A short course of mycophenolate immunosuppression inhibits rejection, but not tolerance, of rat liver allografts in association with inhibition of interleukin-4 and alloantibody responses

Transplantation

Volumn 76, Issue 8, 2003, Pages 1159-1165

  Huang, Wen Hua ^c   Yan, Yiqun ^a   Li, Jian ^a   De Boer, Bastiaan ^c   House, Anthony K ^b   Bishop, G Alex ^a  

^a CENTENARY INSTITUTE   (Australia)

^b PATHWEST LABORATORY MEDICINE   (Australia)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

ALLOANTIBODY; CYTOKINE; GAMMA INTERFERON; IMMUNOGLOBULIN G1; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; MESSENGER RNA; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY RESPONSE; ARTICLE; BILIARY TRACT DISEASE; CONTROLLED STUDY; DRUG EFFICACY; GENE EXPRESSION; GRAFT REJECTION; GRAFT SURVIVAL; IMMUNOSUPPRESSIVE TREATMENT; LIVER FAILURE; LIVER GRAFT; LYMPHOCYTIC INFILTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; T LYMPHOCYTE; TRANSPLANTATION TOLERANCE; TREATMENT OUTCOME;

ANIMALS; CYTOKINES; DRUG ADMINISTRATION SCHEDULE; GENE EXPRESSION; GRAFT REJECTION; IMMUNOHISTOCHEMISTRY; IMMUNOSUPPRESSION; IMMUNOSUPPRESSIVE AGENTS; INTERLEUKIN-4; ISOANTIBODIES; LIVER; LIVER TRANSPLANTATION; MALE; MYCOPHENOLIC ACID; RATS; RATS, INBRED STRAINS; SURVIVAL ANALYSIS; TIME FACTORS; TRANSPLANTATION TOLERANCE; TRANSPLANTATION, HOMOLOGOUS;

EID: 0242300609     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.TP.0000092304.18324.42     Document Type: Article

References (41)

1. Calne RY, Sells RA, Pena JR, et al. Induction of immunological tolerance by porcine liver allografts. Nature 1969; 223: 472.
2. Zimmermann FA, Butcher GW, Davies HS, et al. Techniques for orthotopic liver transplantation in the rat and some studies of the immunologic responses to fully allogeneic liver grafts. Transplant Proc 1979; 11: 571.
3. Bishop GA, Sun J, DeCruz DJ, et al. Tolerance to rat liver allografts. III. Donor cell migration and tolerance-associated cytokine production in peripheral lymphoid tissues. J Immunol 1996; 156: 4925.
4. Qian S, Lu L, Fu F, et al. Apoptosis within spontaneously accepted mouse liver allografts. Evidence for deletion of cytotoxic T cells and implications for tolerance induction. J Immunol 1997; 158: 4654.
5. Sharland AF, Shastry S, Wang C, et al. Kinetics of intragraft cytokine expression, cellular infiltration and cell death in rejection of renal allografts compared with acceptance of liver allografts in a rat model. Early activation and apoptosis is associated with liver graft acceptance. Transplantation 1998; 65: 1370.
6. Wang C, Sun J, Sheil AGR, et al. A short course of methylprednisolone immunosuppression inhibits both rejection and spontaneous acceptance of rat liver allografts. Transplantation 2001; 72: 44.
7. Goddard S, Adams DH. Methylprednisolone therapy for acute rejection: too much of a good thing. Liver Transpl 2002; 8: 535.
8. Huang WH, Yan Y, De Boer B, et al. A short course of cyclosporine immunosuppression inhibits rejection but not tolerance of rat liver allografts. Transplantation 2003; 75: 368.
9. Allison AC, Eugui EM. Immunosuppressive and other effects of mycophenolic acid and an ester prodrug, mycophenolate mofetil. Immunol Rev 1993; 136: 5.
10. Eugui EM, Almquist SJ, Muller CD, et al. Lymphocyte-selective cytostatic and immunosuppressive effects of mycophenolic acid in vitro: role of deoxyguanosine nucleotide depletion. Scand J Immunol 1991; 33: 161.
11. Gummert JF, Barten MJ, Sherwood SW, et al. Pharmacodynamics of immunosuppression by mycophenolic acid: inhibition of both lymphocyte proliferation and activation correlates with pharmacokinetics. J Pharmacol Exp Ther 1999; 291: 1100.
12. Kobashigawa J, Miller L, Renlund D, et al. A randomized active-controlled trial of mycophenolate mofetil in heart transplant recipients. Mycophenolate Mofetil Investigators. Transplantation 1998; 66: 507.
13. Sollinger HW. Mycophenolate mofetil for the prevention of acute rejection in primary cadaveric renal allograft recipients. U. S. Renal Transplant Mycophenolate Mofetil Study Group. Transplantation 1995; 60: 225.
14. Coulombe M, Hao L, Calcinaro F, et al. Tolerance induction in adult animals: comparison of RS-61443 and anti-CD4 treatment. Transplant Proc 1991; 23: 31.
15. Morris RE, Wang J, Blum JR, et al. Immunosuppressive effects of the morpholinoethyl ester of mycophenolic acid (RS-61443) in rat and non-human primate recipients of heart allografts. Transplant Proc 1991; 23: 19.
16. Azuma H, Binder J, Heemann U, et al. Effects of RS61443 on functional and morphological changes in chronically rejecting rat kidney allografts. Transplantation 1995; 59: 460.
17. Allison AC, Eugui EM. Mycophenolate mofetil and its mechanisms of action. Immunopharmacology 2000; 47: 85.
18. Izeradjene K, Revillard JP. Apoptosis of superantigen-activated T cells induced by mycophenolate mofetil treatment. Transplantation 2001; 71: 118.
19. Cohn RG, Mirkovich A, Dunlap B, et al. Mycophenolic acid increases apoptosis, lysosomes and lipid droplets in human lymphoid and monocytic cell lines. Transplantation 1999; 68: 411.
20. Durez P, Appelboom T, Pira C, et al. Antiinflammatory properties of mycophenolate mofetil in murine endotoxemia: inhibition of TNF-alpha and upregulation of IL-10 release. Int J Immunopharmacol 1999; 21: 581.
21. Oliveira JG, Sampaio S, Xavier P, et al. Cytokine analysis before and after mycophenolate mofetil treatment in renal transplantation. Transplant Proc 2000; 32: 2631.
22. Houssin D, Gigou M, Franco D, et al. Specific transplantation tolerance induced by spontaneously tolerated liver allograft in inbred strains of rats. Transplantation 1980; 29: 418.
23. Zimmermann FA, Davies HS, Knoll PP, et al. Orthotopic liver allografts in the rat. The influence of strain combination on the fate of the graft. Transplantation 1984; 37: 406.
24. Tsui TY, Jager MD, Deiwick A, et al. Delayed low-level calcineurin inhibition promotes allospecific tolerance induction by posttransplantation donor leukocyte infusion. Transplantation 2002; 73: 1325.
25. Kamada N, Calne RY. A surgical experience with five hundred thirty liver transplants in the rat. Surgery 1983; 93: 64.
26. Sun J, McCaughan GW, Matsumoto Y, et al. Tolerance to rat liver allografts 1. Differences between tolerance and rejection are more marked in the B cell compared with the T cell or cytokine response. Transplantation 1994; 57: 1349.
27. Yin J, Shackel NA, Zekry A, et al. Real time RT-PCR for measurement of cytokine and growth factor mRNA expression with fluorogenic probes or SYBR Green I. Immunol Cell Biol 2001; 79: 213.
28. Yan Y, Shastry S, Richards C, et al. Posttransplant administration of donor leukocytes induces long-term acceptance of kidney or liver transplants by an activation-associated immune mechanism. J Immunol 2001; 166: 5258.
29. Larsen CP, Elwood ET, Alexander DZ, et al. Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways. Nature 1996; 381: 434.
30. Bishop GA, Wang C, Sharland AF, et al. Spontaneous acceptance of liver transplants in rodents: evidence that liver leucocytes induce recipient T-cell death by neglect. Immunol Cell Biol 2002; 80: 93.
31. Kirk AD, Burkly LC, Batty DS, et al. Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates. Nat Med 1999; 5: 686.
32. Hall BM, Jelbart ME, Gurley KE, et al. Specific unresponsiveness in rats with prolonged cardiac allograft survival after treatment with cyclosporine. Mediation of specific suppression by T helper/inducer cells. J Exp Med 1985; 162: 1683.
33. Hao LM, Calcinaro F, Gill RG, et al. Facilitation of specific tolerance induction in adult mice by RS-61443. Transplantation 1992; 53: 590.
34. Vandenhelder TBM, Benhaim P, Anthony JP, et al. Efficacy of RS-61443 in reversing acute rejection in a rat model of hindlimb allotransplantation. Transplantation 1994; 57: 427.
35. Allison AC, Almquist SJ, Muller CD, et al. In vitro immunosuppressive effects of mycophenolic acid and an ester pro-drug, RS-61443. Transplant Proc 1991; 23: 10.
36. Danovitch G, Deierhoi M, Ferguson R, et al. Mycophenolate mofetil for the treatment of refractory, acute, cellular renal transplant rejection. Transplantation 1996; 61: 722.
37. Eugui EM, Mirkovich A, Allison AC. Lymphocyte-selective antiproliferative and immunosuppressive activity of mycophenolic acid and its morpholinoethyl ester (RS-61443) in rodents. Transplant Proc 1991; 23: 15.
38. Penny MJ, Boyd RA, Hall BM. Mycophenolate mofetil prevents the induction of active Heymann nephritis: association with Th2 cytokine inhibition. J Am Soc Nephrol 1998; 9: 2272.
39. Gianello PR, Sachs DH. Effect of major histocompatibility complex matching on the development of tolerance to primarily vascularized renal allografts: a study in miniature swine. Hum Immunol 1996; 50: 1.
40. Nagy SE, Andersson JP, Andersson UG. Effect of mycophenolate mofetil (RS-61443) on cytokine production: inhibition of superantigen-induced cytokines. Immunopharmacology 1993; 26: 11.
41. Snapper CM, Paul WE. Interferon-gamma and B cell stimulatory factor-1 reciprocally regulate Ig isotype production. Science 1987; 236: 944.