Metagenomic sequencing of the human gut microbiome before and after bariatric surgery in obese patients with type 2 diabetes: Correlation with inflammatory and metabolic parameters

Pharmacogenomics Journal

Volumn 13, Issue 6, 2013, Pages 514-522

  Graessler, J ^a   Qin, Y ^b   Zhong, H ^b   Zhang, J ^b   Licinio, J ^c   Wong, M L ^c   Xu, A ^d   Chavakis, T ^a   Bornstein, A B ^a   Ehrhart Bornstein, M ^a   Lamounier Zepter, V ^a   Lohmann, T ^e   Wolf, T ^e   Bornstein, S R ^a  

^a DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^b BGI SHENZHEN   (China)

^c Australian National University   (Australia)

^d UNIVERSITY OF HONG KONG   (Hong Kong)

^e Dresden Interdisciplinary Adiposity Center   (Germany)

Author keywords

bariatric surgery; diabetes mellitus; inflammation; metabolism; metagenome; Roux en Y gastric bypass

Indexed keywords

C REACTIVE PROTEIN; CARBOHYDRATE; GLUCOSE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PHOSPHOTRANSFERASE; TRIACYLGLYCEROL;

ADULT; ARTICLE; BACTEROIDETES; BARIATRIC SURGERY; BODY MASS; CARBOHYDRATE ANALYSIS; CARBOHYDRATE METABOLISM; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; COPROCOCCUS COMES; ENTEROBACTER; ENTEROBACTER CANCEROGENUS; FAECALIBACTERIUM PRAUSNITZII; FEMALE; FIRMICUTES; GENE FUNCTION; GENETIC ASSOCIATION; GENETIC IDENTIFICATION; GENETIC VARIABILITY; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN CELL; INFLAMMATION; INTESTINE FLORA; MALE; METABOLIC PARAMETERS; METAGENOMICS; MICROBIAL IDENTIFICATION; MORBID OBESITY; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; ORTHOLOGY; POPULATION ABUNDANCE; PRIORITY JOURNAL; PROTEOBACTERIA; SEQUENCE ANALYSIS; SPECIES COMPOSITION; TRIACYLGLYCEROL BLOOD LEVEL;

BACTERIA (MICROORGANISMS); BACTEROIDETES; COPROCOCCUS; ENTEROBACTER CANCEROGENUS; FAECALIBACTERIUM PRAUSNITZII; FIRMICUTES; PROTEOBACTERIA;

ADULT; DIABETES MELLITUS, TYPE 2; FEMALE; GASTRIC BYPASS; HUMANS; INFLAMMATION; MALE; METAGENOME; MICROBIOTA; MIDDLE AGED; OBESITY; POSTOPERATIVE PERIOD;

EID: 84888133800     PISSN: 1470269X     EISSN: 14731150     Source Type: Journal    
DOI: 10.1038/tpj.2012.43     Document Type: Article

References (28)

1. Flint HJ. Obesity and the gut microbiota. J Clin Gastroenterol 2011; 45(Suppl): S128-S132.
2. Ley RE, Backhed F, Turnbaugh P, Lozupone CA, Knight RD, Gordon JI. Obesity alters gut microbial ecology. Proc Natl Acad Sci USA 2005; 102: 11070-11075.
3. Ley RE, Turnbaugh PJ, Klein S, Gordon JI. Microbial ecology: human gut microbes associated with obesity. Nature 2006; 444: 1022-1023.
4. Turnbaugh PJ, Hamady M, Yatsunenko T, Cantarel BL, Duncan A, Ley RE et al. A core gut microbiome in obese and lean twins. Nature 2009; 457: 480-484.
5. Schwiertz A, Taras D, Schafer K, Beijer S, Bos NA, Donus C et al. Microbiota and SCFA in lean and overweight healthy subjects. Obesity (Silver Spring) 2010; 18: 190-195.
6. Larsen N, Vogensen FK, van den Berg FW, Nielsen DS, Andreasen AS, Pedersen BK et al. Gut microbiota in human adults with type 2 diabetes differs from nondiabetic adults. PLoS One 2010; 5: e9085.
7. Tilg H. Obesity, metabolic syndrome, and microbiota: multiple interactions. J Clin Gastroenterol 2010; 44(Suppl 1): S16-S18.
8. Mingrone G, Panunzi S, De Gaetano A, Guidone C, Iaconelli A, Leccesi L et al. Bariatric surgery versus conventional medical therapy for type 2 diabetes. N Engl J Med 2012; 366: 1577-1585.
9. Schauer PR, Kashyap SR, Wolski K, Brethauer SA, Kirwan JP, Pothier CE et al. Bariatric surgery versus intensive medical therapy in obese patients with diabetes. N Engl J Med 2012; 366: 1567-1576.
10. Li JV, Ashrafian H, Bueter M, Kinross J, Sands C, le Roux CW et al. Metabolic surgery profoundly influences gut microbial-host metabolic cross-talk. Gut 2011; 60: 1214-1223.
11. Zhang H, DiBaise JK, Zuccolo A, Kudrna D, Braidotti M, Yu Y et al. Human gut microbiota in obesity and after gastric bypass. Proc Natl Acad Sci USA 2009; 106: 2365-2370.
12. Furet JP, Kong LC, Tap J, Poitou C, Basdevant A, Bouillot JL et al. Differential adaptation of human gut microbiota to bariatric surgery-induced weight loss: links with metabolic and low-grade inflammation markers. Diabetes 2010; 59: 3049-3057.
13. Qin J, Li R, Raes J, Arumugam M, Burgdorf KS, Manichanh C et al. A human gut microbial gene catalogue established by metagenomic sequencing. Nature 2010; 464: 59-65.
14. Manichanh C, Rigottier-Gois L, Bonnaud E, Gloux K, Pelletier E, Frangeul L et al. Reduced diversity of faecal microbiota in Crohn's disease revealed by a metagenomic approach. Gut 2006; 55: 205-211.
15. Li R, Yu C, Li Y, Lam TW, Yiu SM, Kristiansen K et al. SOAP2: an improved ultrafast tool for short read alignment. Bioinformatics 2009; 25: 1966-1967.
16. Guarner F, Malagelada JR. Gut flora in health and disease. Lancet 2003; 361: 512-519.
17. Angelakis E, Armougom F, Million M, Raoult D. The relationship between gut microbiota and weight gain in humans. Future Microbiol 2012; 7: 91-109.
18. DiBaise JK, Zhang H, Crowell MD, Krajmalnik-Brown R, Decker GA, Rittmann BE. Gut microbiota and its possible relationship with obesity. Mayo Clin Proc 2008; 83: 460-469.
19. Hartman AL, Lough DM, Barupal DK, Fiehn O, Fishbein T, Zasloff M et al. Human gut microbiome adopts an alternative state following small bowel transplantation. Proc Natl Acad Sci USA 2009; 106: 17187-17192.
20. Duncan SH, Louis P, Thomson JM, Flint HJ. The role of pH in determining the species composition of the human colonic microbiota. Environ Microbiol 2009; 11: 2112-2122.
21. Buchwald H, Estok R, Fahrbach K, Banel D, Jensen MD, Pories WJ et al. Weight and type 2 diabetes after bariatric surgery: systematic review and meta-analysis. Am J Med 2009; 122: 248-256, e245.
22. Reed MA, Pories WJ, Chapman W, Pender J, Bowden R, Barakat H et al. Roux-en-Y gastric bypass corrects hyperinsulinemia implications for the remission of type 2 diabetes. J Clin Endocrinol Metab 2011; 96: 2525-2531.
23. Campos GM, Rabl C, Peeva S, Ciovica R, Rao M, Schwarz JM et al. Improvement in peripheral glucose uptake after gastric bypass surgery is observed only after substantial weight loss has occurred and correlates with the magnitude of weight lost. J Gastrointest Surg 2010; 14: 15-23.
24. le Roux CW, Welbourn R, Werling M, Osborne A, Kokkinos A, Laurenius A et al. Gut hormones as mediators of appetite and weight loss after Roux-en-Y gastric bypass. Ann Surg 2007; 246: 780-785.
25. Spector D, Shikora S. Neuro-modulation and bariatric surgery for type 2 diabetes mellitus. Int J Clin Pract Suppl 2010; 166: 53-58.
26. Stylopoulos N, Hoppin AG, Kaplan LM. Roux-en-Y gastric bypass enhances energy expenditure and extends lifespan in diet-induced obese rats. Obesity (Silver Spring) 2009; 17: 1839-1847.
27. Nestoridi E, Kvas S, Kucharczyk J, Stylopoulos N. Resting energy expenditure and energetic cost of feeding are augmented after Roux-en-Y gastric bypass in obese mice. Endocrinology 2012; 153: 2234-2244.
28. Kootte RS, Vrieze A, Holleman F, Dallinga-Thie GM, Zoetendal EG, de Vos WM et al. The therapeutic potential of manipulating gut microbiota in obesity and type 2 diabetes mellitus. Diabetes Obes Metab 2012; 14: 112-120.