Insulin resistance in non-diabetic patients with non-alcoholic fatty liver disease: Sites and mechanisms

Diabetologia

Volumn 48, Issue 4, 2005, Pages 634-642

  Bugianesi, E ^a   Gastaldelli, A ^b   Vanni, E ^a   Gambino, R ^c   Cassader, M ^c   Baldi, S ^b   Ponti, V ^a   Pagano, G ^c   Ferrannini, E ^b   Rizzetto, M ^a  

^a UNIVERSITY OF TURIN   (Italy)

^b UNIVERSITY OF PISA   (Italy)

^c UNIVERSITY OF TURIN   (Italy)

Author keywords

Fatty liver; Glucose disposal; Glucose production; Glycerol appearance; Lipoperoxidation

Indexed keywords

GLUCOSE; GLYCEROL; INSULIN; LOW DENSITY LIPOPROTEIN; TRACER;

ADULT; ARTICLE; BLOOD PRESSURE; CALORIMETRY; CLINICAL ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLUCOSE OXIDATION; GLUCOSE TRANSPORT; GLYCOGEN SYNTHESIS; HUMAN; HUMAN TISSUE; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; LIPID BLOOD LEVEL; LIPID OXIDATION; LIPID PEROXIDATION; MALE; NONALCOHOLIC FATTY LIVER; OBESITY; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE;

3-HYDROXYBUTYRIC ACID; ADIPOSE TISSUE; ADULT; BLOOD GLUCOSE; BODY COMPOSITION; C-PEPTIDE; CALORIMETRY, INDIRECT; ENZYMES; FASTING; FATTY ACIDS, NONESTERIFIED; FATTY LIVER; GLUCOSE; GLUCOSE CLAMP TECHNIQUE; GLYCEROL; HUMANS; INSULIN; INSULIN RESISTANCE; LIPID METABOLISM; LIPIDS; LIPOPROTEINS, LDL; LIVER; MALE; MIDDLE AGED; OXIDATION-REDUCTION;

EID: 20944450486     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-005-1682-x     Document Type: Article

References (59)

1. Poonawala A, Nair SP, Thuluvath PJ (2000) Prevalence of obesity and diabetes in patients with cryptogenic cirrhosis: a case-control study. Hepatology 32:689-692
2. Falck-Ytter Y, Younossi ZM, Marchesini G, McCullough AJ (2001) Clinical features and natural history of nonalcoholic steatosis syndromes. Semin Liver Dis 21:17-26
3. Bugianesi E, Leone N, Vanni E et al (2002) Expanding the natural history of nonalcoholic steatohepatitis: from cryptogenic cirrhosis to hepatocellular carcinoma. Gastroenterology 123:134-140
4. Clark JM, Brancati FL, Diehl AM (2003) The prevalence and etiology of elevated aminotransferase levels in the United States. Am J Gastroenterol 98:960-967
5. Nomura H, Kashiwagi S, Hayashi J, Kajiyama W, Tani S, Goto M (1988) Prevalence of fatty liver in a general population of Okinawa, Japan. Jpn J Med 7:142-149
6. Bellentani S, Saccoccio G, Masutti F et al (2000) Prevalence of and risk factors for hepatic steatosis in Northern Italy. Ann Intern Med 132:112-117
7. DeFronzo RA, Ferrannini E (1991) Insulin resistance: a multi-faceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. Diabetes Care 14:173-194
8. Ludwig J, Viaggiano TR, McGill DB, Oh BJ (1980) Nonalcoholic steatohepatitis: Mayo Clinic experience with an hitherto unnamed disease. Mayo Clin Proc 55:434-438
9. Wanless IR, Lentz JS (1990) Fatty liver hepatitis (steatohepatitis) and obesity: an autopsy study with analysis of risk factors. Hepatology 12:1106-1110
10. Lee RG (1989) Nonalcoholic steatohepatitis: a study of 49 patients. Human Pathol 20:594-598
11. Marchesini G, Brizi M, Morselli-Labate AM et al (1999) Association of non-alcoholic fatty liver disease to insulin resistance. Am J Med 107:450-455
12. Chitturi S, Abeygunasekera S, Farrell GC et al (2002) NASH and insulin resistance: insulin secretion and specific association with the insulin resistance syndrome. Hepatology 35:373-379
13. Chalasani N, Deeg MA, Persohn S, Crabb DW (2003) Metabolic and anthropometric evaluation of insulin resistance in nondiabetic patients with nonalcoholic steatohepatitis. Am J Gastroenterol 98:1849-1855
14. Ruhl CE, Everhart JE (2003) Determinants of the association of overweight with elevated serum alanine aminotransferase activity in the United States. Gastroenterology 124:71-79
15. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol In Adults (2001) Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III). JAMA 285:2486-2497
16. Marchesini G, Bugianesi E, Forlani G et al (2003) Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome. Hepatology 37:917-923
17. Bucala R, Makita Z, Koschinsky T, Cerami A, Vlassara H (1993) Lipid advanced glycosylation: pathway for lipid oxidation in vivo. Proc Natl Acad Sci U S A 90:6434-6436
18. Lee KS, Buck M, Houglum K, Chojkier M (1995) Activation of hepatic stellate cells by TGF alpha and collagen type 1 is mediated by oxidative stress through c-myb expression. J Clin Invest 96:2461-2468
19. Bedossa P, Houglum K, Trautwein C, Holstege A, Chojkier M (1994) Stimulation of collagen 1 (I) gene expression is associated with lipid peroxidation in hepatocellular injury: a link to tissue fibrosis? Hepatology 19:1262-1271
20. Expert Committee on the Diagnosis and Classification of Diabetes Mellitus (1997) Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care 20:1183-1197
21. National Diabetes Data Group (1979) Classification and diagnosis of diabetes and other categories of glucose intolerance. Diabetes 28:1039-1057
22. Brunt EM (2001) Nonalcoholic steatohepatitis: definition and pathology. Semin Liver Dis 21:3-16
23. Natali A, Toschi E, Camastra S, Gastaldelli A, Groop L, Ferrannini E, European Group for the Study of Insulin Resistance (2000) Determinants of postabsorptive endogenous glucose output in nondiabetic subjects. Diabetologia 43:1266-1272
24. Lancaster JL, Ghiatas AA, Alyassin A, Kilcoyne RF, Bonora E, DeFronzo RA (1991) Measurement of abdominal fat with T1-weighted MR images. J Magn Reson Imaging 1:363-369
25. De Fronzo RA, Tobin D, Andres R (1979) Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol 237:E214-E223
26. Finegood DT, Bergman RN, Vranic M (1987) Estimation of endogenous glucose production during hyperinsulinemic euglycemic glucose clamps. Diabetes 36:914-924
27. Bugianesi E, Kalhan S, Burkett E, Marchesini G, McCullough A (1998) Quantification of gluconeogenesis in cirrhosis: response to glucagon. Gastroenterology 115:1530-1540
28. Coggan AR, Raguso CA, Gastaldelli A, Sidossis LS, Yeckel CW (2000) Fat metabolism during high-intensity exercise in endurance-trained and untrained men. Metabolism 49:122-128
29. Wolfe R (1992) Radioactive and stable isotope tracers in biomedicine. Wiley-Liss, New York
30. Esterbauer H, Striegl G, Puhl H, Dieber Rothneder M (1989) Continuous monitoring of in vitro oxidation of human low density lipoprotein. Free Radic Res Commun 6:67-75
31. Cominacini L, Garbin U, Fratta Pasini A et al (1998) Troglitazone reduces LDL oxidation and lowers plasma E-selectin concentration in NIDDM patients. Diabetes 47:130-133
32. Cobelli C, Mari A, Ferrannini E (1987) Non-steady state: error analysis of Steele's model and developments for glucose kinetics. Am J Physiol 252:E679-E689
33. Sindelar DK, Chu CA, Venson P, Donahue EP, Neal DW, Cherrington AD (1998) Basal hepatic glucose production is regulated by the portal vein insulin concentration. Diabetes 47:523-529
34. DeFronzo RA, Ferrannini E, Simonson D (1989) Fasting hyperglycemia in non-insulin-dependent diabetes mellitus: contributions of excessive hepatic glucose production and impaired tissue glucose uptake. Metabolism 38:387-395
35. Ferrannini E (1988) The theoretical bases of indirect calorimetry: a review. Metabolism 37:287-301
36. Jensen MD (1999) Regional glycerol and free fatty acid metabolism before and after meal ingestion. Am J Physiol 276:E863-E869
37. Jensen MD, Chandramouli V, Schumann WC et al (2001) Sources of blood glycerol during fasting. Am J Physiol Endocrinol Metab 281:E998-E1004
38. Després JP (1993) Abdominal obesity as important component of insulin-resistance syndrome. Nutrition 9:452-459
39. Bergman N (2000) Non-esterified fatty acids and the liver: why is insulin secreted into the portal vein? Diabetologia 43:946-952
40. Roden M, Stingl H, Chandramouli V et al (2000) Effects of free fatty acid elevation on postabsorptive endogenous glucose production and gluconeogenesis in humans. Diabetes 49:701-707
41. McGarry JD (2002) Banting lecture 2001: dysregulation of fatty acid metabolism in the etiology of type 2 diabetes. Diabetes 51:7-18
42. Marchesini G, Brizi M, Bianchi G et al (2001) Nonalcoholic fatty liver disease: a feature of the metabolic syndrome. Diabetes 50:1844-1850
43. Sanyal AJ, Campbell-Sargent C, Mirshahi F et al (2001) Non-alcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities. Gastroenterology 120:1183-1192
44. Pagano G, Pacini G, Musso G et al (2002) Nonalcoholic steatohepatitis, insulin resistance and metabolic syndrome: further evidence for an etiological association. Hepatology 35:367-372
45. Seppala-Lindroos A, Vehkavaara S, Hakkinen AM et al (2002) Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men. J Clin Endocrinol Metab 8:3023-3028
46. Kelly DE, McKolanis TM, Hegazi RAF, Kuller LH, Kalhan SC (2003) Fatty liver in type 2 diabetes: relation to regional adiposity, fatty acids, and insulin resistance. Am J Physiol Endocrinol Metab 285:E906-E916
47. Wahrenberg H, Lonnqvist F, Arner P (1989) Mechanism underlying regional differences in lipolysis in human adipose tissue. J Clin Invest 84:458-467
48. Lefebvre AM, Laville M, Vega N et al (1998) Depot-specific differences in adipose tissue gene expression in lean and obese subjects. Diabetes 47:98-103
49. Sironi AM, Gastaldelli A, Mari A et al (2004) Visceral fat in hypertension: influence on insulin resistance and beta-cell function. Hypertension 44:127-133
50. Shuldiner AR, Yang R, Gong DW (2001) Resistin, obesity and insulin resistance - the emerging role of the adipocyte as an endocrine organ. N Engl J Med 345:1345-1346
51. Charlton M, Sreekumar R, Rasmussen D, Lindor K, Nair KS (2002) Apolipoprotein synthesis in nonalcoholic steatohepatitis. Hepatology 35:898-904
52. Groop LC, Bonadonna RC, DelPrato S et al (1989) Glucose and free fatty acid metabolism in non-insulin-dependent diabetes mellitus. Evidence for multiple sites of insulin resistance. J Clin Invest 84:205-213
53. Groop LC, Saloranta C, Shank M, Bonadonna RC, Ferrannini E, DeFronzo RA (1991) The role of free fatty acid metabolism in the pathogenesis of insulin resistance in obesity and noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab 72:96-107
54. Eriksson JW, Smith U, Waagstein F, Wysocki M, Jansson PA (1999) Glucose turnover and adipose tissue lipolysis are insulin-resistant in healthy relatives of type 2 diabetes patients: is cellular insulin resistance a secondary phenomenon? Diabetes 48:1572-1578
55. Cavallo-Perin P, Cassader M, Bozzo C et al (1985) Mechanism of insulin resistance in human liver cirrhosis. Evidence of a combined receptor and postreceptor defect. J Clin Invest 75:1659-1665
56. Petrides AS, Groop LC, Riely CA, DeFronzo RA (1991) Effect of physiologic hyperinsulinemia on glucose and lipid metabolism in cirrhosis. J Clin Invest 88:561-570
57. Petrides AS, Vogt C, Schulze-Berge D, Matthews D, Strohmeyer G (1994) Pathogenesis of glucose intolerance and diabetes mellitus in cirrhosis. Hepatology 19:616-627
58. Videla LA, Rodrigo R, Araya J, Poniachik J (2004) Oxidative stress and depletion of hepatic long-chain polyunsaturated fatty acids may contribute to nonalcoholic fatty liver disease. Free Radic Biol Med 37:1499-1507
59. Jankowsky J, Nofer JR, Tepel M et al (1998) Identification of oxidized low-density lipoprotein in human serum by NMR spectroscopy. Clin Sci 95:489-495