Blockade of IL-6-signaling inhibits the pathogenesis of CD4+ T cell-mediated lethal graft-versus-host reaction against minor histocompatibility antigen

Immunology Letters

Volumn 136, Issue 2, 2011, Pages 146-155

  Noguchi, Daisuke ^a   Wakita, Daiko ^a   Ohkuri, Takayuki ^a   Tajima, Masaki ^a   Chamoto, Kenji ^a   Kitamura, Hidemitsu ^a   Nishimura, Takashi ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

Author keywords

Effector T cells; Inflammatory cytokine; Mls antigen; Th17; Treg

Indexed keywords

CD45RB ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 17; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; L SELECTIN; MINOR HISTOCOMPATIBILITY ANTIGEN; MONOCLONAL ANTIBODY; T LYMPHOCYTE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CD4+ T LYMPHOCYTE; CELL REGENERATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DIARRHEA; DISEASE SEVERITY; EYE IRRITATION; EYELID; GRAFT VERSUS HOST REACTION; HISTOPATHOLOGY; IN VIVO STUDY; LIVER; LIVER FAILURE; MORTALITY; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; WILD TYPE;

ADOPTIVE TRANSFER; ANIMALS; ANTIBODIES, MONOCLONAL; CD4-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; FEMALE; GRAFT VS HOST DISEASE; GRAFT VS HOST REACTION; LYMPHOPENIA; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; MINOR HISTOCOMPATIBILITY ANTIGENS; MULTIPLE ORGAN FAILURE; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; RECEPTORS, INTERLEUKIN-6; SIGNAL TRANSDUCTION; T-LYMPHOCYTES, REGULATORY; TH17 CELLS;

EID: 79953024119     PISSN: 01652478     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.imlet.2011.01.004     Document Type: Article

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