhibition of RNA synthesis
    • Perez, C., F. Pelayo, N. E. Vilaboa, and P. Aller. Caffeine attenuates the action of amsacrine and etoposide in U-937 cells by mechanisms which involve inhibition of RNA synthesis. Int. J. Cancer 57:889-893 (1994).
    • (1994) Int. J. Cancer , vol.57 , pp. 889-893
    • Perez, C.1    Pelayo, F.2    Vilaboa, N.E.3    Aller, P.4
  • 20
    • 0023836968 scopus 로고
    • Sister chromatid exchanges, chromosomal aberrations, and cytotoxicity produced by antitumor topoisomerase II inhibitors in sensitive (DC3F) and resistant (DC3F/9-OHE) Chinese hamster cells
    • Pommier, Y., D. Kerrigan, J. M. Covey, C. S. Kao-Shan, and J. Whang-Peng. Sister chromatid exchanges, chromosomal aberrations, and cytotoxicity produced by antitumor topoisomerase II inhibitors in sensitive (DC3F) and resistant (DC3F/9-OHE) Chinese hamster cells. Cancer Res. 48:512-516 (1988).
    • (1988) Cancer Res. , vol.48 , pp. 512-516
    • Pommier, Y.1    Kerrigan, D.2    Covey, J.M.3    Kao-Shan, C.S.4    Whang-Peng, J.5
  • 22
    • 0000536643 scopus 로고
    • DNA topoisomerase-targeting antitumor drugs can be studied in yeast
    • Nitiss, J., and J. C. Wang. DNA topoisomerase-targeting antitumor drugs can be studied in yeast. Proc. Natl. Acad. Sci. USA 85:7501-7505 (1988).
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 7501-7505
    • Nitiss, J.1    Wang, J.C.2
  • 23
    • 0026794617 scopus 로고
    • Amsacrine and etoposide hypersensitivity of yeast cells overexpressing DNA topoisomerase II
    • Nitiss, J. L., Y. X. Liu, P. Harbury, M. Jannatipour, R. Wasserman, and J. C. Wang. Amsacrine and etoposide hypersensitivity of yeast cells overexpressing DNA topoisomerase II. Cancer Res. 52:4467-4472 (1992).
    • (1992) Cancer Res. , vol.52 , pp. 4467-4472
    • Nitiss, J.L.1    Liu, Y.X.2    Harbury, P.3    Jannatipour, M.4    Wasserman, R.5    Wang, J.C.6
  • 24
    • 0024519424 scopus 로고
    • Inducible overexpression, purification, and active site mapping of DNA topoisomerase II from the yeast Saccharomyces cerevisiae
    • Worland, S. T., and J. C. Wang. Inducible overexpression, purification, and active site mapping of DNA topoisomerase II from the yeast Saccharomyces cerevisiae. J. Biol. Chem. 264:4412-4416 (1989).
    • (1989) J. Biol. Chem. , vol.264 , pp. 4412-4416
    • Worland, S.T.1    Wang, J.C.2
  • 25
    • 0019321213 scopus 로고
    • Decatenation of kinetoplast DNA by topoisomerases
    • Marini, J. C., K. G. Miller, and P. T. England. Decatenation of kinetoplast DNA by topoisomerases. J. Biol. Chem. 255:4976-4979 (1980).
    • (1980) J. Biol. Chem. , vol.255 , pp. 4976-4979
    • Marini, J.C.1    Miller, K.G.2    England, P.T.3
  • 26
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford, M. M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:248-254 (1976).
    • (1976) Anal. Biochem. , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 27
    • 0024229066 scopus 로고
    • Evidence that DNA topoisomerase I is necessary for the cytotoxic effects of camptothecin
    • Eng, W. K., L. Faucette, R. K. Johnson, and R. Sternglanz. Evidence that DNA topoisomerase I is necessary for the cytotoxic effects of camptothecin. Mol. Pharmacol. 34:755-760 (1988).
    • (1988) Mol. Pharmacol. , vol.34 , pp. 755-760
    • Eng, W.K.1    Faucette, L.2    Johnson, R.K.3    Sternglanz, R.4
  • 28
    • 0022342251 scopus 로고
    • Cloning of yeast TOP1, the gene encoding DNA topoisomerase I, and construction of mutants defective in both DNA topoisomerase I and DNA topoisomerase II
    • Goto, T., and J. C. Wang. Cloning of yeast TOP1, the gene encoding DNA topoisomerase I, and construction of mutants defective in both DNA topoisomerase I and DNA topoisomerase II. Proc. Natl. Acad. Sci. USA 82: 7178-7182 (1985).
    • (1985) Proc. Natl. Acad. Sci. USA , vol.82 , pp. 7178-7182
    • Goto, T.1    Wang, J.C.2
  • 29
    • 0025893984 scopus 로고
    • Antagonism between camptothecin and topoisomerase II-directed chemotherapeutic agents in a human leukemia cell line
    • Kaufmann, S. H. Antagonism between camptothecin and topoisomerase II-directed chemotherapeutic agents in a human leukemia cell line. Cancer Res. 61:1129-1136 (1991).
    • (1991) Cancer Res. , vol.61 , pp. 1129-1136
    • Kaufmann, S.H.1
  • 30
    • 0028068128 scopus 로고
    • Synergistic effect of inhibitors of topoisomerase I and II on chromosome damage and cell killing in cultured Chinese hamster ovary cells
    • Cortes, F., and J. Pinero. Synergistic effect of inhibitors of topoisomerase I and II on chromosome damage and cell killing in cultured Chinese hamster ovary cells. Cancer Chemother. Pharmacol. 34:411-415 (1994).
    • (1994) Cancer Chemother. Pharmacol. , vol.34 , pp. 411-415
    • Cortes, F.1    Pinero, J.2
  • 31
    • 0001855848 scopus 로고
    • Yeast as a genetic system in the dissection of the mechanism of cell killing by topoisomerase-targeting anti-cancer drugs
    • (M. Potmesil and K. Kohn, eds.). Oxford University Press, London
    • Nitiss, J. L., and J. C. Wang. Yeast as a genetic system in the dissection of the mechanism of cell killing by topoisomerase-targeting anti-cancer drugs, in DNA Tapoisomerases and Cancer (M. Potmesil and K. Kohn, eds.). Oxford University Press, London, 77-91 (1991).
    • (1991) DNA Tapoisomerases and Cancer , pp. 77-91
    • Nitiss, J.L.1    Wang, J.C.2
  • 33
    • 0015937440 scopus 로고
    • Effects of camptothecin on RNA synthesis in L-1210 cells
    • Kessel, D., and R. Dysard. Effects of camptothecin on RNA synthesis in L-1210 cells. Biochim. Biophys. Acta 312:716-721 (1973).
    • (1973) Biochim. Biophys. Acta , vol.312 , pp. 716-721
    • Kessel, D.1    Dysard, R.2
  • 34
  • 35
    • 0025941728 scopus 로고
    • Etoposide (VP-16-213)-induced gene alterations: Potential contribution to cell death
    • Berger, N. A., S. Chatterjee, J. A. Schmotzer, and S. R. Helms. Etoposide (VP-16-213)-induced gene alterations: potential contribution to cell death. Proc. Natl. Acad. Sci. USA 88:8740-8743 (1991).
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 8740-8743
    • Berger, N.A.1    Chatterjee, S.2    Schmotzer, J.A.3    Helms, S.R.4
  • 37
    • 0028341243 scopus 로고
    • Yeast topoisomerase II mutants resistant to anti-topoisomerase agents: Identification and characterization of new yeast topoisomerase II mutants selected for resistance to etoposide
    • Liu, Y. X., Y. Hsiung, M. Jannatipour, Y. Yeh, and J. L. Nitiss. Yeast topoisomerase II mutants resistant to anti-topoisomerase agents: identification and characterization of new yeast topoisomerase II mutants selected for resistance to etoposide. Cancer Res. 54:2943-2951 (1994).
    • (1994) Cancer Res. , vol.54 , pp. 2943-2951
    • Liu, Y.X.1    Hsiung, Y.2    Jannatipour, M.3    Yeh, Y.4    Nitiss, J.L.5
  • 38
    • 0027402476 scopus 로고
    • A temperature sensitive topoisomerase II allele confers temperature dependent drug resistance on amsacrine and etoposide: A genetic system for determining the targets of topoisomerase II inhibitors
    • Nitiss, J. L., Y. X. Liu, and Y. Hsiung. A temperature sensitive topoisomerase II allele confers temperature dependent drug resistance on amsacrine and etoposide: a genetic system for determining the targets of topoisomerase II inhibitors. Cancer Res. 53:89-93 (1993).
    • (1993) Cancer Res. , vol.53 , pp. 89-93
    • Nitiss, J.L.1    Liu, Y.X.2    Hsiung, Y.3
  • 39
    • 0009543358 scopus 로고
    • Isolation of type I and II DNA topoisomerase mutants from fission yeast: Single and double mutants show different phenotypes in cell growth and chromatin organization
    • Uemura, T., and M. Yanagida. Isolation of type I and II DNA topoisomerase mutants from fission yeast: single and double mutants show different phenotypes in cell growth and chromatin organization. EMBO J. 3:1737-1744 (1984).
    • (1984) EMBO J. , vol.3 , pp. 1737-1744
    • Uemura, T.1    Yanagida, M.2


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