메뉴 건너뛰기




Volumn 36, Issue 1, 2014, Pages 115-132

Microbiota and nonalcoholic steatohepatitis

Author keywords

Inflammation; Insulin resistance; Microbiota; Nonalcoholic fatty liver disease (NAFLD); Nonalcoholic steatohepatitis (NASH)

Indexed keywords

ANTIBIOTIC AGENT; CD14 ANTIGEN; ENDOTOXIN; GLUCAGON LIKE PEPTIDE 2; INTERLEUKIN 10; LEPTIN; PREBIOTIC AGENT; PROBIOTIC AGENT; TUMOR NECROSIS FACTOR ALPHA;

EID: 84895864200     PISSN: 18632297     EISSN: 18632300     Source Type: Journal    
DOI: 10.1007/s00281-013-0404-6     Document Type: Review
Times cited : (34)

References (201)
  • 2
    • 77950251400 scopus 로고    scopus 로고
    • A human gut microbial gene catalogue established by metagenomic sequencing
    • Qin J, Li R, Raes J et al (2010) A human gut microbial gene catalogue established by metagenomic sequencing. Nature 464: 59-65
    • (2010) Nature , vol.464 , pp. 59-65
    • Qin, J.1    Li, R.2    Raes, J.3
  • 3
    • 0037129380 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease
    • Angulo P (2002) Nonalcoholic fatty liver disease. N Engl J Med 346:1221-1231
    • (2002) N Engl J Med , vol.346 , pp. 1221-1231
    • Angulo, P.1
  • 4
    • 0036090972 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease
    • Clark JM, Brancati FL, Diehl AM (2002) Nonalcoholic fatty liver disease. Gastroenterology 122:1649-1657 (Pubitemid 34533559)
    • (2002) Gastroenterology , vol.122 , Issue.6 , pp. 1649-1657
    • Clark, J.M.1    Brancati, F.L.2    Diehl, A.M.3
  • 6
    • 0038644536 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis: Summary of an AASLD Single Topic Conference
    • DOI 10.1053/jhep.2003.50193
    • Neuschwander-Tetri BA, Caldwell SH (2003) Nonalcoholic steatohepatitis: summary of an AASLD single topic conference. Hepatology 37:1202-1219 (Pubitemid 36538699)
    • (2003) Hepatology , vol.37 , Issue.5 , pp. 1202-1219
    • Neuschwander-Tetri, B.A.1    Caldwell, S.H.2
  • 7
    • 0036829092 scopus 로고    scopus 로고
    • AGA technical review on nonalcoholic fatty liver disease
    • Sanyal AJ, American Gastroenterological Association (2002) AGA technical review on nonalcoholic fatty liver disease. Gastroenterology 123:1705-1725 (Pubitemid 35231670)
    • (2002) Gastroenterology , vol.123 , Issue.5 , pp. 1705-1725
    • Sanyal, A.J.1
  • 8
    • 79957449923 scopus 로고    scopus 로고
    • Changes in the prevalence of themost common causes of chronic liver diseases in the United States from 1988 to 2008
    • Younossi ZM, Stepanova M, Afendy M et al (2011) Changes in the prevalence of themost common causes of chronic liver diseases in the United States from 1988 to 2008. Clin Gastroenterol Hepatol 9:524-530
    • (2011) Clin Gastroenterol Hepatol , vol.9 , pp. 524-530
    • Younossi, Z.M.1    Stepanova, M.2    Afendy, M.3
  • 9
    • 0036116213 scopus 로고    scopus 로고
    • Non-alcoholic steatohepatitis (NASH): Where are we now and where are we going?
    • Day CP (2002) Non-alcoholic steatohepatitis (NASH): where are we now and where are we going? Gut 50:585-588
    • (2002) Gut , vol.50 , pp. 585-588
    • Day, C.P.1
  • 10
    • 0036454882 scopus 로고    scopus 로고
    • Non-alcoholic steatohepatitis: Definitions and pathogenesis
    • Day CP, Saksena S (2002) Non-alcoholic steatohepatitis: definitions and pathogenesis. J Gastroenterol Hepatol 17:377-384
    • (2002) J Gastroenterol Hepatol , vol.17 , pp. 377-384
    • Day, C.P.1    Saksena, S.2
  • 12
    • 0025178612 scopus 로고
    • The natural history of nonalcoholic steatohepatitis: A follow-up study of forty-two patients for up to 21 years
    • Powell EE, Cooksley WG, Hanson R et al (1990) The natural history of nonalcoholic steatohepatitis: a follow-up study of forty-two patients for up to 21 years. Hepatology 11:74-80 (Pubitemid 20075105)
    • (1990) Hepatology , vol.11 , Issue.1 , pp. 74-80
    • Powell, E.E.1    Cooksley, W.G.E.2    Hanson, R.3    Searle, J.4    Halliday, J.W.5    Powell, L.W.6
  • 15
    • 69949111703 scopus 로고    scopus 로고
    • The core gut microbiome, energy balance and obesity
    • Turnbaugh PJ, Gordon JI (2009) The core gut microbiome, energy balance and obesity. J Physiol 587(17):4153-4158
    • (2009) J Physiol , vol.587 , Issue.17 , pp. 4153-4158
    • Turnbaugh, P.J.1    Gordon, J.I.2
  • 16
    • 33845874101 scopus 로고    scopus 로고
    • An obesity-associated gut microbiome with increased capacity for energy harvest
    • DOI 10.1038/nature05414, PII NATURE05414
    • Turnbaugh PJ, Ley RE, Mahowald MA et al (2006) An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 444(7122):1027-1031 (Pubitemid 46018515)
    • (2006) Nature , vol.444 , Issue.7122 , pp. 1027-1031
    • Turnbaugh, P.J.1    Ley, R.E.2    Mahowald, M.A.3    Magrini, V.4    Mardis, E.R.5    Gordon, J.I.6
  • 17
    • 30044431801 scopus 로고    scopus 로고
    • From fat to inflammation
    • Day CP (2006) From fat to inflammation. Gastroenterology 130: 207-210
    • (2006) Gastroenterology , vol.130 , pp. 207-210
    • Day, C.P.1
  • 19
    • 33745896155 scopus 로고    scopus 로고
    • Recent advances in the relationship between obesity, inflammation, and insulin resistance
    • Bastard JP, Maachi M, Lagathu C et al (2006) Recent advances in the relationship between obesity, inflammation, and insulin resistance. Eur Cytokine Netw 17:4-12
    • (2006) Eur Cytokine Netw , vol.17 , pp. 4-12
    • Bastard, J.P.1    Maachi, M.2    Lagathu, C.3
  • 20
    • 34250773451 scopus 로고    scopus 로고
    • Mechanisms of obesity-associated insulin resistance: Many choices on the menu
    • DOI 10.1101/gad.1550907
    • Qatanani M, Lazar MA (2007) Mechanisms of obesity associated insulin resistance: many choices on the menu. Genes and Development 21(12):1443-1455 (Pubitemid 46955717)
    • (2007) Genes and Development , vol.21 , Issue.12 , pp. 1443-1455
    • Qatanani, M.1    Lazar, M.A.2
  • 21
    • 33845866857 scopus 로고    scopus 로고
    • Inflammation and metabolic disorders
    • Hotamisligil GS (2006) Inflammation and metabolic disorders. Nature 444(7121):860-867
    • (2006) Nature , vol.444 , Issue.7121 , pp. 860-867
    • Hotamisligil, G.S.1
  • 22
    • 47949099098 scopus 로고    scopus 로고
    • Origin and physiological roles of inflammation
    • Medzhitov R (2008) Origin and physiological roles of inflammation. Nature 454(7203):428-435
    • (2008) Nature , vol.454 , Issue.7203 , pp. 428-435
    • Medzhitov, R.1
  • 23
    • 77955362775 scopus 로고    scopus 로고
    • Chronic inflammation in obesity and the metabolic syndrome
    • pii289645
    • Monteiro R, Azevedo I (2010) Chronic inflammation in obesity and the metabolic syndrome. Mediators Inflamm 2010:pii289645
    • (2010) Mediators Inflamm , vol.2010
    • Monteiro, R.1    Azevedo, I.2
  • 26
    • 33644544110 scopus 로고    scopus 로고
    • The liver as an immunological organ
    • Racanelli V, Rehermann B (2006) The liver as an immunological organ. Hepatology 43:54-62
    • (2006) Hepatology , vol.43 , pp. 54-62
    • Racanelli, V.1    Rehermann, B.2
  • 27
    • 0034886143 scopus 로고    scopus 로고
    • Toll-like receptors: Critical proteins linking innate and acquired immunity
    • DOI 10.1038/90609
    • Akira S, Takeda K, Kaisho T (2001) Toll-like receptors: critical proteins linking innate and acquired immunity. Nat Immunol 2:675-680 (Pubitemid 32747155)
    • (2001) Nature Immunology , vol.2 , Issue.8 , pp. 675-680
    • Akira, S.1    Takeda, K.2    Kaisho, T.3
  • 28
    • 66349110620 scopus 로고    scopus 로고
    • Toll-like receptors as targets in chronic liver diseases
    • Mencin A, Kluwe J, Schwabe RF (2009) Toll-like receptors as targets in chronic liver diseases. Gut 58:704-720
    • (2009) Gut , vol.58 , pp. 704-720
    • Mencin, A.1    Kluwe, J.2    Schwabe, R.F.3
  • 29
    • 77950825001 scopus 로고    scopus 로고
    • Alcoholic liver disease and the gut-liver axis
    • Szabo G, Bala S (2010) Alcoholic liver disease and the gut-liver axis. World J Gastroenterol 16:1321-1329
    • (2010) World J Gastroenterol , vol.16 , pp. 1321-1329
    • Szabo, G.1    Bala, S.2
  • 30
    • 34247566510 scopus 로고    scopus 로고
    • The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling
    • DOI 10.1038/nri2079, PII NRI2079
    • O'Neill LA, Bowie AG (2007) The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling. Nat Rev Immunol 7:353-364 (Pubitemid 46674493)
    • (2007) Nature Reviews Immunology , vol.7 , Issue.5 , pp. 353-364
    • O'Neill, L.A.J.1    Bowie, A.G.2
  • 31
    • 33646908228 scopus 로고    scopus 로고
    • Phosphoinositide-Mediated Adaptor Recruitment Controls Toll-like Receptor Signaling
    • DOI 10.1016/j.cell.2006.03.047, PII S0092867406005617
    • Kagan JC, Medzhitov R (2006) Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling. Cell 125:943-955 (Pubitemid 43795199)
    • (2006) Cell , vol.125 , Issue.5 , pp. 943-955
    • Kagan, J.C.1    Medzhitov, R.2
  • 32
    • 33646899303 scopus 로고    scopus 로고
    • Sorting out Toll Signals
    • DOI 10.1016/j.cell.2006.05.014, PII S0092867406006258
    • Fitzgerald KA, Chen ZJ (2006) Sorting out Toll signals. Cell 125: 834-836 (Pubitemid 43795201)
    • (2006) Cell , vol.125 , Issue.5 , pp. 834-836
    • Fitzgerald, K.A.1    Chen, Z.J.2
  • 33
    • 47149105036 scopus 로고    scopus 로고
    • Toll-like receptors and adaptor molecules in liver disease: Update
    • DOI 10.1002/hep.22306
    • Seki E, Brenner DA (2008) Toll-like receptors and adaptor molecules in liver disease: update. Hepatology 48:322-335 (Pubitemid 351975556)
    • (2008) Hepatology , vol.48 , Issue.1 , pp. 322-335
    • Seki, E.1    Brenner, D.A.2
  • 34
    • 33845951211 scopus 로고    scopus 로고
    • DAMPs, PAMPs and alarmins: All we need to know about danger
    • Bianchi ME (2007) DAMPs, PAMPs and alarmins: all we need to know about danger. J Leukoc Biol 81:1-5
    • (2007) J Leukoc Biol , vol.81 , pp. 1-5
    • Bianchi, M.E.1
  • 35
    • 33747040825 scopus 로고    scopus 로고
    • Pattern recognition receptors: A contemporary view on liver diseases
    • DOI 10.1002/hep.21308
    • Szabo G, Dolganiuc A, Mandrekar P (2006) Pattern recognition receptors: a contemporary view on liver diseases. Hepatology 44: 287-298 (Pubitemid 44214866)
    • (2006) Hepatology , vol.44 , Issue.2 , pp. 287-298
    • Szabo, G.1    Dolganiuc, A.2    Mandrekar, P.3
  • 39
    • 27744458510 scopus 로고    scopus 로고
    • NF-kappaB activation, rather than TNF, mediates hepatic inflammation in a murine dietary model of steatohepatitis
    • DOI 10.1053/j.gastro.2005.09.004, PII S0016508505017889
    • Dela Peña A, Leclercq I, Field J et al (2005) NF kappa B activation, rather than TNF, mediates hepatic inflammation in a murine dietary model of steatohepatitis. Gastroenterology 129:1663-1674 (Pubitemid 41597405)
    • (2005) Gastroenterology , vol.129 , Issue.5 , pp. 1663-1674
    • Dela Pena, A.1    Leclercq, I.2    Field, J.3    George, J.4    Jones, B.5    Farrell, G.6
  • 40
    • 9644295733 scopus 로고    scopus 로고
    • Curcumin inhibits NF-kappaB activation and reduces the severity of experimental steatohepatitis in mice
    • DOI 10.1016/j.jhep.2004.08.010, PII S0168827804003800
    • Leclercq IA, Farrell GC, Sempoux C et al (2004) Curcumin inhibits NF-kappaB activation and reduces the severity of experimental steatohepatitis in mice. J Hepatol 41:926-934 (Pubitemid 39575659)
    • (2004) Journal of Hepatology , vol.41 , Issue.6 , pp. 926-934
    • Leclercq, I.A.1    Farrell, G.C.2    Sempoux, C.3    Pena, A.D.4    Horsmans, Y.5
  • 41
    • 40849106735 scopus 로고    scopus 로고
    • The treatment with antibody of TNF-alpha reduces the inflammation, necrosis and fibrosis in the non-alcoholic steatohepatitis induced by methionine- and choline-deficient diet
    • Koca SS, Bahcecioglu IH, Poyrazoglu OK et al (2008) The treatment with antibody of TNF-alpha reduces the inflammation, necrosis and fibrosis in the non-alcoholic steatohepatitis induced by methionine- and choline-deficient diet. Inflammation 31:91-98
    • (2008) Inflammation , vol.31 , pp. 91-98
    • Koca, S.S.1    Bahcecioglu, I.H.2    Poyrazoglu, O.K.3
  • 43
    • 0037265240 scopus 로고    scopus 로고
    • Alternative activation of macrophages
    • Gordon S (2003) Alternative activation of macrophages. Nat Rev Immunol 3:23-35
    • (2003) Nat Rev Immunol , vol.3 , pp. 23-35
    • Gordon, S.1
  • 44
    • 25844437136 scopus 로고    scopus 로고
    • Dietary factors alter hepatic innate immune system in mice with nonalcoholic fatty liver disease
    • DOI 10.1002/hep.20826
    • Li Z, Soloski MJ, Diehl AM (2005) Dietary factors alter hepatic innate immune system in mice with nonalcoholic fatty liver disease. Hepatology 42:880-885 (Pubitemid 41401126)
    • (2005) Hepatology , vol.42 , Issue.4 , pp. 880-885
    • Li, Z.1    Soloski, M.J.2    Diehl, A.M.3
  • 45
    • 0034005303 scopus 로고    scopus 로고
    • Altered hepatic lymphocyte subpopulations in obesity-related murine fatty livers: Potential mechanism for sensitization to liver damage
    • Guebre-Xabier M, Yang S, Lin HZ et al (2000) Altered hepatic lymphocyte subpopulations in obesity-related murine fatty livers: potential mechanism for sensitization to liver damage. Hepatology 31:633-640 (Pubitemid 30118631)
    • (2000) Hepatology , vol.31 , Issue.3 , pp. 633-640
    • Guebre-Xabier, M.1    Yang, S.2    Lin, H.Z.3    Schwenk, R.4    Krzych, U.5    Diehl, A.M.6
  • 46
    • 33745911148 scopus 로고    scopus 로고
    • Favored T helper 1 response in a mouse model of hepatosteatosis is associated with enhanced T cell-mediated hepatitis
    • DOI 10.1002/hep.21221
    • Kremer M, Hines IN, Milton RJ et al (2006) Favored T helper 1 response in a mouse model of hepatosteatosis is associated with enhanced T cell-mediated hepatitis. Hepatology 44:216-227 (Pubitemid 44049154)
    • (2006) Hepatology , vol.44 , Issue.1 , pp. 216-227
    • Kremer, M.1    Hines, I.N.2    Milton, R.J.3    Wheeler, M.D.4
  • 48
    • 0017341656 scopus 로고
    • Microbial ecology of the gastrointestinal tract
    • Savage DC (1977) Microbial ecology of the gastrointestinal tract. Annu Rev Microbiol 31:107-133
    • (1977) Annu Rev Microbiol , vol.31 , pp. 107-133
    • Savage, D.C.1
  • 49
    • 65449128399 scopus 로고    scopus 로고
    • Patterns and scales in gastrointestinal microbial ecology
    • Camp JG, Kanther M, Semova I et al (2009) Patterns and scales in gastrointestinal microbial ecology. Gastroenterology 136:1989-2002
    • (2009) Gastroenterology , vol.136 , pp. 1989-2002
    • Camp, J.G.1    Kanther, M.2    Semova, I.3
  • 50
    • 0032956143 scopus 로고    scopus 로고
    • Developmental microbial ecology of the neonatal gastrointestinal tract
    • Mackie RI, Sghir A, Gaskins HR (1999) Developmental microbial ecology of the neonatal gastrointestinal tract. Am J Clin Nutr 69: 1035-1045
    • (1999) Am J Clin Nutr , vol.69 , pp. 1035-1045
    • Mackie, R.I.1    Sghir, A.2    Gaskins, H.R.3
  • 51
    • 0002447569 scopus 로고    scopus 로고
    • Enteric bacterial flora and bacterial overgrowth syndrome
    • Feldman M, Scharschmidt BF, Sleisenger MH (eds) 6th edn. WB Saunders, Philadelphia
    • Toskes PP, Kumar A (1998) Enteric bacterial flora and bacterial overgrowth syndrome. In: Feldman M, Scharschmidt BF, Sleisenger MH (eds) Sleisenger and Fordtran's gastrointestinal and liver disease, 6th edn. WB Saunders, Philadelphia, pp 1523-1535
    • (1998) Sleisenger and Fordtran's Gastrointestinal and Liver Disease , pp. 1523-1535
    • Toskes, P.P.1    Kumar, A.2
  • 52
    • 85069140084 scopus 로고    scopus 로고
    • Spatial organization of intestinal microbiota in health and disease
    • Wellesley
    • Swidsinski A, Loening-Baucke V (Wellesley, 2010) Spatial organization of intestinal microbiota in health and disease. UpToDate online, 18.1
    • (2010) UpToDate Online , vol.18 , Issue.1
    • Swidsinski, A.1    Loening-Baucke, V.2
  • 53
    • 38349049462 scopus 로고    scopus 로고
    • Polysaccharide utilization by gut bacteria: Potential for new insights from genomic analysis
    • Flint HJ, Bayer EA, Rincon MT et al (2008) Polysaccharide utilization by gut bacteria: potential for new insights from genomic analysis. Nat Rev Microbiol 6(2):121-131
    • (2008) Nat Rev Microbiol , vol.6 , Issue.2 , pp. 121-131
    • Flint, H.J.1    Bayer, E.A.2    Rincon, M.T.3
  • 56
    • 23344442120 scopus 로고    scopus 로고
    • Mechanisms underlying the resistance to diet-induced obesity in germ-free mice
    • Backhed F, Manchester JK, Semenkovich CF et al (2005) Mechanisms underlying the resistance to diet-induced obesity in germ-free mice. Proc Natl Acad Sci U S A 102(31):11070-11075
    • (2005) Proc Natl Acad Sci U S A , vol.102 , Issue.31 , pp. 11070-11075
    • Backhed, F.1    Manchester, J.K.2    Semenkovich, C.F.3
  • 57
    • 77958615207 scopus 로고    scopus 로고
    • Decreased fat storage by Lactobacillus paracasei is associated with increased levels of angiopoietin-like 4 protein (ANGPTL4)
    • Aronsson L, Huang Y, Parini P et al (2010) Decreased fat storage by Lactobacillus paracasei is associated with increased levels of angiopoietin-like 4 protein (ANGPTL4). PLoS One 5(9):e13087
    • (2010) PLoS One , vol.5 , Issue.9
    • Aronsson, L.1    Huang, Y.2    Parini, P.3
  • 58
    • 78049283381 scopus 로고    scopus 로고
    • Hypothalamic Angptl4/Fiaf is a novel regulator of food intake and body weight
    • Kim HK et al (2010) Hypothalamic Angptl4/Fiaf is a novel regulator of food intake and body weight. Diabetes 59(11):2772-2780
    • (2010) Diabetes , vol.59 , Issue.11 , pp. 2772-2780
    • Kim, H.K.1
  • 59
    • 21344449292 scopus 로고    scopus 로고
    • Prevalence of and risk factors for nonalcoholic fatty liver disease: The dionysos nutrition and liver study
    • DOI 10.1002/hep.20734
    • Bedogni G, Miglioli L, Masutti F et al (2005) Prevalence of and risk factors for nonalcoholic fatty liver disease: the Dionysos nutrition and liver study. Hepatology 42:44-52 (Pubitemid 40911310)
    • (2005) Hepatology , vol.42 , Issue.1 , pp. 44-52
    • Bedogni, G.1    Miglioli, L.2    Masutti, F.3    Tiribelli, C.4    Marchesini, G.5    Bellentani, S.6
  • 62
    • 24044467100 scopus 로고    scopus 로고
    • Prevalence of non-alcoholic fatty liver disease and its association with impaired glucose metabolism in Japanese adults
    • DOI 10.1111/j.1464-5491.2005.01582.x
    • Jimba S, Nakagami T, Takahashi M et al (2005) Prevalence of nonalcoholic fatty liver disease and its association with impaired glucose metabolism in Japanese adults. Diabet Med 22:1141-1145 (Pubitemid 41224170)
    • (2005) Diabetic Medicine , vol.22 , Issue.9 , pp. 1141-1145
    • Jimba, S.1    Nakagami, T.2    Takahashi, M.3    Wakamatsu, T.4    Hirota, Y.5    Iwamoto, Y.6    Wasada, T.7
  • 64
    • 70350007954 scopus 로고    scopus 로고
    • Multivariate analysis of risk factors for the development of type 2 diabetes in nonalcoholic fatty liver disease
    • Arase Y, Suzuki F, Ikeda K et al (2009) Multivariate analysis of risk factors for the development of type 2 diabetes in nonalcoholic fatty liver disease. J Gastroenterol 44(10):1064-1070
    • (2009) J Gastroenterol , vol.44 , Issue.10 , pp. 1064-1070
    • Arase, Y.1    Suzuki, F.2    Ikeda, K.3
  • 67
    • 77956266803 scopus 로고    scopus 로고
    • Prevalence of non-alcoholic fatty liver disease and its association with cardiovascular disease in patients with type 1 diabetes
    • Targher G, Bertolini L, Padovani R et al (2010) Prevalence of non-alcoholic fatty liver disease and its association with cardiovascular disease in patients with type 1 diabetes. J Hepatol 53:713-718
    • (2010) J Hepatol , vol.53 , pp. 713-718
    • Targher, G.1    Bertolini, L.2    Padovani, R.3
  • 68
    • 30944455145 scopus 로고    scopus 로고
    • Insulin resistance: A metabolic pathway to chronic liver disease
    • DOI 10.1002/hep.20920
    • Bugianesi E, McCullough AJ, Marchesini G (2005) Insulin resistance: a metabolic pathway to chronic liver disease. Hepatology 42:987-1000 (Pubitemid 43112663)
    • (2005) Hepatology , vol.42 , Issue.5 , pp. 987-1000
    • Bugianesi, E.1    McCullough, A.J.2    Marchesini, G.3
  • 69
  • 71
    • 0042570843 scopus 로고    scopus 로고
    • Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance
    • Virkamaki A, Ueki K, Kahn CR (1999) Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance. J Clin Invest 103:931-943 (Pubitemid 29169600)
    • (1999) Journal of Clinical Investigation , vol.103 , Issue.7 , pp. 931-943
    • Virkamaki, A.1    Ueki, K.2    Kahn, C.R.3
  • 72
    • 0036710280 scopus 로고    scopus 로고
    • IRS proteins and the common path to diabetes
    • White MF (2002) IRS proteins and the common path to diabetes. Am J Physiol Endocrinol Metab 283:413-422
    • (2002) Am J Physiol Endocrinol Metab , vol.283 , pp. 413-422
    • White, M.F.1
  • 74
    • 0035856949 scopus 로고    scopus 로고
    • Insulin signalling and the regulation of glucose and lipid metabolism
    • DOI 10.1038/414799a
    • Saltiel A, Kahn CR (2001) Insulin signalling and the regulation of glucose and lipid metabolism. Nature 414:799-806 (Pubitemid 34000783)
    • (2001) Nature , vol.414 , Issue.6865 , pp. 799-806
    • Saltiel, A.R.1    Kahn, C.R.2
  • 75
    • 34547102518 scopus 로고    scopus 로고
    • Common inhibitory serine sites phosphorylated by IRS-1 kinases, triggered by insulin and inducers of insulin resistance
    • Herschkovitz A, Liu YF, Ilan E et al (2007) Common inhibitory serine sites phosphorylated by IRS-1 kinases, triggered by insulin and inducers of insulin resistance. J Biol Chem 282:18018-18127
    • (2007) J Biol Chem , vol.282 , pp. 18018-18127
    • Herschkovitz, A.1    Liu, Y.F.2    Ilan, E.3
  • 77
    • 0037474274 scopus 로고    scopus 로고
    • c-Jun N-terminal kinase (JNK) mediates feedback inhibition of the insulin signaling cascade
    • DOI 10.1074/jbc.M208359200
    • Lee YH, Giraud J, Davis RJ, White MF (2003) c-Jun N-terminal kinase (JNK) mediates feedback inhibition of the insulin signaling cascade. J Biol Chem 278:2896-2902 (Pubitemid 36801194)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.5 , pp. 2896-2902
    • Lee, Y.H.1    Giraud, J.2    Davis, R.J.3    White, M.F.4
  • 79
    • 34347216368 scopus 로고    scopus 로고
    • Prolonged treatment of primary hepatocytes with oleate induces insulin resistance through p38 mitogen-activated protein kinase
    • DOI 10.1074/jbc.M609701200
    • Liu HY, Collins QF, Xiong Y et al (2007) Prolonged treatment of primary hepatocytes with oleate induces insulin resistance through p38 mitogen-activated protein kinase. J Biol Chem 282:14205-14212 (Pubitemid 47100474)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.19 , pp. 14205-14212
    • Liu, H.-Y.1    Collins, Q.F.2    Xiong, Y.3    Moukdar, F.4    Lupo Jr., E.G.5    Liu, Z.6    Cao, W.7
  • 80
    • 41849127118 scopus 로고    scopus 로고
    • Diet-Induced Obesity Is Linked to Marked but Reversible Alterations in the Mouse Distal Gut Microbiome
    • DOI 10.1016/j.chom.2008.02.015, PII S1931312808000899
    • Turnbaugh PJ, Backhed F, Fulton L et al (2008) Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome. Cell Host Microbe 3(4):213-223 (Pubitemid 351494716)
    • (2008) Cell Host and Microbe , vol.3 , Issue.4 , pp. 213-223
    • Turnbaugh, P.J.1    Backhed, F.2    Fulton, L.3    Gordon, J.I.4
  • 81
    • 56849106496 scopus 로고    scopus 로고
    • The pervasive effects of an antibiotic on the human gut microbiota, as revealed by deep 16S rRNA sequencing
    • Dethlefsen L, Huse S, Sogin ML et al (2008) The pervasive effects of an antibiotic on the human gut microbiota, as revealed by deep 16S rRNA sequencing. PLoS Biol 6(11):e280
    • (2008) PLoS Biol , vol.6 , Issue.11
    • Dethlefsen, L.1    Huse, S.2    Sogin, M.L.3
  • 82
    • 77957262599 scopus 로고    scopus 로고
    • Absence of intestinal microbiota does not protect mice from diet-induced obesity
    • Fleissner CK, Huebel N, Abd El-Bary MM et al (2010) Absence of intestinal microbiota does not protect mice from diet-induced obesity. Br J Nutr 104(6):919-929
    • (2010) Br J Nutr , vol.104 , Issue.6 , pp. 919-929
    • Fleissner, C.K.1    Huebel, N.2    Abd El-Bary, M.M.3
  • 83
    • 33845901507 scopus 로고    scopus 로고
    • Microbial ecology: Human gut microbes associated with obesity
    • DOI 10.1038/4441022a, PII 4441022A
    • Ley RE, Turnbaugh PJ, Klein S et al (2006) Microbial ecology: human gut microbes associated with obesity. Nature 444(7122):1022-1023 (Pubitemid 46018512)
    • (2006) Nature , vol.444 , Issue.7122 , pp. 1022-1023
    • Ley, R.E.1    Turnbaugh, P.J.2    Klein, S.3    Gordon, J.I.4
  • 84
    • 84888133800 scopus 로고    scopus 로고
    • Metagenomic sequencing of the human gut microbiome before and after bariatric surgery in obese patients with type 2 diabetes: Correlation with inflammatory and metabolic parameters
    • Graessler J, Qin Y, Zhong H et al (2013) Metagenomic sequencing of the human gut microbiome before and after bariatric surgery in obese patients with type 2 diabetes: correlation with inflammatory and metabolic parameters. Pharmacogenomics J 13(6):514-22
    • (2013) Pharmacogenomics J , vol.13 , Issue.6 , pp. 514-522
    • Graessler, J.1    Qin, Y.2    Zhong, H.3
  • 85
    • 60549086580 scopus 로고    scopus 로고
    • Human gut microbiota in obesity and after gastric bypass
    • Zhang H et al (2009) Human gut microbiota in obesity and after gastric bypass. Proc Natl Acad Sci U S A 106(7):2365-2370
    • (2009) Proc Natl Acad Sci U S A , vol.106 , Issue.7 , pp. 2365-2370
    • Zhang, H.1
  • 86
    • 70349631208 scopus 로고    scopus 로고
    • Monitoring bacterial community of human gut microbiota reveals an increase in Lactobacillus in obese patients and methanogens in anorexic patients
    • Armougom F, Henry M, Vialettes B et al (2009) Monitoring bacterial community of human gut microbiota reveals an increase in Lactobacillus in obese patients and methanogens in anorexic patients. PLoS One 4(9):e7125
    • (2009) PLoS One , vol.4 , Issue.9
    • Armougom, F.1    Henry, M.2    Vialettes, B.3
  • 87
    • 77954672686 scopus 로고    scopus 로고
    • Gut microbiota composition is associated with body weight, weight gain and biochemical parameters in pregnant women
    • Santacruz A et al (2010) Gut microbiota composition is associated with body weight, weight gain and biochemical parameters in pregnant women. Br J Nutr 104(1):83-92
    • (2010) Br J Nutr , vol.104 , Issue.1 , pp. 83-92
    • Santacruz, A.1
  • 88
    • 49749090139 scopus 로고    scopus 로고
    • Small intestinal bacterial overgrowth in irritable bowel syndrome: Association with colon motility, bowel symptoms, and psychological distress
    • Grover M, Kanazawa M, Palsson OS et al (2008) Small intestinal bacterial overgrowth in irritable bowel syndrome: association with colon motility, bowel symptoms, and psychological distress. Neurogastroenterol Motil 20:998-1008
    • (2008) Neurogastroenterol Motil , vol.20 , pp. 998-1008
    • Grover, M.1    Kanazawa, M.2    Palsson, O.S.3
  • 89
    • 4043116899 scopus 로고    scopus 로고
    • Small intestinal bacterial overgrowth: A framework for understanding irritable bowel syndrome
    • Lin HC (2004) Small intestinal bacterial overgrowth: a framework for understanding irritable bowel syndrome. JAMA 292:852-858
    • (2004) JAMA , vol.292 , pp. 852-858
    • Lin, H.C.1
  • 91
    • 0033636668 scopus 로고    scopus 로고
    • Eradication of small intestinal bacterial overgrowth reduces symptoms of irritable bowel syndrome
    • Pimentel M, Chow EJ, Lin HC (2000) Eradication of small intestinal bacterial overgrowth reduces symptoms of irritable bowel syndrome. Am J Gastroenterol 95:3503-3506
    • (2000) Am J Gastroenterol , vol.95 , pp. 3503-3506
    • Pimentel, M.1    Chow, E.J.2    Lin, H.C.3
  • 92
    • 0037280318 scopus 로고    scopus 로고
    • Normalization of lactulose breath testing correlates with symptom improvement in irritable bowel syndrome: A double-blind, randomized, placebo-controlled study
    • DOI 10.1016/S0002-9270(02)05902-6
    • Pimentel M, Chow EJ, Lin HC (2003) Normalization of lactulose breath testing correlates with symptom improvement in irritable bowel syndrome. a double-blind, randomized, placebo controlled study. Am J Gastroenterol 98:412-419 (Pubitemid 36232393)
    • (2003) American Journal of Gastroenterology , vol.98 , Issue.2 , pp. 412-419
    • Pimentel, M.1    Chow, E.J.2    Lin, H.C.3
  • 93
    • 0037286459 scopus 로고    scopus 로고
    • Methane production during lactulose breath test is associated with gastrointestinal disease presentation
    • DOI 10.1023/A:1021738515885
    • Pimentel M, Mayer AG, Park S, Chow EJ, Hasan A, Kong Y (2003) Methane production during lactulose breath test is associated with gastrointestinal disease presentation. Dig Dis Sci 48:86-92 (Pubitemid 36232767)
    • (2003) Digestive Diseases and Sciences , vol.48 , Issue.1 , pp. 86-92
    • Pimentel, M.1    Mayer, A.G.2    Park, S.3    Chow, E.J.4    Hasan, A.5    Kong, Y.6
  • 94
    • 1842557887 scopus 로고    scopus 로고
    • A link between irritable bowel syndrome and fibromyalgia may be related to findings on lactulose breath testing
    • Pimentel M, Wallace D, Hallegua D, Chow E, Kong Y, Park S, Lin HC (2004) A link between irritable bowel syndrome and fibromyalgia may be related to findings on lactulose breath testing. Ann Rheum Dis 63:450-452
    • (2004) Ann Rheum Dis , vol.63 , pp. 450-452
    • Pimentel, M.1    Wallace, D.2    Hallegua, D.3    Chow, E.4    Kong, Y.5    Park, S.6    Lin, H.C.7
  • 95
    • 43349107591 scopus 로고    scopus 로고
    • High prevalence of small intestinal bacterial overgrowth in patients with morbid obesity: A contributor to severe hepatic steatosis
    • Sabaté JM, Jouët P, Harnois F, Mechler C, Msika S, Grossin M, Coffin B (2008) High prevalence of small intestinal bacterial overgrowth in patients with morbid obesity: a contributor to severe hepatic steatosis. Obes Surg 18:371-377
    • (2008) Obes Surg , vol.18 , pp. 371-377
    • Sabaté, J.M.1    Jouët, P.2    Harnois, F.3    Mechler, C.4    Msika, S.5    Grossin, M.6    Coffin, B.7
  • 97
    • 0035125052 scopus 로고    scopus 로고
    • The role of small intestinal bacterial overgrowth, intestinal permeability, endotoxaemia, and tumour necrosis factor alpha in the pathogenesis of non-alcoholic steatohepatitis
    • DOI 10.1136/gut.48.2.206
    • Wigg AJ, Roberts-Thomson IC, Dymock RB et al (2001) The role of small intestinal bacterial overgrowth, intestinal permeability, endotoxaemia, and tumour necrosis factor alpha in the pathogenesis of non-alcoholic steatohepatitis. Gut 48:206-211 (Pubitemid 32141844)
    • (2001) Gut , vol.48 , Issue.2 , pp. 206-211
    • Wigg, A.J.1    Roberts-Thomson, I.C.2    Dymock, R.B.3    McCarthy, P.J.4    Grose, R.H.5    Cummins, A.G.6
  • 98
    • 39849088160 scopus 로고    scopus 로고
    • Small intestinal bacteria overgrowth decreases small intestinal motility in the NASH rats
    • DOI 10.3748/wjg.14.313
    • Wu WC, Zhao W, Li S (2008) Small intestinal bacteria overgrowth decreases small intestinal motility in the NASH rats. World J Gastroenterol 14(2):313-317 (Pubitemid 351314317)
    • (2008) World Journal of Gastroenterology , vol.14 , Issue.2 , pp. 313-317
    • Wu, W.-C.1    Zhao, W.2    Li, S.3
  • 99
    • 0024317284 scopus 로고
    • Non-alcoholic steatohepatitis associated with small intestinal diverticulosis and bacterial overgrowth
    • Nazim M, Stamp G, Hodgson HJ (1989) Non-alcoholic steatohepatitis associated with small intestinal diverticulosis and bacterial overgrowth. Hepatogastroenterology 36:349-351 (Pubitemid 19284541)
    • (1989) Hepato-Gastroenterology , vol.36 , Issue.5 , pp. 349-351
    • Nazim, M.1    Stamp, G.2    Hodgson, H.J.F.3
  • 100
    • 33846463432 scopus 로고    scopus 로고
    • The role of enterogenous endotoxemia in the pathogenesis of non-alcoholic steatohepatitis
    • Zhao LF, Jia JM, Han DW (2004) The role of enterogenous endotoxemia in the pathogenesis of non-alcoholic steatohepatitis. Zhonghua Ganzangbing Zazhi 12:632
    • (2004) Zhonghua Ganzangbing Zazhi , vol.12 , pp. 632
    • Zhao, L.F.1    Jia, J.M.2    Han, D.W.3
  • 101
    • 23944514253 scopus 로고    scopus 로고
    • Ciprofloxacin suppresses bacterial overgrowth, increases fasting insulin but does not correct low acylated ghrelin concentration in non-alcoholic steatohepatitis
    • DOI 10.1111/j.1365-2036.2005.02562.x
    • Sajjad A, Mottershead M, Syn WK et al (2005) Ciprofloxacin suppresses bacterial overgrowth, increases fasting insulin but does not correct low acylated ghrelin concentration in non-alcoholic steatohepatitis. Aliment Pharmacol Ther 22:291-299 (Pubitemid 41207458)
    • (2005) Alimentary Pharmacology and Therapeutics , vol.22 , Issue.4 , pp. 291-299
    • Sajjad, A.1    Mottershead, M.2    Syn, W.K.3    Jones, R.4    Smith, S.5    Nwokolo, C.U.6
  • 105
    • 0037879075 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease: Lumen-liver interactions and possible role for probiotics
    • DOI 10.1016/S0168-8278(03)00097-7
    • Solga SF, Diehl AM (2003) Non-alcoholic fatty liver disease: lumen-liver interactions and possible role for probiotics. J Hepatol 38:681-687 (Pubitemid 36560657)
    • (2003) Journal of Hepatology , vol.38 , Issue.5 , pp. 681-687
    • Solga, S.F.1    Diehl, A.M.2
  • 107
    • 33847040759 scopus 로고    scopus 로고
    • Increased intestinal permeability in obese mice: New evidence in the pathogenesis of nonalcoholic steatohepatitis
    • Brun P, Castagliuolo I, Leo VD et al (2007) Increased intestinal permeability in obese mice: new evidence in the pathogenesis of nonalcoholic steatohepatitis. American Journal of Physiology 292(2):518-525
    • (2007) American Journal of Physiology , vol.292 , Issue.2 , pp. 518-525
    • Brun, P.1    Castagliuolo, I.2    Leo, V.D.3
  • 108
    • 68949148889 scopus 로고    scopus 로고
    • Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease
    • Miele L, Valenza V, La Torre G et al (2009) Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease. Hepatology 49(6):1877-1887
    • (2009) Hepatology , vol.49 , Issue.6 , pp. 1877-1887
    • Miele, L.1    Valenza, V.2    La Torre, G.3
  • 109
    • 48249125862 scopus 로고    scopus 로고
    • Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice
    • Cani PD, Bibiloni R, Knauf C et al (2008) Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice. Diabetes 57(6):1470-1481
    • (2008) Diabetes , vol.57 , Issue.6 , pp. 1470-1481
    • Cani, P.D.1    Bibiloni, R.2    Knauf, C.3
  • 111
    • 77951679651 scopus 로고    scopus 로고
    • Molecular modulation of intestinal epithelial barrier: Contribution of microbiota
    • doi:10.1155/2010/305879
    • Sharma R, Young C, Neu J (2010) Molecular modulation of intestinal epithelial barrier: contribution of microbiota. J Biomed Biotechnol. doi:10.1155/2010/305879
    • (2010) J Biomed Biotechnol
    • Sharma, R.1    Young, C.2    Neu, J.3
  • 112
    • 65249099918 scopus 로고    scopus 로고
    • Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability
    • Cani PD, Possemiers S, Van de Wiele T et al (2009) Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability. Gut 58:1091-1103
    • (2009) Gut , vol.58 , pp. 1091-1103
    • Cani, P.D.1    Possemiers, S.2    Van De Wiele, T.3
  • 113
    • 63449098729 scopus 로고    scopus 로고
    • Chylomicrons promote intestinal absorption of lipopolysaccharides
    • Ghoshal S, Witta J, Zhong J et al (2009) Chylomicrons promote intestinal absorption of lipopolysaccharides. J Lipid Res 50:90-97
    • (2009) J Lipid Res , vol.50 , pp. 90-97
    • Ghoshal, S.1    Witta, J.2    Zhong, J.3
  • 114
    • 0035078484 scopus 로고    scopus 로고
    • Etiopathogenesis of nonalcoholic steatohepatitis
    • Chitturi S, Farrell GC (2001) Etiopathogenesis of nonalcoholic steatohepatitis. Semin Liver Dis 21:27-41 (Pubitemid 32240484)
    • (2001) Seminars in Liver Disease , vol.21 , Issue.1 , pp. 27-41
    • Chitturi, S.1    Farrell, G.C.2
  • 115
    • 77950419928 scopus 로고    scopus 로고
    • Elevated endotoxin levels in non-alcoholic fatty liver disease
    • Lond
    • Harte AL, da Silva NF, Creely SJ et al (2010) Elevated endotoxin levels in non-alcoholic fatty liver disease. J Inflamm (Lond) 7:15
    • (2010) J Inflamm , vol.7 , pp. 15
    • Harte, A.L.1    Da Silva, N.F.2    Creely, S.J.3
  • 116
    • 67349139869 scopus 로고    scopus 로고
    • Lipopolysaccharide triggered TNF-alpha-induced hepatocyte apoptosis in a murine non-alcoholic steatohepatitis model
    • Kudo H, Takahara T, Yata Y et al (2009) Lipopolysaccharide triggered TNF-alpha-induced hepatocyte apoptosis in a murine non-alcoholic steatohepatitis model. J Hepatol 51:168-175
    • (2009) J Hepatol , vol.51 , pp. 168-175
    • Kudo, H.1    Takahara, T.2    Yata, Y.3
  • 118
    • 0018170966 scopus 로고
    • Portal and systemic bacteraemia and endotoxaemia in liver disease
    • Triger DR, Boyer TD, Levin J (1978) Portal and systemic bacteraemia and endotoxaemia in liver disease. Gut 19:935-939 (Pubitemid 9032823)
    • (1978) Gut , vol.19 , Issue.10 , pp. 935-939
    • Triger, D.R.1    Boyer, T.D.2    Levin, J.3
  • 119
    • 0017685906 scopus 로고
    • Endotoxin and bacteria in portal blood
    • Jacob AI, Goldberg PK, Bloom N et al (1977) Endotoxin and bacteria in portal blood. Gastroenterology 72:1268-1270 (Pubitemid 8116697)
    • (1977) Gastroenterology , vol.72 , Issue.6 , pp. 1268-1270
    • Jacob, A.I.1    Goldberg, P.K.2    Bloom, N.3
  • 120
    • 84863508993 scopus 로고    scopus 로고
    • Hyperresponsivity to low-dose endotoxin during progression to nonalcoholic steatohepatitis is regulated by leptin-mediated signaling
    • Imajo K, Fujita K, Yoneda M et al (2012) Hyperresponsivity to low-dose endotoxin during progression to nonalcoholic steatohepatitis is regulated by leptin-mediated signaling. Cell Metab 16:44-54
    • (2012) Cell Metab , vol.16 , pp. 44-54
    • Imajo, K.1    Fujita, K.2    Yoneda, M.3
  • 121
    • 38049023478 scopus 로고    scopus 로고
    • Sensitivity of mice to lipopolysaccharide is increased by a high saturated fat and cholesterol diet
    • Lond
    • Huang H, Liu T, Rose JL et al (2007) Sensitivity of mice to lipopolysaccharide is increased by a high saturated fat and cholesterol diet. J Inflamm (Lond) 12(4):22
    • (2007) J Inflamm , vol.12 , Issue.4 , pp. 22
    • Huang, H.1    Liu, T.2    Rose, J.L.3
  • 122
    • 52049124227 scopus 로고    scopus 로고
    • Attenuation of the cardiovascular andmetabolic complications of obesity in CD14 knockout mice
    • Roncon-Albuquerque R Jr, Moreira-Rodrigues M, Faria B et al (2008) Attenuation of the cardiovascular andmetabolic complications of obesity in CD14 knockout mice. Life Sci 83:502-510
    • (2008) Life Sci , vol.83 , pp. 502-510
    • Roncon-Albuquerque Jr., R.1    Moreira-Rodrigues, M.2    Faria, B.3
  • 123
    • 0028981285 scopus 로고
    • CD14 enhances cellular responses to endotoxin without imparting ligand-specific recognition
    • Delude RL, Savedra R Jr, Zhao H et al (1995) CD14 enhances cellular responses to endotoxin without imparting ligand-specific recognition. Proc Natl Acad Sci U S A 92:9288-9292
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 9288-9292
    • Delude, R.L.1    Savedra Jr., R.2    Zhao, H.3
  • 126
    • 0036074141 scopus 로고    scopus 로고
    • Lipopolysaccharides in liver injury: Molecular mechanisms of Kupffer cell activation
    • Su GL (2002) Lipopolysaccharides in liver injury: molecular mechanisms of Kupffer cell activation. Am J Physiol Gastrointest Liver Physiol 283:256-265
    • (2002) Am J Physiol Gastrointest Liver Physiol , vol.283 , pp. 256-265
    • Su, G.L.1
  • 127
    • 0025166114 scopus 로고
    • CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein
    • Wright SD, Ramos RA, Tobias PS et al (1990) CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science 249:1431-1433
    • (1990) Science , vol.249 , pp. 1431-1433
    • Wright, S.D.1    Ramos, R.A.2    Tobias, P.S.3
  • 128
    • 33746131326 scopus 로고    scopus 로고
    • Increased risk of NASH in patients carrying the C(-159)T polymorphism in the CD14 gene promoter region [9]
    • DOI 10.1136/gut.2006.093336
    • Brun P, Castagliuolo I, Floreani AR et al (2006) Increased risk of NASH in patients carrying the C(2159)T polymorphism in the CD14 gene promoter region. Gut 55:1212 (Pubitemid 44085699)
    • (2006) Gut , vol.55 , Issue.8 , pp. 1212
    • Brun, P.1    Castagliuolo, I.2    Floreani, A.R.3    Buda, A.4    Blasone, L.5    Palu, G.6    Martines, D.7
  • 130
    • 0029073613 scopus 로고
    • Weight-reducing effects of the plasma protein encoded by the obese gene
    • Halaas JL, Gajiwala KS, Maffei M et al (1995) Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269:543-546
    • (1995) Science , vol.269 , pp. 543-546
    • Halaas, J.L.1    Gajiwala, K.S.2    Maffei, M.3
  • 134
    • 28644450804 scopus 로고    scopus 로고
    • A proposed model linking inflammation to obesity, diabetes, and periodontal infections
    • DOI 10.1902/jop.2005.76.11-S.2075
    • Genco RJ, Grossi SG, Ho A et al (2005) A proposed model linking inflammation to obesity, diabetes, and periodontal infections. J Periodontol 76:2075-2084 (Pubitemid 41748956)
    • (2005) Journal of Periodontology , vol.76 , Issue.11 SUPPL. , pp. 2075-2084
    • Genco, R.J.1    Grossi, S.G.2    Ho, A.3    Nishimura, F.4    Murayama, Y.5
  • 135
    • 28644432523 scopus 로고    scopus 로고
    • Systemic effects of periodontitis: Epidemiology of periodontal disease and cardiovascular disease
    • DOI 10.1902/jop.2005.76.11-S.2089
    • Beck JD, Offenbacher S (2005) Systemic effects of periodontitis: epidemiology of periodontal disease and cardiovascular disease. J Periodontol 76:2089-2100 (Pubitemid 41748958)
    • (2005) Journal of Periodontology , vol.76 , Issue.11 SUPPL. , pp. 2089-2100
    • Beck, J.D.1    Offenbacher, S.2
  • 137
    • 0037226509 scopus 로고    scopus 로고
    • Periodontal disease, tooth loss, and incidence of ischemic stroke
    • DOI 10.1161/01.STR.0000052974.79428.0C
    • Joshipura KJ, Hung HC, Rimm EB et al (2003) Periodontal disease, tooth loss, and incidence of ischemic stroke. Stroke 34:47-52 (Pubitemid 36070799)
    • (2003) Stroke , vol.34 , Issue.1 , pp. 47-52
    • Joshipura, K.J.1    Hung, H.-C.2    Rimm, E.B.3    Willett, W.C.4    Ascherio, A.5
  • 138
    • 80053417622 scopus 로고    scopus 로고
    • The collagen-binding protein of Streptococcus mutans is involved in haemorrhagic stroke
    • Nakano K, Hokamura K, Taniguchi N et al (2011) The collagen-binding protein of Streptococcus mutans is involved in haemorrhagic stroke. Nat Commun 27(2):485
    • (2011) Nat Commun , vol.27 , Issue.2 , pp. 485
    • Nakano, K.1    Hokamura, K.2    Taniguchi, N.3
  • 139
    • 0032110201 scopus 로고    scopus 로고
    • Potential pathogenic mechanisms of periodontitis associated pregnancy complications
    • Offenbacher S, Jared HL, O'Reilly PG et al (1998) Potential pathogenic mechanisms of periodontitis associated pregnancy complications. Ann Periodontol 3:233-250
    • (1998) Ann Periodontol , vol.3 , pp. 233-250
    • Offenbacher, S.1    Jared, H.L.2    O'Reilly, P.G.3
  • 140
    • 84859753092 scopus 로고    scopus 로고
    • Infection of specific strains of Streptococcus mutans, oral bacteria, confers a risk of ulcerative colitis
    • Kojima A, Nakano K, Wada K et al (2012) Infection of specific strains of Streptococcus mutans, oral bacteria, confers a risk of ulcerative colitis. Sci Rep 2:332
    • (2012) Sci Rep , vol.2 , pp. 332
    • Kojima, A.1    Nakano, K.2    Wada, K.3
  • 141
    • 42449126712 scopus 로고    scopus 로고
    • Oral health and mortality risk from pneumonia in the elderly
    • Awano S, Ansai T, Takata Y et al (2008) Oral health and mortality risk from pneumonia in the elderly. J Dent Res 87:334-339
    • (2008) J Dent Res , vol.87 , pp. 334-339
    • Awano, S.1    Ansai, T.2    Takata, Y.3
  • 142
    • 0027469006 scopus 로고
    • Periodontal disease: The sixth complication of diabetes mellitus
    • Loe H (1993) Periodontal disease: the sixth complication of diabetes mellitus. Diabetes Care 16:329-334
    • (1993) Diabetes Care , vol.16 , pp. 329-334
    • Loe, H.1
  • 145
    • 0033180667 scopus 로고    scopus 로고
    • Antibiotic resistance in the subgingival microflora in patients with adult periodontitis. A comparative survey between Spain and the Netherlands
    • van Winkelhoff AJ, Herrera D, Winkel EG et al (1999) Antibiotic resistance in the subgingival microflora in patients with adult periodontitis. A comparative survey between Spain and the Netherlands. Nederlands tijdschrift voor tandheelkunde 106:290-294
    • (1999) Nederlands Tijdschrift Voor Tandheelkunde , vol.106 , pp. 290-294
    • Van Winkelhoff, A.J.1    Herrera, D.2    Winkel, E.G.3
  • 147
    • 0015662489 scopus 로고
    • Relationship of bacteremia to tooth brushing in patients with periodontitis
    • Sconyer JR, Crawford JJ, Moriarty JD (1973) Relationship of bacteremia to tooth brushing in patients with periodontitis. J Am Dent Assoc 87:616-622
    • (1973) J Am Dent Assoc , vol.87 , pp. 616-622
    • Sconyer, J.R.1    Crawford, J.J.2    Moriarty, J.D.3
  • 148
    • 0019196188 scopus 로고
    • Dental flossing and its relationship to transient bacteremia
    • Caroll GC, Sebor RJ (1980) Dental flossing and its relationship to transient bacteremia. J Periodontol 51:691-692
    • (1980) J Periodontol , vol.51 , pp. 691-692
    • Caroll, G.C.1    Sebor, R.J.2
  • 149
    • 33646685234 scopus 로고    scopus 로고
    • Incidence of bacteremia after chewing, tooth brushing and scaling in individuals with periodontal inflammation
    • DOI 10.1111/j.1600-051X.2006.00924.x
    • Forner L, Larsen T, Kilian M et al (2006) Incidence of bacteremia after chewing, tooth brushing and scaling in individuals with periodontal inflammation. J Clin Periodontol 33:401-407 (Pubitemid 43742620)
    • (2006) Journal of Clinical Periodontology , vol.33 , Issue.6 , pp. 401-407
    • Forner, L.1    Larsen, T.2    Kilian, M.3    Holmstrup, P.4
  • 150
    • 1442351868 scopus 로고    scopus 로고
    • Associations between periodontal disease and risk for atherosclerosis, cardiovascular disease, and stroke. A systematic review
    • Scannapieco FA, Bush RB, Paju S (2003) Associations between periodontal disease and risk for atherosclerosis, cardiovascular disease, and stroke. A systematic review. Ann Periodontol 8:38-53
    • (2003) Ann Periodontol , vol.8 , pp. 38-53
    • Scannapieco, F.A.1    Bush, R.B.2    Paju, S.3
  • 152
    • 0033202582 scopus 로고    scopus 로고
    • Periodontitis-atherosclerosis syndrome: An expanded model of pathogenesis
    • Offenbacher S, Madianos PN, Champagne CM et al (1999) Periodontitis-atherosclerosis syndrome: an expanded model of pathogenesis. J Periodontal Res 34:346-352
    • (1999) J Periodontal Res , vol.34 , pp. 346-352
    • Offenbacher, S.1    Madianos, P.N.2    Champagne, C.M.3
  • 154
    • 12844258040 scopus 로고    scopus 로고
    • Relationship of periodontal bacterium genotypic variations with periodontitis in type 2 diabetic patients
    • DOI 10.2337/diacare.28.2.433
    • Ojima M, Takeda M, Yoshioka H et al (2005) Relationship of periodontal bacterium genotypic variations with periodontitis in type 2 diabetic patients. Diabetes Care 28:433-434 (Pubitemid 40170956)
    • (2005) Diabetes Care , vol.28 , Issue.2 , pp. 433-434
    • Ojima, M.1    Takeda, M.2    Yoshioka, H.3    Nomura, M.4    Tanaka, N.5    Kato, T.6    Shizukuishi, S.7    Amano, A.8
  • 155
    • 84856836048 scopus 로고    scopus 로고
    • Involvement of a periodontal pathogen, Porphyromonas gingivalis on the pathogenesis of non-alcoholic fatty liver disease
    • Yoneda M, Naka S, Nakano K et al (2012) Involvement of a periodontal pathogen, Porphyromonas gingivalis on the pathogenesis of non-alcoholic fatty liver disease. BMC Gastroenterol 12:16
    • (2012) BMC Gastroenterol , vol.12 , pp. 16
    • Yoneda, M.1    Naka, S.2    Nakano, K.3
  • 156
    • 33344468233 scopus 로고    scopus 로고
    • Neutrophils and immunity: Challenges and opportunities
    • Nathan C (2006) Neutrophils and immunity: challenges and opportunities. Nat Rev Immunol 6:173-182
    • (2006) Nat Rev Immunol , vol.6 , pp. 173-182
    • Nathan, C.1
  • 157
    • 77957590676 scopus 로고    scopus 로고
    • Clinical and experimental pancreatic islet transplantation to striated muscle: Establishment of a vascular system similar to that in native islets
    • Christoffersson G, Henriksnas J, Johansson L et al (2010) Clinical and experimental pancreatic islet transplantation to striated muscle: establishment of a vascular system similar to that in native islets. Diabetes 59:2569-2578
    • (2010) Diabetes , vol.59 , pp. 2569-2578
    • Christoffersson, G.1    Henriksnas, J.2    Johansson, L.3
  • 158
    • 77952865796 scopus 로고    scopus 로고
    • Phagocyte partnership during the onset and resolution of inflammation
    • Soehnlein O, Lindbom L (2010) Phagocyte partnership during the onset and resolution of inflammation. Nat Rev Immunol 10:427-439
    • (2010) Nat Rev Immunol , vol.10 , pp. 427-439
    • Soehnlein, O.1    Lindbom, L.2
  • 159
    • 79959634861 scopus 로고    scopus 로고
    • Pattern recognition receptors and the innate immune response to viral infection
    • Thompson MR, Kaminski JJ, Kurt-Jones EA et al (2011) Pattern recognition receptors and the innate immune response to viral infection. Viruses 3:920-940
    • (2011) Viruses , vol.3 , pp. 920-940
    • Thompson, M.R.1    Kaminski, J.J.2    Kurt-Jones, E.A.3
  • 161
    • 79959793959 scopus 로고    scopus 로고
    • Non-alcoholic steatohepatitis-induced fibrosis: Toll-like receptors, reactive oxygen species and Jun N-terminal kinase
    • Brenner DA, Seki E, Taura K et al (2010) Non-alcoholic steatohepatitis-induced fibrosis: Toll-like receptors, reactive oxygen species and Jun N-terminal kinase. Hepatol Res 41:683-686
    • (2010) Hepatol Res , vol.41 , pp. 683-686
    • Brenner, D.A.1    Seki, E.2    Taura, K.3
  • 162
    • 61749096745 scopus 로고    scopus 로고
    • DAMPs ramp up drug toxicity
    • Maher JJ (2009) DAMPs ramp up drug toxicity. J Clin Invest 119: 246-249
    • (2009) J Clin Invest , vol.119 , pp. 246-249
    • Maher, J.J.1
  • 163
    • 78649526394 scopus 로고    scopus 로고
    • Sterile inflammation: Sensing and reacting to damage
    • Chen GY, Nunez G (2010) Sterile inflammation: sensing and reacting to damage. Nat Rev Immunol 10:826-837
    • (2010) Nat Rev Immunol , vol.10 , pp. 826-837
    • Chen, G.Y.1    Nunez, G.2
  • 164
    • 41149118513 scopus 로고    scopus 로고
    • How dying cells alert the immune system to danger
    • DOI 10.1038/nri2215, PII NRI2215
    • Kono H, Rock K (2008) How dying cells alert the immune system to danger. Nat Rev Immunol 8:279-289 (Pubitemid 351432799)
    • (2008) Nature Reviews Immunology , vol.8 , Issue.4 , pp. 279-289
    • Kono, H.1    Rock, K.L.2
  • 165
    • 0028201732 scopus 로고
    • Tolerance, danger, and the extended family
    • Matzinger P (1994) Tolerance, danger, and the extended family. Annu Rev Immunol 12:991-1045
    • (1994) Annu Rev Immunol , vol.12 , pp. 991-1045
    • Matzinger, P.1
  • 167
    • 33646867426 scopus 로고    scopus 로고
    • Mechanisms of liver injury. II. Mechanisms of neutrophil-induced liver cell injury during hepatic ischemia-reperfusion and other acute inflammatory conditions
    • Jaeschke H (2006) Mechanisms of liver injury. II. Mechanisms of neutrophil-induced liver cell injury during hepatic ischemia-reperfusion and other acute inflammatory conditions. Am J Physiol Gastrointest Liver Physiol 290(6):1083-1088
    • (2006) Am J Physiol Gastrointest Liver Physiol , vol.290 , Issue.6 , pp. 1083-1088
    • Jaeschke, H.1
  • 169
    • 33645461206 scopus 로고    scopus 로고
    • High mobility group box 1 protein interacts withmultiple Toll-like receptors
    • Park JS, Gamboni-Robertson F, He Q et al (2006) High mobility group box 1 protein interacts withmultiple Toll-like receptors. Am J Physiol Cell Physiol 290:917-924
    • (2006) Am J Physiol Cell Physiol , vol.290 , pp. 917-924
    • Park, J.S.1    Gamboni-Robertson, F.2    He, Q.3
  • 170
    • 0035281548 scopus 로고    scopus 로고
    • HMG1 and 2, and related 'architectural' DNA-binding proteins
    • DOI 10.1016/S0968-0004(01)01801-1, PII S0968000401017984
    • Thomas JO, Travers AA (2001) HMG1 and 2, and related architectural DNA-binding proteins. Trends Biochem Sci 26(3):167-174 (Pubitemid 32197576)
    • (2001) Trends in Biochemical Sciences , vol.26 , Issue.3 , pp. 167-174
    • Thomas, J.O.1    Travers, A.A.2
  • 171
    • 61449116805 scopus 로고    scopus 로고
    • Bacterial endotoxin induces the release of high mobility group box 1 via the IFN-beta signaling pathway
    • Kim JH, Kim SJ, Lee IS et al (2009) Bacterial endotoxin induces the release of high mobility group box 1 via the IFN-beta signaling pathway. J Immunol 182:2458-2466
    • (2009) J Immunol , vol.182 , pp. 2458-2466
    • Kim, J.H.1    Kim, S.J.2    Lee, I.S.3
  • 173
    • 33845333359 scopus 로고    scopus 로고
    • The extracellular release of HMGB1 during apoptotic cell death
    • Bell CW, Jiang W, Reich CF et al (2006) The extracellular release of HMGB1 during apoptotic cell death. Am J Physiol Cell Physiol 291(6):1318-1325
    • (2006) Am J Physiol Cell Physiol , vol.291 , Issue.6 , pp. 1318-1325
    • Bell, C.W.1    Jiang, W.2    Reich, C.F.3
  • 174
    • 0037062934 scopus 로고    scopus 로고
    • Release of chromatin protein HMGB1 by necrotic cells triggers inflammation
    • DOI 10.1038/nature00858
    • Scaffidi P, Misteli T, Bianchi ME (2002) Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Nature 18(6894):191-195 (Pubitemid 34773774)
    • (2002) Nature , vol.418 , Issue.6894 , pp. 191-195
    • Scaffidi, P.1    Misteli, T.2    Bianchi, M.E.3
  • 176
    • 65349182352 scopus 로고    scopus 로고
    • Probiotics reduce the inflammatory response induced by a high-fat diet in the liver of young rats
    • Esposito E, Iacono A, Bianco G et al (2009) Probiotics reduce the inflammatory response induced by a high-fat diet in the liver of young rats. J Nutr 139:905-911
    • (2009) J Nutr , vol.139 , pp. 905-911
    • Esposito, E.1    Iacono, A.2    Bianco, G.3
  • 178
    • 0036677340 scopus 로고    scopus 로고
    • Gut-liver axis: A new point of attack to treat chronic liver damage?
    • Loguercio C, De Simone T, Federico A et al (2002) Gut-liver axis: a new point of attack to treat chronic liver damage? Am J Gastroenterol 97:2144-6
    • (2002) Am J Gastroenterol , vol.97 , pp. 2144-2146
    • Loguercio, C.1    De Simone, T.2    Federico, A.3
  • 180
    • 67650901984 scopus 로고    scopus 로고
    • Pharmacological interventions for nonalcoholic fatty liver disease in adults and in children: A systematic review
    • Socha P, Horvath A, Vajro P et al (2009) Pharmacological interventions for nonalcoholic fatty liver disease in adults and in children: a systematic review. J Pediatr Gastroenterol Nutr 48:587-596
    • (2009) J Pediatr Gastroenterol Nutr , vol.48 , pp. 587-596
    • Socha, P.1    Horvath, A.2    Vajro, P.3
  • 181
    • 80054873943 scopus 로고    scopus 로고
    • Effect of a probiotic on liver aminotransferases in nonalcoholic fatty liver disease patients: A double blind randomized clinical trial
    • Aller R, De Luis DA, Izaola O et al (2011) Effect of a probiotic on liver aminotransferases in nonalcoholic fatty liver disease patients: a double blind randomized clinical trial. Eur Rev Med Pharmacol Sci 9: 1090-1095
    • (2011) Eur Rev Med Pharmacol Sci , vol.9 , pp. 1090-1095
    • Aller, R.1    De Luis, D.A.2    Izaola, O.3
  • 182
    • 85027931445 scopus 로고    scopus 로고
    • Effects of Lactobacillus rhamousus strain GG in pediatric obesity-related liver disease
    • Vajro P, Mandato C, Licenziati MR et al (2011) Effects of Lactobacillus rhamousus strain GG in pediatric obesity-related liver disease. J Pediatr Gastroenterol Nutr 52:740-743
    • (2011) J Pediatr Gastroenterol Nutr , vol.52 , pp. 740-743
    • Vajro, P.1    Mandato, C.2    Licenziati, M.R.3
  • 183
    • 78149272756 scopus 로고    scopus 로고
    • Prebiotic effects: Metabolic and health benefits
    • Roberfroid M, Gibson GR, Hoyles L et al (2010) Prebiotic effects: metabolic and health benefits. Br J Nutr 104(2):1-63
    • (2010) Br J Nutr , vol.104 , Issue.2 , pp. 1-63
    • Roberfroid, M.1    Gibson, G.R.2    Hoyles, L.3
  • 184
    • 84858607359 scopus 로고    scopus 로고
    • Prebiotic fiber modulation of the gut microbiota improves risk factors for obesity and the metabolic syndrome
    • Parnell JA, Reimer RA (2012) Prebiotic fiber modulation of the gut microbiota improves risk factors for obesity and the metabolic syndrome. Gut Microbes 1:29-34
    • (2012) Gut Microbes , vol.1 , pp. 29-34
    • Parnell, J.A.1    Reimer, R.A.2
  • 185
    • 33745882961 scopus 로고    scopus 로고
    • Reduced monocyte HLA-DR expression: A novel biomarker of disease severity and outcome in acetaminophen-induced acute liver failure
    • DOI 10.1002/hep.21240
    • Antoniades CG, Berry PA, Davies ET et al (2006) Reduced monocyte HLA-DR expression: a novel biomarker of disease severity and outcome in acetaminophen-induced acute liver failure. Hepatology 44(1):34-43 (Pubitemid 44049137)
    • (2006) Hepatology , vol.44 , Issue.1 , pp. 34-43
    • Antoniades, C.G.1    Berry, P.A.2    Davies, E.T.3    Hussain, M.4    Bernal, W.5    Vergani, D.6    Wendon, J.7
  • 187
    • 0025964069 scopus 로고
    • Hepatic injury associated with small intestinal bacterial overgrowth in rats is prevented by metronidazole and tetracycline
    • Lichtman SN, Keku J, Schwab JH et al (1991) Hepatic injury associated with small intestinal bacterial overgrowth in rats is prevented by metronidazole and tetracycline. Gastroenterology 100(2):513-519
    • (1991) Gastroenterology , vol.100 , Issue.2 , pp. 513-519
    • Lichtman, S.N.1    Keku, J.2    Schwab, J.H.3
  • 188
    • 0020065283 scopus 로고
    • Hepatic steatosis after intestinal bypass. Prevention and reversal by metronidazole, irrespective of protein calorie malnutrition
    • Drenick EJ (1982) Hepatic steatosis after intestinal bypass. Prevention and reversal by metronidazole, irrespective of protein calorie malnutrition. Gastroenterology 82:535-548
    • (1982) Gastroenterology , vol.82 , pp. 535-548
    • Drenick, E.J.1
  • 189
    • 0020026596 scopus 로고
    • Effect of antibiotics in the prevention of jejunoileal bypass-induced liver dysfunction
    • Vanderhoof JA, Tuma DJ, Antonson DL et al (1982) Effect of antibiotics in the prevention of jejunoileal bypass-induced liver dysfunction. Digestion 23(1):9-15 (Pubitemid 12150620)
    • (1982) Digestion , vol.23 , Issue.1 , pp. 9-15
    • Vanderhoof, J.A.1    Tuma, D.J.2    Antonson, D.L.3    Sorrell, M.F.4
  • 190
    • 43049161319 scopus 로고    scopus 로고
    • Antibiotics protect against fructose-induced hepatic lipid accumulation in mice: Role of endotoxin
    • Bergheim I, Weber S, Vos M et al (2008) Antibiotics protect against fructose-induced hepatic lipid accumulation in mice: role of endotoxin. J Hepatol 48(6):983-992
    • (2008) J Hepatol , vol.48 , Issue.6 , pp. 983-992
    • Bergheim, I.1    Weber, S.2    Vos, M.3
  • 191
    • 20644436704 scopus 로고    scopus 로고
    • Nonsurgical approaches for the treatment of periodontal diseases
    • Ryan ME (2005) Nonsurgical approaches for the treatment of periodontal diseases. Dent Clinics North Am 49:611-636
    • (2005) Dent Clinics North Am , vol.49 , pp. 611-636
    • Ryan, M.E.1
  • 192
    • 84895888339 scopus 로고
    • Periodontal disease part II: Overview of treatment modalities
    • Deporter DA (1988) Periodontal disease part II: overview of treatment modalities. Can Fam Physician 34:1391-1392
    • (1988) Can Fam Physician , vol.34 , pp. 1391-1392
    • Deporter, D.A.1
  • 193
    • 0023811412 scopus 로고
    • Periodontal disease part III: Chemotherapeutics
    • Freeman E (1988) Periodontal disease part III: chemotherapeutics. Can Fam Physician 34:1395-1397
    • (1988) Can Fam Physician , vol.34 , pp. 1395-1397
    • Freeman, E.1
  • 194
    • 73249115526 scopus 로고    scopus 로고
    • Non-surgical chemotherapeutic treatment strategies for the management of periodontal diseases
    • Krayer JW, Leite RS, Kirkwood KL (2010) Non-surgical chemotherapeutic treatment strategies for the management of periodontal diseases. Dent Clin North Am 54:13-33
    • (2010) Dent Clin North Am , vol.54 , pp. 13-33
    • Krayer, J.W.1    Leite, R.S.2    Kirkwood, K.L.3
  • 195
    • 0037464510 scopus 로고    scopus 로고
    • Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. Adults
    • DOI 10.1056/NEJMoa021423
    • Calle EE, Rodriguez C, Walker-Thurmond K et al (2003) Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med 348: 1625-1638 (Pubitemid 36459468)
    • (2003) New England Journal of Medicine , vol.348 , Issue.17 , pp. 1625-1638
    • Calle, E.E.1    Rodriguez, C.2    Walker-Thurmond, K.3    Thun, M.J.4
  • 196
    • 60549110250 scopus 로고    scopus 로고
    • The impact of obesity and diabetes mellitus on the risk of hepatocellular carcinoma
    • Polesel J, Zucchetto A, Montella M et al (2009) The impact of obesity and diabetes mellitus on the risk of hepatocellular carcinoma. Ann Oncol 20:353-357
    • (2009) Ann Oncol , vol.20 , pp. 353-357
    • Polesel, J.1    Zucchetto, A.2    Montella, M.3
  • 197
    • 58849090967 scopus 로고    scopus 로고
    • Hepatocellular carcinoma in patients with nonalcoholic steatohepatitis
    • Hashimoto E, Yatsuji S, Tobari M et al (2009) Hepatocellular carcinoma in patients with nonalcoholic steatohepatitis. J Gastroenterol 44:89-95
    • (2009) J Gastroenterol , vol.44 , pp. 89-95
    • Hashimoto, E.1    Yatsuji, S.2    Tobari, M.3
  • 198
    • 63349085247 scopus 로고    scopus 로고
    • Hepatocellular carcinomas in patients with metabolic syndrome often develop without significant liver fibrosis: A pathological analysis
    • Paradis V, Zalinski S, Chelbi E et al (2009) Hepatocellular carcinomas in patients with metabolic syndrome often develop without significant liver fibrosis: a pathological analysis. Hepatology 49:851-859
    • (2009) Hepatology , vol.49 , pp. 851-859
    • Paradis, V.1    Zalinski, S.2    Chelbi, E.3
  • 199
    • 1942534221 scopus 로고    scopus 로고
    • Different presentation of hepatitis B-related hepatocellular carcinoma in a cohort of 1863 young and old patients - Implications for screening
    • DOI 10.1111/j.1365-2036.2004.01912.x
    • Lam CM, Chan AOO, Ho P et al (2004) Different presentation of hepatitis B-related hepatocellular carcinoma in a cohort of 1863 young and old patients: implications for screening. Aliment Pharmacol Ther 19:771-777 (Pubitemid 38496643)
    • (2004) Alimentary Pharmacology and Therapeutics , vol.19 , Issue.7 , pp. 771-777
    • Lam, C.-M.1    Chan, A.O.O.2    Ho, P.3    Ng, I.O.-L.4    Lo, C.M.5    Liu, C.L.6    Poon, R.T.P.7    Fan, S.T.8
  • 201
    • 84879888338 scopus 로고    scopus 로고
    • Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome
    • Yoshimoto S, Loo TM, Atarashi K et al (2013) Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome. Nature 499:97-101
    • (2013) Nature , vol.499 , pp. 97-101
    • Yoshimoto, S.1    Loo, T.M.2    Atarashi, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.