IL-6-deficient mice show impaired inflammatory response in a model of myosin-induced experimental myositis

Journal of Neuroimmunology

Volumn 176, Issue 1-2, 2006, Pages 9-15

  Scuderi, Flavia ^a   Mannella, Francesca ^a   Marino, Mariapaola ^a   Provenzano, Carlo ^a   Bartoccioni, Emanuela ^a  

^a CATHOLIC UNIVERSITY   (Italy)

Author keywords

IL 6; Inflammation; Muscle; Muscle based gene therapy

Indexed keywords

INTERLEUKIN 6; MYOSIN; PERTUSSIS TOXIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; CYTOKINE RELEASE; FEMALE; INFLAMMATION; MALE; MOUSE; MUSCLE INJURY; MYOSITIS; NECROSIS; NONHUMAN; PRIORITY JOURNAL; RABBIT;

ANIMALS; ANTIBODY FORMATION; DISEASE MODELS, ANIMAL; FEMALE; INFLAMMATION; INTERLEUKIN-6; LYMPHOCYTE ACTIVATION; MALE; MICE; MYOSINS; MYOSITIS;

EID: 33746078847     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2006.03.026     Document Type: Article

References (30)

1. Baron P., Galimberti D., Meda L., Scarpini E., Conti G., Cogiamanian F., and Scarlato G. Production of IL-6 by human myoblasts stimulated with Abeta: relevance in the pathogenesis of IBM. Neurology 57 (2001) 1561-1565
2. Bartoccioni E., Michaelis D., and Hohlfeld R. Constitutive and cytokine-induced production of interleukin-6 by human myoblasts. Immunol. Lett. 42 (1994) 135-138
3. Bartoccioni E., Gallucci S., Scuderi F., Ricci E., Servidei S., Broccolini A., and Tonali P. MHC class I, MHC class II and intercellular adhesion molecule-1 (ICAM-1) expression in inflammatory myopathies. Clin. Exp. Immunol. 95 (1994) 166-172
4. Bartoccioni E., Scuderi F., Marino M., and Provenzano C. IL-6, monocyte infiltration and parenchymal cells. Trends Immunol. 24 (2003) 299-300
5. Dalakas M.C. Inflammatory myopathies. Recent advances in pathogenesis and therapy. Adv. Neurol. 88 (2002) 253-271
6. de Hooge A.S.K., van de Loo F.A.J., Arntz O.J., and van den Berg W. Involvement of IL-6, apart from its role in immunity, in mediating a chronic response during experimental arthritis. Am. J. Pathol. 157 (2000) 2081-2091
7. De Rossi M., Bernasconi P., Baggi F., de Waal Malefyt R., and Mantegazza R. Cytokines and chemokines are both expressed by human myoblasts: possible relevance for the immune pathogenesis of muscle inflammation. Int. Immunol. 12 (2000) 1329-1335
8. Deng C., Goluszko E., Tuzun E., Yang H., and Christadoss P. Resistance to experimental autoimmune myasthenia gravis in IL-6-deficient mice is associated with reduced germinal center formation and C3 production. J. Immunol. 169 (2002) 1077-1083
9. Eriksson U., Kurrer M.O., Schmitz N., Marsch S.C., Fontana A., Eugster H.P., and Kopf M. Interleukin-6-deficient mice resist development of autoimmune myocarditis associated with impaired upregulation of complement C3. Circulation 107 (2003) 320-325
10. Eugster H.P., Frei K., Kopf M., Lassmann H., and Fontana A. IL-6-deficient mice resist myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis. Eur. J. Immunol. 28 (1998) 2178-2187
11. Gallucci S., Provenzano C., Mazzarelli P., Scuderi F., and Bartoccioni E. Myoblasts produce IL-6 in response to inflammatory stimuli. Int. Immunol. 10 (1998) 267-273
12. Goletz T.J., Klimpel K.R., Leppla S.H., Keith J.M., and Berzofsky J.A. Delivery of antigens to the MHC class I pathway using bacterial toxins. Hum. Immunol. 54 (1997) 129-136
13. Hohlfeld R., Engel A.G., Goebels N., and Behrens L. Cellular immune mechanisms in inflammatory myopathies. Curr. Opin. Rheumatol. 9 (1997) 520-526
14. Hurst S.M., Wilkinson T.S., McLoughlin R.M., Jones S., Horiuchi S., Yamamoto N., Rose-John S., Fuller G.M., Topley N., and Jones S.A. IL-6 and its soluble receptor orchestrate a temporal switch in the pattern of leukocyte recruitment seen during acute inflammation. Immunity 14 (2001) 705-714
15. Jones S.A., and Rose-John S. The role of soluble receptors in cytokine biology: the agonistic properties of the sIL-6R/IL-6 complex. Biochim. Biophys. Acta 1592 (2002) 251-263
16. Kaplanski G., Marin V., Montero-Julian F., Mantovani A., and Farnarier C. IL-6: a regulator of the transition from neutrophil to monocyte recruitment during inflammation. Trends Immunol. 24 (2003) 25-29
17. Klouche M., Bhakdi S., Hemmes M., and Rose-John S. Novel path to activation of vascular smooth muscle cells: up-regulation of gp130 creates an autocrine activation loop by IL-6 and its soluble receptor. J. Immunol. 163 (1999) 4583-4589
18. Kojima T., Tanuma N., Aikawa Y., Shin T., Sasaki A., and Matsumoto Y. Myosin-induced autoimmune polymyositis in the rat. J. Neurol. Sci. 151 (1997) 141-148
19. Kopf M., Baumann H., Freer G., Freudenberg M., Lamers M., Kishimoto T., Zinkernagel R., Bluethmann H., and Kohler G. Impaired immune and acute-phase responses in interleukin-6-deficient mice. Nature 368 (1994) 339-342
20. Matsubara S., Shima T., and Takamori M. Experimental allergic myositis in SJL/J mice immunized with rabbit myosin B fraction: immunohistochemical analysis and transfer. Acta Neuropathol. 85 (1993) 138-144
21. Mazzarelli P., Scuderi F., Mistretta G., Provenzano C., and Bartoccioni E. Effect of transforming growth factor-beta 1 on secretion of interleukin-6 in human myoblasts. J. Neuroimmunol. 87 (1998) 185-188
22. Mendel I., Katz A., Kozak N., Ben-Nun A., and Revel M. IL-6 functions in autoimmune encephalomyelitis: a study in gene-targeted mice. Eur. J. Immunol. 28 (1998) 1727-1737
23. Nemoto H., Bhopale M.K., Constantinescu C.S., Schotland D., and Rostami A. Skeletal muscle myosin is the autoantigen for experimental autoimmune myositis. Exp. Mol. Pathol. 74 (2003) 238-243
24. Okuda Y., Sakoda S., Bernard C.C., Fujimura H., Saeki Y., Kishimoto T., and Yanagihara T. IL-6-deficient mice are resistant to the induction of experimental autoimmune encephalomyelitis provoked by myelin oligodendrocyte glycoprotein. Int. Immunol. 10 (1998) 703-708
25. Romano M., Sironi M., Toniatti C., Polentarutti N., Fruscella P., Ghezzi P., Faggioni R., Luini W., van Hinsbergh V., Sozzani S., Bussolino F., Poli V., Ciliberto G., and Mantovani A. Role of IL-6 and its soluble receptor in induction of chemokines and leukocyte recruitment. Immunity 6 (1997) 315-325
26. Ryan M., McCarthy L., Rappuoli R., Mahon B.P., and Millis K.H. Pertussis toxin potentiates Th1 and Th2 responses to co-injected antigen: adjuvant action is associated with enhanced regulatory cytokine production and expression of the co-stimulatory molecules B7-1, B7-2 and CD28. Int. Immunol. 10 (1998) 651-662
27. Samoilova E.B., Horton J.L., Hilliard B., Liu T.S., and Chen Y. IL-6-deficient mice are resistant to experimental autoimmune encephalomyelitis: roles of IL6 in the activation and differentiation of autoreactive T cells. J. Immunol. 161 (1998) 6480-6486
28. Skuk D., Vilquin J.T., and Tremblay J.P. Experimental and therapeutic approaches to muscular dystrophies. Curr. Opin. Neurol. 15 (2002) 563-569
29. Tidball J.G. Inflammatory processes in muscle injury and repair. Am. J. Physiol., Regul. Integr. Comp. Physiol. 288 (2005) 345-353
30. Tidball J.G., and Wehling-Henricks M. Damage and inflammation in muscular dystrophy: potential implications and relationships with autoimmune myositis. Curr. Opin. Rheumatol. 17 (2005) 707-713