Immunobiology of allograft rejection in the absence of IFN-γ: CD8+ effector cells develop independently of CD4+ cells and CD40-CD40 ligand interactions

Journal of Immunology

Volumn 166, Issue 5, 2001, Pages 3248-3255

  Bishop, D K ^a   Wood, S C ^a   Eichwald, E J ^a   Orosz, C G ^a  

^a UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD40 ANTIGEN; CD8 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 4; MONOCLONAL ANTIBODY;

ANIMAL CELL; ANTIGEN BINDING; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; EFFECTOR CELL; EOSINOPHIL; FEMALE; GRAFT REJECTION; GRAFT SURVIVAL; HISTOPATHOLOGY; IMMUNOBIOLOGY; MOUSE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

EID: 0035284893     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.166.5.3248     Document Type: Article

References (44)

1. Suppression of skin allograft rejection in mice by anti-CD3 monoclonal antibodies without cytokine-related side effects
2. The effect of anti-L3T4 monoclonal antibody treatment on first-set rejection of murine cardiac allografts
3. Costimulatory function and expression of CD40 ligand, CD80, and CD86 in vascularized murine cardiac allograft rejection
4. Transplantation Tolerance Induced by CTLA4-1g
5. Exposure to T helper 2 cytokines in vivo before encounter with antigen selects for T helper subsets via alterations in antigen-presenting cell function
6. Overlapping patterns of activation by human endothelial cells by interleukin 1, tumor necrosis factor and immune interferon
7. T cell infiltration into class II MHC-disparate allografts and acute rejection is dependent on the IFN-γ-induced chemokine Mig
8. Cytokine gene expression in rejecting cardiac allografts
9. Acute rejection of vascularized heart allografts in the absence of IFN gamma
10. IFN-γ is critical for long-term allograft survival induced by blocking the CD28 and CD40 ligand T cell costimulation pathways
11. Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways
12. Primarily vascularized allografts of hearts in mice: The role of H-2D, H-2K, and Non-H-2 antigens in rejection
13. High resolution characterization of cytokine-producing alloreactivity in naïve and allograft-primed mice
14. Mobilization of T lymphocytes following cardiac transplantation: Evidence that CD4-positive cells are required for cytotoxic T lymphocyte activation, inflammatory endothelial development, graft infiltration, and acute allograft rejection
15. Generation of T-cell memory
16. + T cells results in Th2 cytokine production and alternate mechanisms of allograft rejection
17. + T cells
18. + T cell responses: The alternative approaches
19. Evidence for a nonclassical pathway of graft rejection involving interleukin 5 and eosinophils
20. Are Th2 helper T lymphocytes beneficial, deleterious, or irrelevant in promoting allograft survival?
21. An eosinophil-dependent mechanism for the antitumor effect of interleukin-4
22. Analysis of the Th1/Th2 paradigm in transplantation: Interferon-γ deficiency converts Th1-type proislet allograft rejection to a Th2-type xenograft-like response
23. + T lymphocytes and IFN-γ
24. In vivo effects of anti-IL-4 monoclonal antibody on neonatal induction of tolerance and on an associated autoimmune syndrome
25. Anti-IL-4 antibody prevents graft-versus-host disease in mice after bone marrow transplantation. The IgE allotype is an important marker of graft-versus-host disease
26. Anti-IL-4 treatment of Schistosoma mansoni-infected mice inhibits development of T cells and non-B, non-T cells expressing Th2 cytokines while decreasing egg-induced hepatic fibrosis
27. Successful induction of adjuvant arthritis in mice by treatment with a monoclonal antibody against IL-4
28. Impaired alloantigen-mediated T cell apoptosis and failure to induce long-term allograft survival in IL-2-deficient mice
29. Alloantigen-reactive Th1 development in IL-12-deficient mice
30. + T cells
31. + T-cell responses in acute rejection
32. + T cells
33. Identification of a CD8 T cell that can independently mediate autoimmune diabetes development in the complete absence of CD4 T cell helper functions
34. Cutting edge: Tumor secreted heat shock-fusion protein elicits CD8 cells for rejection
35. + T cells
36. + T cells
37. CD4-positive helper T lymphocytes mediate mouse cardiac allograft rejection independent of donor alloantigen specific cytotoxic T lymphocytes
38. + Th2 response in BALB/c mice infected with Leishmania major
39. + T cells can be primed in vitro to produce IL-4
40. IL-4 diminishes perforin-mediated and increases Fas ligand-mediated cytotoxicity in vivo
41. Genetic regulation of cytokine synthesis: Consequences for acute and chronic organ allograft rejection
42. Genotyping for polymorphisms in interferon-γ, interleukin-10, transforming growth factor-β1 and tumour necrosis factor-α genes: A technical report
43. Prolonged murine cardiac allograft acceptance: Characteristics of persistent active alloimmunity after treatment with gallium nitrate versus anti-CD4 monoclonal antibody
44. Mechanisms of graft acceptance: Evidence that plasminogen activator controls donor-reactive delayed-type hypersensitivity responses in cardiac allograft acceptor mice