Prolonged treatment of primary hepatocytes with oleate induces insulin resistance through p38 mitogen-activated protein kinase

Journal of Biological Chemistry

Volumn 282, Issue 19, 2007, Pages 14205-14212

  Liu, Hui Yu ^a   Collins, Qu Fan ^a   Xiong, Yan ^a,b   Moukdar, Fatiha ^a   Lupo Jr , Edgar G ^a   Liu, Zhenqi ^c   Cao, Wenhong ^a,d  

^a HAMNER INSTITUTES FOR HEALTH SCIENCES   (United States)

^b CENTRAL SOUTH UNIVERSITY   (China)

^c UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

^d DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYMES; ESTERS; FATTY ACIDS; INSULIN; NITROGEN; PHOSPHORYLATION;

FREE FATTY ACID (FFA); GLUCONEOGENESIS; HEPATOCYTES;

CELLS;

INSULIN; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; OLEIC ACID; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; SMALL INTERFERING RNA; ANTIDIABETIC AGENT; CASPASE 3; INSULIN RECEPTOR SUBSTRATE 1 PROTEIN; INSULIN RECEPTOR SUBSTRATE 2 PROTEIN; INSULIN RECEPTOR SUBSTRATE-1 PROTEIN; INSULIN RECEPTOR SUBSTRATE-2 PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOPROTEIN; PROTEIN KINASE B; PTEN PROTEIN, MOUSE; SIGNAL PEPTIDE; TYROSINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GLUCONEOGENESIS; INSULIN RESISTANCE; LIVER CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; ANIMAL; APOPTOSIS; C57BL MOUSE; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; IMMUNOPRECIPITATION; METABOLISM; PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CASPASE 3; GLUCONEOGENESIS; HEPATOCYTES; HYPOGLYCEMIC AGENTS; IMMUNOPRECIPITATION; INSULIN; INSULIN RESISTANCE; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MICE, INBRED C57BL; MITOGEN-ACTIVATED PROTEIN KINASES; OLEIC ACID; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TYROSINE;

EID: 34347216368     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M609701200     Document Type: Article

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