Early pre-engraftment, functional, in vitro responsiveness of T lymphocytes in allotransplanted, acute leukemia patients: Proliferation and release of a broad profile of cytokines, possibly predictive of graft-versus-host disease

European Cytokine Network

Volumn 21, Issue 1, 2010, Pages 40-49

  Liseth, Knut ^a   Sjo, Malvin ^a   Paulsen, Kristin ^b   Bruserud, Øystein ^a,b   Ersvaer, Elisabeth ^b  

^a HAUKELAND UNIVERSITY HOSPITAL   (Norway)

^b UNIVERSITY OF BERGEN   (Norway)

Author keywords

Allogeneic stem cell transplantation; IFN ; IL 17; Pancytopenia; T cells

Indexed keywords

BUSULFAN; CD3 ANTIBODY; CYCLOPHOSPHAMIDE; CYCLOSPORIN; CYTOKINE; GAMMA INTERFERON; GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 4; INTERLEUKIN 6; METHOTREXATE; MONOCLONAL ANTIBODY CD28; TUMOR NECROSIS FACTOR ALPHA;

ACUTE LEUKEMIA; ADULT; ALLOTRANSPLANTATION; ARTICLE; BLOOD; CLINICAL ARTICLE; CYTOKINE RELEASE; CYTOPENIA; DONOR; ENGRAFTMENT; FEMALE; GRAFT VERSUS HOST REACTION; HLA SYSTEM; HUMAN; IN VITRO STUDY; LYMPHOCYTE PROLIFERATION; MALE; MYELOABLATIVE CONDITIONING; PERIPHERAL BLOOD STEM CELL; PERIPHERAL BLOOD STEM CELL TRANSPLANTATION; PREDICTION; T LYMPHOCYTE;

ADOLESCENT; ADULT; CELL PROLIFERATION; CYTOKINES; FEMALE; GRAFT VS HOST DISEASE; HUMANS; INTERFERON-GAMMA; LYMPHOCYTE ACTIVATION; LYMPHOCYTE COUNT; MALE; MIDDLE AGED; PERIPHERAL BLOOD STEM CELL TRANSPLANTATION; PRECURSOR T-CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PROGNOSIS; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; TRANSPLANTATION CONDITIONING; TRANSPLANTATION, HOMOLOGOUS;

EID: 77149124935     PISSN: 11485493     EISSN: None     Source Type: Journal    
DOI: 10.1684/ecn.2009.0181     Document Type: Article

References (52)

1. Suciu S, Mandelli F, de Witte T, et al. Allogeneic compared with autologous stem cell transplantation in the treatment of patients younger than 46 years with acute myeloid leukemia (AML) in first complete remission (CR1): an intention-to-treat analysis of the EORTC/GIMEMAAML-10 trial. Blood 2003; 102: 1232.
2. Couban S, Simpson DR, Barnett MJ, et al. A randomized multicenter comparison of bone marrow and peripheral blood in recipients of matched sibling allogeneic transplants for myeloid malignancies. Blood 2002; 100: 1525.
3. Vellenga E, van Agthoven M, Croockewit AJ, et al. Autologous peripheral blood stem cell transplantation in patients with relapsed lymphoma results in accelerated haematopoietic reconstitution, improved quality of life and cost reduction compared with bone marrow transplantation: the Hovon 22 study. Br J Haematol 2001; 114: 319.
4. Vose JM, Sharp G, Chan WC, et al. Autologous transplantation for aggressive non-Hodgkin's lymphoma: results of a randomized trial evaluating graft source and minimal residual disease. J Clin Oncol 2002; 20: 2344.
5. Ho VT, Soiffer RJ. The history and future of T-cell depletion as graft-versus-host disease prophylaxis for allogeneic hematopoietic stem cell transplantation. Blood 2001; 98: 3192.
6. Aversa F, Tabilio A, Velardi A, et al. Treatment of high-risk acute leukemia with T-cell-depleted stem cells from related donors with one fully mismatched HLA haplotype. N Engl J Med 1998; 339: 1186.
7. Savage WJ, Bleesing JJ, Douek D, et al. Lymphocyte reconstitution following non-myeloablative hematopoietic stem cell transplantation follows two patterns depending on age and donor/ recipient chimerism. Bone Marrow Transplant 2001; 28: 463.
8. Derdouch S, Gay W, Negre D, et al. Reconstitution of the myeloid and lymphoid compartments after the transplantation of autologous and genetically modified CD34+ bone marrow cells, following gamma irradiation in cynomolgus macaques. Retrovirology 2008; 5: 50.
9. Bomberger C, Singh-Jairam M, Rodey G, et al. Lymphoid reconstitution after autologous PBSC transplantation with FACS-sorted CD34+ hematopoietic progenitors. Blood 1998; 91: 2588.
10. Soiffer RJ, Bosserman L, Murray C, Cochran K, Daley J, Ritz J. Reconstitution of T-cell function after CD6-depleted allogeneic bone marrow transplantation. Blood 1990; 75: 2076.
11. Autran B, Malphettes M, Dhedin N, Gorochov G, Leblond V, Debre P. Studies of T cell reconstitution after hematopoietic stem cell transplant. Hematol Cell Ther 1997; 39: 252.
12. Crooks GM, Weinberg K, Mackall C. Immune reconstitution: from stem cells to lymphocytes. Biol Blood Marrow Transplant 2006; 12: 42.
13. Talmadge JE. Lymphocyte subset recovery following allogeneic bone marrow transplantation: CD4(+)-cell count and transplantrelated mortality. Bone Marrow Transplant 2008; 41: 19.
14. Rozans MK, Smith BR, Burakoff SJ, Miller RA. Long-lasting deficit of functional T cell precursors in human bone marrow transplant recipients revealed by limiting dilution methods. J Immunol 1986; 136: 4040.
15. Mackall CL, Hakim FT, Gress RE. Restoration of T-cell homeostasis after T-cell depletion. Semin Immunol 1997; 9: 339.
16. Mackall CL, Bare CV, Granger LA, Sharrow SO, Titus JA, Gress RE. Thymic-independent T cell regeneration occurs via antigendriven expansion of peripheral T cells resulting in a repertoire that is limited in diversity and prone to skewing. J Immunol 1996; 156: 4609.
17. Mackall CL, Granger L, Sheard MA, Cepeda R, Gress RE. T-cell regeneration after bone marrow transplantation: differential CD45 isoform expression on thymic-derived versus thymic-independent progeny. Blood 1993; 82: 2585.
18. Ashihara E, Shimazaki C, Yamagata N, et al. Reconstitution of lymphocyte subsets after peripheral blood stem cell transplantation: two-color flow cytometric analysis. Bone Marrow Transplant 1994; 13: 377.
19. Kumar S, Chen MG, Gastineau DA, et al. Effect of slow lymphocyte recovery and type of graft-versus-host disease prophylaxis on relapse after allogeneic bone marrow transplantation for acute myelogenous leukemia. Bone Marrow Transplant 2001; 28: 951.
20. Wendelbo O, Bruserud O. Functional evaluation of proliferative T cell responses in patients with severe T lymphopenia: characterization of optimal culture conditions and standardized activation signals for a simple whole blood assay. J Hematother Stem Cell Res 2003; 12: 525.
21. Bruserud O, Ulvestad E. Acute myelogenous leukemia blasts as accessory cells during in vitro T lymphocyte activation. Cell Immunol 2000; 206: 36.
22. Ersvaer E, Hampson P, Hatfield K, et al. T cells remaining after intensive chemotherapy for acute myelogenous leukemia show a broad cytokine release profile including high levels of interferongamma that can be further increased by a novel protein kinase C agonist PEP005. Cancer Immunol Immunother 2007; 56: 913.
23. Bruserud O, Hamann W, Patel S, Ehninger G, Schmidt H, Pawelec G. IFN-gamma and TNF-alpha secretion by CD4+ and CD8+ TCR alpha beta + T-cell clones derived early after allogeneic bone marrow transplantation. Eur J Haematol 1993; 51: 73.
24. Bruserud O, Ulvestad E, Berentsen S, Bergheim J, Nesthus I. T-lymphocyte functions in acute leukaemia patients with severe chemotherapy-induced cytopenia: characterization of clonogenic T-cell proliferation. Scand J Immunol 1998; 47: 54.
25. Socie G, Ratajczak P, Leboeuf C, et al. Th17/Treg in Human Graft-Versus-Host-Disease (GvHD) of the Gastro-Intestinal (GI) Tract. Blood (ASH Annual Meeting Abstracts) 2008; 112.
26. Broxmeyer HE, Starnes T, Ramsey H, et al. The IL-17 cytokine family members are inhibitors of human hematopoietic progenitor proliferation. Blood 2006; 108: 770.
27. Lenkei R, Bratt G, Holmberg V, Muirhead K, Sandstrom E. Indicators of T-cell activation: correlation between quantitative CD38 expression and soluble CD8 levels in asymptomatic HIV+ individuals and healthy controls. Cytometry 1998; 33: 115.
28. Barge RM, Brouwer RE, Beersma MF, et al. Comparison of allogeneic T cell-depleted peripheral blood stem cell and bone marrow transplantation: effect of stem cell source on short- and longterm outcome. Bone Marrow Transplant 2001; 27: 1053.
29. Krenger W, Ferrara JL. Dysregulation of cytokines during graftversus-host disease. J Hematother 1996; 5: 3.
30. Dickinson AM, Cavet J, Cullup H, Wang XN, Sviland L, Middleton PG. GvHD risk assessment in hematopoietic stem cell transplantation: role of cytokine gene polymorphisms and an in vitro human skin explant model. Hum Immunol 2001; 62: 1266.
31. Kappel LW, Goldberg GL, King CG, et al. IL-17 contributes to CD4-mediated graft-versus-host disease. Blood 2009; 113: 945.
32. Yi T, Zhao D, Lin CL, et al. Absence of donor Th17 leads to augmented Th1 differentiation and exacerbated acute graftversus-host disease. Blood 2008; 112: 2101.
33. Talmadge JE, Reed E, Ino K, et al. Rapid immunologic reconstitution following transplantation with mobilized peripheral blood stem cells as compared to bone marrow. Bone Marrow Transplant 1997; 19: 161.
34. Biggar WD, Park BH, Good RA. Immunologic reconstitution. Annu Rev Med 1973; 24: 135.
35. Sharp JG, Kessinger A, Lynch JC, Pavletic ZS, Joshi SS. Blood stem cell transplantation: factors influencing cellular immunological reconstitution. J Hematother Stem Cell Res 2000; 9: 971.
36. Ersvaer E, Hampson P, Wendelbo O, Lord JM, Gjertsen BT, Bruserud O. Circulating T cells in patients with untreated acute myelogenous leukemia are heterogeneous and can be activated through the CD3/TCR complex. Hematology 2007; 12: 199.
37. Bruserud O, Ulvestad E. Cytokine responsiveness of mitogenactivated T cells derived from acute leukemia patients with chemotherapy-induced leukopenia. J Interferon Cytokine Res 2000; 20: 947.
38. Wendelbo O, Nesthus I, Sjo M, Ernst P, Bruserud O. Cellular immune responses in multiple myeloma patients with treatmentinduced cytopenia early after high-dose chemotherapy and autologous peripheral blood stem cell transplantation. Leuk Res 2004; 28: 461.
39. Prentice HG, Blacklock HA, Janossy G, et al. Depletion of T lymphocytes in donor marrow prevents significant graftversus-host disease in matched allogeneic leukaemic marrow transplant recipients. Lancet 1984; 1: 472.
40. Thiant S, Yakoub-Agha I, Terriou L, Jouet J, Dessaint J, Labalette M. Correlation between plasma interleukin 7 and interleukin 15 levels and acute graft versus host disease and relapse in patients undergoing myeloablative allogeneic stem cell transplantation. Bone Marrow Transplantation 2009; 43 (Suppl. 1): S15 (abstract 153).
41. Cavet J, Dickinson AM, Norden J, Taylor PR, Jackson GH, Middleton PG. Interferon-gamma and interleukin-6 gene polymorphisms associate with graft-versus-host disease in HLAmatched sibling bone marrow transplantation. Blood 2001; 98: 1594.
42. Dlubek D, Jaskula E, Sedzimirska M, Lange J, Lange A. Increased proportion of TH17+ cells in patients post hsct heralds overt aGVHD. Bone Marrow Transplantation 2009; 43 (Suppl. 1): S122 (abstract 527).
43. Yeh SP, Liao YM, Chiu CF, Lo WJ, Lin CL. The frequencies of T helper 1, T helper 2 in CD4+ T cells and plasma interleukin-10 are good biomarkers of graft versus host disease. Bone Marrow Transplantation 2009; 43 (Suppl. 1): S124 (abstract 533).
44. Gaffen SL, Kramer JM, Yu JJ, Shen F. The IL-17 cytokine family. Vitam Horm 2006; 74: 255.
45. Kramer JM, Gaffen SL. Interleukin-17: a new paradigm in inflammation, autoimmunity, and therapy. J Periodontol 2007; 78: 1083.
46. Chen Z, O'Shea JJ. Th17 cells: a new fate for differentiating helper T cells. Immunol Res 2008; 41: 8.
47. Radhakrishnan S, Cabrera R, Schenk EL, et al. Reprogrammed FoxP3+ T regulatory cells become IL-17+ antigen-specific autoimmune effectors in vitro and in vivo. J Immunol 2008; 181: 3137.
48. Wolf D, Wolf AM, Fong D, et al. Regulatory T-cells in the graft and the risk of acute graft-versus-host disease after allogeneic stem cell transplantation. Transplantation 2007; 83: 1107.
49. Edinger M, Powrie F, Chakraverty R. Regulatory mechanisms in graft-versus-host responses. Biol Blood Marrow Transplant 2008; 15: 2.
50. Engelhardt B, Jagasia M, Rock MT, et al. Circulating Gut- or Skin-Homing Regulatory T Cells (Tregs) Predict Whether Acute Graft-Versus-Host Disease (aGVHD) Occurs in Gut or Skin Following Allogeneic Stem Cell Transplantation (ASCT). Blood 2008; 112 (Suppl. 1): S11 (abstract 717).
51. Carlson MJ, West ML, Coghill JM, Panoskaltsis-Mortari A, Blazar JS. In vitro-differentiated TH17 cells mediate lethal acute graft-versus-host disease with severe cutaneous and pulmonary pathologic manifestations. Blood 2009; 113: 1365.
52. Paczesny S, Krijanovski OI, Braun TM, et al. A biomarker panel for acute graft-versus-host disease. Blood 2009; 113: 273.