Trifluoromethyl-promoted homocamptothecins: Synthesis and biological activity

European Journal of Medicinal Chemistry

Volumn 45, Issue 7, 2010, Pages 2726-2732

  Zhu, Lingjian ^a   Miao, Zhenyuan ^a   Sheng, Chunquan ^a   Guo, Wei ^a   Yao, Jianzhong ^a   Liu, Wenfeng ^a   Che, Xiaoying ^a   Wang, Wenya ^a   Cheng, Pengfei ^a   Zhang, Wannian ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Biological activity; Camptothecin; Homocamptothecin; Synthesis; Trifluoromethyl group

Indexed keywords

1 (2 AMINO 5 (TRIFLUOROMETHYL)PHENYL)ETHANONE; 1 (2 AMINO 5 BROMOPHENYL) 2, 2, 2 TRIFLUOROETHANONE; 1 (2 AMINO 5 BROMOPHENYL)ETHANONE; 1 (2 AMINO 5 CHLOROPHENYL) 2, 2, 2 TRIFLUOROETHANONE; 1 (2 AMINO 5 HYDROXYPHENYL) 2, 2, 2 TRIFLUOROETHANONE; 1 (2 AMINO 5 HYDROXYPHENYL)ETHANONE; 1 (2 AMINO 5 METHOXYPHENYL) 2, 2, 2 TRIFLUOROETHANONE; 1 (2 AMINO 5 METHOXYPHENYL)ETHANONE; 1 (2 AMINO 5 TRIFLUOROMETHYLPHENYL) 2, 2, 2 TRIFLUOROETHANONE; 1 (2 AMINO 6 METHOXYPHENYL) 2, 2, 2 TRIFLUOROETHANONE; 1 (2 AMINO 6 METHOXYPHENYL)ETHANONE; 1 (2 AMINOPHENYL) 2, 2, 2 TRIFLUOROETHANONE; 1 (2 AMINOPHENYL)ETHANONE; 10 BROMO 7 METHYLHOMOCAMPTOTHECIN; 10 BROMO 7 TRIFLUOROMETHYLHOMOCAMPTOTHECIN; 10 CHLORO 7 TRIFLUOROMETHYLHOMOCAMPTOTHECIN; 10 HYDROXY 7 METHYLHOMOCAMPTOTHECIN; 10 HYDROXY 7 TRIFLUOROMETHYLHOMOCAMPTOTHECIN; 10 METHOXY 7 METHYLHOMOCAMPTOTHECIN; 10 METHOXY 7 TRIFLUOROMETHYLHOMOCAMPTOTHECIN; 10 TRIFLUOROMETHYL 7 METHYLHOMOCAMPTOTHECIN; 10 TRIFLUOROMETHYL 7 TRIFLUOROMETHYLHOMOCAMPTOTHECIN; 7 TRIFLUOROMETHYLHOMOCAMPTOTHECIN; 9 METHOXY 7 METHYLHOMOCAMPTOTHECIN; 9 METHOXY 7 TRIFLUOROMETHYLHOMOCAMPTOTHECIN; ANTINEOPLASTIC AGENT; CAMPTOTHECIN DERIVATIVE; DNA TOPOISOMERASE INHIBITOR; FLUORINE DERIVATIVE; TOPOTECAN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOLOGICAL ACTIVITY; CANCER CELL CULTURE; CYTOTOXICITY; DNA CLEAVAGE; DRUG METABOLISM; DRUG STRUCTURE; DRUG SYNTHESIS; IN VITRO STUDY; IN VIVO STUDY; LUNG CANCER; MOUSE; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTINEOPLASTIC AGENTS; CAMPTOTHECIN; CELL LINE, TUMOR; DNA; DNA TOPOISOMERASES, TYPE I; HALOGENATION; HUMANS; MALE; MICE;

EID: 77954348852     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.02.051     Document Type: Article

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