Differential effects of the absence of interferon-γ and IL-4 in acute graft-versus-host disease after allogeneic bone marrow transplantation in mice

Journal of Clinical Investigation

Volumn 102, Issue 9, 1998, Pages 1742-1748

  Murphy, William J ^a   Welniak, Lisbeth A ^a   Taub, Dennis D ^d   Wiltrout, Robert H ^b   Taylor, Patricia A ^e   Vallera, Daniel A ^e   Kopf, Manfred ^c   Young, Howard ^b   Longo, Dan L ^d   Blazar, Bruce R ^e  

^a SAIC FREDERICK INC   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c BASEL INSTITUTE FOR IMMUNOLOGY   (Switzerland)

^d NATIONAL INSTITUTE ON AGING   (United States)

^e UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Bone marrow transplant; Cytokine knockout; Graft versus host disease; IFN; IL 4

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 4; MITOGENIC AGENT; NEUTRALIZING ANTIBODY;

ACUTE DISEASE; ALLOGENIC BONE MARROW TRANSPLANTATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENTEROPATHY; FEMALE; GRAFT VERSUS HOST REACTION; LIVER DISEASE; MORTALITY; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; SKIN DISEASE; SPLEEN CELL; T LYMPHOCYTE; WEIGHT REDUCTION;

EID: 0032211796     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI3906     Document Type: Article

References (32)

1. Ferrara, J.L., K. Cookc, L. Pan, and W. Krenger. 1996. The immunopathophysiology of acute graft-versus-host disease. Stem Cells 14:473-489.
2. Krenger, W., and J. Ferrara. 1996. Dysregulation of cytokines during graft-versus-host disease. J. Hematother. 5:3-14.
3. Krenger, W., and J. Ferrara. 1996. Graft-versus-host disease and the Th1 Th2 paradigm. Immunol. Res. 15:50-73.
4. Storb, R. 1995. Bone marrow transplantation. Transplantation. Proc. 27:2649-2652.
5. Bunjes, D., M. Theobald. T. Nierle, R, Arnold, and H. Heimpel. 1995. Presence of host-specific interleukin-2-secreting T helper cell precursors correlates closely with active primary and secondary chronic graft-versus-host disease. Bone Marrow Transplant. 15:727-732.
6. Williamson, E., P. Garside, J.A. Bradley, I.A. More, and A.M. Mowat. 1997. Neutralizing IL-12 during induction of murine acute graft-versus-host disease polarizes the cytokine profile toward a Th2-type alloimmune response and confers long term protection from disease. J. Immunol. 159:1208-1215.
7. Sykes, M., M.L. Romick, and D.H. Sachs. 1990. Interleukin 2 prevents graft-vs-host disease while preserving the graft-vs-leukemia effect of allogeneic T cells. Proc. Natl. Acad. Sci. USA. 87:5633-5637.
8. Sykes, M., G.L. Szot, P.L. Nguyen, and D.A. Pearson. 1995. Interleukin-12 inhibits murine graft-versus-host disease. Blood. 86:2429-2438.
9. + donor T cells fail to induce experimental acute graft-versus-host disease. J. Immunol. 155:585-593.
10. Krenger, W., K. Cooke, J. Crawford, S. Sonis, R. Simmons, L. Pan, J. Delmonte, J.M. Karandikar, and J. Ferrara. 1996. Transplantation of polarized type 2 donor T cells reduces mortality caused by experimental graft-versus-host disease. Transplantation. 9:1278-1286.
11. Blazar, B.R., P.A. Taylor, S. Smith, and D.A. Vallera. 1995. Interleukin-10 administration decreases survival in murine recipients of major histocompatibility complex disparate donor bone marrow grafts. Blood. 85:842-851.
12. Blazar, B.R., P.A. Taylor, A. Panoskaltsis-Mortari, G.S. Gray, and D.A. Vallera. 1995. Co-blockade of the LFA-1: ICAM and CD28/B7 pathways is a highly effective means of preventing acute lethal graft-versus-host disease induced by fully MHC disparate donor grafts. Blood. 85:2607-2618.
13. Kopf, M., G. Le Gros, M. Bachmann, M-C. Lamers, H. Bluethmann, and G. Kohler. 1993. Disruption of the murine IL-4 gene blocks Th2 cytokine responses. Nature. 151:245-248.
14. Hogarth, P., S. Folkard, M. Taylor, and A. Bioano. 1995. Accelerated clearance of Onchocerca microfilariae and resistance to reinfection in interleukin-4 gene knockout mice. Parasite Immunol 12:653-659.
15. Sykes, M., D.A. Pearson, and G.L. Szot. 1995. GVHD protection is not inhibited by cyclosporine and is maximal when IL-2 is given over a 25 h period beginning on the day following bone marrow transplantation. Bone Marrow Transplant. 15:395-399.
16. Dalton, O.K., S. Pius-Meek, S. Keshav, I.S. Figari, A. Bradley, and T.A. Stewart. 1993. Multiple defects of immune cell function in mice with disrupted IFN-γ genes. Science. 259:1739-1742.
17. Krenger, W., G. Falzarano, and J. Delmonte. 1996. Interferon-γ suppresses T cell proliferation to mitogen via the nitric oxide pathway during experimental acute graft-versus-host disease. Blood. 88:1113-1121.
18. Brok, H.P., P.J. Heidt, P.M. van der Meide. C. Zurcher, and J.M. Vossen. 1993. IFN-γ prevents graft-versus-host disease after allogeneic bone marrow transplantation in mice. J. Immunol. 151:6451-6459.
19. Brok, H.P.M., J.M. Vossen, and J.P. Heidt. 1997. IFN-γ-mediated prevention of graft-versus-host disease: development of immune competent and allo-tolerant T cells in chimeric mice. Bone Marrow Transplant. 19:601-606.
20. Wall, D. A., and K.C. Sheehan. 1994. The role of tumor necrosis factor-α and IFN-γ in graft-versus-host disease and related immunodeficiency. Transplantation. 57:273-279.
21. Raisanen-Sokolowski, A., P.L. Mottram, T. Glysing-Jensen, A. Satoskar, and M.E. Russell. 1997. Heart transplants in IFN-γ, interleukin 4, and IL-10 knockout mice. J. Clin. Invest. 100:2449-2459.
22. Segal, B.M., B.K. Dwyer, and E.M. Shevach. 1998. An interleukin (IL)-IO/IL-12 immunoregulatory circuit controls susceptibility to autoimmune disease. J. Exp. Med.187: 537-546.
23. Ferber, I.A., S. Brocke, C. Taylor-Edwards, W. Ridgway, C. Dinisco, L. Steinman, D. Dalton, and C.G. Fathman. 1996. Mice with a disrupted IFN-γ gene are susceptible to the induction of experimental autoimmune encephalo-myelitis (EAE). J. Immunol. 156:5-7.
24. Billiau, A., H. Heremans, F. Vandekerckhove, R. Dijkmans, H. Sobis, E. Meulepas, and H. Carton. 1988. Enhancement of experimental allergic encephalomyelitis in mice by antibodies against IFN-γ. J. Immunol. 140: 1506-1510.
25. Strom, T., P. Roy-Chaudhury, R. Manfro, X. Zheng, P. Nickerson, K. Wood, and A. Bushell. 1996. The Th1/Th2 paradigm and allograft response. Curr. Opin. Immunol. 8:688-702.
26. Krenger, W., K. Snyder, and S. Smith. 1994. Effects of exogenous interleukin-10 in a murine model of graft-versus-host disease to minor histocompatibility antigens. Transplantation. 58:1251-1257.
27. + lymphoid engraftment. J. Immunol. 152:1004-1013.
28. Ushiyama, C., T. Hirano, H. Miyajima, K. Okumura, Z. Ovary, and H. Hashimoto. 1995. Anti-IL-4 antibody prevents graft-versus-host disease in mice after bone marrow transplantation. J. Immunol. 154:2687-2696.
29. Reiner, S.L. and R.M. Locksley, 1995. The regulation of immunity to Leishmania major. Annti. Rev. Immunol. 13:151-177.
30. Hill, G.R., J.M. Crawford, K.R. Cooke, Y.S. Brinson, L. Pan, and J.L.M. Ferrara. 1997. Total body irradiation and acute graft-versus-host disease: The role of gastrointestinal damage and inflammatory cytokines. Blood. 90:3204-3213.
31. Ellison, C., J.M. Fischer, K.T. HayGlass, and J.G. Gartner. 1998. Murine graft-versus-host disease in an F1-hybrid model using IFN-γ gene knockout donors. J. Immunol. 161:631-640.
32. Murphy, W.J., and D.L. Longo. 1997. The potential role of NK cells in the separation of graft-versus-tumor effects from graft-versus-tumor effects from graft-versus host disease after allogeneic bone marrow transplantation. Immunol. Rev. 157:167-176.