Esters and amides of 2,3-dimethoxy-8,9-methylenedioxy-benzo[i] phenanthridine-12-carboxylic acid: Potent cytotoxic and topoisomerase I-targeting agents

Bioorganic and Medicinal Chemistry

Volumn 13, Issue 24, 2005, Pages 6782-6794

  Zhu, Shejin ^a   Ruchelman, Alexander L ^a   Zhou, Nai ^b   Liu, Angela A ^b   Liu, Leroy F ^b,c   LaVoie, Edmond J ^a,c  

^a RUTGERS UNIVERSITY   (United States)

^b RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^c RUTGERS CANCER INSTITUTE OF NEW JERSEY   (United States)

Author keywords

Antitumor; Benzo i phenanthridine; Cytotoxic; Topoisomerase I

Indexed keywords

2,3 DIMETHOXY 8,9 METHYLENEDIOXYBENZO[I]PHENANTHRIDINE 12 CARBOXYLIC ACID 2 (4 METHYLPIPERAZIN 1 YL)ETHYLAMIDE; 2,3 DIMETHOXY 8,9 METHYLENEDIOXYBENZO[I]PHENANTHRIDINE 12 CARBOXYLIC ACID 2 (N,N DIETHYLAMINO)ETHYLAMIDE; 2,3 DIMETHOXY 8,9 METHYLENEDIOXYBENZO[I]PHENANTHRIDINE 12 CARBOXYLIC ACID 2 (N,N DIMETHYLAMINO) 1 METHYLETHYL ESTER; 2,3 DIMETHOXY 8,9 METHYLENEDIOXYBENZO[I]PHENANTHRIDINE 12 CARBOXYLIC ACID 2 (N,N DIMETHYLAMINO) 1 METHYLETHYLAMIDE; 2,3 DIMETHOXY 8,9 METHYLENEDIOXYBENZO[I]PHENANTHRIDINE 12 CARBOXYLIC ACID 2 (N,N DIMETHYLAMINO) 1,1 METHYLETHYL ESTER; 2,3 DIMETHOXY 8,9 METHYLENEDIOXYBENZO[I]PHENANTHRIDINE 12 CARBOXYLIC ACID 2 (N,N DIMETHYLAMINO)ETHYL ESTER; 2,3 DIMETHOXY 8,9 METHYLENEDIOXYBENZO[I]PHENANTHRIDINE 12 CARBOXYLIC ACID 2 (N,N DIMETHYLAMINO)ETHYLAMIDE; 2,3 DIMETHOXY 8,9 METHYLENEDIOXYBENZO[I]PHENANTHRIDINE 12 CARBOXYLIC ACID 2 (N,N DIMETHYLAMINO)PROPYLAMIDE; 2,3 DIMETHOXY 8,9 METHYLENEDIOXYBENZO[I]PHENANTHRIDINE 12 CARBOXYLIC ACID 2 (PIPERIDIN 1 YL)ETHYLAMIDE; 2,3 DIMETHOXY 8,9 METHYLENEDIOXYBENZO[I]PHENANTHRIDINE 12 CARBOXYLIC ACID 2 (PYRROLIDIN 1 YL)ETHYLAMIDE; 2,3 DIMETHOXY 8,9 METHYLENEDIOXYBENZO[I]PHENANTHRIDINE 12 CARBOXYLIC ACID 3 (DIMETHYLAMINO)PROPYLAMIDE; 2,3 DIMETHOXY 8,9 METHYLENEDIOXYBENZO[I]PHENANTHRIDINE 12 CARBOXYLIC ACID 3 (N,N DIMETHYLAMINO)PROPYL ESTER; 2,3 DIMETHOXY 8,9 METHYLENEDIOXYBENZO[I]PHENANTHRIDINE 12 CARBOXYLIC ACID ETHYL ESTER; 2,3 DIMETHOXY 8,9 METHYLENEDIOXYBENZO[I]PHENANTHRIDINE 12 CARBOXYLIC ACID N METHYL N [2 (N,N DIMETHYLAMINO)ETHYL]AMIDE; 2,3 DIMETHOXY 8,9 METHYLENEDIOXYBENZO[I]PHENANTHRIDINE 12 CARBOXYLIC ACID N,N BIS[2 (N,N DIMETHYLAMINO)ETHYL]AMIDE; 2,3 DIMETHOXY 8,9 METHYLENEDIOXYBENZO[I]PHENANTHRIDINE 12 CARBOXYLIX ACID 2 (N BENZYL N METHYLAMINO)ETHYLAMIDE; 2,3 DIMETHOXY 8,9 METHYLENEDIOXYBENZO[I]PHENANTHRIDINE 12 CARBOXYLIX ACID 2 (N,N DIBENZYL)ETHYLAMIDE; AMIDE; ARC 111; CYTOTOXIC AGENT; DNA TOPOISOMERASE INHIBITOR; ESTER DERIVATIVE; TOPOTECAN; TOPOVALE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL LINE; CONTROLLED STUDY; CYTOTOXICITY; DRUG POTENCY; HUMAN; HUMAN CELL; IC 50; MOUSE; NONHUMAN;

AMIDES; CAMPTOTHECIN; CELL LINE; CELL SURVIVAL; DNA; DNA TOPOISOMERASES, TYPE I; ENZYME INHIBITORS; ESTERS; HUMANS; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; TOPOTECAN;

ANIMALIA;

EID: 27644546583     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.07.033     Document Type: Article

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