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Volumn 60, Issue 8, 2009, Pages 2505-2512

Therapeutic effects of interleukin-6 blockade in a murine model of polymyositis that does not require interleukin-17A

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 17; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR ANTIBODY; MONOCLONAL ANTIBODY; PROTEIN C; UNCLASSIFIED DRUG;

EID: 68049088818     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.24689     Document Type: Article
Times cited : (87)

References (50)
  • 1
    • 0141651951 scopus 로고    scopus 로고
    • Polymyositis and dermatomyositis
    • Dalakas MC, Hohlfeld R. Polymyositis and dermatomyositis. Lancet 2003;362:971-82.
    • (2003) Lancet , vol.362 , pp. 971-982
    • Dalakas, M.C.1    Hohlfeld, R.2
  • 2
    • 68049097679 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled trial of infliximab in patients with polymyositis and dermatomyositis [abstract]
    • Coyle K, Pokrovnichka A, French K, Joe G, Shrader J, Swan L, et al. A randomized, double-blind, placebo-controlled trial of infliximab in patients with polymyositis and dermatomyositis [abstract]. Arthritis Rheum 2008;58 Suppl 9:S923-4.
    • (2008) Arthritis Rheum , vol.58 , Issue.SUPPL. 9
    • Coyle, K.1    Pokrovnichka, A.2    French, K.3    Joe, G.4    Shrader, J.5    Swan, L.6
  • 4
    • 8944230654 scopus 로고    scopus 로고
    • Differential expression of perforin in muscle-infiltrating T cells in polymyositis and dermatomyositis
    • Goebels N, Michaelis D, Engelhardt M, Huber S, Bender A, Pongratz D, et al. Differential expression of perforin in muscle-infiltrating T cells in polymyositis and dermatomyositis. J Clin Invest 1996;97:2905-10.
    • (1996) J Clin Invest , vol.97 , pp. 2905-2910
    • Goebels, N.1    Michaelis, D.2    Engelhardt, M.3    Huber, S.4    Bender, A.5    Pongratz, D.6
  • 5
    • 0024338394 scopus 로고
    • Aberrant expression of class II MHC antigens by skeletal muscle endothelial cells in experimental autoimmune myositis
    • Rosenberg NL, Kotzin BL. Aberrant expression of class II MHC antigens by skeletal muscle endothelial cells in experimental autoimmune myositis. J Immunol 1989;142:4289-94.
    • (1989) J Immunol , vol.142 , pp. 4289-4294
    • Rosenberg, N.L.1    Kotzin, B.L.2
  • 6
    • 0030461548 scopus 로고    scopus 로고
    • Experimental autoimmune myositis in SJL/J mice produced by immunization with syngeneic myosin B fraction: Transfer by both immunoglobulin G and T cells
    • Matsubara S, Okumura S. Experimental autoimmune myositis in SJL/J mice produced by immunization with syngeneic myosin B fraction: transfer by both immunoglobulin G and T cells. J Neurol Sci 1996;144:171-5.
    • (1996) J Neurol Sci , vol.144 , pp. 171-175
    • Matsubara, S.1    Okumura, S.2
  • 7
    • 0032850960 scopus 로고    scopus 로고
    • Dysferlin deletion in SJL mice (SJL-Dysf) defines a natural model for limb girdle muscular dystrophy 2B
    • Bittner RE, Anderson LV, Burkhardt E, Bashir R, Vafiadaki E, Ivanova S, et al. Dysferlin deletion in SJL mice (SJL-Dysf) defines a natural model for limb girdle muscular dystrophy 2B. Nat Genet 1999;23:141-2.
    • (1999) Nat Genet , vol.23 , pp. 141-142
    • Bittner, R.E.1    Anderson, L.V.2    Burkhardt, E.3    Bashir, R.4    Vafiadaki, E.5    Ivanova, S.6
  • 8
    • 34247217343 scopus 로고    scopus 로고
    • A new murine model to define the critical pathologic and therapeutic mediators of polymyositis
    • Sugihara T, Sekine C, Nakae T, Kohyama K, Harigai M, Iwakura Y, et al. A new murine model to define the critical pathologic and therapeutic mediators of polymyositis. Arthritis Rheum 2007;56:1304-14.
    • (2007) Arthritis Rheum , vol.56 , pp. 1304-1314
    • Sugihara, T.1    Sekine, C.2    Nakae, T.3    Kohyama, K.4    Harigai, M.5    Iwakura, Y.6
  • 9
    • 0032945827 scopus 로고    scopus 로고
    • Identification of the A-band localization domain of myosin binding proteins C and H (MyBP-C, MyBP-H) in skeletal muscle
    • Gilbert R, Cohen JA, Pardo S, Basu A, Fischman DA. Identification of the A-band localization domain of myosin binding proteins C and H (MyBP-C, MyBP-H) in skeletal muscle. J Cell Sci 1999;112(Pt 1):69-79.
    • (1999) J Cell Sci , vol.112 , Issue.PART 1 , pp. 69-79
    • Gilbert, R.1    Cohen, J.A.2    Pardo, S.3    Basu, A.4    Fischman, D.A.5
  • 10
    • 0030904859 scopus 로고    scopus 로고
    • Cytokine production in muscle tissue of patients with idiopathic inflammatory myopathies
    • Lundberg I, Ulfgren AK, Nyberg P, Andersson U, Klareskog L. Cytokine production in muscle tissue of patients with idiopathic inflammatory myopathies. Arthritis Rheum 1997;40:865-74.
    • (1997) Arthritis Rheum , vol.40 , pp. 865-874
    • Lundberg, I.1    Ulfgren, A.K.2    Nyberg, P.3    Andersson, U.4    Klareskog, L.5
  • 12
    • 0027992589 scopus 로고
    • Elevated serum levels of interleukin-1 receptor antagonist in polymyositis/dermatomyositis: A biologic marker of disease activity with a possible role in the lack of acute-phase protein response
    • Gabay C, Gay-Croisier F, Roux-Lombard P, Meyer O, Maineti C, Guerne PA, et al. Elevated serum levels of interleukin-1 receptor antagonist in polymyositis/dermatomyositis: a biologic marker of disease activity with a possible role in the lack of acute-phase protein response. Arthritis Rheum 1994;37:1744-51.
    • (1994) Arthritis Rheum , vol.37 , pp. 1744-1751
    • Gabay, C.1    Gay-Croisier, F.2    Roux-Lombard, P.3    Meyer, O.4    Maineti, C.5    Guerne, P.A.6
  • 13
    • 0023847979 scopus 로고
    • B cell stimulatory factor-2 is involved in the differentiation of cytotoxic T lymphocytes
    • Takai Y, Wong GG, Clark SC, Burakoff SJ, Herrmann SH. B cell stimulatory factor-2 is involved in the differentiation of cytotoxic T lymphocytes. J Immunol 1988;140:508-12.
    • (1988) J Immunol , vol.140 , pp. 508-512
    • Takai, Y.1    Wong, G.G.2    Clark, S.C.3    Burakoff, S.J.4    Herrmann, S.H.5
  • 14
    • 0023803252 scopus 로고
    • IL-6/BSF-2 functions as a killer helper factor in the in vitro induction of cytotoxic T cells
    • Okada M, Kitahara M, Kishimoto S, Matsuda T, Hirano T, Kishimoto T. IL-6/BSF-2 functions as a killer helper factor in the in vitro induction of cytotoxic T cells. J Immunol 1988;141:1543-9.
    • (1988) J Immunol , vol.141 , pp. 1543-1549
    • Okada, M.1    Kitahara, M.2    Kishimoto, S.3    Matsuda, T.4    Hirano, T.5    Kishimoto, T.6
  • 15
    • 32244442562 scopus 로고    scopus 로고
    • TGFβ in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells
    • Veldhoen M, Hocking RJ, Atkins CJ, Locksley RM, Stockinger B. TGFβ in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 2006;24:179-89.
    • (2006) Immunity , vol.24 , pp. 179-189
    • Veldhoen, M.1    Hocking, R.J.2    Atkins, C.J.3    Locksley, R.M.4    Stockinger, B.5
  • 16
    • 0036754255 scopus 로고    scopus 로고
    • Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses
    • Nakae S, Komiyama Y, Nambu A, Sudo K, Iwase M, Homma I, et al. Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses. Immunity 2002;17:375-87.
    • (2002) Immunity , vol.17 , pp. 375-387
    • Nakae, S.1    Komiyama, Y.2    Nambu, A.3    Sudo, K.4    Iwase, M.5    Homma, I.6
  • 17
    • 33745321276 scopus 로고    scopus 로고
    • IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis
    • Komiyama Y, Nakae S, Matsuki T, Nambu A, Ishigame H, Kakuta S, et al. IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis. J Immunol 2006;177:566-73.
    • (2006) J Immunol , vol.177 , pp. 566-573
    • Komiyama, Y.1    Nakae, S.2    Matsuki, T.3    Nambu, A.4    Ishigame, H.5    Kakuta, S.6
  • 19
    • 1042267236 scopus 로고    scopus 로고
    • Treatment with a neutralizing anti-murine interleukin-17 antibody after the onset of collagen-induced arthritis reduces joint inflammation, cartilage destruction, and bone erosion
    • Lubberts E, Koenders MI, Oppers-Walgreen B, van den Bersselaar L, Coenen-de Roo CJ, Joosten LA, et al. Treatment with a neutralizing anti-murine interleukin-17 antibody after the onset of collagen-induced arthritis reduces joint inflammation, cartilage destruction, and bone erosion. Arthritis Rheum 2004;50:650-9.
    • (2004) Arthritis Rheum , vol.50 , pp. 650-659
    • Lubberts, E.1    Koenders, M.I.2    Oppers-Walgreen, B.3    van den Bersselaar, L.4    Coenen-de Roo, C.J.5    Joosten, L.A.6
  • 20
    • 30944452780 scopus 로고    scopus 로고
    • Therapeutic efficacy of IL-17 neutralization in murine experimental autoimmune encephalomyelitis
    • Hofstetter HH, Ibrahim SM, Koczan D, Kruse N, Weishaupt A, Toyka KV, et al. Therapeutic efficacy of IL-17 neutralization in murine experimental autoimmune encephalomyelitis. Cell Immunol 2005;237:123-30.
    • (2005) Cell Immunol , vol.237 , pp. 123-130
    • Hofstetter, H.H.1    Ibrahim, S.M.2    Koczan, D.3    Kruse, N.4    Weishaupt, A.5    Toyka, K.V.6
  • 21
    • 33751242743 scopus 로고    scopus 로고
    • Neutralization of IL-17 by active vaccination inhibits IL-23-dependent autoimmune myocarditis
    • Sonderegger I, Rohn TA, Kurrer MO, Iezzi G, Zou Y, Kastelein RA, et al. Neutralization of IL-17 by active vaccination inhibits IL-23-dependent autoimmune myocarditis. Eur J Immunol 2006;36:2849-56.
    • (2006) Eur J Immunol , vol.36 , pp. 2849-2856
    • Sonderegger, I.1    Rohn, T.A.2    Kurrer, M.O.3    Iezzi, G.4    Zou, Y.5    Kastelein, R.A.6
  • 22
    • 0032536542 scopus 로고    scopus 로고
    • Interleukin 6 is required for the development of collagen-induced arthritis
    • Alonzi T, Fattori E, Lazzaro D, Costa P, Probert L, Kollias G, et al. Interleukin 6 is required for the development of collagen-induced arthritis. J Exp Med 1998;187:461-8.
    • (1998) J Exp Med , vol.187 , pp. 461-468
    • Alonzi, T.1    Fattori, E.2    Lazzaro, D.3    Costa, P.4    Probert, L.5    Kollias, G.6
  • 23
    • 0033503152 scopus 로고    scopus 로고
    • Delayed onset and reduced severity of collagen-induced arthritis in interleukin-6-deficient mice
    • Sasai M, Saeki Y, Ohshima S, Nishioka K, Mima T, Tanaka T, et al. Delayed onset and reduced severity of collagen-induced arthritis in interleukin-6-deficient mice. Arthritis Rheum 1999;42:1635-43.
    • (1999) Arthritis Rheum , vol.42 , pp. 1635-1643
    • Sasai, M.1    Saeki, Y.2    Ohshima, S.3    Nishioka, K.4    Mima, T.5    Tanaka, T.6
  • 24
    • 0032534730 scopus 로고    scopus 로고
    • IL-6-deficient mice are resistant to experimental autoimmune encephalomyelitis: Roles of IL-6 in the activation and differentiation of autoreactive T cells
    • Samoilova EB, Horton JL, Hilliard B, Liu TS, Chen Y. IL-6-deficient mice are resistant to experimental autoimmune encephalomyelitis: roles of IL-6 in the activation and differentiation of autoreactive T cells. J Immunol 1998;161:6480-6.
    • (1998) J Immunol , vol.161 , pp. 6480-6486
    • Samoilova, E.B.1    Horton, J.L.2    Hilliard, B.3    Liu, T.S.4    Chen, Y.5
  • 25
    • 0037458105 scopus 로고    scopus 로고
    • Interleukin-6-deficient mice resist development of autoimmune myocarditis associated with impaired upregulation of complement C3
    • Eriksson U, Kurrer MO, Schmitz N, Marsch SC, Fontana A, Eugster HP, et al. Interleukin-6-deficient mice resist development of autoimmune myocarditis associated with impaired upregulation of complement C3. Circulation 2003;107:320-5.
    • (2003) Circulation , vol.107 , pp. 320-325
    • Eriksson, U.1    Kurrer, M.O.2    Schmitz, N.3    Marsch, S.C.4    Fontana, A.5    Eugster, H.P.6
  • 26
    • 0032429668 scopus 로고    scopus 로고
    • Blockage of interleukin-6 receptor ameliorates joint disease in murine collagen-induced arthritis
    • Takagi N, Mihara M, Moriya Y, Nishimoto N, Yoshizaki K, Kishimoto T, et al. Blockage of interleukin-6 receptor ameliorates joint disease in murine collagen-induced arthritis. Arthritis Rheum 1998;41:2117-21.
    • (1998) Arthritis Rheum , vol.41 , pp. 2117-2121
    • Takagi, N.1    Mihara, M.2    Moriya, Y.3    Nishimoto, N.4    Yoshizaki, K.5    Kishimoto, T.6
  • 27
    • 0029411144 scopus 로고
    • Administration of neutralizing antibodies to interleukin-6 (IL-6) reduces experimental autoimmune encephalomyelitis and is associated with elevated levels of IL-6 bioactivity in central nervous system and circulation
    • Gijbels K, Brocke S, Abrams JS, Steinman L. Administration of neutralizing antibodies to interleukin-6 (IL-6) reduces experimental autoimmune encephalomyelitis and is associated with elevated levels of IL-6 bioactivity in central nervous system and circulation. Mol Med 1995;1:795-805.
    • (1995) Mol Med , vol.1 , pp. 795-805
    • Gijbels, K.1    Brocke, S.2    Abrams, J.S.3    Steinman, L.4
  • 28
    • 48249148236 scopus 로고    scopus 로고
    • IL-6 blockade inhibits the induction of myelin antigen-specific Th17 cells and Th1 cells in experimental autoimmune encephalomyelitis
    • Serada S, Fujimoto M, Mihara M, Koike N, Ohsugi Y, Nomura S, et al. IL-6 blockade inhibits the induction of myelin antigen-specific Th17 cells and Th1 cells in experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A 2008;105:9041-6.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 9041-9046
    • Serada, S.1    Fujimoto, M.2    Mihara, M.3    Koike, N.4    Ohsugi, Y.5    Nomura, S.6
  • 29
    • 0028328436 scopus 로고
    • Impaired immune and acute-phase responses in interleukin-6-deficient mice
    • Kopf M, Baumann H, Freer G, Freudenberg M, Lamers M, Kishimoto T, et al. Impaired immune and acute-phase responses in interleukin-6-deficient mice. Nature 1994;368:339-42.
    • (1994) Nature , vol.368 , pp. 339-342
    • Kopf, M.1    Baumann, H.2    Freer, G.3    Freudenberg, M.4    Lamers, M.5    Kishimoto, T.6
  • 32
    • 33646417072 scopus 로고    scopus 로고
    • The IL-23/IL-17 axis in inflammation
    • Iwakura Y, Ishigame H. The IL-23/IL-17 axis in inflammation. J Clin Invest 2006;116:1218-22.
    • (2006) J Clin Invest , vol.116 , pp. 1218-1222
    • Iwakura, Y.1    Ishigame, H.2
  • 33
    • 0344585384 scopus 로고    scopus 로고
    • Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice
    • Nakae S, Nambu A, Sudo K, Iwakura Y. Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice. J Immunol 2003;171:6173-7.
    • (2003) J Immunol , vol.171 , pp. 6173-6177
    • Nakae, S.1    Nambu, A.2    Sudo, K.3    Iwakura, Y.4
  • 34
    • 58149231532 scopus 로고    scopus 로고
    • Differential roles of interleukin-17A and -17F in host defense against mucoepithelial bacterial infection and allergic responses
    • Ishigame H, Kakuta S, Nagai T, Kadoki M, Nambu A, Komiyama Y, et al. Differential roles of interleukin-17A and -17F in host defense against mucoepithelial bacterial infection and allergic responses. Immunity 2009;30:108-19.
    • (2009) Immunity , vol.30 , pp. 108-119
    • Ishigame, H.1    Kakuta, S.2    Nagai, T.3    Kadoki, M.4    Nambu, A.5    Komiyama, Y.6
  • 36
    • 40049103352 scopus 로고    scopus 로고
    • IL-22 is expressed by Th17 cells in an IL-23-dependent fashion, but not required for the development of autoimmune encephalomyelitis
    • Kreymborg K, Etzensperger R, Dumoutier L, Haak S, Rebollo A, Buch T, et al. IL-22 is expressed by Th17 cells in an IL-23-dependent fashion, but not required for the development of autoimmune encephalomyelitis. J Immunol 2007;179:8098-104.
    • (2007) J Immunol , vol.179 , pp. 8098-8104
    • Kreymborg, K.1    Etzensperger, R.2    Dumoutier, L.3    Haak, S.4    Rebollo, A.5    Buch, T.6
  • 37
    • 33750815930 scopus 로고    scopus 로고
    • CD8+ IL-17-producing T cells are important in effector functions for the elicitation of contact hypersensitivity responses
    • He D, Wu L, Kim HK, Li H, Elmets CA, Xu H. CD8+ IL-17-producing T cells are important in effector functions for the elicitation of contact hypersensitivity responses. J Immunol 2006;177:6852-8.
    • (2006) J Immunol , vol.177 , pp. 6852-6858
    • He, D.1    Wu, L.2    Kim, H.K.3    Li, H.4    Elmets, C.A.5    Xu, H.6
  • 38
    • 34547769911 scopus 로고    scopus 로고
    • Induction of a distinct CD8 Tnc17 subset by transforming growth factor-β and interleukin-6
    • Liu SJ, Tsai JP, Shen CR, Sher YP, Hsieh CL, Yeh YC, et al. Induction of a distinct CD8 Tnc17 subset by transforming growth factor-β and interleukin-6. J Leukoc Biol 2007;82:354-60.
    • (2007) J Leukoc Biol , vol.82 , pp. 354-360
    • Liu, S.J.1    Tsai, J.P.2    Shen, C.R.3    Sher, Y.P.4    Hsieh, C.L.5    Yeh, Y.C.6
  • 39
    • 0037376738 scopus 로고    scopus 로고
    • Interleukin-17 increases the effects of IL-1β on muscle cells: Arguments for the role of T cells in the pathogenesis of myositis
    • Chevrel G, Page G, Granet C, Streichenberger N, Varennes A, Miossec P. Interleukin-17 increases the effects of IL-1β on muscle cells: arguments for the role of T cells in the pathogenesis of myositis. J Neuroimmunol 2003;137:125-33.
    • (2003) J Neuroimmunol , vol.137 , pp. 125-133
    • Chevrel, G.1    Page, G.2    Granet, C.3    Streichenberger, N.4    Varennes, A.5    Miossec, P.6
  • 40
    • 0029913380 scopus 로고    scopus 로고
    • Identification of cardiac myosin peptides capable of inducing autoimmune myocarditis in BALB/c mice
    • Pummerer CL, Luze K, Grassl G, Bachmaier K, Offner F, Burrell SK, et al. Identification of cardiac myosin peptides capable of inducing autoimmune myocarditis in BALB/c mice. J Clin Invest 1996;97:2057-62.
    • (1996) J Clin Invest , vol.97 , pp. 2057-2062
    • Pummerer, C.L.1    Luze, K.2    Grassl, G.3    Bachmaier, K.4    Offner, F.5    Burrell, S.K.6
  • 41
    • 33746078847 scopus 로고    scopus 로고
    • IL-6-deficient mice show impaired inflammatory response in a model of myosin-induced experimental myositis
    • Scuderi F, Mannella F, Marino M, Provenzano C, Bartoccioni E. IL-6-deficient mice show impaired inflammatory response in a model of myosin-induced experimental myositis. J Neuroimmunol 2006;176:9-15.
    • (2006) J Neuroimmunol , vol.176 , pp. 9-15
    • Scuderi, F.1    Mannella, F.2    Marino, M.3    Provenzano, C.4    Bartoccioni, E.5
  • 43
    • 0030891228 scopus 로고    scopus 로고
    • Role of IL-6 and its soluble receptor in induction of chemokines and leukocyte recruitment
    • Romano M, Sironi M, Toniatti C, Polentarutti N, Fruscella P, Ghezzi P, et al. Role of IL-6 and its soluble receptor in induction of chemokines and leukocyte recruitment. Immunity 1997;6:315-25.
    • (1997) Immunity , vol.6 , pp. 315-325
    • Romano, M.1    Sironi, M.2    Toniatti, C.3    Polentarutti, N.4    Fruscella, P.5    Ghezzi, P.6
  • 44
    • 0031471861 scopus 로고    scopus 로고
    • Retrograde inflammatory signaling from neutrophils to endothelial cells by soluble interleukin-6 receptor α
    • Modur V, Li Y, Zimmerman GA, Prescott SM, McIntyre TM. Retrograde inflammatory signaling from neutrophils to endothelial cells by soluble interleukin-6 receptor α. J Clin Invest 1997;100:2752-6.
    • (1997) J Clin Invest , vol.100 , pp. 2752-2756
    • Modur, V.1    Li, Y.2    Zimmerman, G.A.3    Prescott, S.M.4    McIntyre, T.M.5
  • 45
    • 34447300492 scopus 로고    scopus 로고
    • Study of active controlled monotherapy used for rheumatoid arthritis, an IL-6 inhibitor (SAMURAI): Evidence of clinical and radiographic benefit from an x ray reader-blinded randomised controlled trial of tocilizumab
    • Nishimoto N, Hashimoto J, Miyasaka N, Yamamoto K, Kawai S, Takeuchi T, et al. Study of active controlled monotherapy used for rheumatoid arthritis, an IL-6 inhibitor (SAMURAI): evidence of clinical and radiographic benefit from an x ray reader-blinded randomised controlled trial of tocilizumab. Ann Rheum Dis 2007;66:1162-7.
    • (2007) Ann Rheum Dis , vol.66 , pp. 1162-1167
    • Nishimoto, N.1    Hashimoto, J.2    Miyasaka, N.3    Yamamoto, K.4    Kawai, S.5    Takeuchi, T.6
  • 46
    • 64949190561 scopus 로고    scopus 로고
    • Long-term safety and efficacy of tocilizumab, an anti-interleukin-6 receptor monoclonal antibody, in monotherapy, in patients with rheumatoid arthritis (the STREAM study): Evidence of safety and efficacy in a 5-year extension study
    • E-pub ahead of print
    • Nishimoto N, Miyasaka N, Yamamoto K, Kawai S, Takeuchi T, Azuma J. Long-term safety and efficacy of tocilizumab, an anti-interleukin-6 receptor monoclonal antibody, in monotherapy, in patients with rheumatoid arthritis (the STREAM study): evidence of safety and efficacy in a 5-year extension study. Ann Rheum Dis 2008. E-pub ahead of print.
    • (2008) Ann Rheum Dis
    • Nishimoto, N.1    Miyasaka, N.2    Yamamoto, K.3    Kawai, S.4    Takeuchi, T.5    Azuma, J.6
  • 47
    • 27144488346 scopus 로고    scopus 로고
    • Humanized anti-interleukin-6 receptor antibody treatment of multicentric Castleman disease
    • Nishimoto N, Kanakura Y, Aozasa K, Johkoh T, Nakamura M, Nakano S, et al. Humanized anti-interleukin-6 receptor antibody treatment of multicentric Castleman disease. Blood 2005;106:2627-32.
    • (2005) Blood , vol.106 , pp. 2627-2632
    • Nishimoto, N.1    Kanakura, Y.2    Aozasa, K.3    Johkoh, T.4    Nakamura, M.5    Nakano, S.6
  • 49
    • 37449022587 scopus 로고    scopus 로고
    • Interleukin-6 is an essential regulator of satellite cell-mediated skeletal muscle hypertrophy
    • Serrano AL, Baeza-Raja B, Perdiguero E, Jardi M, Munoz-Canoves P. Interleukin-6 is an essential regulator of satellite cell-mediated skeletal muscle hypertrophy. Cell Metab 2008;7:33-44.
    • (2008) Cell Metab , vol.7 , pp. 33-44
    • Serrano, A.L.1    Baeza-Raja, B.2    Perdiguero, E.3    Jardi, M.4    Munoz-Canoves, P.5
  • 50
    • 33749236201 scopus 로고    scopus 로고
    • Immunization of mice with T cell-dependent antigens promotes IL-6 and TNF-α production in muscle cells
    • Tuzun E, Li J, Wanasen N, Soong L, Christadoss P. Immunization of mice with T cell-dependent antigens promotes IL-6 and TNF-α production in muscle cells. Cytokine 2006;35:100-6.
    • (2006) Cytokine , vol.35 , pp. 100-106
    • Tuzun, E.1    Li, J.2    Wanasen, N.3    Soong, L.4    Christadoss, P.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.