Absence of donor Thl7 leads to augmented Thl differentiation and exacerbated acute graft-versus-host disease

Blood

Volumn 112, Issue 5, 2008, Pages 2101-2110

  Yi, Tangsheng ^a,c   Zhao, Dongchang ^b,c   Lin, Chia Lei ^b,c   Zhang, Chunyan ^b,c   Chen, Ying ^b,c   Todorov, Ivan ^b   LeBon, Thomas ^a   Kandeel, Fouad ^b   Forman, Stephen ^c   Zeng, Defu ^a,c  

^a Graduate School of Biological Science

^b Endocrinology and Metabolism

^c CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR; GAMMA INTERFERON; INTERLEUKIN 17; CHEMOKINE; PRIMER DNA;

ACUTE GRAFT VERSUS HOST DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BAGG ALBINO MOUSE; C57BL 6 MOUSE; CD4+ T LYMPHOCYTE; CELL DIFFERENTIATION; CONTROLLED STUDY; DENDRITIC CELL; DISEASE EXACERBATION; DISEASE SEVERITY; GRAFT RECIPIENT; HISTOPATHOLOGY; INTERFERON PRODUCTION; LYMPHOCYTIC INFILTRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TH1 CELL; TH17 CELL; TISSUE INJURY; ALLOTRANSPLANTATION; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CLASSIFICATION; CYTOLOGY; DONOR; DRUG ANTAGONISM; GENE EXPRESSION; GENETICS; GRAFT VERSUS HOST REACTION; HELPER CELL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; IMMUNOLOGY; MOUSE MUTANT; NUCLEOTIDE SEQUENCE; PATHOLOGY; SERODIAGNOSIS; T LYMPHOCYTE SUBPOPULATION;

ANIMALS; BASE SEQUENCE; CELL DIFFERENTIATION; CHEMOKINES; DNA PRIMERS; GENE EXPRESSION; GRAFT VS HOST DISEASE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; INTERFERON TYPE II; INTERLEUKIN-17; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; NEUTRALIZATION TESTS; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, HELPER-INDUCER; TH1 CELLS; TISSUE DONORS; TRANSPLANTATION, HOMOLOGOUS;

EID: 52649136967     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2007-12-126987     Document Type: Article

References (60)

1. Ferrara J. Antin J. The pathophysiology of graftvs.-host disease. In: Blume KG, Forman SJ, Appelbaum FR. eds. Thomas' Hematopoietic Cell Transplantation. Maiden, MA: Blackwell Publishing: 2004:353-368.
2. Chakraverty Ft. Sykes M. The role of antigenpresenting cells in triggering graft-versus-host disease and graft-versus-leukemia. Blood. 2007; 110:9-17.
3. Teshima T, Ordemann R, Reddy P. et al. Acute graft-versus-host disease does not require alloantigen expression on host epithelium. Nat Med. 2002;8:575-581.
4. Shlomchik WD, Couzens MS, Tang CB, et al. Prevention of graft versus host disease by inactivation of host antigen-presenting cells. Science. 1999;285:412-415.
5. Duffner UA. MaedaY Cooke KR, et al. Host dendritic cells alone are sufficient to initiate acute graft-versus-host disease. J Immunol. 2004;172: 7393-7398.
6. Blazar BR, Korngold R, Vallera DA. Recent advances in graft-versus-host disease (GVHD) prevention. Immunol Rev. 1997;157:79-109.
7. Fowler DH, Kurasawa K, Smith R, Eckhaus MA, Gress RE. Donor CD4-enriched cells of Th2 cytokine phenotype regulate graft-versus-host disease without impairing allogeneic engraftment in sublethally irradiated mice. Blood. 1994:84:3540-3549.
8. Pan L, Delmonte J, Jr., Jalonen CK, Ferrara JL. Pretreatment of donor mice with granulocyte colony-stimulating factor polarizes donor T lymphocytes toward type-2 cytokine production and reduces severity of experimental graft-versushost disease. Blood. 1995:86:4422-4429.
9. Murphy WJ, Welniak LA, Taub DD, et al. Differential effects of the absence of interferon-gamma and IL-4 in acute graft-versus-host disease after allogeneic bone marrow transplantation in mice. J Clin Invest. 1998;102:1742-1748.
10. Yang YG, Dey BR, Sergio JJ, Pearson DA, Sykes M. Donor-derived interferon gamma is required for inhibition of acute graft-versus-host disease by interleukin 12. J Clin Invest. 1998:102:2126-2135.
11. Nikolic B, Lee S, Branson RT, Grusby MJ, Sykes M. Th1 and Th2 mediate acute graft-versus-host disease, each with distinct end-organ targets. J Clin Invest. 2000;105:1289-1298.
12. Weaver CT, Hatton RD, Mangan PR, Harrington LE. IL-17 family cytokines and the expanding diversity of effector T cell lineages. Annu Rev Immunol. 2007;25:821-852.
13. Bettelli E, Carrier Y, Gao W, et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature. 2006:441:235-238.
14. Mangan PR, Harrington LE, O'Quinn DB, et al. Transforming growth factor-beta induces development of the T(H)17 lineage. Nature. 2006;441: 231-234.
15. Veldhoen M, Hocking RJ, Atkins CJ, Locksley RM, Stockinger B. TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity. 2006;24:179-189.
16. Kastelein RA, Hunter CA, Cua DJ. Discovery and biology of IL-23 and IL-27: related but functionally distinct regulators of inflammation. Annu Rev Immunol. 2007;25:221-242.
17. Langrish CL, Chen Y, Blumenschein WM, et al. IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J Exp Med. 2005201:233-240.
18. Aggarwal S, Ghilardi N, Xie MH, de Sauvage FJ, GurneyAL. lnterleukin-23 promotes adistinct CD4 T cell activation state characterized by the production of interleukin-17. J Biol Chem. 2003; 278:1910-1914.
19. Ivanov II, McKenzie BS, Zhou L, et al. The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17 + T helper cells. Cell. 2006;126:1121-1133.
20. Liu SJ, Tsai JP, Shen CR, et al. Induction of a distinct CDS Tnc17 subset by transforming growth factor-beta and interleukin-6. J Leukoc Biol. 2007; 82:354-360.
21. Park H, Li Z, Yang XO, et al. Adistinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol. 2005;6:1133-1141.
22. Ye P, Rodriguez FH, Kanaly S, et al. Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defense. J Exp Med. 2001; 194:519-527.
23. Huang W, Na L, Fidel PL, Schwarzenberger P. Requirement of interleukin-17A for systemic anti-Candida albicans host defense in mice. J Infect Dis. 2004;190:624-631.
24. Hirota K, Hashimoto M, Yoshitomi H, et al. T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis. J Exp Med. 2007:204:41-47.
25. Hue S, Ahern P, Buonocore S, et al. lnterleukin-23 drives innate and T cell-mediated intestinal inflammation. J Exp Med. 2006;203:2473-2483.
26. Komiyama Y, Nakae S, Matsuki T, et al. IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis. J Immunol. 2006;177:566-573.
27. Chen Y, Langrish CL, McKenzie B, et al. Anti-IL-23 therapy inhibits multiple inflammatory pathways and ameliorates autoimmune encephalomyelitis. J Clin Invest. 2006;116:1317-1326.
28. Tsaknaridis L, Spencer L, Culbertson N, et al. Functional assay for human CD4+CD25+Treg cells reveals an age-dependent loss of suppressive activity. J Neurosci Res. 2003;74:296-308.
29. Andoh A, Fujino S, Bamba S, et al. IL-17 selectively down-regulates TNF-alpha-induced RAN-TES gene expression in human colonic subepithelial myofibroblasts. J Immunol. 2002;169: 1683-1687.
30. Kanda N, Koike S, Watanabe S. IL-17 suppresses TNF-alpha-induced GGL27 production through induction of COX-2 in human keratinocytes. J Allergy Clin Immunol. 2005; 116:1144-1150.
31. Schnyder B, Schnyder-Candrian S, Pansky A, et al. IL-17 reduces TNF-induced Rantes and VCAM-1 expression. Cytokine. 2005;31:191-202.
32. OgawaA, Andoh A, Araki Y, BarnbaT, Fujiyama Y. Neutralization of interleukin-17 aggravates dextran sulfate sodium-induced colitis in mice. Clin Immunol. 2004;110:55-62.
33. Schnyder-Gandrian S, Togbe D, Couillin I, et al. Interleukin-17 is a negative regulator of established allergic asthma. J Exp Med. 2006;203: 2715-2725.
34. Liang Y Huang T, Zhang C, et al. Donor CD8 + Tcells facilitate induction of chimerism and tolerance without GVHD in autoimmune NOD mice conditioned with anti-CD3 mAb. Blood. 2005;105: 2180-2188.
35. Zhang C, Lou J, Li N.et al. Donor CD8+ T cells mediate graft-versus-leukemia activity without clinical signs of graft-versus-host disease in recipients conditioned with anti-CD3 monoclonal antibody. J Immunol. 2007;178:838-850.
36. Cooke KR, Kobzik L, Martin TR, et al. An experimental model of idiopathic pneumonia syndrome after bone marrow transplantation: I. The roles of minor H antigens and endotoxin. Blood. 1996;88: 3230-3239.
37. Mapara MY, Leng C, Kim YM, et al. Expression of chemokines in GVHD target organs is influenced by conditioning and genetic factors and amplified by GVHR. Biol Blood Marrow Transplant. 2006; 12:623-634.
38. Zhang C, Todorov I, Zhang Z, et al. Donor CD4+ T and B cells in transplants induce chronic graftversus-host disease with autoimmune manifestations. Blood. 2006;107:2993-3001.
39. Zhang C, Todorov I, Lin CL, et al. Elimination of insulitis and augmentation of islet beta cell regeneration via induction of chimerism in overtly diabetic NOD mice. Proc Natl Acad Sci U S A. 2007; 104:2337-2342.
40. Yang F Huang X, Yi T, Yen Y Moore DD, Huang W. Spontaneous development of liver tumors in the absence of the bile acid receptor farnesoid X receptor. Cancer Res. 2007;67:863-867.
41. Kaplan DH, Anderson BE, McNiff JM, Jain D, Shlomchik MJ, Shlomchik WD. Target antigens determine graft-versus-host disease phenotype. J Immunol. 2004;173:5467-5475.
42. Nakae S, Komiyama Y, Nambu A, et al. Antigenspecific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses. Immunity. 2002; 17:375-387.
43. Borsotti C, Franklin AR, Lu SX, et al. Absence of donor T-cell-derived soluble TNF decreases graftversus-host disease without impairing graft-versus-tumor activity. Blood. 2007;110:783-786.
44. Zella D, Barabitskaja O, Burns JM, et al. Interferon-gamma increases expression of chemokine receptors CCR1, CCR3, and CCR5, but not CXCR4 in monocytoid U937 cells. Blood. 1998;91:4444-4450.
45. Kim JJ. Nottingham LK, Sin Jl, et al. CDS positive Tcells influence antigen-specific immune responses through the expression of chemokines. J Clin Invest. 1998:102:1112-1124.
46. Wysocki CA, Jiang Q, Panoskaltsis-Mortari A, et al. Critical role for CCR5 in the function of donor CD4+CD25+ regulatory T cells during acute graft-versus-host disease. Blood. 2005;106:3300-3307.
47. Chakraverty R, Cote D, Buchli J, et al. An inflammatory checkpoint regulates recruitment of graftversus-host reactive Tcells to peripheral tissues. J Exp Med. 2006;203:2021-2031.
48. Murai M, Yoneyama H, HaradaA, et al. Active participation of CCR5(+)CD8(+) T lymphocytes in the pathogenesis of liver injury in graft-versushost disease. J Clin Invest. 1999;104:49-57.
49. Antonysamy MA, Fanslow WC, Fu F, et al. Evidence for a role of IL-17 in organ allograft rejection: IL-17 promotes the functional differentiation of dendritic cell progenitors. J Immunol. 1999; 162:577-584.
50. Nakae S, Iwakura Y Suto H, Galli SJ. Phenotypic differences between Th 1 and Th17 cells and negative regulation of Th1 cell differentiation by IL-17. J Leukoc Biol. 2007;81:1258-1268.
51. Mowat AM. Antibodies to IFN-gamma prevent immunologically mediated intestinal damage in murine graft-versus-host reaction. Immunology. 1989;68:18-23.
52. Blazar BR, Carreno BM, Panoskaltsis-Mortari A, et al. Blockade of programmed death-1 engagement accelerates graft-versus-host disease lethality by an I FN-gamma-dependent mechanism. J Immunol. 2003;171:1272-1277.
53. Olson TS, Ley K. Chemokines and chemokine receptors in leukocyte trafficking. Am J Physiol Regul Integr Comp Physiol. 2002;283:R7-28.
54. Wysocki CA, Panoskaltsis-Mortari A, Blazar BR, Serody JS. Leukocyte migration and graft-versushost disease. Blood. 2005;105:4191-4199.
55. Murphy KM, Reiner SL. The lineage decisions of helperT cells. Nat Rev Immunol. 2002;2:933-944.
56. Bettelli E, Oukka M, Kuchroo VK.T(H)-17 cells in the circle of immunity and autoimmunity. Nat Immunol. 2007;8:345-350.
57. Harrington LE, Hatton RD, Mangan PR, et al. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol. 2005;6:1123-1132.
58. Becker C, Dornhoff H, Neufert C. et al. Cutting edge: IL-23 cross-regulates IL-12 production in T cell-dependent experimental colitis. J Immunol. 2006:177:2760-2764.
59. Asavaroengchai W, Wang H, Wang S, et al. An essential role for I FN-gamma in regulation of alloreactive CDS Tcells following allogeneic hematopoietic cell transplantation. Biol Blood Marrow Transplant. 2007;13:46-55.
60. Burrnan AC, BanovicT, Kuns RD.et al. IFN-gamma differentially controls the development of idiopathic pneumonia syndrome and GVHD of the gastrointestinal tract. Blood. 2007;110:1064-1072.