메뉴 건너뛰기




Volumn 8, Issue 7, 2009, Pages 538-542

Interleukin-6 as a key player in systemic inflammation and joint destruction

Author keywords

Arthritis; Bone; Inflammation; Interleukin 6; Tocilizumab

Indexed keywords

AMINOTRANSFERASE; ATLIZUMAB; DISEASE MODIFYING ANTIRHEUMATIC DRUG; GLYCOPROTEIN GP 130; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; LIPID; LIVER ENZYME; METHOTREXATE; PLACEBO; TUMOR NECROSIS FACTOR INHIBITOR;

EID: 67349104400     PISSN: 15689972     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.autrev.2009.01.012     Document Type: Review
Times cited : (321)

References (40)
  • 1
    • 0024360388 scopus 로고
    • The biology of interleukin-6
    • Kishimoto T. The biology of interleukin-6. Blood 74 (1989) 1-10
    • (1989) Blood , vol.74 , pp. 1-10
    • Kishimoto, T.1
  • 3
    • 0020081571 scopus 로고
    • Induction of proliferation and Igs-production in human B leukemic cells by antiimmunoglobulins and T cell factors
    • Yoshizaki K., Nakagawa T., Kaieda T., Muraguchi A., Yamamura Y., and Kishimoto T. Induction of proliferation and Igs-production in human B leukemic cells by antiimmunoglobulins and T cell factors. J Immunol 128 (1982) 1296-1301
    • (1982) J Immunol , vol.128 , pp. 1296-1301
    • Yoshizaki, K.1    Nakagawa, T.2    Kaieda, T.3    Muraguchi, A.4    Yamamura, Y.5    Kishimoto, T.6
  • 4
    • 32244442562 scopus 로고    scopus 로고
    • TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells
    • Veldhoen M., Hocking J.R., Atkins J.C., Locksley M.R., and Stockinger B. TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 24 (2006) 179-189
    • (2006) Immunity , vol.24 , pp. 179-189
    • Veldhoen, M.1    Hocking, J.R.2    Atkins, J.C.3    Locksley, M.R.4    Stockinger, B.5
  • 5
    • 0027421831 scopus 로고
    • Interleukin-6 in biology and medicine
    • Akira S., and Kishimoto T.T. Interleukin-6 in biology and medicine. Adv Immunol 54 (1993) 1-78
    • (1993) Adv Immunol , vol.54 , pp. 1-78
    • Akira, S.1    Kishimoto, T.T.2
  • 6
    • 0023887261 scopus 로고
    • Recombinant human interleukin-6 (IL-6/BSF-2/HSF) regulates the synthesis of acute phase proteins in human hepatocytes
    • Castell J.V., Gomez-Lechon M.J., David M., Hirano T., Kishimoto T., and Heinrich P.C. Recombinant human interleukin-6 (IL-6/BSF-2/HSF) regulates the synthesis of acute phase proteins in human hepatocytes. FEBS Lett 232 (1988) 347-350
    • (1988) FEBS Lett , vol.232 , pp. 347-350
    • Castell, J.V.1    Gomez-Lechon, M.J.2    David, M.3    Hirano, T.4    Kishimoto, T.5    Heinrich, P.C.6
  • 7
    • 0029147155 scopus 로고
    • Toxicity and efficacy of escalating dosages of recombinant human interleukin-6 after chemotherapy in patients with breast cancer or non-small-cell lung cancer
    • Veldhuis G.J., Willemse P.H.B., Sleijfer D.T., van der Groaf W.T.A., Groen H.J.M., Limburg P.C., et al. Toxicity and efficacy of escalating dosages of recombinant human interleukin-6 after chemotherapy in patients with breast cancer or non-small-cell lung cancer. J Clin Oncol 13 (1995) 2585-2593
    • (1995) J Clin Oncol , vol.13 , pp. 2585-2593
    • Veldhuis, G.J.1    Willemse, P.H.B.2    Sleijfer, D.T.3    van der Groaf, W.T.A.4    Groen, H.J.M.5    Limburg, P.C.6
  • 8
    • 0038798085 scopus 로고    scopus 로고
    • Anti-interleukin-6 receptor antibody therapy reduces vascular endothelial growth factor production in rheumatoid arthritis
    • Nakahara H., Song J., Sugimoto M., Hagihara K., Kishimoto T., Yoshizaki K., et al. Anti-interleukin-6 receptor antibody therapy reduces vascular endothelial growth factor production in rheumatoid arthritis. Arthritis Rheum 48 (2003) 1521-1529
    • (2003) Arthritis Rheum , vol.48 , pp. 1521-1529
    • Nakahara, H.1    Song, J.2    Sugimoto, M.3    Hagihara, K.4    Kishimoto, T.5    Yoshizaki, K.6
  • 9
    • 18344410191 scopus 로고    scopus 로고
    • Blockade of interleukin-6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in Crohn's disease and experimental colitis in vivo
    • Atreya R., Mudter J., Finotto S., Mullberg J., Jostock T., Wirtz S., et al. Blockade of interleukin-6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in Crohn's disease and experimental colitis in vivo. Nat Med 6 (2000) 583-588
    • (2000) Nat Med , vol.6 , pp. 583-588
    • Atreya, R.1    Mudter, J.2    Finotto, S.3    Mullberg, J.4    Jostock, T.5    Wirtz, S.6
  • 10
    • 0024592982 scopus 로고
    • Synovium as a source of interleukin 6 in vitro. Contribution to local and systemic manifestations of arthritis
    • Guerne P.A., Zuraw B.L., Vaughan J.H., Carson D.A., and Lotz M. Synovium as a source of interleukin 6 in vitro. Contribution to local and systemic manifestations of arthritis. J Clin Invest 83 (1989) 585-592
    • (1989) J Clin Invest , vol.83 , pp. 585-592
    • Guerne, P.A.1    Zuraw, B.L.2    Vaughan, J.H.3    Carson, D.A.4    Lotz, M.5
  • 11
    • 0023942493 scopus 로고
    • Interleukin-6 in synovial fluid and serum of patients with rheumatoid arthritis and other inflammatory arthritides
    • Houssiau F.A., Devogelaer J.P., Van Damme J., de Deuxchaisnes C.N., and Van Snick J. Interleukin-6 in synovial fluid and serum of patients with rheumatoid arthritis and other inflammatory arthritides. Arthritis Rheum 31 (1988) 784-788
    • (1988) Arthritis Rheum , vol.31 , pp. 784-788
    • Houssiau, F.A.1    Devogelaer, J.P.2    Van Damme, J.3    de Deuxchaisnes, C.N.4    Van Snick, J.5
  • 12
    • 0027518860 scopus 로고
    • Serum interleukin 6 levels in rheumatoid arthritis: correlations with clinical and laboratory indices of disease activity
    • Madhok R., Crilly A., Watson J., and Capell H.A. Serum interleukin 6 levels in rheumatoid arthritis: correlations with clinical and laboratory indices of disease activity. Ann Rheum Dis 52 (1993) 232-234
    • (1993) Ann Rheum Dis , vol.52 , pp. 232-234
    • Madhok, R.1    Crilly, A.2    Watson, J.3    Capell, H.A.4
  • 14
    • 0037037586 scopus 로고    scopus 로고
    • A point mutation of Tyr-759 in interleukin 6 family cytokine receptor subunit gp130 causes autoimmune arthritis
    • Atsumi T., Ishihara K., Kamimura D., Ikushima H., Ohtani T., Hirota S., et al. A point mutation of Tyr-759 in interleukin 6 family cytokine receptor subunit gp130 causes autoimmune arthritis. J Exp Med 196 (2002) 979-990
    • (2002) J Exp Med , vol.196 , pp. 979-990
    • Atsumi, T.1    Ishihara, K.2    Kamimura, D.3    Ikushima, H.4    Ohtani, T.5    Hirota, S.6
  • 15
    • 0032429668 scopus 로고    scopus 로고
    • Blockage of interleukin-6 receptor ameliorates joint disease in murine collagen-induced arthritis
    • Takagi N., Mihara M., Moriya Y., Nishimoto N., Yoshizaki K., Kishimoto T., et al. Blockage of interleukin-6 receptor ameliorates joint disease in murine collagen-induced arthritis. Arthritis Rheum 41 (1998) 2117-2121
    • (1998) Arthritis Rheum , vol.41 , pp. 2117-2121
    • Takagi, N.1    Mihara, M.2    Moriya, Y.3    Nishimoto, N.4    Yoshizaki, K.5    Kishimoto, T.6
  • 16
    • 0035090840 scopus 로고    scopus 로고
    • Humanized antibody to human interleukin-6 receptor inhibits the development of collagen arthritis in cynomolgus monkeys
    • Mihara M., Kotoh M., Nishimoto N., Oda Y., Kumagai E., Takagi N., et al. Humanized antibody to human interleukin-6 receptor inhibits the development of collagen arthritis in cynomolgus monkeys. Clin Immunol 98 (2001) 319-326
    • (2001) Clin Immunol , vol.98 , pp. 319-326
    • Mihara, M.1    Kotoh, M.2    Nishimoto, N.3    Oda, Y.4    Kumagai, E.5    Takagi, N.6
  • 18
    • 2342510407 scopus 로고    scopus 로고
    • IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin
    • Nemeth E., Rivera S., Gabayan V., Keller C., Taudorf S., Pedersen B.K., et al. IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J Clin Invest 113 (2004) 1271-1276
    • (2004) J Clin Invest , vol.113 , pp. 1271-1276
    • Nemeth, E.1    Rivera, S.2    Gabayan, V.3    Keller, C.4    Taudorf, S.5    Pedersen, B.K.6
  • 19
    • 0343163257 scopus 로고
    • Interleukin-6 enhancement of interleukin-3-dependent proliferation of multipotential hemopoietic progenitors
    • Ikebuchi K., Wong G.G., Clark S.C., Ihle J.N., Hirai Y., and Ogawa M. Interleukin-6 enhancement of interleukin-3-dependent proliferation of multipotential hemopoietic progenitors. Proc Natl Acad Sci USA 84 (1987) 9035-9039
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 9035-9039
    • Ikebuchi, K.1    Wong, G.G.2    Clark, S.C.3    Ihle, J.N.4    Hirai, Y.5    Ogawa, M.6
  • 22
    • 27744503664 scopus 로고    scopus 로고
    • Plasma IL-6 concentration is inversely related to insulin sensitivity, and acute phase proteins associate with glucose and lipid metabolism in healthy subjects
    • Heliovaara M.K., Teppo A.M., Karonen S.L., Tuominen J.A., and Ebeling P. Plasma IL-6 concentration is inversely related to insulin sensitivity, and acute phase proteins associate with glucose and lipid metabolism in healthy subjects. Diabetes Obes Metab 7 (2005) 729-736
    • (2005) Diabetes Obes Metab , vol.7 , pp. 729-736
    • Heliovaara, M.K.1    Teppo, A.M.2    Karonen, S.L.3    Tuominen, J.A.4    Ebeling, P.5
  • 23
    • 0035908632 scopus 로고    scopus 로고
    • C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus
    • Pradhan A.D., Manson J.E., Rifai N., Buring J.E., and Ridker P.M. C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. JAMA 286 (2001) 327-334
    • (2001) JAMA , vol.286 , pp. 327-334
    • Pradhan, A.D.1    Manson, J.E.2    Rifai, N.3    Buring, J.E.4    Ridker, P.M.5
  • 25
    • 37649021327 scopus 로고    scopus 로고
    • Circadian rhythms in arthritis: hormonal effects on the immune/inflammatory reaction
    • Cutolo M., and Straub R.H. Circadian rhythms in arthritis: hormonal effects on the immune/inflammatory reaction. Autoimmun Rev 7 (2008) 223-228
    • (2008) Autoimmun Rev , vol.7 , pp. 223-228
    • Cutolo, M.1    Straub, R.H.2
  • 26
    • 0033552883 scopus 로고    scopus 로고
    • Atherosclerosis-an inflammatory disease
    • Ross R. Atherosclerosis-an inflammatory disease. N Eng J Med 340 (1999) 115-126
    • (1999) N Eng J Med , vol.340 , pp. 115-126
    • Ross, R.1
  • 27
    • 0034681920 scopus 로고    scopus 로고
    • Elevation of tumor necrosis factor-alpha and increased risk of recurrent coronary events after myocardial infarction
    • Ridker P.M., Rifai N., Pfeifer M., Sacks F., Lepage S., and Braunwald E. Elevation of tumor necrosis factor-alpha and increased risk of recurrent coronary events after myocardial infarction. Circulation 101 (2000) 1767-1772
    • (2000) Circulation , vol.101 , pp. 1767-1772
    • Ridker, P.M.1    Rifai, N.2    Pfeifer, M.3    Sacks, F.4    Lepage, S.5    Braunwald, E.6
  • 30
    • 0028925088 scopus 로고
    • Bone marrow, cytokines, and bone remodeling. Emerging insights into the pathophysiology of osteoporosis
    • Manolagas S.C., and Jilka R.L. Bone marrow, cytokines, and bone remodeling. Emerging insights into the pathophysiology of osteoporosis. N Engl J Med 332 (1995) 305-311
    • (1995) N Engl J Med , vol.332 , pp. 305-311
    • Manolagas, S.C.1    Jilka, R.L.2
  • 32
    • 0028180435 scopus 로고
    • 17 beta-Estradiol inhibits expression of human interleukin-6 promoter-reporter constructs by a receptor-dependent mechanism
    • Pottratz S., Bellido T., Mocharla H., Crabb D., and Manolagas S.C. 17 beta-Estradiol inhibits expression of human interleukin-6 promoter-reporter constructs by a receptor-dependent mechanism. J Clin Invest 93 (1994) 944-950
    • (1994) J Clin Invest , vol.93 , pp. 944-950
    • Pottratz, S.1    Bellido, T.2    Mocharla, H.3    Crabb, D.4    Manolagas, S.C.5
  • 33
    • 0026777433 scopus 로고
    • Increased osteoclast development after estrogen loss: mediation by interleukin-6
    • Jilka R.L., Hangoc G., Girasole G., Passeri G., Williams D.C., Abrams J.S., et al. Increased osteoclast development after estrogen loss: mediation by interleukin-6. Science 257 (1992) 88-91
    • (1992) Science , vol.257 , pp. 88-91
    • Jilka, R.L.1    Hangoc, G.2    Girasole, G.3    Passeri, G.4    Williams, D.C.5    Abrams, J.S.6
  • 34
    • 0036899812 scopus 로고    scopus 로고
    • Therapeutic benefit of blocking interleukin-6 activity with an anti-interleukin-6 receptor monoclonal antibody in rheumatoid arthritis: a randomized, double-blind, placebo-controlled, dose-escalation trial
    • Choy E.H., Isenberg D.A., Garrood T., Farrow S., Ioannou Y., Bird H., et al. Therapeutic benefit of blocking interleukin-6 activity with an anti-interleukin-6 receptor monoclonal antibody in rheumatoid arthritis: a randomized, double-blind, placebo-controlled, dose-escalation trial. Arthritis Rheum 46 (2002) 3143-3150
    • (2002) Arthritis Rheum , vol.46 , pp. 3143-3150
    • Choy, E.H.1    Isenberg, D.A.2    Garrood, T.3    Farrow, S.4    Ioannou, Y.5    Bird, H.6
  • 35
    • 2642558925 scopus 로고    scopus 로고
    • Treatment of rheumatoid arthritis with humanized anti-interleukin-6 receptor antibody: a multicenter, double-blind, placebo-controlled trial
    • Nishimoto N., Yoshizaki K., Miyasaka N., Yamamoto K., Kawai S., Takeuchi T., et al. Treatment of rheumatoid arthritis with humanized anti-interleukin-6 receptor antibody: a multicenter, double-blind, placebo-controlled trial. Arthritis Rheum 50 (2004) 1761-1769
    • (2004) Arthritis Rheum , vol.50 , pp. 1761-1769
    • Nishimoto, N.1    Yoshizaki, K.2    Miyasaka, N.3    Yamamoto, K.4    Kawai, S.5    Takeuchi, T.6
  • 36
    • 33749363027 scopus 로고    scopus 로고
    • Double-blind randomized controlled clinical trial of the interleukin-6 receptor antagonist, tocilizumab, in European patients with rheumatoid arthritis who had an incomplete response to methotrexate
    • Maini R.N., Taylor P.C., Szechinski J., Pavelka K., Bröll J., Balint G., et al. Double-blind randomized controlled clinical trial of the interleukin-6 receptor antagonist, tocilizumab, in European patients with rheumatoid arthritis who had an incomplete response to methotrexate. Arthritis Rheum 54 (2006) 2817-2829
    • (2006) Arthritis Rheum , vol.54 , pp. 2817-2829
    • Maini, R.N.1    Taylor, P.C.2    Szechinski, J.3    Pavelka, K.4    Bröll, J.5    Balint, G.6
  • 37
    • 40749114497 scopus 로고    scopus 로고
    • Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): a double-blind, placebo-controlled, randomised trial
    • Smolen J.S., Beaulieu A., Rubbert-Roth A., Ramos-Remus C., Rovensky J., Alecock E., et al. Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): a double-blind, placebo-controlled, randomised trial. Lancet 371 (2008) 987-997
    • (2008) Lancet , vol.371 , pp. 987-997
    • Smolen, J.S.1    Beaulieu, A.2    Rubbert-Roth, A.3    Ramos-Remus, C.4    Rovensky, J.5    Alecock, E.6
  • 38
    • 54949150604 scopus 로고    scopus 로고
    • Interleukin-6 receptor inhibition with tocilizumab reduces disease activity in rheumatoid arthritis with inadequate response to disease-modifying antirheumatic drugs: the tocilizumab in combination with traditional disease-modifying antirheumatic drug therapy study
    • Genovese M.C., McKay J.D., Nasonov E.L., Mysler E.F., da Silva N.A., Alecock E., et al. Interleukin-6 receptor inhibition with tocilizumab reduces disease activity in rheumatoid arthritis with inadequate response to disease-modifying antirheumatic drugs: the tocilizumab in combination with traditional disease-modifying antirheumatic drug therapy study. Arthritis Rheum 58 (2008) 2968-2980
    • (2008) Arthritis Rheum , vol.58 , pp. 2968-2980
    • Genovese, M.C.1    McKay, J.D.2    Nasonov, E.L.3    Mysler, E.F.4    da Silva, N.A.5    Alecock, E.6
  • 39
    • 52149099504 scopus 로고    scopus 로고
    • IL-6 receptor inhibition with tocilizumab improves treatment outcomes in patients with rheumatoid arthritis refractory to anti-tumour necrosis factor biologicals: results from a 24-week multicentre randomised placebo-controlled trial
    • Emery P., Keystone E., Tony H.P., Cantagrel A., van Vollenhoven R., Sanchez A., et al. IL-6 receptor inhibition with tocilizumab improves treatment outcomes in patients with rheumatoid arthritis refractory to anti-tumour necrosis factor biologicals: results from a 24-week multicentre randomised placebo-controlled trial. Ann Rheum Dis 67 (2008) 1516-1523
    • (2008) Ann Rheum Dis , vol.67 , pp. 1516-1523
    • Emery, P.1    Keystone, E.2    Tony, H.P.3    Cantagrel, A.4    van Vollenhoven, R.5    Sanchez, A.6
  • 40
    • 34447300492 scopus 로고    scopus 로고
    • Study of active controlled monotherapy used for rheumatoid arthritis, an IL-6 inhibitor (SAMURAI): evidence of clinical and radiographic benefit from an x ray reader-blinded randomised controlled trial of tocilizumab
    • Nishimoto N., Hashimoto J., Miyasaka N., Yamamoto K., Kawai S., Takeuchi T., et al. Study of active controlled monotherapy used for rheumatoid arthritis, an IL-6 inhibitor (SAMURAI): evidence of clinical and radiographic benefit from an x ray reader-blinded randomised controlled trial of tocilizumab. Ann Rheum Dis 66 (2007) 1162-1167
    • (2007) Ann Rheum Dis , vol.66 , pp. 1162-1167
    • Nishimoto, N.1    Hashimoto, J.2    Miyasaka, N.3    Yamamoto, K.4    Kawai, S.5    Takeuchi, T.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.