Blockade of interleukin-6 signaling suppresses experimental autoimmune uveoretinitis by the inhibition of inflammatory Th17 responses

Experimental Eye Research

Volumn 91, Issue 2, 2010, Pages 162-170

  Hohki, Satoshi ^a   Ohguro, Nobuyuki ^a   Haruta, Hiroshi ^a   Nakai, Kei ^a   Terabe, Fumitaka ^b   Serada, Satoshi ^b   Fujimoto, Minoru ^b   Nomura, Shintaro ^a   Kawahata, Hirohisa ^c   Kishimoto, Tadamitsu ^d   Naka, Tetsuji ^b  

^a OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

^b National Institute of Biomedical Innovation   (Japan)

^c MORINOMIYA UNIVERSITY OF MEDICAL SCIENCES   (Japan)

^d OSAKA UNIVERSITY   (Japan)

Author keywords

Anti mouse IL 6 receptor monoclonal antibody; Anti TNF mAb; Experimental autoimmune uveoretinitis; Th1 cells; Th17 cells; Treg cells

Indexed keywords

CNTO 5048; IMMUNOGLOBULIN G; INTERLEUKIN 6; INTERPHOTORECEPTOR RETINOID BINDING PROTEIN; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY MR16 1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; DRUG MECHANISM; EXPERIMENTAL AUTOIMMUNE UVEORETINITIS; FEMALE; HELPER CELL; IMMUNIZATION; INFLAMMATORY CELL; LYMPHOCYTE DIFFERENTIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; SIGNAL TRANSDUCTION; TH17 CELL; UVEORETINITIS;

ANIMALS; ANTIBODIES, MONOCLONAL; AUTOIMMUNE DISEASES; CELL DIFFERENTIATION; CELLS, CULTURED; DISEASE MODELS, ANIMAL; EYE PROTEINS; FEMALE; INTERLEUKIN-17; INTERLEUKIN-6; MICE; MICE, INBRED C57BL; RECEPTORS, INTERLEUKIN-6; RETINITIS; RETINOL-BINDING PROTEINS; SIGNAL TRANSDUCTION; T-LYMPHOCYTES, HELPER-INDUCER; TUMOR NECROSIS FACTOR-ALPHA; UVEITIS;

EID: 77954952358     PISSN: 00144835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exer.2010.04.009     Document Type: Article

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