Roles of B cells in rheumatoid arthritis

Arthritis Research and Therapy

Volumn 5, Issue SUPPL. 4, 2003, Pages

  Silverman, Gregg J ^a   Carson, Dennis A ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

Antigen presentation; Autoantibody; Immune complexes; Immunity; Synovitis; Tolerance

Indexed keywords

CHEMOKINE; COMPLEMENT; CYTOKINE; PROTEIN ANTIBODY; RHEUMATOID FACTOR;

ANGIOGENESIS; ANTIGEN ANTIBODY COMPLEX; ANTIGEN PRESENTING CELL; B LYMPHOCYTE; CELL INFILTRATION; COMPLEMENT ACTIVATION; CYTOKINE PRODUCTION; HUMAN; HYPERPLASIA; IMMUNE RESPONSE; JOINT; LEUKOCYTE; LYMPHATIC SYSTEM; LYMPHOCYTE DEPLETION; LYMPHOCYTE FUNCTION; PATHOGENESIS; PROTEIN EXPRESSION; REVIEW; RHEUMATOID ARTHRITIS; SYNOVIUM; T LYMPHOCYTE ACTIVATION; TREATMENT OUTCOME;

ANIMALS; ANTIGEN PRESENTATION; ANTIGEN-ANTIBODY COMPLEX; ARTHRITIS, RHEUMATOID; AUTOANTIBODIES; B-LYMPHOCYTES; CITRULLINE; DISEASE MODELS, ANIMAL; GLUCOSE-6-PHOSPHATE ISOMERASE; HUMANS; MAST CELLS; MICE; SYNOVITIS;

EID: 1242330309     PISSN: 14786354     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (61)

1. Vaughan JH, Chihara T: Lymphocyte function in rheumatic disorders. Arch Intern Med 1975, 135:1324-1328.
2. Kaplan RA, Curd JG, Deheer DH, Carson DA, Pangburn MK, Muller-Eberhard HJ, Vaughan JH: Metabolism of C4 and factor B in rheumatoid arthritis. Relation to rheumatoid factor. Arthritis Rheum 1980, 23:911-920.
3. Ruddy S, Britton MC, Schur PH, Austen KF: Complement components in synovial fluid: activation and fixation in seropositive rheumatoid arthritis. Ann NY Acad Sci 1969, 168:161-172.
4. Ruddy S, Austen KF: The complement system in rheumatoid synovitis. I. An analysis of complement component activities in rheumatoid synovial fluids. Arthritis Rheum 1970, 13:713-723.
5. Goldstein I M, Weissmann G: Generation of C5-derived lysosomal enzyme-releasing activity (C5a) by lysates of leukocyte lysosomes. J Immunol 1974, 113:1583-1588.
6. Borel JF, Keller HU, Sorkin E: Studies on chemotaxis. XI. Effect on neutrophils of lysosomal and other subcellular fractions from leukocytes. Int Arch Allergy Appl Immunol 1969, 35:194-205.
7. Tanimoto K, Cooper NR, Johnson JS, Vaughan JH: Complement fixation by rheumatoid factor. J Clin Invest 1975, 55:437-445.
8. Youinou PY, Morrow JW, Lettin AW, Lydyard PM, Roitt IM: Specificity of plasma cells in the rheumatoid synovium. I. Immunoglobulin class of antiglobulin-producing cells. Scand J Immunol 1984, 20:307-315.
9. Fehr K, Velvart M, Rauber M, Knopfel M, Baici A, Salgam P, Boni A: Production of agglutinators and rheumatoid factors in plasma cells of rheumatoid and nonrheumatoid synovial tissues. Arthritis Rheum 1981, 24:510-519.
10. Harris J, Vaughan JH: Transfusion studies in rheumatoid arthritis patients. Arthritis Rheum 1961, 4:47-55.
11. Sutton BJ, Corper AL, Sohi MK, Jefferis R, Beale D, Taussig MJ: The structure of a human rheumatoid factor bound to IgG Fc. Adv Exp Med Biol 1998, 435:41-50.
12. Takemura S, Klimiuk PA, Braun A, Goronzy JJ, Weyand CM: T cell activation in rheumatoid synovium is B cell dependent. J Immunol 2001, 167:4710-4718.
13. Kouskoff V, Korganow AS, Duchatelle V, Degott C, Benoist C, Mathis D: Organ-specific disease provoked by systemic autoimmunity. Cell 1996, 87:811-822.
14. Matsumoto I, Maccioni M, Lee DM, Maurice M, Simmons B, Brenner M, Mathis D, Benoist C: How antibodies to a ubiquitous cytoplasmic enzyme may provoke joint-specific autoimmune disease. Nat Immunol 2002, 3:360-365.
15. Maccioni M, Zeder-Lutz G, Huang H, Ebel C, Gerber P, Hergueux J, Marchal P, Duchatelle V, Degott C, van Regenmortel M, Benoist C, Mathis D: Arthritogenic monoclonal antibodies from K/BxN mice. J Exp Med 2002, 195:1071-1077.
16. Ji H, Ohmura K, Mahmood U, Lee DM, Hofhuis FM, Boackle SA, Takahashi K, Holers VM, Walport M, Gerard C, Ezekowitz A, Carroll MC, Brenner M, Weissleder R, Verbeek JS, Duchatelle V, Degott C, Benoist C, Mathis D: Arthritis critically dependent on innate immune system players. Immunity 2002, 16:157-168.
17. Solomon S, Kolb C, Mohanty S, Jeisy-Walder E, Preyer R, Schollhorn V, Illges H: Transmission of antibody-induced arthritis is independent of complement component 4 (C4) and the complement receptors 1 and 2 (CD21/35). Eur J Immunol 2002, 32:644-651.
18. Sylvestre D, Clynes R, Ma M, Warren H, Carroll MC, Ravetch JV: Immunoglobulin G-mediated inflammatory responses develop normally in complement-deficient mice. J Exp Med 1996, 184:2385-2392.
19. Abrahams VM, Cambridge G, Lydyard PM, Edwards JC: Induction of tumor necrosis factor alpha production by adhered human monocytes: a key role for Fcgamma receptor type IIIa in rheumatoid arthritis. Arthritis Rheum 2000, 43:608-616.
20. Edwards JC, Cambridge G, Abrahams VM: Do self-perpetuating B lymphocytes drive human autoimmune disease? Immunology 1999, 97:188-196.
21. Shushakova N, Skokowa J, Schulman J, Baumann U, Zwirner J, Schmidt RE, Gessner JE: C5a anaphylatoxin is a major regulator of activating versus inhibitory FcgammaRs in immune complex-induced lung disease. J Clin Invest 2002, 110:1823-1830.
22. Crisp AJ, Chapman CM, Kirkham SE, Schiller AL, Krane SM: Articular mastocytosis in rheumatoid arthritis. Arthritis Rheum 1984, 27:845-851.
23. Sylvestre DL, Ravetch JV: A dominant role for mast cell Fc receptors in the Arthus reaction. Immunity 1996, 5:387-390.
24. Tetlow LC, Woolley DE: Mast cells, cytokines, and metalloproteinases at the rheumatoid lesion: dual immunolocalisation studies. Ann Rheum Dis 1995, 54:896-903.
25. Lee DM, Friend DS, Gurish MF, Benoist C, Mathis D, Brenner MB: Mast cells: a cellular link between autoantibodies and inflammatory arthritis. Science 2002, 297:1689-1692.
26. Schaller M, Burton DR, Ditzel HJ: Autoantibodies to GPI in rheumatoid arthritis: linkage between an animal model and human disease. Nat Immunol 2001, 2:746-753.
27. Kassahn D, Kolb C, Solomon S, Bochtler P, Illges H: Few human autoimmune sera detect GPI. Nat Immunol 2002, 3:411-412; author reply 412-413.
28. Schubert D, Schmidt M, Zaiss D, Jungblut PR, Kamradt T: Autoantibodies to GPI and creatine kinase in RA. Nat Immunol 2002, 3:411; author reply 412-413.
29. Herve CA, Wait R, Venables PJ: Glucose-6-phosphate isomerase is not a specific autoantigen in rheumatoid arthritis. Rheumatology 2003, 42:986-988.
30. Matsumoto I, Lee DM, Goldbach-Mansky R, Sumida T, Hitchon CA, Schur PH, Anderson RJ, Coblyn JS, Weinblatt ME, Brenner M, Duclos B, Pasquali JL, El-Gabalawy H, Mathis D, Benoist C: Low prevalence of antibodies to glucose-6-phosphate isomerase in patients with rheumatoid arthritis and a spectrum of other chronic autoimmune disorders. Arthritis Rheum 2003, 48:944-954.
31. Rowley M, Tait B, Mackay IR, Cunningham T, Phillips B: Collagen antibodies in rheumatoid arthritis. Significance of antibodies to denatured collagen and their association with HLA-DR4. Arthritis Rheum 1986, 29:174-184.
32. Verheijden GF, Rijnders AW, Bos E, Coenen-de Roo CJ, van Staveren CJ, Miltenburg AM, Meijerink JH, Elewaut D, de Keyser F, Veys E, Boots AM: Human cartilage glycoprotein-39 as a candidate autoantigen in rheumatoid arthritis. Arthritis Rheum 1997, 40:1115-1125.
33. Li NL, Zhang DO, Zhou KY, Cartman A, Leroux JY, Poole AR, Zhang YP: Isolation and characteristics of autoreactive T cells specific to aggrecan G1 domain from rheumatoid arthritis patients. Cell Res 2000, 10:39-49.
34. Goldbach-Mansky R, Lee J, McCoy A, Hoxworth J, Yarboro C, Smolen JS, Steiner G, Rosen A, Zhang C, Menard HA, Zhou Z J, Palosuo T, Van Venrooij WJ, Wilder RL, Klippel JH, Schumacher HR Jr, El-Gabalawy HS: Rheumatoid arthritis associated autoantibodies in patients with synovitis of recent onset. Arthritis Res 2000, 2:236-243.
35. Schellekens GA, Visser H, de Jong BA, van den Hoogen FH, Hazes JM, Breedveld FC, van Venrooij WJ: The diagnostic properties of rheumatoid arthritis antibodies recognizing a cyclic citrullinated peptide. Arthritis Rheum 2000, 43:155-163.
36. van Boekel MA, Vossenaar ER, van den Hoogen FH, van Venrooij WJ: Autoantibody systems in rheumatoid arthritis: specificity, sensitivity and diagnostic value. Arthritis Res 2002, 4:87-93.
37. Asaga H, Ishigami A: Protein deimination in the rat brain after kainate administration: citrulline-containing proteins as a novel marker of neurodegeneration. Neurosci Lett 2001, 299:5-8.
38. Wahle M, Pierer M, Krause A, Kolker S, Baerwald CG: Decreased catecholamine-induced cell death in B lymphocytes from patients with rheumatoid arthritis. Ann NY Acad Sci 2002, 966:425-428.
39. Shimaoka Y, Attrep JF, Hirano T, Ishihara K, Suzuki R, Toyosaki T, Ochi T, Lipsky PE: Nurse-like cells from bone marrow and synovium of patients with rheumatoid arthritis promote survival and enhance function of human B cells. J Clin Invest 1998, 102:606-618.
40. Lopez-Hoyos M, Marquina R, Tamayo E, Gonzalez-Rojas J, Izui S, Merino R, Merino J: Defects in the regulation of B cell apoptosis are required for the production of citrullinated peptide autoantibodies in mice. Arthritis Rheum 2003, 48:2353-2361.
41. Hill JA, Southwood S, Sette A, Jevnikar AM, Bell DA, Cairns E: The conversion of arginine to citrulline allows for a high-affinity peptide interaction with the rheumatoid arthritis-associated HLA-DRB1*0401 MHC class II molecule. J Immunol 2003, 171:538-541.
42. Wagner UG, Kurtin PJ, Wahner A, Brackertz M, Berry DJ, Goronzy JJ, Weyand CM: The role of CD8+ CD40L+ T cells in the formation of germinal centers in rheumatoid synovitis. J Immunol 1998, 161:6390-6397.
43. Schroder AE, Greiner A, Seyfert C, Berek C: Differentiation of B cells in the nonlymphoid tissue of the synovial membrane of patients with rheumatoid arthritis. Proc Natl Acad Sci USA 1996, 93:221-225.
44. Krenn V, Schalhorn N, Greiner A, Molitoris R, Konig A, Gohlke F, Muller-Hermelink HK: Immunohistochemical analysis of proliferating and antigen-presenting cells in rheumatoid synovial tissue. Rheumatol Int 1996, 15:239-247.
45. Kim HJ, Krenn V, Steinhauser G, Berek C: Plasma cell development in synovial germinal centers in patients with rheumatoid and reactive arthritis. J Immunol 1999, 162:3053-3062.
46. Weyand CM, Goronzy JJ: Ectopic germinal center formation in rheumatoid synovitis. Ann NY Acad Sci 2003, 987:140-149.
47. Voswinkel J, Weisgerber K, Pfreundschuh M, Gause A: B lymphocyte involvement in ankylosing spondylitis: the heavy chain variable segment gene repertoire of B lymphocytes from germinal center-like foci in the synovial membrane indicates antigen selection. Arthritis Res 2001, 3:189-195.
48. Magalhaes R, Gehrke T, Souto-Carneiro MM, Kriegsmann J, Krenn V: Extensive plasma cell infiltration with crystal IgG inclusions and mutated IgV(H) gene in an osteoarthritis patient with lymphoplasmacellular synovitis. A case report. Pathol Res Pract 2002, 198:45-50.
49. Shiokawa S, Matsumoto N, Nishimura J: Clonal analysis of B cells in the osteoarthritis synovium. Ann Rheum Dis 2001, 60: 802-805.
50. Takemura S, Braun A, Crowson C, Kurtin PJ, Cofield RH, O'Fallon WM, Goronzy JJ, Weyand CM: Lymphoid neogenesis in rheumatoid synovitis. J Immunol 2001, 167:1072-1080.
51. Luther SA, Bidgol A, Hargreaves DC, Schmidt A, Xu Y, Paniyadi J, Matloubian M, Cyster JG: Differing activities of homeostatic chemokines CCL19, CCL21, and CXCL12 in lymphocyte and dendritic cell recruitment and lymphoid neogenesis. J Immunol 2002, 169:424-433.
52. Weyand CM, Braun A, Takemura S, Goronzy JJ: Lymphoid microstructures in rheumatoid synovitis. Curr Dir Autoimmun 2001, 3:168-187.
53. Seki T, Selby J, Haupl T, Winchester R: Use of differential subtraction method to identify genes that characterize the phenotype of cultured rheumatoid arthritis synoviocytes. Arthritis Rheum 1998, 41:1356-1364.
54. Dechanet J, Merville P, Durand I, Banchereau J, Miossec P: The ability of synoviocytes to support terminal differentiation of activated B cells may explain plasma cell accumulation in rheumatoid synovium. J Clin Invest 1995, 95:456-463.
55. Hauser AE, Debes GF, Arce S, Cassese G, Hamann A, Radbruch A, Manz RA: Chemotactic responsiveness toward ligands for CXCR3 and CXCR4 is regulated on plasma blasts during the time course of a memory immune response. J Immunol 2002, 169:1277-1282.
56. Cassese G, Arce S, Hauser AE, Lehnert K, Moewes B, Mostarac M, Muehlinghaus G, Szyska M, Radbruch A, Manz RA: Plasma cell survival is mediated by synergistic effects of cytokines and adhesion-dependent signals. J Immunol 2003, 171:1684-1690.
57. Tan SM, Xu D, Roschke V, Perry JW, Arkfeld DG, Ehresmann GR, Migone TS, Hilbert DM, Stohl W: Local production of B lymphocyte stimulator protein and APRIL in arthritic joints of patients with inflammatory arthritis. Arthritis Rheum 2003, 48:982-992.
58. Meffre E, Davis E, Schiff C, Cunningham-Rundles C, Ivashkiv LB, Staudt LM, Young JW, Nussenzweig MC: Circulating human B cells that express surrogate light chains and edited receptors. Nat Immunol 2000, 1:207-213.
59. Wang YH, Stephan RP, Scheffold A, Kunkel D, Karasuyama H, Radbruch A, Cooper MD: Differential surrogate light chain expression governs B-cell differentiation. Blood 2002, 99:2459:2467.
60. Silverman GJ, Weisman S: Rituximab therapy and autoimmune disorders: prospects for anti-B cell therapy. Arthritis Rheum 2003, 48:1484-1492.
61. Nishimoto N, Yoshizaki K, Maeda K, Kuritani T, Deguchi H, Sato B, Imai N, Suemura M, Kakehi T, Takagi N, Kishimoto T: Toxicity, pharmacokinetics, and dose-finding study of repetitive treatment with the humanized anti-interleukin 6 receptor antibody MRA in rheumatoid arthritis. Phase I/II clinical study. J Rheumatol 2003, 30:1426-1435.