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Volumn 47, Issue 2, 2014, Pages 163-173

Inhibition of the Interleukin-6 Signaling Pathway: A Strategy to Induce Immune Tolerance

Author keywords

Autoimmune diseases; Immune tolerance; Inhibition; Interleukin 6; Signaling pathway; Th17; Transplantation rejection; Treg

Indexed keywords

IL6 PROTEIN, HUMAN; IMMUNOLOGIC FACTOR; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; MONOCLONAL ANTIBODY;

EID: 84896417933     PISSN: 10800549     EISSN: 15590267     Source Type: Journal    
DOI: 10.1007/s12016-014-8413-3     Document Type: Review
Times cited : (26)

References (173)
  • 1
    • 0022499547 scopus 로고
    • Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin
    • PID: 3491322, COI: 1:CAS:528:DyaL2sXnvFGjuw%3D%3D
    • Hirano T, Yasukawa K, Harada H et al (1986) Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin. Nature 324(6092):73–76
    • (1986) Nature , vol.324 , Issue.6092 , pp. 73-76
    • Hirano, T.1    Yasukawa, K.2    Harada, H.3
  • 2
    • 79957673711 scopus 로고    scopus 로고
    • IL-6 signaling in autoimmunity, chronic inflammation and inflammation-associated cancer
    • PID: 21377916, COI: 1:CAS:528:DC%2BC3MXntV2ltbk%3D
    • Neurath MF, Finotto S (2011) IL-6 signaling in autoimmunity, chronic inflammation and inflammation-associated cancer. Cytokine Growth Factor Rev 22(2):83–89
    • (2011) Cytokine Growth Factor Rev , vol.22 , Issue.2 , pp. 83-89
    • Neurath, M.F.1    Finotto, S.2
  • 3
    • 42649129014 scopus 로고    scopus 로고
    • Systematic review of the association between circulating interleukin-6 (IL-6) and cancer
    • PID: 18387296, COI: 1:CAS:528:DC%2BD1cXlslWltrY%3D
    • Heikkila K, Ebrahim S, Lawlor DA (2008) Systematic review of the association between circulating interleukin-6 (IL-6) and cancer. Eur J Cancer 44(7):937–945
    • (2008) Eur J Cancer , vol.44 , Issue.7 , pp. 937-945
    • Heikkila, K.1    Ebrahim, S.2    Lawlor, D.A.3
  • 4
    • 77954096689 scopus 로고    scopus 로고
    • IL-6: regulator of Treg/Th17 balance
    • PID: 20583029, COI: 1:CAS:528:DC%2BC3cXotVOkurc%3D
    • Kimura A, Kishimoto T (2010) IL-6: regulator of Treg/Th17 balance. Eur J Immunol 40(7):1830–1835
    • (2010) Eur J Immunol , vol.40 , Issue.7 , pp. 1830-1835
    • Kimura, A.1    Kishimoto, T.2
  • 5
    • 84873171130 scopus 로고    scopus 로고
    • Therapeutic implications of tocilizumab, a humanized anti-interleukin-6 receptor antibody, for various immune-mediated diseases: an update review
    • Toshio T, Atsushi O, Yoshihito S, Masashi N, Atsushi K, Tadamitsu K (2012) Therapeutic implications of tocilizumab, a humanized anti-interleukin-6 receptor antibody, for various immune-mediated diseases: an update review. Curr Rheumatol Rev 8(3):209–226
    • (2012) Curr Rheumatol Rev , vol.8 , Issue.3 , pp. 209-226
    • Toshio, T.1    Atsushi, O.2    Yoshihito, S.3    Masashi, N.4    Atsushi, K.5    Tadamitsu, K.6
  • 6
    • 84925549112 scopus 로고    scopus 로고
    • The paradigm of IL-6: from basic science to medicine
    • PID: 12110143
    • Naka T, Nishimoto N, Kishimoto T (2002) The paradigm of IL-6: from basic science to medicine. Arthritis Res 4(Suppl 3):S233–S242
    • (2002) Arthritis Res , vol.4 , pp. S233-S242
    • Naka, T.1    Nishimoto, N.2    Kishimoto, T.3
  • 7
    • 33748117796 scopus 로고    scopus 로고
    • Interleukin-6: discovery of a pleiotropic cytokine
    • PID: 16899106
    • Kishimoto T (2006) Interleukin-6: discovery of a pleiotropic cytokine. Arthritis Res Ther 8(Suppl 2):S2
    • (2006) Arthritis Res Ther , vol.8 , pp. S2
    • Kishimoto, T.1
  • 8
    • 0029559254 scopus 로고
    • Interleukins and colony stimulating factors in human myeloid leukemia cell lines
    • PID: 8750618, COI: 1:STN:280:DyaK28zltF2lsQ%3D%3D
    • Hassan HT, Drexler HG (1995) Interleukins and colony stimulating factors in human myeloid leukemia cell lines. Leuk Lymphoma 20(1–2):1–15
    • (1995) Leuk Lymphoma , vol.20 , Issue.1-2 , pp. 1-15
    • Hassan, H.T.1    Drexler, H.G.2
  • 9
    • 0037064543 scopus 로고    scopus 로고
    • Ex vivo expansion of hematopoietic stem cells by cytokines
    • PID: 12421675, COI: 1:CAS:528:DC%2BD38Xotl2nsrk%3D
    • Heike T, Nakahata T (2002) Ex vivo expansion of hematopoietic stem cells by cytokines. Biochim Biophys Acta 1592(3):313–321
    • (2002) Biochim Biophys Acta , vol.1592 , Issue.3 , pp. 313-321
    • Heike, T.1    Nakahata, T.2
  • 10
    • 79952281184 scopus 로고    scopus 로고
    • Angiogenesis and immunity: a bidirectional link potentially relevant for the monitoring of antiangiogenic therapy and the development of novel therapeutic combination with immunotherapy
    • PID: 21249423, COI: 1:CAS:528:DC%2BC3MXitlKltL8%3D
    • Tartour E, Pere H, Maillere B et al (2011) Angiogenesis and immunity: a bidirectional link potentially relevant for the monitoring of antiangiogenic therapy and the development of novel therapeutic combination with immunotherapy. Cancer Metastasis Rev 30(1):83–95
    • (2011) Cancer Metastasis Rev , vol.30 , Issue.1 , pp. 83-95
    • Tartour, E.1    Pere, H.2    Maillere, B.3
  • 11
    • 60949088752 scopus 로고    scopus 로고
    • Cytokine and cytokine receptor gene polymorphisms and their functionality
    • PID: 19038572, COI: 1:CAS:528:DC%2BD1MXivVers7s%3D
    • Smith AJ, Humphries SE (2009) Cytokine and cytokine receptor gene polymorphisms and their functionality. Cytokine Growth Factor Rev 20(1):43–59
    • (2009) Cytokine Growth Factor Rev , vol.20 , Issue.1 , pp. 43-59
    • Smith, A.J.1    Humphries, S.E.2
  • 12
    • 84861697180 scopus 로고    scopus 로고
    • Plasticity and cross-talk of interleukin 6-type cytokines
    • PID: 22595692, COI: 1:CAS:528:DC%2BC38XntFaitrk%3D
    • Garbers C, Hermanns HM, Schaper F et al (2012) Plasticity and cross-talk of interleukin 6-type cytokines. Cytokine Growth Factor Rev 23(3):85–97
    • (2012) Cytokine Growth Factor Rev , vol.23 , Issue.3 , pp. 85-97
    • Garbers, C.1    Hermanns, H.M.2    Schaper, F.3
  • 13
    • 79955470407 scopus 로고    scopus 로고
    • The soluble interleukin 6 receptor: generation and role in inflammation and cancer
    • PID: 21145125, COI: 1:CAS:528:DC%2BC3MXlsVyhu7s%3D
    • Chalaris A, Garbers C, Rabe B, Rose-John S, Scheller J (2011) The soluble interleukin 6 receptor: generation and role in inflammation and cancer. Eur J Cell Biol 90(6):484–494
    • (2011) Eur J Cell Biol , vol.90 , Issue.6 , pp. 484-494
    • Chalaris, A.1    Garbers, C.2    Rabe, B.3    Rose-John, S.4    Scheller, J.5
  • 14
    • 33748848714 scopus 로고    scopus 로고
    • Interleukin-6 biology is coordinated by membrane-bound and soluble receptors: role in inflammation and cancer
    • PID: 16707558, COI: 1:CAS:528:DC%2BD28Xot1Ons7c%3D
    • Rose-John S, Scheller J, Elson G, Jones SA (2006) Interleukin-6 biology is coordinated by membrane-bound and soluble receptors: role in inflammation and cancer. J Leukoc Biol 80(2):227–236
    • (2006) J Leukoc Biol , vol.80 , Issue.2 , pp. 227-236
    • Rose-John, S.1    Scheller, J.2    Elson, G.3    Jones, S.A.4
  • 15
    • 84875402648 scopus 로고    scopus 로고
    • Inhibition of the IL-6 signaling pathway: a strategy to combat chronic inflammatory diseases and cancer
    • PID: 23107589, COI: 1:CAS:528:DC%2BC38XhsF2hsL%2FE
    • Ataie-Kachoie P, Pourgholami MH, Morris DL (2013) Inhibition of the IL-6 signaling pathway: a strategy to combat chronic inflammatory diseases and cancer. Cytokine Growth Factor Rev 24(2):163–173
    • (2013) Cytokine Growth Factor Rev , vol.24 , Issue.2 , pp. 163-173
    • Ataie-Kachoie, P.1    Pourgholami, M.H.2    Morris, D.L.3
  • 16
    • 0041677606 scopus 로고    scopus 로고
    • Principles of interleukin (IL)-6-type cytokine signalling and its regulation
    • PID: 12773095, COI: 1:CAS:528:DC%2BD3sXmtF2hurs%3D
    • Heinrich PC, Behrmann I, Haan S, Hermanns HM, Muller-Newen G, Schaper F (2003) Principles of interleukin (IL)-6-type cytokine signalling and its regulation. Biochem J 374(Pt. 1):1–20
    • (2003) Biochem J , vol.374 , pp. 1-20
    • Heinrich, P.C.1    Behrmann, I.2    Haan, S.3    Hermanns, H.M.4    Muller-Newen, G.5    Schaper, F.6
  • 17
    • 0027499295 scopus 로고
    • Phosphorylation at threonine-235 by a ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL6
    • PID: 8384717, COI: 1:CAS:528:DyaK3sXitVKrtrY%3D
    • Nakajima T, Kinoshita S, Sasagawa T et al (1993) Phosphorylation at threonine-235 by a ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL6. Proc Natl Acad Sci U S A 90(6):2207–2211
    • (1993) Proc Natl Acad Sci U S A , vol.90 , Issue.6 , pp. 2207-2211
    • Nakajima, T.1    Kinoshita, S.2    Sasagawa, T.3
  • 18
    • 32044466838 scopus 로고    scopus 로고
    • Exploiting the PI3K/AKT pathway for cancer drug discovery
    • PID: 16341064, COI: 1:CAS:528:DC%2BD2MXht1yktbjI
    • Hennessy BT, Smith DL, Ram PT, Lu Y, Mills GB (2005) Exploiting the PI3K/AKT pathway for cancer drug discovery. Nat Rev Drug Discov 4(12):988–1004
    • (2005) Nat Rev Drug Discov , vol.4 , Issue.12 , pp. 988-1004
    • Hennessy, B.T.1    Smith, D.L.2    Ram, P.T.3    Lu, Y.4    Mills, G.B.5
  • 19
    • 77952668738 scopus 로고    scopus 로고
    • Naphtho[1,2-b] furan-4,5-dione induces apoptosis of oral squamous cell carcinoma: involvement of EGF receptor/PI3K/Akt signaling pathway
    • PID: 20371243, COI: 1:CAS:528:DC%2BC3cXlvVejsro%3D
    • Chien CM, Lin KL, Su JC et al (2010) Naphtho[1,2-b] furan-4,5-dione induces apoptosis of oral squamous cell carcinoma: involvement of EGF receptor/PI3K/Akt signaling pathway. Eur J Pharmacol 636(1–3):52–58
    • (2010) Eur J Pharmacol , vol.636 , Issue.1-3 , pp. 52-58
    • Chien, C.M.1    Lin, K.L.2    Su, J.C.3
  • 20
    • 33646577466 scopus 로고    scopus 로고
    • Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
    • PID: 16648838, COI: 1:CAS:528:DC%2BD28XksVGns7g%3D
    • Bettelli E, Carrier Y, Gao W et al (2006) Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 441(7090):235–238
    • (2006) Nature , vol.441 , Issue.7090 , pp. 235-238
    • Bettelli, E.1    Carrier, Y.2    Gao, W.3
  • 21
    • 33646560950 scopus 로고    scopus 로고
    • Transforming growth factor-beta induces development of the T(H)17 lineage
    • PID: 16648837, COI: 1:CAS:528:DC%2BD28XksVGns7k%3D
    • Mangan PR, Harrington LE, O’Quinn DB et al (2006) Transforming growth factor-beta induces development of the T(H)17 lineage. Nature 441(7090):231–234
    • (2006) Nature , vol.441 , Issue.7090 , pp. 231-234
    • Mangan, P.R.1    Harrington, L.E.2    O’Quinn, D.B.3
  • 22
    • 33748588423 scopus 로고    scopus 로고
    • + T helper cells
    • PID: 16990136, COI: 1:CAS:528:DC%2BD28XhtVCnsrrE
    • + T helper cells. Cell 126(6):1121–1133
    • (2006) Cell , vol.126 , Issue.6 , pp. 1121-1133
    • Ivanov, I.I.1    McKenzie, B.S.2    Zhou, L.3
  • 23
    • 37849048599 scopus 로고    scopus 로고
    • T helper 17 lineage differentiation is programmed by orphan nuclear receptors RORa and RORg
    • PID: 18164222, COI: 1:CAS:528:DC%2BD1cXht1Ontrs%3D
    • Yang XO, Pappu BP, Nurieva R et al (2008) T helper 17 lineage differentiation is programmed by orphan nuclear receptors RORa and RORg. Immunity 28(1):29–39
    • (2008) Immunity , vol.28 , Issue.1 , pp. 29-39
    • Yang, X.O.1    Pappu, B.P.2    Nurieva, R.3
  • 24
    • 66949157620 scopus 로고    scopus 로고
    • IL-27 blocks RORc expression to inhibit lineage commitment of Th17 cells
    • PID: 19380822, COI: 1:CAS:528:DC%2BD1MXkslKhsLg%3D
    • Diveu C, McGeachy MJ, Boniface K et al (2009) IL-27 blocks RORc expression to inhibit lineage commitment of Th17 cells. J Immunol 182(9):5748–5756
    • (2009) J Immunol , vol.182 , Issue.9 , pp. 5748-5756
    • Diveu, C.1    McGeachy, M.J.2    Boniface, K.3
  • 25
    • 34247122412 scopus 로고    scopus 로고
    • Stat3 and Stat4 direct development of IL-17-secreting Th cells
    • PID: 17404271, COI: 1:CAS:528:DC%2BD2sXjslWjsLo%3D
    • Mathur AN, Chang HC, Zisoulis DG et al (2007) Stat3 and Stat4 direct development of IL-17-secreting Th cells. J Immunol 178(8):4901–4907
    • (2007) J Immunol , vol.178 , Issue.8 , pp. 4901-4907
    • Mathur, A.N.1    Chang, H.C.2    Zisoulis, D.G.3
  • 26
    • 34547514211 scopus 로고    scopus 로고
    • IL-6-dependent and -independent pathways in the development of interleukin 17-producing T helper cells
    • PID: 17623780, COI: 1:CAS:528:DC%2BD2sXosVWnsrk%3D
    • Kimura A, Naka T, Kishimoto T (2007) IL-6-dependent and -independent pathways in the development of interleukin 17-producing T helper cells. Proc Natl Acad Sci U S A 104(29):12099–12104
    • (2007) Proc Natl Acad Sci U S A , vol.104 , Issue.29 , pp. 12099-12104
    • Kimura, A.1    Naka, T.2    Kishimoto, T.3
  • 27
    • 43449135305 scopus 로고    scopus 로고
    • TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function
    • PID: 18368049, COI: 1:CAS:528:DC%2BD1cXls12msL4%3D
    • Zhou L, Lopes JE, Chong MM et al (2008) TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function. Nature 453(192):236–240
    • (2008) Nature , vol.453 , Issue.192 , pp. 236-240
    • Zhou, L.1    Lopes, J.E.2    Chong, M.M.3
  • 29
    • 74049164847 scopus 로고    scopus 로고
    • Regulatory T cells exert checks and balances on self tolerance and autoimmunity
    • PID: 20016504, COI: 1:CAS:528:DC%2BD1MXhsFKnsbrO
    • Wing K, Sakaguchi S (2010) Regulatory T cells exert checks and balances on self tolerance and autoimmunity. Nat Immunol 11(1):7–13
    • (2010) Nat Immunol , vol.11 , Issue.1 , pp. 7-13
    • Wing, K.1    Sakaguchi, S.2
  • 30
    • 33746342994 scopus 로고    scopus 로고
    • + natural regulatory T cells in dominant self tolerance and autoimmune disease
    • PID: 16903903, COI: 1:CAS:528:DC%2BD28XpvFegsbY%3D
    • + natural regulatory T cells in dominant self tolerance and autoimmune disease. Immunol Rev 212:8–27
    • (2006) Immunol Rev , vol.212 , pp. 8-27
    • Sakaguchi, S.1    Ono, M.2    Setoguchi, R.3
  • 31
    • 85027958582 scopus 로고    scopus 로고
    • Th17: contributors to allograft rejection and a barrier to the induction of transplantation tolerance
    • PID: 21378605
    • Chadha R, Heidt S, Jones ND, Wood KJ (2011) Th17: contributors to allograft rejection and a barrier to the induction of transplantation tolerance. Transplantation 91(9):939–945
    • (2011) Transplantation , vol.91 , Issue.9 , pp. 939-945
    • Chadha, R.1    Heidt, S.2    Jones, N.D.3    Wood, K.J.4
  • 32
    • 67649210785 scopus 로고    scopus 로고
    • Relative roles of Th1 and Th17 effector cells in allograft rejection
    • PID: 19337142
    • Atalar K, Afzali B, Lord G, Lombardi G (2009) Relative roles of Th1 and Th17 effector cells in allograft rejection. Curr Opin Organ Transplant 14(1):23–29
    • (2009) Curr Opin Organ Transplant , vol.14 , Issue.1 , pp. 23-29
    • Atalar, K.1    Afzali, B.2    Lord, G.3    Lombardi, G.4
  • 33
    • 77955230058 scopus 로고    scopus 로고
    • Inflammation and the balance of Treg and Th17 cells in transplant rejection and tolerance
    • PID: 20613526
    • Hanidziar D, Koulmanda M (2010) Inflammation and the balance of Treg and Th17 cells in transplant rejection and tolerance. Curr Opin Organ Transplant 15(4):411–415
    • (2010) Curr Opin Organ Transplant , vol.15 , Issue.4 , pp. 411-415
    • Hanidziar, D.1    Koulmanda, M.2
  • 35
    • 77956506975 scopus 로고    scopus 로고
    • Interleukin-17 promotes early allograft inflammation
    • PID: 20651239, COI: 1:CAS:528:DC%2BC3cXht1KmsbzP
    • Gorbacheva V, Fan R, Li X, Valujskikh A (2010) Interleukin-17 promotes early allograft inflammation. Am J Pathol 177(3):1265–1273
    • (2010) Am J Pathol , vol.177 , Issue.3 , pp. 1265-1273
    • Gorbacheva, V.1    Fan, R.2    Li, X.3    Valujskikh, A.4
  • 36
    • 74049089202 scopus 로고    scopus 로고
    • Transfer of tolerance to collagen type V suppresses T-helper-cell-17 lymphocyte-mediated acute lung transplant rejection
    • PID: 20029330, COI: 1:CAS:528:DC%2BD1MXhs1Wjsb3N
    • Braun RK, Molitor-Dart M, Wigfield C et al (2009) Transfer of tolerance to collagen type V suppresses T-helper-cell-17 lymphocyte-mediated acute lung transplant rejection. Transplantation 88(12):1341–1348
    • (2009) Transplantation , vol.88 , Issue.12 , pp. 1341-1348
    • Braun, R.K.1    Molitor-Dart, M.2    Wigfield, C.3
  • 37
    • 73349094069 scopus 로고    scopus 로고
    • Role of T cell TGFbeta signaling and IL-17 in allograft acceptance and fibrosis associated with chronic rejection
    • PID: 19917689, COI: 1:CAS:528:DC%2BD1MXhsVehsbbI
    • Faust SM, Lu G, Marini BL et al (2009) Role of T cell TGFbeta signaling and IL-17 in allograft acceptance and fibrosis associated with chronic rejection. J Immunol 183(11):7297–7306
    • (2009) J Immunol , vol.183 , Issue.11 , pp. 7297-7306
    • Faust, S.M.1    Lu, G.2    Marini, B.L.3
  • 38
    • 77955873442 scopus 로고    scopus 로고
    • Stem cell mobilization with G-CSF induces type 17 differentiation and promotes scleroderma
    • PID: 20435882, COI: 1:CAS:528:DC%2BC3cXhtVCku73K
    • Hill GR, Olver SD, Kuns RD et al (2010) Stem cell mobilization with G-CSF induces type 17 differentiation and promotes scleroderma. Blood 116(5):819–828
    • (2010) Blood , vol.116 , Issue.5 , pp. 819-828
    • Hill, G.R.1    Olver, S.D.2    Kuns, R.D.3
  • 39
    • 75149118145 scopus 로고    scopus 로고
    • T helper17 cells are sufficient but not necessary to induce acute graft-versus-host disease
    • PID: 19804837, COI: 1:CAS:528:DC%2BC3cXjt1GmsL4%3D
    • Iclozan C, Yu Y, Liu C et al (2010) T helper17 cells are sufficient but not necessary to induce acute graft-versus-host disease. Biol Blood Marrow Transplant 16(2):170–178
    • (2010) Biol Blood Marrow Transplant , vol.16 , Issue.2 , pp. 170-178
    • Iclozan, C.1    Yu, Y.2    Liu, C.3
  • 40
    • 60849118676 scopus 로고    scopus 로고
    • In vitro-differentiated TH17 cells mediate lethal acute graft-versus-host disease with severe cutaneous and pulmonary pathologic manifestations
    • PID: 18957685, COI: 1:CAS:528:DC%2BD1MXitV2ru7k%3D
    • Carlson MJ, West ML, Coghill JM, Panoskaltsis-Mortari A, Blazar BR, Serody JS (2009) In vitro-differentiated TH17 cells mediate lethal acute graft-versus-host disease with severe cutaneous and pulmonary pathologic manifestations. Blood 113(6):1365–1374
    • (2009) Blood , vol.113 , Issue.6 , pp. 1365-1374
    • Carlson, M.J.1    West, M.L.2    Coghill, J.M.3    Panoskaltsis-Mortari, A.4    Blazar, B.R.5    Serody, J.S.6
  • 41
    • 36348980530 scopus 로고    scopus 로고
    • Absence of regulatory T-cell control of TH1 and TH17 cells is responsible for the autoimmune-mediated pathology in chronic graft-versus-host disease
    • PID: 17693581, COI: 1:CAS:528:DC%2BD2sXhtlarurjL
    • Chen X, Vodanovic-Jankovic S, Johnson B, Keller M, Komorowski R, Drobyski WR (2007) Absence of regulatory T-cell control of TH1 and TH17 cells is responsible for the autoimmune-mediated pathology in chronic graft-versus-host disease. Blood 110(10):3804–3813
    • (2007) Blood , vol.110 , Issue.10 , pp. 3804-3813
    • Chen, X.1    Vodanovic-Jankovic, S.2    Johnson, B.3    Keller, M.4    Komorowski, R.5    Drobyski, W.R.6
  • 42
    • 52649136967 scopus 로고    scopus 로고
    • Absence of donor Th17 leads to augmented Th1 differentiation and exacerbated acute graft-versus-host disease
    • PID: 18596226, COI: 1:CAS:528:DC%2BD1cXhtVyksrzO
    • Yi T, Zhao D, Lin CL et al (2008) Absence of donor Th17 leads to augmented Th1 differentiation and exacerbated acute graft-versus-host disease. Blood 112(5):2101–2110
    • (2008) Blood , vol.112 , Issue.5 , pp. 2101-2110
    • Yi, T.1    Zhao, D.2    Lin, C.L.3
  • 43
    • 0032211796 scopus 로고    scopus 로고
    • Differential effects of the absence of interferon-gamma and IL-4 in acute graft-versus-host disease after allogeneic bone marrow transplantation in mice
    • PID: 9802888, COI: 1:CAS:528:DyaK1cXnt1Oqt7g%3D
    • Murphy WJ, Welniak LA, Taub DD et al (1998) Differential effects of the absence of interferon-gamma and IL-4 in acute graft-versus-host disease after allogeneic bone marrow transplantation in mice. J Clin Invest 102(9):1742–1748
    • (1998) J Clin Invest , vol.102 , Issue.9 , pp. 1742-1748
    • Murphy, W.J.1    Welniak, L.A.2    Taub, D.D.3
  • 44
    • 0032535087 scopus 로고    scopus 로고
    • Donor-derived interferon gamma is required for inhibition of acute graft-versus-host disease by interleukin 12
    • PID: 9854048, COI: 1:CAS:528:DyaK1MXmtFOj
    • Yang YG, Dey BR, Sergio JJ, Pearson DA, Sykes M (1998) Donor-derived interferon gamma is required for inhibition of acute graft-versus-host disease by interleukin 12. J Clin Invest 102(12):2126–2135
    • (1998) J Clin Invest , vol.102 , Issue.12 , pp. 2126-2135
    • Yang, Y.G.1    Dey, B.R.2    Sergio, J.J.3    Pearson, D.A.4    Sykes, M.5
  • 45
    • 70449494642 scopus 로고    scopus 로고
    • Reciprocal differentiation and tissue-specific pathogenesis of Th1, Th2, and Th17 cells in graft-versus host disease
    • PID: 19602708, COI: 1:CAS:528:DC%2BD1MXht12qur3J
    • Yi T, Chen Y, Wang L et al (2009) Reciprocal differentiation and tissue-specific pathogenesis of Th1, Th2, and Th17 cells in graft-versus host disease. Blood 114(14):3101–3112
    • (2009) Blood , vol.114 , Issue.14 , pp. 3101-3112
    • Yi, T.1    Chen, Y.2    Wang, L.3
  • 46
    • 73349105621 scopus 로고    scopus 로고
    • Interleukin-17-producing T-helper cells as new potential player mediating graft-versus-host disease in patients undergoing allogeneic stem-cell transplantation
    • PID: 19996925, COI: 1:CAS:528:DC%2BD1MXhsFent73N
    • Dander E, Balduzzi A, Zappa G et al (2009) Interleukin-17-producing T-helper cells as new potential player mediating graft-versus-host disease in patients undergoing allogeneic stem-cell transplantation. Transplantation 88(11):1261–1272
    • (2009) Transplantation , vol.88 , Issue.11 , pp. 1261-1272
    • Dander, E.1    Balduzzi, A.2    Zappa, G.3
  • 47
    • 84862908181 scopus 로고    scopus 로고
    • Synthetic retinoid Am80 ameliorates chronic graft-versus-host disease by down-regulating Th1 and Th17
    • PID: 22077062, COI: 1:CAS:528:DC%2BC38XpvFGquw%3D%3D
    • Nishimori H, Maeda Y, Teshima T et al (2012) Synthetic retinoid Am80 ameliorates chronic graft-versus-host disease by down-regulating Th1 and Th17. Blood 119(1):285–295
    • (2012) Blood , vol.119 , Issue.1 , pp. 285-295
    • Nishimori, H.1    Maeda, Y.2    Teshima, T.3
  • 48
    • 64349091740 scopus 로고    scopus 로고
    • Effect of immunosuppressant blood levels on serum concentration of interleukin-17 and-23 in stable liver transplant recipients
    • Fbrega E, Lopez-Hoyos M, San Segundo D, Casafont F, Benito MJ, Pons-Romero F (2009) Effect of immunosuppressant blood levels on serum concentration of interleukin-17 and-23 in stable liver transplant recipients. Transplant Proc 41(3):1025–1027
    • (2009) Transplant Proc , vol.41 , Issue.3 , pp. 1025-1027
    • Fbrega, E.1    Lopez-Hoyos, M.2    San Segundo, D.3    Casafont, F.4    Benito, M.J.5    Pons-Romero, F.6
  • 49
    • 0034765223 scopus 로고    scopus 로고
    • IL-17 expression as a possible predictive parameter for subclinical renal allograft rejection
    • PID: 11692212, COI: 1:CAS:528:DC%2BD3MXptF2qsrk%3D
    • Hsieh HG, Loong CC, Lui WY, Chen A, Lin CY (2001) IL-17 expression as a possible predictive parameter for subclinical renal allograft rejection. Transpl Int 14(5):287–298
    • (2001) Transpl Int , vol.14 , Issue.5 , pp. 287-298
    • Hsieh, H.G.1    Loong, C.C.2    Lui, W.Y.3    Chen, A.4    Lin, C.Y.5
  • 50
    • 0036063633 scopus 로고    scopus 로고
    • Evidence for the early involvement of interleukin 17 in human and experimental renal allograft rejection
    • PID: 12115878, COI: 1:CAS:528:DC%2BD38XmtVSkurk%3D
    • Loong CC, Hsieh HG, Lui WY, Chen A, Lin CY (2002) Evidence for the early involvement of interleukin 17 in human and experimental renal allograft rejection. J Pathol 197(3):322–332
    • (2002) J Pathol , vol.197 , Issue.3 , pp. 322-332
    • Loong, C.C.1    Hsieh, H.G.2    Lui, W.Y.3    Chen, A.4    Lin, C.Y.5
  • 51
    • 33748286452 scopus 로고    scopus 로고
    • The role of interleukin interleukin-17 during acute rejection after lung transplantation
    • PID: 16585086, COI: 1:CAS:528:DC%2BD28Xkt1Kkurg%3D
    • Vanaudenaerde BM, Dupont LJ, Wuyts WA et al (2006) The role of interleukin interleukin-17 during acute rejection after lung transplantation. Eur Respir J 27(4):779–787
    • (2006) Eur Respir J , vol.27 , Issue.4 , pp. 779-787
    • Vanaudenaerde, B.M.1    Dupont, L.J.2    Wuyts, W.A.3
  • 52
    • 78851472301 scopus 로고    scopus 로고
    • IL-17-producing T cells contribute to acute graft-versus-host disease in patients undergoing unmanipulated blood and marrow transplantation
    • PID: 21268020, COI: 1:CAS:528:DC%2BC3MXpvFCisg%3D%3D
    • Zhao XY, Xu LL, Lu SY, Huang XJ (2011) IL-17-producing T cells contribute to acute graft-versus-host disease in patients undergoing unmanipulated blood and marrow transplantation. Eur J Immunol 41(2):514–526
    • (2011) Eur J Immunol , vol.41 , Issue.2 , pp. 514-526
    • Zhao, X.Y.1    Xu, L.L.2    Lu, S.Y.3    Huang, X.J.4
  • 53
    • 84874971070 scopus 로고    scopus 로고
    • Donor Th17 cells and IL-21 may contribute to the development of chronic graft-versus-host disease after allogeneic transplantation
    • PID: 23280509, COI: 1:CAS:528:DC%2BC3sXhs1eku7g%3D
    • Zhao XY, Lv M, Xu LL, Qian X, Huang XJ (2013) Donor Th17 cells and IL-21 may contribute to the development of chronic graft-versus-host disease after allogeneic transplantation. Eur J Immunol 43(3):838–850
    • (2013) Eur J Immunol , vol.43 , Issue.3 , pp. 838-850
    • Zhao, X.Y.1    Lv, M.2    Xu, L.L.3    Qian, X.4    Huang, X.J.5
  • 54
    • 84867505772 scopus 로고    scopus 로고
    • Graft-versus-host disease induced graft-versus-leukemia effect: greater impact on relapse and disease-free survival after reduced intensity conditioning
    • PID: 22766220
    • Weisdorf D, Zhang MJ, Arora M, Horowitz MM, Rizzo JD, Eapen M (2012) Graft-versus-host disease induced graft-versus-leukemia effect: greater impact on relapse and disease-free survival after reduced intensity conditioning. Biol Blood Marrow Transplant 18(11):1727–1733
    • (2012) Biol Blood Marrow Transplant , vol.18 , Issue.11 , pp. 1727-1733
    • Weisdorf, D.1    Zhang, M.J.2    Arora, M.3    Horowitz, M.M.4    Rizzo, J.D.5    Eapen, M.6
  • 55
    • 84871228768 scopus 로고    scopus 로고
    • Impact of graft-versus-host disease after reduced-intensity conditioning allogeneic stem cell transplantation for acute myeloid leukemia: a report from the acute leukemia working party of the European group for blood and marrow transplantation
    • PID: 22699419, COI: 1:CAS:528:DC%2BC38XhvVChs7rO
    • Baron F, Labopin M, Niederwieser D et al (2012) Impact of graft-versus-host disease after reduced-intensity conditioning allogeneic stem cell transplantation for acute myeloid leukemia: a report from the acute leukemia working party of the European group for blood and marrow transplantation. Leukemia 26(12):2462–2468
    • (2012) Leukemia , vol.26 , Issue.12 , pp. 2462-2468
    • Baron, F.1    Labopin, M.2    Niederwieser, D.3
  • 57
    • 78149464264 scopus 로고    scopus 로고
    • Prognostic significance of genetic variants in the IL-23/Th17 pathway for the outcome of T cell-depleted allogeneic stem cell transplantation
    • PID: 20173782, COI: 1:CAS:528:DC%2BC3cXhtl2gurvM
    • Carvalho A, Cunha C, Di Ianni M et al (2010) Prognostic significance of genetic variants in the IL-23/Th17 pathway for the outcome of T cell-depleted allogeneic stem cell transplantation. Bone Marrow Transplant 45(11):1645–1652
    • (2010) Bone Marrow Transplant , vol.45 , Issue.11 , pp. 1645-1652
    • Carvalho, A.1    Cunha, C.2    Di Ianni, M.3
  • 58
    • 77149124935 scopus 로고    scopus 로고
    • Early pre-engraftment, functional, in vitro responsiveness of T lymphocytes in allotransplanted, acute leukemia patients: proliferation and release of a broad profile of cytokines, possibly predictive of graft-versus-host disease
    • PID: 20146989, COI: 1:CAS:528:DC%2BC3cXjt12ju70%3D
    • Liseth K, Sjo M, Paulsen K, Bruserud O, Ersvaer E (2010) Early pre-engraftment, functional, in vitro responsiveness of T lymphocytes in allotransplanted, acute leukemia patients: proliferation and release of a broad profile of cytokines, possibly predictive of graft-versus-host disease. Eur Cytokine Netw 21(1):40–49
    • (2010) Eur Cytokine Netw , vol.21 , Issue.1 , pp. 40-49
    • Liseth, K.1    Sjo, M.2    Paulsen, K.3    Bruserud, O.4    Ersvaer, E.5
  • 59
    • 59649098784 scopus 로고    scopus 로고
    • IL-17 contributes to CD4-mediated graft-versus-host disease
    • PID: 18931341, COI: 1:CAS:528:DC%2BD1MXhtlGhu7w%3D
    • Kappel LW, Goldberg GL, King CG et al (2009) IL-17 contributes to CD4-mediated graft-versus-host disease. Blood 113(4):945–952
    • (2009) Blood , vol.113 , Issue.4 , pp. 945-952
    • Kappel, L.W.1    Goldberg, G.L.2    King, C.G.3
  • 60
    • 80855128779 scopus 로고    scopus 로고
    • Prevention of GVHD while sparing GVL effect by targeting Th1 and Th17 transcription factor T-bet and RORγt
    • PID: 21856864, COI: 1:CAS:528:DC%2BC3MXhsVOgsrbL
    • Yu Y, Wang D, Liu C et al (2011) Prevention of GVHD while sparing GVL effect by targeting Th1 and Th17 transcription factor T-bet and RORγt. Blood 118(18):5011–5020
    • (2011) Blood , vol.118 , Issue.18 , pp. 5011-5020
    • Yu, Y.1    Wang, D.2    Liu, C.3
  • 61
    • 79960531246 scopus 로고    scopus 로고
    • Regulatory T-cells and IL-17-producing cells in graft-versus-host disease
    • PID: 21751953, COI: 1:CAS:528:DC%2BC3MXovVKqtbs%3D
    • Teshima T, Maeda Y, Ozaki K (2011) Regulatory T-cells and IL-17-producing cells in graft-versus-host disease. Immunotherapy 3(7):833–852
    • (2011) Immunotherapy , vol.3 , Issue.7 , pp. 833-852
    • Teshima, T.1    Maeda, Y.2    Ozaki, K.3
  • 62
    • 78650442609 scopus 로고    scopus 로고
    • GVHD is associated with the expansion of tissue-localized Th1 and not Th17 cells
    • PID: 20864580, COI: 1:CAS:528:DC%2BC3MXhtFGrsrY%3D
    • Broady R, Yu J, Chow V et al (2010) GVHD is associated with the expansion of tissue-localized Th1 and not Th17 cells. Blood 116(25):5748–5751
    • (2010) Blood , vol.116 , Issue.25 , pp. 5748-5751
    • Broady, R.1    Yu, J.2    Chow, V.3
  • 63
    • 77956538770 scopus 로고    scopus 로고
    • Th17/Treg ratio in human graft-versus-host disease
    • PID: 20484086, COI: 1:CAS:528:DC%2BC3cXhtFensbvF
    • Ratajczak P, Janin A, Peffault de Latour R et al (2010) Th17/Treg ratio in human graft-versus-host disease. Blood 116(7):1165–1171
    • (2010) Blood , vol.116 , Issue.7 , pp. 1165-1171
    • Ratajczak, P.1    Janin, A.2    Peffault de Latour, R.3
  • 64
    • 33846915397 scopus 로고    scopus 로고
    • + regulatory T cells in the induction and maintenance of transplantation tolerance
    • COI: 1:CAS:528:DC%2BD1cXhtVamtL8%3D
    • + regulatory T cells in the induction and maintenance of transplantation tolerance. Transplant Immunol 17(2):120–129
    • (2007) Transplant Immunol , vol.17 , Issue.2 , pp. 120-129
    • Zhang, Y.1    Liu, C.2    Yang, X.M.3    Lv, Y.4
  • 65
    • 31544467631 scopus 로고    scopus 로고
    • + cells in the recipient
    • PID: 16415106, COI: 1:CAS:528:DC%2BD28XovVGjug%3D%3D
    • + cells in the recipient. Int Immunol 18(2):279–289
    • (2006) Int Immunol , vol.18 , Issue.2 , pp. 279-289
    • Zheng, S.G.1    Meng, L.2    Wang, J.H.3
  • 66
    • 0036467522 scopus 로고    scopus 로고
    • CD25+CD4+ regulatory T cells prevent graft rejection: CTLA-4- and IL-10-dependent immunoregulation of alloresponses
    • PID: 11801641, COI: 1:CAS:528:DC%2BD38XpsFensg%3D%3D
    • Kingsley CI, Karim M, Bushell AR, Wood KJ (2002) CD25+CD4+ regulatory T cells prevent graft rejection: CTLA-4- and IL-10-dependent immunoregulation of alloresponses. J Immunol 168(3):1080–1086
    • (2002) J Immunol , vol.168 , Issue.3 , pp. 1080-1086
    • Kingsley, C.I.1    Karim, M.2    Bushell, A.R.3    Wood, K.J.4
  • 67
    • 0037025943 scopus 로고    scopus 로고
    • Donor-type CD4(+)CD25(+) regulatory T cells suppress lethal acute graft-versus-host disease after allogeneic bone marrow transplantation
    • PID: 12163567, COI: 1:CAS:528:DC%2BD38XmtVOhtLY%3D
    • Hoffmann P, Ermann J, Edinger M, Fathman CG, Strober S (2002) Donor-type CD4(+)CD25(+) regulatory T cells suppress lethal acute graft-versus-host disease after allogeneic bone marrow transplantation. J Exp Med 196(3):389–399
    • (2002) J Exp Med , vol.196 , Issue.3 , pp. 389-399
    • Hoffmann, P.1    Ermann, J.2    Edinger, M.3    Fathman, C.G.4    Strober, S.5
  • 68
    • 2442484053 scopus 로고    scopus 로고
    • + regulatory T cells for immunologic self-tolerance and negative control of immune responses
    • PID: 15032588, COI: 1:CAS:528:DC%2BD2cXktlOgsLo%3D
    • + regulatory T cells for immunologic self-tolerance and negative control of immune responses. Annu Rev Immunol 22(4):531–562
    • (2004) Annu Rev Immunol , vol.22 , Issue.4 , pp. 531-562
    • Sakaguchi, S.1
  • 69
    • 85047692469 scopus 로고    scopus 로고
    • + T cells via a CD30-dependent mechanism
    • PID: 14722622, COI: 1:CAS:528:DC%2BD2cXmsVyqtw%3D%3D
    • + T cells via a CD30-dependent mechanism. J Clin Invest 113(2):310–317
    • (2004) J Clin Invest , vol.113 , Issue.2 , pp. 310-317
    • Dai, Z.1    Li, Q.2    Wang, Y.3
  • 70
    • 0346690399 scopus 로고    scopus 로고
    • + regulatory T cells favor immune reconstitution and control graft-versus-host disease while maintaining graft-versus-leukemia
    • PID: 14660744, COI: 1:CAS:528:DC%2BD3sXpslens7o%3D
    • + regulatory T cells favor immune reconstitution and control graft-versus-host disease while maintaining graft-versus-leukemia. J Clin Invest 112(11):1688–1696
    • (2003) J Clin Invest , vol.112 , Issue.11 , pp. 1688-1696
    • Trenado, A.1    Charlotte, F.2    Fisson, S.3
  • 71
    • 0025058971 scopus 로고
    • Specific unresponsiveness in rats with prolonged cardiac allograft survival after treatment with cyclosporine. III. Further characterization of the CD4+ suppressor cell and its mechanisms of action
    • PID: 2136906, COI: 1:CAS:528:DyaK3cXhtFWlu7w%3D
    • Hall BM, Pearce NW, Gurley KE, Dorsch SE (1990) Specific unresponsiveness in rats with prolonged cardiac allograft survival after treatment with cyclosporine. III. Further characterization of the CD4+ suppressor cell and its mechanisms of action. J Exp Med 171(1):141–157
    • (1990) J Exp Med , vol.171 , Issue.1 , pp. 141-157
    • Hall, B.M.1    Pearce, N.W.2    Gurley, K.E.3    Dorsch, S.E.4
  • 72
    • 0035869432 scopus 로고    scopus 로고
    • IL-10 is required for regulatory T cells to mediate tolerance to alloantigens in vivo
    • PID: 11238621, COI: 1:CAS:528:DC%2BD3MXitVGnuro%3D
    • Hara M, Kingsley CI, Niimi M et al (2001) IL-10 is required for regulatory T cells to mediate tolerance to alloantigens in vivo. J Immunol 166(6):3789–3796
    • (2001) J Immunol , vol.166 , Issue.6 , pp. 3789-3796
    • Hara, M.1    Kingsley, C.I.2    Niimi, M.3
  • 73
    • 0035806276 scopus 로고    scopus 로고
    • CD4(+)CD25(+) immune regulatory cells are required for induction of tolerance to alloantigen via costimulatory blockade
    • PID: 11390438, COI: 1:CAS:528:DC%2BD3MXktFyiurY%3D
    • Taylor PA, Noelle RJ, Blazar BR (2001) CD4(+)CD25(+) immune regulatory cells are required for induction of tolerance to alloantigen via costimulatory blockade. J Exp Med 193(11):1311–1318
    • (2001) J Exp Med , vol.193 , Issue.11 , pp. 1311-1318
    • Taylor, P.A.1    Noelle, R.J.2    Blazar, B.R.3
  • 74
    • 0035881234 scopus 로고    scopus 로고
    • Regulatory T cells induced by 1 alpha, 25-dihydroxyvitamin D3 and mycophenolate mofetil treatment mediate transplantation tolerance
    • PID: 11489974, COI: 1:CAS:528:DC%2BD3MXlvFeqtLg%3D
    • Gregori S, Casorati M, Amuchastegui S, Smiroldo S, Davalli AM, Adorini L (2001) Regulatory T cells induced by 1 alpha, 25-dihydroxyvitamin D3 and mycophenolate mofetil treatment mediate transplantation tolerance. J Immunol 167(4):1945–1953
    • (2001) J Immunol , vol.167 , Issue.4 , pp. 1945-1953
    • Gregori, S.1    Casorati, M.2    Amuchastegui, S.3    Smiroldo, S.4    Davalli, A.M.5    Adorini, L.6
  • 75
    • 0036498560 scopus 로고    scopus 로고
    • Tracking the immunoregulatory mechanisms active during allograft tolerance
    • PID: 11859115, COI: 1:CAS:528:DC%2BD38XhvVegsrk%3D
    • Sanchez-Fueyo A, Weber M, Domenig C, Strom TB, Zheng XX (2002) Tracking the immunoregulatory mechanisms active during allograft tolerance. J Immunol 168(5):2274–2281
    • (2002) J Immunol , vol.168 , Issue.5 , pp. 2274-2281
    • Sanchez-Fueyo, A.1    Weber, M.2    Domenig, C.3    Strom, T.B.4    Zheng, X.X.5
  • 76
    • 0037124359 scopus 로고    scopus 로고
    • Identification of regulatory T cells in tolerated allografts
    • PID: 12070291, COI: 1:CAS:528:DC%2BD38XkslWht7k%3D
    • Graca L, Cobbold SP, Waldmann H (2002) Identification of regulatory T cells in tolerated allografts. J Exp Med 195(12):1641–1646
    • (2002) J Exp Med , vol.195 , Issue.12 , pp. 1641-1646
    • Graca, L.1    Cobbold, S.P.2    Waldmann, H.3
  • 77
    • 0029150110 scopus 로고
    • Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
    • PID: 7636184, COI: 1:CAS:528:DyaK2MXntFWnurs%3D
    • Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M (1995) Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 155(3):1151–1164
    • (1995) J Immunol , vol.155 , Issue.3 , pp. 1151-1164
    • Sakaguchi, S.1    Sakaguchi, N.2    Asano, M.3    Itoh, M.4    Toda, M.5
  • 78
    • 0035180065 scopus 로고    scopus 로고
    • + regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance
    • PID: 11722621, COI: 1:CAS:528:DC%2BD3MXpt1eis7c%3D
    • + regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance. Immunol Rev 182(1):18–32
    • (2001) Immunol Rev , vol.182 , Issue.1 , pp. 18-32
    • Sakaguchi, S.1    Sakaguchi, N.2    Shimizu, J.3
  • 79
    • 10744228165 scopus 로고    scopus 로고
    • Favorably tipping the balance between cytopathic and regulatory T cells to create transplantation tolerance
    • PID: 14563315, COI: 1:CAS:528:DC%2BD3sXosF2ku7g%3D
    • Zheng XX, Sanchez-Fueyo A, Sho M, Domenig C, Sayegh MH, Strom TB (2003) Favorably tipping the balance between cytopathic and regulatory T cells to create transplantation tolerance. Immunity 19(4):503–514
    • (2003) Immunity , vol.19 , Issue.4 , pp. 503-514
    • Zheng, X.X.1    Sanchez-Fueyo, A.2    Sho, M.3    Domenig, C.4    Sayegh, M.H.5    Strom, T.B.6
  • 80
    • 0037111521 scopus 로고    scopus 로고
    • + T cell mediated graft rejection: implications for anti-CD154 immunotherapy
    • PID: 12421913
    • + T cell mediated graft rejection: implications for anti-CD154 immunotherapy. J Immunol 169(10):5401–5404
    • (2002) J Immunol , vol.169 , Issue.10 , pp. 5401-5404
    • van Maurik, A.1    Herber, M.2    Wood, K.J.3    Jones, N.D.4
  • 81
    • 0037218548 scopus 로고    scopus 로고
    • + immunoregulatory CD4 T cells mediate acquired central transplantation tolerance
    • PID: 12496410, COI: 1:CAS:528:DC%2BD3sXhtFGqsQ%3D%3D
    • + immunoregulatory CD4 T cells mediate acquired central transplantation tolerance. J Immunol 170(1):279–286
    • (2003) J Immunol , vol.170 , Issue.1 , pp. 279-286
    • Trani, J.1    Moore, D.J.2    Jarrett, B.P.3
  • 82
    • 0036604283 scopus 로고    scopus 로고
    • Both CD4(+)CD25(+) and CD4(+)CD25(−) regulatory cells mediate dominant transplantation tolerance
    • PID: 12023351, COI: 1:CAS:528:DC%2BD38XktFCrsLo%3D
    • Graca L, Thompson S, Lin CY, Adams E, Cobbold SP, Waldmann H (2002) Both CD4(+)CD25(+) and CD4(+)CD25(−) regulatory cells mediate dominant transplantation tolerance. J Immunol 168(11):5558–5565
    • (2002) J Immunol , vol.168 , Issue.11 , pp. 5558-5565
    • Graca, L.1    Thompson, S.2    Lin, C.Y.3    Adams, E.4    Cobbold, S.P.5    Waldmann, H.6
  • 83
    • 33244467229 scopus 로고    scopus 로고
    • Low circulating regulatory T-cell levels after acute rejection in liver transplantation
    • Demirkiran A, Kok A, Kwekkeboom J et al (2006) Low circulating regulatory T-cell levels after acute rejection in liver transplantation. Liver Transplant 12(2):277–284
    • (2006) Liver Transplant , vol.12 , Issue.2 , pp. 277-284
    • Demirkiran, A.1    Kok, A.2    Kwekkeboom, J.3
  • 84
    • 32844455072 scopus 로고    scopus 로고
    • + regulatory T cells: CD25 and IL-2
    • PID: 16146782, COI: 1:CAS:528:DC%2BD2MXhtlSrurbN
    • + regulatory T cells: CD25 and IL-2. Front Biosci 11:921–927
    • (2006) Front Biosci , vol.11 , pp. 921-927
    • Thornton, A.M.1
  • 85
    • 33747801470 scopus 로고    scopus 로고
    • + regulatory T cells through a STAT dependent mechanism and induces the expansion of these cells in vivo
    • PID: 16645171, COI: 1:CAS:528:DC%2BD28Xpt1SltLg%3D
    • + regulatory T cells through a STAT dependent mechanism and induces the expansion of these cells in vivo. Blood 108(5):1571–1579
    • (2006) Blood , vol.108 , Issue.5 , pp. 1571-1579
    • Zorn, E.1    Nelson, E.A.2    Mohseni, M.3
  • 86
    • 15844404353 scopus 로고    scopus 로고
    • Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways
    • PID: 8632801, COI: 1:CAS:528:DyaK28XjsVWgtrg%3D
    • Larsen CP, Elwood ET, Alexander DZ et al (1996) Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways. Nature 381(6581):434–438
    • (1996) Nature , vol.381 , Issue.6581 , pp. 434-438
    • Larsen, C.P.1    Elwood, E.T.2    Alexander, D.Z.3
  • 87
    • 0035881424 scopus 로고    scopus 로고
    • Weaning of immunosuppression in living donor liver transplant recipients
    • PID: 11502975, COI: 1:CAS:528:DC%2BD3MXmslyjt7c%3D
    • Takatsuki M, Uemoto S, Inomata Y et al (2001) Weaning of immunosuppression in living donor liver transplant recipients. Transplantation 72(3):449–454
    • (2001) Transplantation , vol.72 , Issue.3 , pp. 449-454
    • Takatsuki, M.1    Uemoto, S.2    Inomata, Y.3
  • 88
    • 20144386839 scopus 로고    scopus 로고
    • Long-term acceptance of porcine pulmonary allografts without chronic rejection
    • PID: 15808551, COI: 1:CAS:528:DC%2BD2MXivFShtr0%3D
    • Shoji T, Muniappan A, Guenther DA et al (2005) Long-term acceptance of porcine pulmonary allografts without chronic rejection. Transplant Proc 37(1):72–74
    • (2005) Transplant Proc , vol.37 , Issue.1 , pp. 72-74
    • Shoji, T.1    Muniappan, A.2    Guenther, D.A.3
  • 89
    • 20744439119 scopus 로고    scopus 로고
    • The influence of mycophenolate mofetil upon the maturation and allostimulatory activity of cultured dendritic cell progenitors and the effects of tolerance induction in allograft recipients
    • PID: 16029632, COI: 1:CAS:528:DC%2BD28Xjt1OqtL0%3D
    • Han CH, Li HF, Wang YX et al (2005) The influence of mycophenolate mofetil upon the maturation and allostimulatory activity of cultured dendritic cell progenitors and the effects of tolerance induction in allograft recipients. Zhonghua YiXue ZaZhi 85(19):1327–1332
    • (2005) Zhonghua YiXue ZaZhi , vol.85 , Issue.19 , pp. 1327-1332
    • Han, C.H.1    Li, H.F.2    Wang, Y.X.3
  • 90
    • 0242300609 scopus 로고    scopus 로고
    • A short course of mycophenolate immunosuppression inhibits rejection, but not tolerance, of rat liver allografts in association with inhibition of interleukin-4 and alloantibody responses
    • PID: 14578746, COI: 1:CAS:528:DC%2BD3sXosVajs7c%3D
    • Huang WH, Yan Y, Li J, De Boer B, House AK, Bishop GA (2003) A short course of mycophenolate immunosuppression inhibits rejection, but not tolerance, of rat liver allografts in association with inhibition of interleukin-4 and alloantibody responses. Transplantation 76(8):1159–1165
    • (2003) Transplantation , vol.76 , Issue.8 , pp. 1159-1165
    • Huang, W.H.1    Yan, Y.2    Li, J.3    De Boer, B.4    House, A.K.5    Bishop, G.A.6
  • 91
    • 24744467139 scopus 로고    scopus 로고
    • + T cell development for contact hypersensitivity responses
    • PID: 16000396, COI: 1:CAS:528:DC%2BD2MXhtVSksb3F
    • + T cell development for contact hypersensitivity responses. J Leukoc Biol 78(3):725–735
    • (2005) J Leukoc Biol , vol.78 , Issue.3 , pp. 725-735
    • Kish, D.D.1    Gorbachev, A.V.2    Fairchild, R.L.3
  • 92
    • 0036467337 scopus 로고    scopus 로고
    • The role of the IL-2 pathway in costimulation blockade-resistant rejection of allografts
    • PID: 11801646, COI: 1:CAS:528:DC%2BD38XpsFentw%3D%3D
    • Jones TR, Ha J, Williams MA et al (2002) The role of the IL-2 pathway in costimulation blockade-resistant rejection of allografts. J Immunol 168(3):1123–1130
    • (2002) J Immunol , vol.168 , Issue.3 , pp. 1123-1130
    • Jones, T.R.1    Ha, J.2    Williams, M.A.3
  • 93
    • 0038576227 scopus 로고    scopus 로고
    • The influence of immunosuppressive drugs on tolerance induction through bone marrow transplantation with costimulation blockade
    • PID: 12433677, COI: 1:CAS:528:DC%2BD3sXivVWnsLc%3D
    • Blaha P, Bigenzahn S, Koporc Z et al (2003) The influence of immunosuppressive drugs on tolerance induction through bone marrow transplantation with costimulation blockade. Blood 101(7):2886–2893
    • (2003) Blood , vol.101 , Issue.7 , pp. 2886-2893
    • Blaha, P.1    Bigenzahn, S.2    Koporc, Z.3
  • 95
    • 81755184476 scopus 로고    scopus 로고
    • Anti-interleukin-6 receptor antibody, tocilizumab, for the treatment of autoimmune diseases
    • PID: 21419125, COI: 1:CAS:528:DC%2BC3MXhsFSis7%2FE
    • Tanaka T, Narazaki M, Kishimoto T (2011) Anti-interleukin-6 receptor antibody, tocilizumab, for the treatment of autoimmune diseases. FEBS Lett 585(23):3699–3709
    • (2011) FEBS Lett , vol.585 , Issue.23 , pp. 3699-3709
    • Tanaka, T.1    Narazaki, M.2    Kishimoto, T.3
  • 96
    • 84862908496 scopus 로고    scopus 로고
    • Therapeutic targeting of the interleukin-6 receptor
    • PID: 21910626, COI: 1:CAS:528:DC%2BC38XjsV2nt78%3D
    • Tanaka T, Narazaki M, Kishimoto T (2012) Therapeutic targeting of the interleukin-6 receptor. Annu Rev Pharmacol Toxicol 52:199–219
    • (2012) Annu Rev Pharmacol Toxicol , vol.52 , pp. 199-219
    • Tanaka, T.1    Narazaki, M.2    Kishimoto, T.3
  • 97
    • 34447300492 scopus 로고    scopus 로고
    • Study of active controlled monotherapy used for rheumatoid arthritis, an IL-6 inhibitor (SAMURAI): evidence of clinical and radiographic benefit from an x-ray reader-blinded randomized controlled trial of tocilizumab
    • PID: 17485422, COI: 1:CAS:528:DC%2BD2sXhtVKltL7O
    • Nishimoto N, Hashimoto J, Miyasaka N et al (2007) Study of active controlled monotherapy used for rheumatoid arthritis, an IL-6 inhibitor (SAMURAI): evidence of clinical and radiographic benefit from an x-ray reader-blinded randomized controlled trial of tocilizumab. Ann Rheum Dis 66(9):1162–1167
    • (2007) Ann Rheum Dis , vol.66 , Issue.9 , pp. 1162-1167
    • Nishimoto, N.1    Hashimoto, J.2    Miyasaka, N.3
  • 98
    • 54949150604 scopus 로고    scopus 로고
    • Interleukin-6 receptor inhibition with tocilizumab reduces disease activity in rheumatoid arthritis with inadequate response to disease-modifying antirheumatic drugs: the tocilizumab in combination with traditional disease modifying antirheumatic drug therapy study
    • PID: 18821691, COI: 1:CAS:528:DC%2BD1cXht12rur%2FJ
    • Genovese MC, McKay JD, Nasonov EL et al (2008) Interleukin-6 receptor inhibition with tocilizumab reduces disease activity in rheumatoid arthritis with inadequate response to disease-modifying antirheumatic drugs: the tocilizumab in combination with traditional disease modifying antirheumatic drug therapy study. Arthritis Rheum 58(10):2968–2980
    • (2008) Arthritis Rheum , vol.58 , Issue.10 , pp. 2968-2980
    • Genovese, M.C.1    McKay, J.D.2    Nasonov, E.L.3
  • 99
    • 52149099504 scopus 로고    scopus 로고
    • IL-6 receptor inhibition with tocilizumab improves treatment outcomes in patients with rheumatoid arthritis refractory to antitumor necrosis factor biologicals: results from a 24-week multicentre randomized placebo controlled trial
    • PID: 18625622, COI: 1:CAS:528:DC%2BD1cXhtl2gsbbI
    • Emery P, Keystone E, Tony HP et al (2008) IL-6 receptor inhibition with tocilizumab improves treatment outcomes in patients with rheumatoid arthritis refractory to antitumor necrosis factor biologicals: results from a 24-week multicentre randomized placebo controlled trial. Ann Rheum Dis 67(11):1516–1523
    • (2008) Ann Rheum Dis , vol.67 , Issue.11 , pp. 1516-1523
    • Emery, P.1    Keystone, E.2    Tony, H.P.3
  • 100
    • 40749114497 scopus 로고    scopus 로고
    • Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): a double blind, placebo-controlled, randomized trial
    • PID: 18358926, COI: 1:CAS:528:DC%2BD1cXjs1Sltbc%3D
    • Smolen JS, Beaulieu A, Rubbert-Roth A et al (2008) Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): a double blind, placebo-controlled, randomized trial. Lancet 371(9617):987–997
    • (2008) Lancet , vol.371 , Issue.9617 , pp. 987-997
    • Smolen, J.S.1    Beaulieu, A.2    Rubbert-Roth, A.3
  • 101
    • 60149105639 scopus 로고    scopus 로고
    • Study of active controlled tocilizumab monotherapy for rheumatoid arthritis patients with an inadequate response to methotrexate (SATORI): significant reduction in disease activity and serum vascular endothelial growth factor by IL-6 receptor inhibition therapy
    • PID: 18979150, COI: 1:CAS:528:DC%2BD1MXhsFKmsLk%3D
    • Nishimoto N, Miyasaka N, Yamamoto K et al (2009) Study of active controlled tocilizumab monotherapy for rheumatoid arthritis patients with an inadequate response to methotrexate (SATORI): significant reduction in disease activity and serum vascular endothelial growth factor by IL-6 receptor inhibition therapy. Mod Rheumatol 19(1):12–19
    • (2009) Mod Rheumatol , vol.19 , Issue.1 , pp. 12-19
    • Nishimoto, N.1    Miyasaka, N.2    Yamamoto, K.3
  • 102
    • 73449118587 scopus 로고    scopus 로고
    • Comparison of tocilizumab monotherapy versus methotrexate monotherapy in patients with moderate to severe rheumatoid arthritis: the AMBITION study
    • PID: 19297346, COI: 1:CAS:528:DC%2BC3cXhtFOls78%3D
    • Jones G, Sebba A, Gu J et al (2010) Comparison of tocilizumab monotherapy versus methotrexate monotherapy in patients with moderate to severe rheumatoid arthritis: the AMBITION study. Ann Rheum Dis 69(1):88–96
    • (2010) Ann Rheum Dis , vol.69 , Issue.1 , pp. 88-96
    • Jones, G.1    Sebba, A.2    Gu, J.3
  • 103
    • 79953680176 scopus 로고    scopus 로고
    • Tocilizumab inhibits structural joint damage in rheumatoid arthritis patients with inadequate responses to methotrexate: results from the double-blind treatment phase of a randomized placebo-controlled trial of tocilizumab safety and prevention of structural joint damage at one year
    • PID: 21360490, COI: 1:CAS:528:DC%2BC3MXksFWrsr4%3D
    • Kremer JM, Blanco R, Brzosko M et al (2011) Tocilizumab inhibits structural joint damage in rheumatoid arthritis patients with inadequate responses to methotrexate: results from the double-blind treatment phase of a randomized placebo-controlled trial of tocilizumab safety and prevention of structural joint damage at one year. Arthritis Rheum 63(3):609–621
    • (2011) Arthritis Rheum , vol.63 , Issue.3 , pp. 609-621
    • Kremer, J.M.1    Blanco, R.2    Brzosko, M.3
  • 105
    • 77956646068 scopus 로고    scopus 로고
    • Safety and efficacy profiles of tocilizumabmonotherapy in Japanese patients with rheumatoid arthritis: meta-analysis of six initial trials and five long-term extensions
    • PID: 20221663, COI: 1:CAS:528:DC%2BC3cXntVGiurY%3D
    • Nishimoto N, Ito K, Takagi N (2010) Safety and efficacy profiles of tocilizumabmonotherapy in Japanese patients with rheumatoid arthritis: meta-analysis of six initial trials and five long-term extensions. Mod Rheumatol 20(3):222–232
    • (2010) Mod Rheumatol , vol.20 , Issue.3 , pp. 222-232
    • Nishimoto, N.1    Ito, K.2    Takagi, N.3
  • 106
    • 79952013541 scopus 로고    scopus 로고
    • Risk of adverse events including serious infections in rheumatoid arthritis patients treated with tocilizumab: a systemic literature review and meta-analysis of randomized controlled trials
    • PID: 21078627, COI: 1:CAS:528:DC%2BC3MXis1Cgsbg%3D
    • Campbell L, Chen C, Bhagat SS, Parker RA, Ostor AJ (2011) Risk of adverse events including serious infections in rheumatoid arthritis patients treated with tocilizumab: a systemic literature review and meta-analysis of randomized controlled trials. Rheumatology 50(3):552–562
    • (2011) Rheumatology , vol.50 , Issue.3 , pp. 552-562
    • Campbell, L.1    Chen, C.2    Bhagat, S.S.3    Parker, R.A.4    Ostor, A.J.5
  • 107
    • 0025990288 scopus 로고
    • Elevated levels of endogenous IL-6 in systemic lupus erythematosus: a putative role in pathogenesis
    • PID: 2051017, COI: 1:CAS:528:DyaK3MXlsFKksrw%3D
    • Linker-Israeli M, Deans RJ, Wallace DJ, Prehn J, Ozeri-Chen T, Klinenberg JR (1991) Elevated levels of endogenous IL-6 in systemic lupus erythematosus: a putative role in pathogenesis. J Immunol 147(1):117–123
    • (1991) J Immunol , vol.147 , Issue.1 , pp. 117-123
    • Linker-Israeli, M.1    Deans, R.J.2    Wallace, D.J.3    Prehn, J.4    Ozeri-Chen, T.5    Klinenberg, J.R.6
  • 108
    • 0027237857 scopus 로고
    • Urinary levels of IL-6 in patients with active lupus nephritis
    • PID: 8358870, COI: 1:STN:280:DyaK3szmsFSqtA%3D%3D
    • Iwano M, Dohi K, Hirata E et al (1993) Urinary levels of IL-6 in patients with active lupus nephritis. Clin Nephrol 40(1):16–21
    • (1993) Clin Nephrol , vol.40 , Issue.1 , pp. 16-21
    • Iwano, M.1    Dohi, K.2    Hirata, E.3
  • 109
    • 0025285835 scopus 로고
    • Elevated levels of interleukin-6 in cerebrospinal fluid from patients with systemic lupus erythematosus and central nervous system involvement
    • PID: 2346520, COI: 1:STN:280:DyaK3c3mslGnsg%3D%3D
    • Hirohata S, Miyamoto T (1990) Elevated levels of interleukin-6 in cerebrospinal fluid from patients with systemic lupus erythematosus and central nervous system involvement. Arthritis Rheum 33(5):644–649
    • (1990) Arthritis Rheum , vol.33 , Issue.5 , pp. 644-649
    • Hirohata, S.1    Miyamoto, T.2
  • 110
    • 0031861643 scopus 로고    scopus 로고
    • IL-6 receptor blockage inhibits the onset of autoimmune kidney disease in NZB/WF1 mice
    • PID: 9649207, COI: 1:CAS:528:DyaK1cXkt1Ojsr0%3D
    • Mihara M, Takagi N, Takeda Y, Ohsugi Y (1998) IL-6 receptor blockage inhibits the onset of autoimmune kidney disease in NZB/WF1 mice. Clin Exp Immunol 112(5):397–402
    • (1998) Clin Exp Immunol , vol.112 , Issue.5 , pp. 397-402
    • Mihara, M.1    Takagi, N.2    Takeda, Y.3    Ohsugi, Y.4
  • 111
    • 33750011260 scopus 로고    scopus 로고
    • Anti-interleukin-6 monoclonal antibody inhibits autoimmune responses in a murine model of systemic lupus erythematosus
    • Liang B, Gardner DB, Griswold DE, Bugelski PJ, Song XY (2008) Anti-interleukin-6 monoclonal antibody inhibits autoimmune responses in a murine model of systemic lupus erythematosus. Immunology 119(3):296–305
    • (2008) Immunology , vol.119 , Issue.3 , pp. 296-305
    • Liang, B.1    Gardner, D.B.2    Griswold, D.E.3    Bugelski, P.J.4    Song, X.Y.5
  • 112
    • 75749113331 scopus 로고    scopus 로고
    • Tocilizumab in systemic lupus erythematosus: data on safety, preliminary efficacy, and impact on circulating plasma cells from an open label phase I dosage-escalation study
    • PID: 20112381, COI: 1:CAS:528:DC%2BC3cXhtFGnu7zK
    • Illei GG, Shirota Y, Yarboro CH et al (2010) Tocilizumab in systemic lupus erythematosus: data on safety, preliminary efficacy, and impact on circulating plasma cells from an open label phase I dosage-escalation study. Arthritis Rheum 62(2):542–552
    • (2010) Arthritis Rheum , vol.62 , Issue.2 , pp. 542-552
    • Illei, G.G.1    Shirota, Y.2    Yarboro, C.H.3
  • 113
    • 84890508411 scopus 로고    scopus 로고
    • Plasma IL-6 levels correlate with clinical and ultrasound measures of arthritis in patients with systemic lupus erythematosus
    • PID: 24243775, COI: 1:STN:280:DC%2BC2c7nvFemug%3D%3D
    • Ball EM, Gibson DS, Bell AL, Rooney MR (2014) Plasma IL-6 levels correlate with clinical and ultrasound measures of arthritis in patients with systemic lupus erythematosus. Lupus 23(1):46–56
    • (2014) Lupus , vol.23 , Issue.1 , pp. 46-56
    • Ball, E.M.1    Gibson, D.S.2    Bell, A.L.3    Rooney, M.R.4
  • 114
    • 79956065767 scopus 로고    scopus 로고
    • Interleukin-6 promotes arthritis and joint deformation in patients with systemic lupus erythematosus
    • PID: 21422077, COI: 1:CAS:528:DC%2BC3MXosVOrsbY%3D
    • Eilertsen GØ, Nikolaisen C, Becker-Merok A, Nossent JC (2011) Interleukin-6 promotes arthritis and joint deformation in patients with systemic lupus erythematosus. Lupus 20(6):607–613
    • (2011) Lupus , vol.20 , Issue.6 , pp. 607-613
    • Eilertsen, G.Ø.1    Nikolaisen, C.2    Becker-Merok, A.3    Nossent, J.C.4
  • 115
    • 84863968239 scopus 로고    scopus 로고
    • Successful tocilizumab and tacrolimus treatment in a patient with rheumatoid arthritis complicated by systemic lupus erythematosus
    • PID: 22433919, COI: 1:STN:280:DC%2BC38votFelsQ%3D%3D
    • Maeshima K, Ishii K, Torigoe M et al (2012) Successful tocilizumab and tacrolimus treatment in a patient with rheumatoid arthritis complicated by systemic lupus erythematosus. Lupus 21(9):1003–1006
    • (2012) Lupus , vol.21 , Issue.9 , pp. 1003-1006
    • Maeshima, K.1    Ishii, K.2    Torigoe, M.3
  • 116
    • 84859757911 scopus 로고    scopus 로고
    • Successful use of interleukin-6 antagonist tocilizumab in a patient with refractory cutaneous lupus and urticarial vasculitis
    • PID: 22334272
    • Makol A, Gibson LE, Michet CJ (2012) Successful use of interleukin-6 antagonist tocilizumab in a patient with refractory cutaneous lupus and urticarial vasculitis. J Clin Rheumatol 18(2):92–95
    • (2012) J Clin Rheumatol , vol.18 , Issue.2 , pp. 92-95
    • Makol, A.1    Gibson, L.E.2    Michet, C.J.3
  • 117
    • 84872742722 scopus 로고    scopus 로고
    • Successful treatment of massive intractable pericardial effusion in a patient with systemic lupus erythematosus with tocilizumab
    • Kamata Y, Minota S (2012) Successful treatment of massive intractable pericardial effusion in a patient with systemic lupus erythematosus with tocilizumab. BMJ Case Rep 2012
    • (2012) BMJ Case Rep , pp. 2012
    • Kamata, Y.1    Minota, S.2
  • 118
    • 0031911610 scopus 로고    scopus 로고
    • Serum levels of interleukin 6 (IL-6), oncostatin M, soluble IL-6 receptor, and soluble gp130 in patients with systemic sclerosis
    • PID: 9489824, COI: 1:STN:280:DyaK1c7kvFClug%3D%3D
    • Hasegawa M, Sato S, Fujimoto M, Ihn H, Kikuchi K, Takehara K (1998) Serum levels of interleukin 6 (IL-6), oncostatin M, soluble IL-6 receptor, and soluble gp130 in patients with systemic sclerosis. J Rheumatol 25(2):308–313
    • (1998) J Rheumatol , vol.25 , Issue.2 , pp. 308-313
    • Hasegawa, M.1    Sato, S.2    Fujimoto, M.3    Ihn, H.4    Kikuchi, K.5    Takehara, K.6
  • 119
    • 78049421175 scopus 로고    scopus 로고
    • The skin of patients with systemic sclerosis softened during the treatment with anti-IL-6 receptor antibody tocilizumab
    • PID: 20819796, COI: 1:CAS:528:DC%2BC3cXhsVejsbzE
    • Shima Y, Kuwahara Y, Murota H et al (2010) The skin of patients with systemic sclerosis softened during the treatment with anti-IL-6 receptor antibody tocilizumab. Rheumatology 49(12):2408–2412
    • (2010) Rheumatology , vol.49 , Issue.12 , pp. 2408-2412
    • Shima, Y.1    Kuwahara, Y.2    Murota, H.3
  • 120
    • 0030904859 scopus 로고    scopus 로고
    • Cytokine production in muscle tissue of patients with idiopathic inflammatory myopathies
    • PID: 9153548, COI: 1:CAS:528:DyaK2sXjsV2hsLw%3D
    • Lundberg I, Ulfgren AK, Nyberg P, Andersson U, Klareskog L (1997) Cytokine production in muscle tissue of patients with idiopathic inflammatory myopathies. Arthritis Rheum 40(5):865–874
    • (1997) Arthritis Rheum , vol.40 , Issue.5 , pp. 865-874
    • Lundberg, I.1    Ulfgren, A.K.2    Nyberg, P.3    Andersson, U.4    Klareskog, L.5
  • 122
    • 33746078847 scopus 로고    scopus 로고
    • IL-6-deficient mice show impaired inflammatory response in a model of myosin-induced experimental myositis
    • PID: 16725212, COI: 1:CAS:528:DC%2BD28XntlCrs7s%3D
    • Scuderi F, Mannella F, Marino M, Provenzano C, Bartoccioni E (2006) IL-6-deficient mice show impaired inflammatory response in a model of myosin-induced experimental myositis. J Neuroimmunol 176(1–2):9–15
    • (2006) J Neuroimmunol , vol.176 , Issue.1-2 , pp. 9-15
    • Scuderi, F.1    Mannella, F.2    Marino, M.3    Provenzano, C.4    Bartoccioni, E.5
  • 123
    • 68049088818 scopus 로고    scopus 로고
    • Therapeutic effects of interleukin-6 blockade in a murine model of polymyositis that does not require interleukin-17A
    • PID: 19644888, COI: 1:CAS:528:DC%2BD1MXhtV2hsLfE
    • Okiyama N, Sugihara T, Iwakura Y, Yokozeki H, Miyasaka N, Kohsaka H (2009) Therapeutic effects of interleukin-6 blockade in a murine model of polymyositis that does not require interleukin-17A. Arthritis Rheum 60(8):2505–2512
    • (2009) Arthritis Rheum , vol.60 , Issue.8 , pp. 2505-2512
    • Okiyama, N.1    Sugihara, T.2    Iwakura, Y.3    Yokozeki, H.4    Miyasaka, N.5    Kohsaka, H.6
  • 124
    • 79959478448 scopus 로고    scopus 로고
    • Therapeutic effect of tocilizumab on two patients with polymyositis
    • PID: 21515628
    • Narazaki M, Hagihara K, Shima Y, Ogata A, Kishimoto T, Tanaka T (2011) Therapeutic effect of tocilizumab on two patients with polymyositis. Rheumatology 50(7):1344–1346
    • (2011) Rheumatology , vol.50 , Issue.7 , pp. 1344-1346
    • Narazaki, M.1    Hagihara, K.2    Shima, Y.3    Ogata, A.4    Kishimoto, T.5    Tanaka, T.6
  • 125
    • 47349103031 scopus 로고    scopus 로고
    • Polymyalgia rheumatica and giant-cell arteritis
    • PID: 18640460
    • Salvarani C, Cantini F, Hunder GG (2008) Polymyalgia rheumatica and giant-cell arteritis. Lancet 372(9634):234–245
    • (2008) Lancet , vol.372 , Issue.9634 , pp. 234-245
    • Salvarani, C.1    Cantini, F.2    Hunder, G.G.3
  • 126
    • 0033529390 scopus 로고    scopus 로고
    • Interleukin-6 and RANTES in Takayasu arteritis: a guide for therapeutic decisions?
    • PID: 10393681, COI: 1:STN:280:DyaK1Mzit1Clsg%3D%3D
    • Noris M, Daina E, Gamba S, Bonazzola S, Remuzzi G (1999) Interleukin-6 and RANTES in Takayasu arteritis: a guide for therapeutic decisions? Circulation 100(1):55–60
    • (1999) Circulation , vol.100 , Issue.1 , pp. 55-60
    • Noris, M.1    Daina, E.2    Gamba, S.3    Bonazzola, S.4    Remuzzi, G.5
  • 127
    • 42449088420 scopus 로고    scopus 로고
    • Successful treatment of a patient with Takayasu arteritis using a humanized anti-interleukin-6 receptor antibody
    • PID: 18383395, COI: 1:CAS:528:DC%2BD1cXltFGitrY%3D
    • Nishimoto N, Nakahara H, Yoshio-Hoshino N, Mima T (2008) Successful treatment of a patient with Takayasu arteritis using a humanized anti-interleukin-6 receptor antibody. Arthritis Rheum 58(4):1197–1200
    • (2008) Arthritis Rheum , vol.58 , Issue.4 , pp. 1197-1200
    • Nishimoto, N.1    Nakahara, H.2    Yoshio-Hoshino, N.3    Mima, T.4
  • 129
    • 4344641291 scopus 로고    scopus 로고
    • Novel therapy for Crohn’s disease targeting IL-6 signaling
    • PID: 15268624, COI: 1:CAS:528:DC%2BD2cXlvVSju70%3D
    • Ito H (2004) Novel therapy for Crohn’s disease targeting IL-6 signaling. Expert Opin Ther Targets 8(4):287–294
    • (2004) Expert Opin Ther Targets , vol.8 , Issue.4 , pp. 287-294
    • Ito, H.1
  • 130
    • 0034193039 scopus 로고    scopus 로고
    • IL-6 is required for the development of Th1 cell-mediated murine colitis
    • PID: 10779797, COI: 1:CAS:528:DC%2BD3cXivFWmu7g%3D
    • Yamamoto M, Yoshizaki K, Kishimoto T, Ito H (2000) IL-6 is required for the development of Th1 cell-mediated murine colitis. J Immunol 164(9):4878–4882
    • (2000) J Immunol , vol.164 , Issue.9 , pp. 4878-4882
    • Yamamoto, M.1    Yoshizaki, K.2    Kishimoto, T.3    Ito, H.4
  • 131
    • 11144358366 scopus 로고    scopus 로고
    • A pilot randomized trial of a human anti-interleukin-6 receptor monoclonal antibody in active Crohn’s disease
    • PID: 15057738, COI: 1:CAS:528:DC%2BD2cXkt1Krsbo%3D
    • Ito H, Takazoe M, Fukuda Y et al (2004) A pilot randomized trial of a human anti-interleukin-6 receptor monoclonal antibody in active Crohn’s disease. Gastroenterology 126(4):989–996
    • (2004) Gastroenterology , vol.126 , Issue.4 , pp. 989-996
    • Ito, H.1    Takazoe, M.2    Fukuda, Y.3
  • 132
    • 61349092994 scopus 로고    scopus 로고
    • Sustained response to tocilizumab, anti-interleukin-6 receptor antibody, in two patients with refractory relapsing polychondritis
    • PID: 19106169, COI: 1:CAS:528:DC%2BD1MXisVSmsbk%3D
    • Kawai M, Hagihara K, Hirano T et al (2009) Sustained response to tocilizumab, anti-interleukin-6 receptor antibody, in two patients with refractory relapsing polychondritis. Rheumatology 48(3):318–319
    • (2009) Rheumatology , vol.48 , Issue.3 , pp. 318-319
    • Kawai, M.1    Hagihara, K.2    Hirano, T.3
  • 133
    • 83255170953 scopus 로고    scopus 로고
    • Successful treatment of acquired hemophilia A, complicated by chronic GVHD, with tocilizumab
    • PID: 21240617
    • Nishida S, Kawasaki T, Kashiwagi H et al (2011) Successful treatment of acquired hemophilia A, complicated by chronic GVHD, with tocilizumab. Mod Rheumatol 21(4):420–422
    • (2011) Mod Rheumatol , vol.21 , Issue.4 , pp. 420-422
    • Nishida, S.1    Kawasaki, T.2    Kashiwagi, H.3
  • 134
    • 48249148236 scopus 로고    scopus 로고
    • IL-6 blockade inhibits the induction of myelin antigen-specific Th17 cells and Th1 cells in experimental autoimmune encephalomyelitis
    • PID: 18577591, COI: 1:CAS:528:DC%2BD1cXosVCitbY%3D
    • Serada S, Fujimoto M, Mihara M et al (2008) IL-6 blockade inhibits the induction of myelin antigen-specific Th17 cells and Th1 cells in experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A 105(26):9041–9046
    • (2008) Proc Natl Acad Sci U S A , vol.105 , Issue.26 , pp. 9041-9046
    • Serada, S.1    Fujimoto, M.2    Mihara, M.3
  • 135
    • 0028858556 scopus 로고
    • Cutting edge: human IL-17: a novel cytokine derived from T-cells
    • PID: 7499828, COI: 1:CAS:528:DyaK2MXpvVertbk%3D
    • Yao Z, Painter SL, Fanslow WC et al (1995) Cutting edge: human IL-17: a novel cytokine derived from T-cells. J Immunol 155(12):5483–5486
    • (1995) J Immunol , vol.155 , Issue.12 , pp. 5483-5486
    • Yao, Z.1    Painter, S.L.2    Fanslow, W.C.3
  • 136
    • 84892186027 scopus 로고    scopus 로고
    • Current data on IL-17 and Th17 cells and implications for graft versus host disease
    • Normanton M, Marti LC (2013) Current data on IL-17 and Th17 cells and implications for graft versus host disease. Einstein (Sao Paulo) 11(2):237–246
    • (2013) Einstein (Sao Paulo) , vol.11 , Issue.2 , pp. 237-246
    • Normanton, M.1    Marti, L.C.2
  • 137
    • 77953980528 scopus 로고    scopus 로고
    • IL-6: from its discovery to clinical applications
    • PID: 20410258, COI: 1:CAS:528:DC%2BC3cXlsFSls7c%3D
    • Kishimoto T (2010) IL-6: from its discovery to clinical applications. Int Immunol 22(5):347–352
    • (2010) Int Immunol , vol.22 , Issue.5 , pp. 347-352
    • Kishimoto, T.1
  • 138
    • 77954952358 scopus 로고    scopus 로고
    • Blockade of interleukin-6 signaling suppresses experimental autoimmune uveoretinitis by the inhibition of inflammatory Th17 responses
    • PID: 20420831, COI: 1:CAS:528:DC%2BC3cXovFynu7Y%3D
    • Hohki S, Ohguro N, Haruta H et al (2010) Blockade of interleukin-6 signaling suppresses experimental autoimmune uveoretinitis by the inhibition of inflammatory Th17 responses. Exp Eye Res 91(2):162–170
    • (2010) Exp Eye Res , vol.91 , Issue.2 , pp. 162-170
    • Hohki, S.1    Ohguro, N.2    Haruta, H.3
  • 139
    • 57349083145 scopus 로고    scopus 로고
    • Interleukin-6 blockade suppresses autoimmune arthritis in mice by the inhibition of inflammatory Th17 responses
    • PID: 19035481, COI: 1:CAS:528:DC%2BD1MXmt1ymsQ%3D%3D
    • Fujimoto M, Serada S, Mihara M et al (2008) Interleukin-6 blockade suppresses autoimmune arthritis in mice by the inhibition of inflammatory Th17 responses. Arthritis Rheum 58(12):3710–3719
    • (2008) Arthritis Rheum , vol.58 , Issue.12 , pp. 3710-3719
    • Fujimoto, M.1    Serada, S.2    Mihara, M.3
  • 140
    • 78751469023 scopus 로고    scopus 로고
    • Interleukin-6 modulates graft-versus-host responses after experimental allogeneic bone marrow transplantation
    • PID: 21047980, COI: 1:CAS:528:DC%2BC3MXhtVemuw%3D%3D
    • Tawara I, Koyama M, Liu C et al (2011) Interleukin-6 modulates graft-versus-host responses after experimental allogeneic bone marrow transplantation. Clin Cancer Res 17(1):77–88
    • (2011) Clin Cancer Res , vol.17 , Issue.1 , pp. 77-88
    • Tawara, I.1    Koyama, M.2    Liu, C.3
  • 141
    • 84870516776 scopus 로고    scopus 로고
    • IL-6 blockade attenuates the development of murine sclerodermatous chronic graft-versus-host disease
    • PID: 22810302
    • Huu DL, Matsushita T, Jin G et al (2012) IL-6 blockade attenuates the development of murine sclerodermatous chronic graft-versus-host disease. J Invest Dermatol 132(12):2752–2761
    • (2012) J Invest Dermatol , vol.132 , Issue.12 , pp. 2752-2761
    • Huu, D.L.1    Matsushita, T.2    Jin, G.3
  • 142
    • 79953024119 scopus 로고    scopus 로고
    • + T cell-mediated lethal graft-versus-host reaction against minor histocompatibility antigen
    • PID: 21256159, COI: 1:CAS:528:DC%2BC3MXjvV2mu7g%3D
    • + T cell-mediated lethal graft-versus-host reaction against minor histocompatibility antigen. Immunol Lett 136(2):146–155
    • (2011) Immunol Lett , vol.136 , Issue.2 , pp. 146-155
    • Noguchi, D.1    Wakita, D.2    Ohkuri, T.3
  • 143
    • 68249160054 scopus 로고    scopus 로고
    • Blockade of interleukin-6 signaling augments regulatory T-cell reconstitution and attenuates the severity of graft-versus-host disease
    • PID: 19491393, COI: 1:CAS:528:DC%2BD1MXpsVGjsr0%3D
    • Chen X, Das R, Komorowski R et al (2009) Blockade of interleukin-6 signaling augments regulatory T-cell reconstitution and attenuates the severity of graft-versus-host disease. Blood 114(4):891–900
    • (2009) Blood , vol.114 , Issue.4 , pp. 891-900
    • Chen, X.1    Das, R.2    Komorowski, R.3
  • 144
    • 77950299026 scopus 로고    scopus 로고
    • TLR signals promote IL-6/IL-17-dependent transplant rejection
    • PID: 19414775, COI: 1:CAS:528:DC%2BD1MXltlyntbg%3D
    • Chen L, Ahmed E, Wang T et al (2009) TLR signals promote IL-6/IL-17-dependent transplant rejection. J Immunol 182(10):6217–6225
    • (2009) J Immunol , vol.182 , Issue.10 , pp. 6217-6225
    • Chen, L.1    Ahmed, E.2    Wang, T.3
  • 145
    • 84879496417 scopus 로고    scopus 로고
    • Jagged2-signaling promotes IL-6-dependent transplant rejection
    • PID: 23526606, COI: 1:CAS:528:DC%2BC3sXmvVWjsLY%3D
    • Riella LV, Yang J, Chock S et al (2013) Jagged2-signaling promotes IL-6-dependent transplant rejection. Eur J Immunol 43(6):1449–1458
    • (2013) Eur J Immunol , vol.43 , Issue.6 , pp. 1449-1458
    • Riella, L.V.1    Yang, J.2    Chock, S.3
  • 146
    • 78049508308 scopus 로고    scopus 로고
    • Effectiveness and safety of tocilizumab, an anti-interleukin-6 receptor monoclonal antibody, in a patient with refractory GI graft-versus-host disease
    • Gergis U, Arnason J, Yantiss R et al (2010) Effectiveness and safety of tocilizumab, an anti-interleukin-6 receptor monoclonal antibody, in a patient with refractory GI graft-versus-host disease. J Clin Oncol 28(30):602–604
    • (2010) J Clin Oncol , vol.28 , Issue.30 , pp. 602-604
    • Gergis, U.1    Arnason, J.2    Yantiss, R.3
  • 147
    • 81255163590 scopus 로고    scopus 로고
    • Tocilizumab for the treatment of steroid refractory graft-versus-host disease
    • Drobyski WR, Pasquini M, Kovatovic K et al (2011) Tocilizumab for the treatment of steroid refractory graft-versus-host disease. Biol Blood Marrow Transplant 17(12):1855–1877
    • (2011) Biol Blood Marrow Transplant , vol.17 , Issue.12 , pp. 1855-1877
    • Drobyski, W.R.1    Pasquini, M.2    Kovatovic, K.3
  • 148
    • 85019244389 scopus 로고    scopus 로고
    • Tocilizumab in the treatment of steroid refractory graft versus host disease: a single institutional experience
    • Roddy JVF, Haverkos BM, McBride A, et al (2013) Tocilizumab in the treatment of steroid refractory graft versus host disease: a single institutional experience. 2013; ASH (abstract): 2067
    • (2013) 2013; ASH (abstract): 2067
    • Roddy, J.V.F.1    Haverkos, B.M.2    McBride, A.3
  • 149
    • 84869755800 scopus 로고    scopus 로고
    • Targeting interleukin-6: all the way to treat autoimmune and inflammatory diseases
    • PID: 23136551, COI: 1:CAS:528:DC%2BC38Xhs1OitrnO
    • Tanaka T, Kishimoto T (2012) Targeting interleukin-6: all the way to treat autoimmune and inflammatory diseases. Int J Biol Sci 8(9):1227–1236
    • (2012) Int J Biol Sci , vol.8 , Issue.9 , pp. 1227-1236
    • Tanaka, T.1    Kishimoto, T.2
  • 150
    • 67349104400 scopus 로고    scopus 로고
    • Interleukin-6 as a key player in systemic inflammation and joint destruction
    • PID: 19189867, COI: 1:CAS:528:DC%2BD1MXovFaqs70%3D
    • Fonseca JE, Santos MJ, Canhao H, Choy E (2009) Interleukin-6 as a key player in systemic inflammation and joint destruction. Autoimmun Rev 8(7):538–542
    • (2009) Autoimmun Rev , vol.8 , Issue.7 , pp. 538-542
    • Fonseca, J.E.1    Santos, M.J.2    Canhao, H.3    Choy, E.4
  • 151
    • 33748092926 scopus 로고    scopus 로고
    • Interleukin-6 and rheumatic diseases
    • PID: 16899108
    • Lipsky PE (2006) Interleukin-6 and rheumatic diseases. Arthritis Res Ther 8(Suppl 2):S4
    • (2006) Arthritis Res Ther , vol.8 , pp. S4
    • Lipsky, P.E.1
  • 152
    • 0023851809 scopus 로고    scopus 로고
    • The essential role of B cell stimulatory factor 2 (BSF-2/IL-6) for the terminal differentiation of B cells
    • Muraguchi A, Hirano T, Tang B (1998) The essential role of B cell stimulatory factor 2 (BSF-2/IL-6) for the terminal differentiation of B cells. J Exp Med 167(2):332–344
    • (1998) J Exp Med , vol.167 , Issue.2 , pp. 332-344
    • Muraguchi, A.1    Hirano, T.2    Tang, B.3
  • 153
    • 24744435772 scopus 로고    scopus 로고
    • Directing transition from innate to acquired immunity: defining a role for IL-6
    • PID: 16148087, COI: 1:CAS:528:DC%2BD2MXpslCmtbg%3D
    • Jones SA (2005) Directing transition from innate to acquired immunity: defining a role for IL-6. J Immunol 175(6):3463–34638
    • (2005) J Immunol , vol.175 , Issue.6 , pp. 3463-34638
    • Jones, S.A.1
  • 154
    • 66249120016 scopus 로고    scopus 로고
    • IL-6 produced by immune complex-activated follicular dendritic cells promotes germinal center reactions, IgG responses and somatic hypermutation
    • PID: 19461124, COI: 1:CAS:528:DC%2BD1MXms1agtbs%3D
    • Wu Y, El Shikh ME, El Sayed RM, Best AM, Szakal AK, Tew JG (2009) IL-6 produced by immune complex-activated follicular dendritic cells promotes germinal center reactions, IgG responses and somatic hypermutation. Int Immunol 21(6):745–756
    • (2009) Int Immunol , vol.21 , Issue.6 , pp. 745-756
    • Wu, Y.1    El Shikh, M.E.2    El Sayed, R.M.3    Best, A.M.4    Szakal, A.K.5    Tew, J.G.6
  • 155
    • 0032538991 scopus 로고    scopus 로고
    • Interleukin 6 influences germinal center development and antibody production via a contribution of C3 complement component
    • PID: 9815267, COI: 1:CAS:528:DyaK1cXnsVKksr0%3D
    • Kopf M, Herren S, Wiles MV, Pepys MB, Kosco-Vilbois MH (1998) Interleukin 6 influences germinal center development and antibody production via a contribution of C3 complement component. J Exp Med 188(10):1895–1906
    • (1998) J Exp Med , vol.188 , Issue.10 , pp. 1895-1906
    • Kopf, M.1    Herren, S.2    Wiles, M.V.3    Pepys, M.B.4    Kosco-Vilbois, M.H.5
  • 157
    • 1242330309 scopus 로고    scopus 로고
    • Roles of B cells in rheumatoid arthritis
    • PID: 15180890
    • Silverman GJ, Carson DA (2003) Roles of B cells in rheumatoid arthritis. Arthritis Res Ther 5(Suppl 4):S1–S6
    • (2003) Arthritis Res Ther , vol.5 , pp. S1-S6
    • Silverman, G.J.1    Carson, D.A.2
  • 158
    • 47249109393 scopus 로고    scopus 로고
    • Understanding the mechanistic basis in rheumatoid arthritis for clinical response to anti-CD20 therapy: the B-cell roadblock hypothesis
    • PID: 18613836, COI: 1:CAS:528:DC%2BD1cXptlGlsLs%3D
    • Silverman GJ, Boyle DL (2008) Understanding the mechanistic basis in rheumatoid arthritis for clinical response to anti-CD20 therapy: the B-cell roadblock hypothesis. Immunol Rev 223(1):175–185
    • (2008) Immunol Rev , vol.223 , Issue.1 , pp. 175-185
    • Silverman, G.J.1    Boyle, D.L.2
  • 159
    • 79955569760 scopus 로고    scopus 로고
    • In vivo effects of the anti-interleukin-6 receptor inhibitor tocilizumab on the B cell compartment
    • PID: 21305508, COI: 1:CAS:528:DC%2BC3MXltlGhtL4%3D
    • Roll P, Muhammad K, Schumann M (2011) In vivo effects of the anti-interleukin-6 receptor inhibitor tocilizumab on the B cell compartment. Arthritis Rheum 63(5):1255–1264
    • (2011) Arthritis Rheum , vol.63 , Issue.5 , pp. 1255-1264
    • Roll, P.1    Muhammad, K.2    Schumann, M.3
  • 160
    • 80055093209 scopus 로고    scopus 로고
    • Anti-IL-6 receptor antibody (tocilizumab): a B cell targeting therapy
    • PID: 21813064, COI: 1:STN:280:DC%2BC3MfisF2qtQ%3D%3D
    • Snir A, Kessel A, Haj T, Rosner I, Slobodin G, Toubi E (2011) Anti-IL-6 receptor antibody (tocilizumab): a B cell targeting therapy. Clin Exp Rheumatol 29(4):697–700
    • (2011) Clin Exp Rheumatol , vol.29 , Issue.4 , pp. 697-700
    • Snir, A.1    Kessel, A.2    Haj, T.3    Rosner, I.4    Slobodin, G.5    Toubi, E.6
  • 161
    • 79959807954 scopus 로고    scopus 로고
    • Impact of IL-6 receptor inhibition on human memory B cells in vivo: impaired somatic hypermutation in preswitch memory B cells and modulation of mutational targeting in memory B cells
    • PID: 21551509, COI: 1:CAS:528:DC%2BC3MXhtV2ru73M
    • Muhammad K, Roll P, Seibold T (2011) Impact of IL-6 receptor inhibition on human memory B cells in vivo: impaired somatic hypermutation in preswitch memory B cells and modulation of mutational targeting in memory B cells. Ann Rheum Dis 70(8):1507–1510
    • (2011) Ann Rheum Dis , vol.70 , Issue.8 , pp. 1507-1510
    • Muhammad, K.1    Roll, P.2    Seibold, T.3
  • 162
    • 84860702710 scopus 로고    scopus 로고
    • Immunology mini-review: the basics of Th17 and interleukin-6 in transplantation
    • PID: 22564619, COI: 1:CAS:528:DC%2BC38Xmslyisbo%3D
    • Nakagiri T, Inoue M, Minami M, Shintani Y, Okumura M (2012) Immunology mini-review: the basics of Th17 and interleukin-6 in transplantation. Transplant Proc 44(4):1035–1040
    • (2012) Transplant Proc , vol.44 , Issue.4 , pp. 1035-1040
    • Nakagiri, T.1    Inoue, M.2    Minami, M.3    Shintani, Y.4    Okumura, M.5
  • 163
    • 0026680680 scopus 로고
    • Mobilization of T lymphocytes following cardiac transplantation: evidence that CD4-positive cells are required for cytotoxic T lymphocyte activation, inflammatory endothelial development, graft infiltration, and acute allograft rejection
    • PID: 1533070, COI: 1:STN:280:DyaK383ivFynuw%3D%3D
    • Bishop DK, Shelby J, Eichwald EJ (1992) Mobilization of T lymphocytes following cardiac transplantation: evidence that CD4-positive cells are required for cytotoxic T lymphocyte activation, inflammatory endothelial development, graft infiltration, and acute allograft rejection. Transplantation 53(4):849–857
    • (1992) Transplantation , vol.53 , Issue.4 , pp. 849-857
    • Bishop, D.K.1    Shelby, J.2    Eichwald, E.J.3
  • 164
    • 0025074414 scopus 로고
    • Induction of donor-specific unresponsiveness to cardiac allografts in rats by pretransplant anti-CD4 monoclonal antibody therapy
    • PID: 1976282, COI: 1:STN:280:DyaK3czosFGgtw%3D%3D
    • Shizuru JA, Seydel KB, Flavin TF (1990) Induction of donor-specific unresponsiveness to cardiac allografts in rats by pretransplant anti-CD4 monoclonal antibody therapy. Transplantation 50(3):366–373
    • (1990) Transplantation , vol.50 , Issue.3 , pp. 366-373
    • Shizuru, J.A.1    Seydel, K.B.2    Flavin, T.F.3
  • 165
    • 0029661947 scopus 로고    scopus 로고
    • + cells are essential for allorejection
    • PID: 8920888, COI: 1:CAS:528:DyaK28XmvFaitr0%3D
    • + cells are essential for allorejection. J Exp Med 184(5):2013–2018
    • (1996) J Exp Med , vol.184 , Issue.5 , pp. 2013-2018
    • Krieger, N.R.1    Yin, D.P.2    Fathman, C.G.3
  • 167
    • 79953882417 scopus 로고    scopus 로고
    • Human umbilical cord blood-derived stromal cells, a new resource in the suppression of acute graft-versus-host disease in haploidentical stem cell transplantation in sublethally irradiated mice
    • PID: 21349838, COI: 1:CAS:528:DC%2BC3MXksVKlsro%3D
    • Zhang C, Chen XH, Zhang X et al (2011) Human umbilical cord blood-derived stromal cells, a new resource in the suppression of acute graft-versus-host disease in haploidentical stem cell transplantation in sublethally irradiated mice. J Biol Chem 286(15):13723–13732
    • (2011) J Biol Chem , vol.286 , Issue.15 , pp. 13723-13732
    • Zhang, C.1    Chen, X.H.2    Zhang, X.3
  • 168
    • 77749304021 scopus 로고    scopus 로고
    • IL-4 induces protection of vascular endothelial cells against killing by complement and mellitin through lipid biosynthesis
    • PID: 20017192, COI: 1:CAS:528:DC%2BC3cXjtVWkuro%3D
    • Black SM, Schott ME, Batdorf BH (2010) IL-4 induces protection of vascular endothelial cells against killing by complement and mellitin through lipid biosynthesis. Eur J Immunol 40(3):803–812
    • (2010) Eur J Immunol , vol.40 , Issue.3 , pp. 803-812
    • Black, S.M.1    Schott, M.E.2    Batdorf, B.H.3
  • 170
    • 0037408497 scopus 로고    scopus 로고
    • IL-6 production by pulmonary dendritic cells impedes Th1 immune responses
    • PID: 12707321, COI: 1:CAS:528:DC%2BD3sXjtVKgu7w%3D
    • Dodge IL, Carr MW, Cernadas M, Brenner MB (2003) IL-6 production by pulmonary dendritic cells impedes Th1 immune responses. J Immunol 170(9):4457–4464
    • (2003) J Immunol , vol.170 , Issue.9 , pp. 4457-4464
    • Dodge, I.L.1    Carr, M.W.2    Cernadas, M.3    Brenner, M.B.4
  • 171
    • 0034502224 scopus 로고    scopus 로고
    • Inhibition of Th1 differentiation by IL-6 is mediated by SOCS1
    • PID: 11163196, COI: 1:CAS:528:DC%2BD3MXjsVKltQ%3D%3D
    • Diehl S, Anguita J, Hoffmeyer A et al (2000) Inhibition of Th1 differentiation by IL-6 is mediated by SOCS1. Immunity 13(6):805–815
    • (2000) Immunity , vol.13 , Issue.6 , pp. 805-815
    • Diehl, S.1    Anguita, J.2    Hoffmeyer, A.3
  • 173
    • 0031984320 scopus 로고    scopus 로고
    • Augmentation of naive, Th1 and Th2 effector CD4 responses by IL-6, IL-1 and TNF
    • PID: 9485207, COI: 1:CAS:528:DyaK1cXpvVyhtA%3D%3D
    • Joseph SB, Miner KT, Croft M (1998) Augmentation of naive, Th1 and Th2 effector CD4 responses by IL-6, IL-1 and TNF. Eur J Immunol 28(1):277–289
    • (1998) Eur J Immunol , vol.28 , Issue.1 , pp. 277-289
    • Joseph, S.B.1    Miner, K.T.2    Croft, M.3


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