메뉴 건너뛰기




Volumn 23, Issue 12, 2013, Pages 721-728

PharmGKB summary: Very important pharmacogene information for cytochrome P450, family 2, subfamily C, polypeptide 8

Author keywords

CYP2C8; CYP2C8*3; Metabolism; Pharmacogenetics; Pharmacogenomics; PharmGKB

Indexed keywords

AMIODARONE; AMODIAQUINE; ARACHIDONIC ACID; BISPHOSPHONIC ACID DERIVATIVE; CERIVASTATIN; CHLOROQUINE; CYTOCHROME P450 2C8; CYTOCHROME P450 3A4; DICLOFENAC; FLUINDOSTATIN; GEMFIBROZIL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IBUPROFEN; IMATINIB; KETOCONAZOLE; METHADONE; MONTELUKAST; MORPHINE; NONSTEROID ANTIINFLAMMATORY AGENT; PACLITAXEL; PIOGLITAZONE; QUERCETIN; REPAGLINIDE; RETINOID; ROSIGLITAZONE; SIMVASTATIN; TRIMETHOPRIM; UNINDEXED DRUG; VERAPAMIL; XENOBIOTIC AGENT;

EID: 84895075481     PISSN: 17446872     EISSN: 17446880     Source Type: Journal    
DOI: 10.1097/FPC.0b013e3283653b27     Document Type: Article
Times cited : (41)

References (150)
  • 1
    • 0028590127 scopus 로고
    • Biochemistry and molecular biology of the human CYP2C subfamily
    • Goldstein JA, de Morais SM. Biochemistry and molecular biology of the human CYP2C subfamily. Pharmacogenetics 1994; 4:285-299.
    • (1994) Pharmacogenetics , vol.4 , pp. 285-299
    • Goldstein, J.A.1    De Morais, S.M.2
  • 2
    • 0028237729 scopus 로고
    • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: Studies with liver microsomes of 30 Japanese and 30 caucasians
    • Shimada T, Yamazaki H, Mimura M, Inui Y, Guengerich FP. Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians. J Pharmacol Exp Ther 1994; 270:414-423.
    • (1994) J Pharmacol Exp Ther , vol.270 , pp. 414-423
    • Shimada, T.1    Yamazaki, H.2    Mimura, M.3    Inui, Y.4    Guengerich, F.P.5
  • 3
    • 0030834058 scopus 로고    scopus 로고
    • Human cytochrome P450 enzymes: A status report summarizing their reactions, substrates, inducers, and inhibitors
    • Rendic S, Di Carlo FJ. Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors. Drug Metab Rev 1997; 29:413-580.
    • (1997) Drug Metab Rev , vol.29 , pp. 413-580
    • Rendic, S.1    Di Carlo, F.J.2
  • 4
    • 19144368324 scopus 로고    scopus 로고
    • Cytochrome P450 2C8: Substrates, inhibitors, pharmacogenetics, and clinical relevance
    • Totah RA, Rettie AE. Cytochrome P450 2C8: substrates, inhibitors, pharmacogenetics, and clinical relevance. Clin Pharmacol Ther 2005; 77:341-352.
    • (2005) Clin Pharmacol Ther , vol.77 , pp. 341-352
    • Totah, R.A.1    Rettie, A.E.2
  • 5
    • 0032604625 scopus 로고    scopus 로고
    • Gene structure of CYP2C8 and extrahepatic distribution of the human CYP2Cs
    • Klose TS, Blaisdell JA, Goldstein JA. Gene structure of CYP2C8 and extrahepatic distribution of the human CYP2Cs. J Biochem Mol Toxicol 1999; 13:289-295.
    • (1999) J Biochem Mol Toxicol , vol.13 , pp. 289-295
    • Klose, T.S.1    Blaisdell, J.A.2    Goldstein, J.A.3
  • 6
    • 1542364450 scopus 로고    scopus 로고
    • Structure of human microsomal cytochrome P450 2C8. Evidence for a peripheral fatty acid binding site
    • Schoch GA, Yano JK, Wester MR, Griffin KJ, Stout CD, Johnson EF. Structure of human microsomal cytochrome P450 2C8. Evidence for a peripheral fatty acid binding site. J Biol Chem 2004; 279:9497-9503.
    • (2004) J Biol Chem , vol.279 , pp. 9497-9503
    • Schoch, G.A.1    Yano, J.K.2    Wester, M.R.3    Griffin, K.J.4    Stout, C.D.5    Johnson, E.F.6
  • 7
    • 47749092044 scopus 로고    scopus 로고
    • Determinants of cytochrome P450 2C8 substrate binding: Structures of complexes with montelukast, troglitazone, felodipine, and 9-cisretinoic acid
    • Schoch GA, Yano JK, Sansen S, Dansette PM, Stout CD, Johnson EF. Determinants of cytochrome P450 2C8 substrate binding: structures of complexes with montelukast, troglitazone, felodipine, and 9-cisretinoic acid. J Biol Chem 2008; 283:17227-17237.
    • (2008) J Biol Chem , vol.283 , pp. 17227-17237
    • Schoch, G.A.1    Yano, J.K.2    Sansen, S.3    Dansette, P.M.4    Stout, C.D.5    Johnson, E.F.6
  • 8
    • 4644301430 scopus 로고    scopus 로고
    • The structure of human microsomal cytochrome P450 3A4 determined by X-ray crystallography to 2.05-A resolution
    • Yano JK, Wester MR, Schoch GA, Griffin KJ, Stout CD, Johnson EF. The structure of human microsomal cytochrome P450 3A4 determined by X-ray crystallography to 2.05-A resolution. J Biol Chem 2004; 279:38091-38094.
    • (2004) J Biol Chem , vol.279 , pp. 38091-38094
    • Yano, J.K.1    Wester, M.R.2    Schoch, G.A.3    Griffin, K.J.4    Stout, C.D.5    Johnson, E.F.6
  • 9
    • 27544516024 scopus 로고    scopus 로고
    • Structural diversity of human xenobioticmetabolizing cytochrome P450 monooxygenases
    • Johnson EF, Stout CD. Structural diversity of human xenobioticmetabolizing cytochrome P450 monooxygenases. Biochem Biophys Res Commun 2005; 338:331-336.
    • (2005) Biochem Biophys Res Commun , vol.338 , pp. 331-336
    • Johnson, E.F.1    Stout, C.D.2
  • 10
    • 0033783019 scopus 로고    scopus 로고
    • A significant role of human cytochrome P450 2C8 in amiodarone N-deethylation: An approach to predict the contribution with relative activity factor
    • Ohyama K, Nakajima M, Nakamura S, Shimada N, Yamazaki H, Yokoi T. A significant role of human cytochrome P450 2C8 in amiodarone N-deethylation: an approach to predict the contribution with relative activity factor. Drug Metab Dispos 2000; 28:1303-1310.
    • (2000) Drug Metab Dispos , vol.28 , pp. 1303-1310
    • Ohyama, K.1    Nakajima, M.2    Nakamura, S.3    Shimada, N.4    Yamazaki, H.5    Yokoi, T.6
  • 11
    • 0036154008 scopus 로고    scopus 로고
    • Amodiaquine clearance and its metabolism to N-desethylamodiaquine is mediated by CYP2C8: A new high affinity and turnover enzyme-specific probe substrate
    • Li XQ, Bjorkman A, Andersson TB, Ridderstrom M, Masimirembwa CM. Amodiaquine clearance and its metabolism to N-desethylamodiaquine is mediated by CYP2C8: a new high affinity and turnover enzyme-specific probe substrate. J Pharmacol Exp Ther 2002; 300:399-407.
    • (2002) J Pharmacol Exp Ther , vol.300 , pp. 399-407
    • Li, X.Q.1    Bjorkman, A.2    Andersson, T.B.3    Ridderstrom, M.4    Masimirembwa, C.M.5
  • 12
    • 0037518218 scopus 로고    scopus 로고
    • In vitro metabolism of chloroquine: Identification of CYP2C8, CYP3A4, and CYP2D6 as the main isoforms catalyzing n-desethylchloroquine formation
    • Projean D, Baune B, Farinotti R, Flinois JP, Beaune P, Taburet AM, et al. In vitro metabolism of chloroquine: identification of CYP2C8, CYP3A4, and CYP2D6 as the main isoforms catalyzing N-desethylchloroquine formation. Drug Metab Dispos 2003; 31:748-754.
    • (2003) Drug Metab Dispos , vol.31 , pp. 748-754
    • Projean, D.1    Baune, B.2    Farinotti, R.3    Flinois, J.P.4    Beaune, P.5    Taburet, A.M.6
  • 13
    • 2342578929 scopus 로고    scopus 로고
    • Cytochrome P450 2C8 and CYP3A4/5 are involved in chloroquine metabolism in human liver microsomes
    • Kim KA, Park JY, Lee JS, Lim S. Cytochrome P450 2C8 and CYP3A4/5 are involved in chloroquine metabolism in human liver microsomes. Arch Pharm Res 2003; 26:631-637.
    • (2003) Arch Pharm Res , vol.26 , pp. 631-637
    • Kim, K.A.1    Park, J.Y.2    Lee, J.S.3    Lim, S.4
  • 14
    • 0036892714 scopus 로고    scopus 로고
    • Gemfibrozil inhibits CYP2C8-mediated cerivastatin metabolism in human liver microsomes
    • Wang JS, Neuvonen M, Wen X, Backman JT, Neuvonen PJ. Gemfibrozil inhibits CYP2C8-mediated cerivastatin metabolism in human liver microsomes. Drug Metab Dispos 2002; 30:1352-1356.
    • (2002) Drug Metab Dispos , vol.30 , pp. 1352-1356
    • Wang, J.S.1    Neuvonen, M.2    Wen, X.3    Backman, J.T.4    Neuvonen, P.J.5
  • 15
    • 79955033811 scopus 로고    scopus 로고
    • Reevaluation of the microsomal metabolism of montelukast: Major contribution by CYP2C8 at clinically relevant concentrations
    • Filppula AM, Laitila J, Neuvonen PJ, Backman JT. Reevaluation of the microsomal metabolism of montelukast: major contribution by CYP2C8 at clinically relevant concentrations. Drug Metab Dispos 2011; 39:904-911.
    • (2011) Drug Metab Dispos , vol.39 , pp. 904-911
    • Filppula, A.M.1    Laitila, J.2    Neuvonen, P.J.3    Backman, J.T.4
  • 16
    • 0028036727 scopus 로고
    • Selective biotransformation of taxol to 6 alpha-hydroxytaxol by human cytochrome P450 2C8
    • Rahman A, Korzekwa KR, Grogan J, Gonzalez FJ, Harris JW. Selective biotransformation of taxol to 6 alpha-hydroxytaxol by human cytochrome P450 2C8. Cancer Res 1994; 54:5543-5546.
    • (1994) Cancer Res , vol.54 , pp. 5543-5546
    • Rahman, A.1    Korzekwa, K.R.2    Grogan, J.3    Gonzalez, F.J.4    Harris, J.W.5
  • 18
    • 0032818309 scopus 로고    scopus 로고
    • Characterization of the cytochrome P450 enzymes involved in the in vitro metabolism of rosiglitazone
    • Baldwin SJ, Clarke SE, Chenery RJ. Characterization of the cytochrome P450 enzymes involved in the in vitro metabolism of rosiglitazone. Br J Clin Pharmacol 1999; 48:424-432.
    • (1999) Br J Clin Pharmacol , vol.48 , pp. 424-432
    • Baldwin, S.J.1    Clarke, S.E.2    Chenery, R.J.3
  • 19
    • 33745703773 scopus 로고    scopus 로고
    • Pioglitazone is metabolised by CYP2C8 and CYP3A4 in vitro: Potential for interactions with CYP2C8 inhibitors
    • Jaakkola T, Laitila J, Neuvonen PJ, Backman JT. Pioglitazone is metabolised by CYP2C8 and CYP3A4 in vitro: potential for interactions with CYP2C8 inhibitors. Basic Clin Pharmacol Toxicol 2006; 99:44-51.
    • (2006) Basic Clin Pharmacol Toxicol , vol.99 , pp. 44-51
    • Jaakkola, T.1    Laitila, J.2    Neuvonen, P.J.3    Backman, J.T.4
  • 20
    • 0032725398 scopus 로고    scopus 로고
    • Oxidation of troglitazone to a quinone-type metabolite catalyzed by cytochrome P-450 2C8 and P-450 3A4 in human liver microsomes
    • Yamazaki H, Shibata A, Suzuki M, Nakajima M, Shimada N, Guengerich FP, et al. Oxidation of troglitazone to a quinone-type metabolite catalyzed by cytochrome P-450 2C8 and P-450 3A4 in human liver microsomes. Drug Metab Dispos 1999; 27:1260-1266.
    • (1999) Drug Metab Dispos , vol.27 , pp. 1260-1266
    • Yamazaki, H.1    Shibata, A.2    Suzuki, M.3    Nakajima, M.4    Shimada, N.5    Guengerich, F.P.6
  • 21
    • 0042318871 scopus 로고    scopus 로고
    • CYP2C8 and CYP3A4 are the principal enzymes involved in the human in vitro biotransformation of the insulin secretagogue repaglinide
    • Bidstrup TB, Bjornsdottir I, Sidelmann UG, Thomsen MS, Hansen KT. CYP2C8 and CYP3A4 are the principal enzymes involved in the human in vitro biotransformation of the insulin secretagogue repaglinide. Br J Clin Pharmacol 2003; 56:305-314.
    • (2003) Br J Clin Pharmacol , vol.56 , pp. 305-314
    • Bidstrup, T.B.1    Bjornsdottir, I.2    Sidelmann, U.G.3    Thomsen, M.S.4    Hansen, K.T.5
  • 22
    • 0037378805 scopus 로고    scopus 로고
    • Cytochrome P450 2C8 and flavincontaining monooxygenases are involved in the metabolism of tazarotenic acid in humans
    • Attar M, Dong D, Ling KH, Tang-Liu DD. Cytochrome P450 2C8 and flavincontaining monooxygenases are involved in the metabolism of tazarotenic acid in humans. Drug Metab Dispos 2003; 31:476-481.
    • (2003) Drug Metab Dispos , vol.31 , pp. 476-481
    • Attar, M.1    Dong, D.2    Ling, K.H.3    Tang-Liu, D.D.4
  • 23
    • 70649100416 scopus 로고    scopus 로고
    • Cytochrome P450 2C8 pharmacogenetics: A review of clinical studies
    • Daily EB, Aquilante CL. Cytochrome P450 2C8 pharmacogenetics: a review of clinical studies. Pharmacogenomics 2009; 10:1489-1510.
    • (2009) Pharmacogenomics , vol.10 , pp. 1489-1510
    • Daily, E.B.1    Aquilante, C.L.2
  • 24
    • 0030857031 scopus 로고    scopus 로고
    • Regioselective and stereoselective metabolism of ibuprofen by human cytochrome P450 2C
    • Hamman MA, Thompson GA, Hall SD. Regioselective and stereoselective metabolism of ibuprofen by human cytochrome P450 2C. Biochem Pharmacol 1997; 54:33-41.
    • (1997) Biochem Pharmacol , vol.54 , pp. 33-41
    • Hamman, M.A.1    Thompson, G.A.2    Hall, S.D.3
  • 26
    • 0032937343 scopus 로고    scopus 로고
    • The 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor fluvastatin: Effect on human cytochrome P-450 and implications for metabolic drug interactions
    • Fischer V, Johanson L, Heitz F, Tullman R, Graham E, Baldeck JP, et al. The 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor fluvastatin: effect on human cytochrome P-450 and implications for metabolic drug interactions. Drug Metab Dispos 1999; 27:410-416.
    • (1999) Drug Metab Dispos , vol.27 , pp. 410-416
    • Fischer, V.1    Johanson, L.2    Heitz, F.3    Tullman, R.4    Graham, E.5    Baldeck, J.P.6
  • 27
    • 0038336614 scopus 로고    scopus 로고
    • The human hepatic metabolism of simvastatin hydroxy acid is mediated primarily by CYP3A, and not CYP2D6
    • Prueksaritanont T, Ma B, Yu N. The human hepatic metabolism of simvastatin hydroxy acid is mediated primarily by CYP3A, and not CYP2D6. Br J Clin Pharmacol 2003; 56:120-124.
    • (2003) Br J Clin Pharmacol , vol.56 , pp. 120-124
    • Prueksaritanont, T.1    Ma, B.2    Yu, N.3
  • 28
    • 0029591169 scopus 로고
    • Cytochromes of the P450 2C subfamily are the major enzymes involved in the O-demethylation of verapamil in humans
    • Busse D, Cosme J, Beaune P, Kroemer HK, Eichelbaum M. Cytochromes of the P450 2C subfamily are the major enzymes involved in the O-demethylation of verapamil in humans. Naunyn Schmiedebergs Arch Pharmacol 1995; 353:116-121.
    • (1995) Naunyn Schmiedebergs Arch Pharmacol , vol.353 , pp. 116-121
    • Busse, D.1    Cosme, J.2    Beaune, P.3    Kroemer, H.K.4    Eichelbaum, M.5
  • 29
    • 0032897280 scopus 로고    scopus 로고
    • Cytochrome P450 isoforms involved in metabolism of the enantiomers of verapamil and norverapamil
    • Tracy TS, Korzekwa KR, Gonzalez FJ, Wainer IW. Cytochrome P450 isoforms involved in metabolism of the enantiomers of verapamil and norverapamil. Br J Clin Pharmacol 1999; 47:545-552.
    • (1999) Br J Clin Pharmacol , vol.47 , pp. 545-552
    • Tracy, T.S.1    Korzekwa, K.R.2    Gonzalez, F.J.3    Wainer, I.W.4
  • 30
    • 0141631451 scopus 로고    scopus 로고
    • Identification of CYP3A4 and CYP2C8 as the major cytochrome P450 s responsible for morphine n-demethylation in human liver microsomes
    • Projean D, Morin PE, Tu TM, Ducharme J. Identification of CYP3A4 and CYP2C8 as the major cytochrome P450 s responsible for morphine N-demethylation in human liver microsomes. Xenobiotica 2003; 33:841-854.
    • (2003) Xenobiotica , vol.33 , pp. 841-854
    • Projean, D.1    Morin, P.E.2    Tu, T.M.3    Ducharme, J.4
  • 31
    • 0038193696 scopus 로고    scopus 로고
    • Involvement of CYP3A4, CYP2C8, and CYP2D6 in the metabolism of (R)- and (S)-methadone in vitro
    • Wang JS, DeVane CL. Involvement of CYP3A4, CYP2C8, and CYP2D6 in the metabolism of (R)- and (S)-methadone in vitro. Drug Metab Dispos 2003; 31:742-747.
    • (2003) Drug Metab Dispos , vol.31 , pp. 742-747
    • Wang, J.S.1    Devane, C.L.2
  • 32
    • 77958523673 scopus 로고    scopus 로고
    • Participation of CYP2C8 and CYP3A4 in the N-demethylation of imatinib in human hepatic microsomes
    • Nebot N, Crettol S, d'Esposito F, Tattam B, Hibbs DE, Murray M. Participation of CYP2C8 and CYP3A4 in the N-demethylation of imatinib in human hepatic microsomes. Br J Pharmacol 2010; 161:1059-1069.
    • (2010) Br J Pharmacol , vol.161 , pp. 1059-1069
    • Nebot, N.1    Crettol, S.2    D'Esposito, F.3    Tattam, B.4    Hibbs, D.E.5    Murray, M.6
  • 33
    • 84871540169 scopus 로고    scopus 로고
    • Autoinhibition of CYP3A4 leads to important role of CYP2C8 in imatinib metabolism: Variability in CYP2C8 activity may alter plasma concentrations and response
    • Filppula AM, Neuvonen M, Laitila J, Neuvonen PJ, Backman JT. Autoinhibition of CYP3A4 leads to important role of CYP2C8 in imatinib metabolism: variability in CYP2C8 activity may alter plasma concentrations and response. Drug Metab Dispos 2013; 41:50-59.
    • (2013) Drug Metab Dispos , vol.41 , pp. 50-59
    • Filppula, A.M.1    Neuvonen, M.2    Laitila, J.3    Neuvonen, P.J.4    Backman, J.T.5
  • 34
    • 0029039791 scopus 로고
    • Arachidonic acid metabolism by human cytochrome P450s 2C8, 2C9, 2E1, and 1A2: Regioselective oxygenation and evidence for a role for CYP2C enzymes in arachidonic acid epoxygenation in human liver microsomes
    • Rifkind AB, Lee C, Chang TK,Waxman DJ. Arachidonic acid metabolism by human cytochrome P450s 2C8, 2C9, 2E1, and 1A2: regioselective oxygenation and evidence for a role for CYP2C enzymes in arachidonic acid epoxygenation in human liver microsomes. Arch Biochem Biophys 1995; 320:380-389.
    • (1995) Arch Biochem Biophys , vol.320 , pp. 380-389
    • Rifkind, A.B.1    Lee, C.2    Chang, T.K.3    Waxman, D.J.4
  • 35
    • 0029122098 scopus 로고
    • Molecular cloning, expression and characterization of an endogenous human cytochrome P450 arachidonic acid epoxygenase isoform
    • Zeldin DC, DuBois RN, Falck JR, Capdevila JH. Molecular cloning, expression and characterization of an endogenous human cytochrome P450 arachidonic acid epoxygenase isoform. Arch Biochem Biophys 1995; 322:76-86.
    • (1995) Arch Biochem Biophys , vol.322 , pp. 76-86
    • Zeldin, D.C.1    Dubois, R.N.2    Falck, J.R.3    Capdevila, J.H.4
  • 37
    • 0033213785 scopus 로고    scopus 로고
    • Participation of CYP2C8 in retinoic acid 4-hydroxylation in human hepatic microsomes
    • Nadin L, Murray M. Participation of CYP2C8 in retinoic acid 4-hydroxylation in human hepatic microsomes. Biochem Pharmacol 1999; 58:1201-1208.
    • (1999) Biochem Pharmacol , vol.58 , pp. 1201-1208
    • Nadin, L.1    Murray, M.2
  • 38
    • 0034664168 scopus 로고    scopus 로고
    • Identification of human cytochrome P450 isoforms that contribute to all-trans-retinoic acid 4-hydroxylation
    • McSorley LC, Daly AK. Identification of human cytochrome P450 isoforms that contribute to all-trans-retinoic acid 4-hydroxylation. Biochem Pharmacol 2000; 60:517-526.
    • (2000) Biochem Pharmacol , vol.60 , pp. 517-526
    • McSorley, L.C.1    Daly, A.K.2
  • 39
    • 0033674630 scopus 로고    scopus 로고
    • Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites
    • Marill J, Cresteil T, Lanotte M, Chabot GG. Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites. Mol Pharmacol 2000; 58:1341-1348.
    • (2000) Mol Pharmacol , vol.58 , pp. 1341-1348
    • Marill, J.1    Cresteil, T.2    Lanotte, M.3    Chabot, G.G.4
  • 40
    • 76749094018 scopus 로고    scopus 로고
    • Human CYP2C8: Structure, substrate specificity, inhibitor selectivity, inducers and polymorphisms
    • Lai XS, Yang LP, Li XT, Liu JP, Zhou ZW, Zhou SF. Human CYP2C8: structure, substrate specificity, inhibitor selectivity, inducers and polymorphisms. Curr Drug Metab 2009; 10:1009-1047.
    • (2009) Curr Drug Metab , vol.10 , pp. 1009-1047
    • Lai, X.S.1    Yang, L.P.2    Li, X.T.3    Liu, J.P.4    Zhou, Z.W.5    Zhou, S.F.6
  • 42
    • 0036266778 scopus 로고    scopus 로고
    • Trimethoprim and sulfamethoxazole are selective inhibitors of CYP2C8 and CYP2C9, respectively
    • Wen X, Wang JS, Backman JT, Laitila J, Neuvonen PJ. Trimethoprim and sulfamethoxazole are selective inhibitors of CYP2C8 and CYP2C9, respectively. Drug Metab Dispos 2002; 30:631-635.
    • (2002) Drug Metab Dispos , vol.30 , pp. 631-635
    • Wen, X.1    Wang, J.S.2    Backman, J.T.3    Laitila, J.4    Neuvonen, P.J.5
  • 43
    • 0038684075 scopus 로고    scopus 로고
    • Drug interactions of paclitaxel metabolism in human liver microsomes
    • Bun SS, Ciccolini J, Bun H, Aubert C, Catalin J. Drug interactions of paclitaxel metabolism in human liver microsomes. J Chemother 2003; 15:266-274.
    • (2003) J Chemother , vol.15 , pp. 266-274
    • Bun, S.S.1    Ciccolini, J.2    Bun, H.3    Aubert, C.4    Catalin, J.5
  • 44
    • 14044256740 scopus 로고    scopus 로고
    • Examination of 209 drugs for inhibition of cytochrome P450 2C8
    • Walsky RL, Gaman EA, Obach RS. Examination of 209 drugs for inhibition of cytochrome P450 2C8. J Clin Pharmacol 2005; 45:68-78.
    • (2005) J Clin Pharmacol , vol.45 , pp. 68-78
    • Walsky, R.L.1    Gaman, E.A.2    Obach, R.S.3
  • 45
    • 33750994952 scopus 로고    scopus 로고
    • The effects of human CYP2C8 genotype and fluvoxamine on the pharmacokinetics of rosiglitazone in healthy subjects
    • Pedersen RS, Damkier P, Brosen K. The effects of human CYP2C8 genotype and fluvoxamine on the pharmacokinetics of rosiglitazone in healthy subjects. Br J Clin Pharmacol 2006; 62:682-689.
    • (2006) Br J Clin Pharmacol , vol.62 , pp. 682-689
    • Pedersen, R.S.1    Damkier, P.2    Brosen, K.3
  • 46
    • 84892992744 scopus 로고    scopus 로고
    • The tyrosine kinase inhibitor nilotinib selectively inhibits CYP2C8 activities in human liver microsomes
    • [Epub ahead of print]
    • Kim MJ, Lee JW, Oh KS, Choi CS, Kim KH, Han WS, et al. The tyrosine kinase inhibitor nilotinib selectively inhibits CYP2C8 activities in human liver microsomes. Drug Metab Pharmacokinet 2013. [Epub ahead of print].
    • (2013) Drug Metab Pharmacokinet
    • Kim, M.J.1    Lee, J.W.2    Oh, K.S.3    Choi, C.S.4    Kim, K.H.5    Han, W.S.6
  • 47
    • 4644301418 scopus 로고    scopus 로고
    • Gemfibrozil and its glucuronide inhibit the organic anion transporting polypeptide 2 (OATP2/ OATP1B1:SLC21A6)-mediated hepatic uptake and CYP2C8-mediated metabolism of cerivastatin: Analysis of the mechanism of the clinically relevant drug-drug interaction between cerivastatin and gemfibrozil
    • Shitara Y, Hirano M, Sato H, Sugiyama Y. Gemfibrozil and its glucuronide inhibit the organic anion transporting polypeptide 2 (OATP2/ OATP1B1:SLC21A6)-mediated hepatic uptake and CYP2C8-mediated metabolism of cerivastatin: analysis of the mechanism of the clinically relevant drug-drug interaction between cerivastatin and gemfibrozil. J Pharmacol Exp Ther 2004; 311:228-236.
    • (2004) J Pharmacol Exp Ther , vol.311 , pp. 228-236
    • Shitara, Y.1    Hirano, M.2    Sato, H.3    Sugiyama, Y.4
  • 48
    • 29944446317 scopus 로고    scopus 로고
    • Glucuronidation converts gemfibrozil to a potent, metabolism-dependent inhibitor of CYP2C8: Implications for drug-drug interactions
    • Ogilvie BW, Zhang D, Li W, Rodrigues AD, Gipson AE, Holsapple J, et al. Glucuronidation converts gemfibrozil to a potent, metabolism-dependent inhibitor of CYP2C8: implications for drug-drug interactions. Drug Metab Dispos 2006; 34:191-197.
    • (2006) Drug Metab Dispos , vol.34 , pp. 191-197
    • Ogilvie, B.W.1    Zhang, D.2    Li, W.3    Rodrigues, A.D.4    Gipson, A.E.5    Holsapple, J.6
  • 49
    • 67650996771 scopus 로고    scopus 로고
    • Benzylic oxidation of gemfibrozil-1-O-betaglucuronide by P450 2C8 leads to heme alkylation and irreversible inhibition
    • Baer BR, DeLisle RK, Allen A. Benzylic oxidation of gemfibrozil-1-O- betaglucuronide by P450 2C8 leads to heme alkylation and irreversible inhibition. Chem Res Toxicol 2009; 22:1298-1309.
    • (2009) Chem Res Toxicol , vol.22 , pp. 1298-1309
    • Baer, B.R.1    Delisle, R.K.2    Allen, A.3
  • 50
    • 84860014528 scopus 로고    scopus 로고
    • Gemfibrozil is a strong inactivator of CYP2C8 in very small multiple doses
    • Honkalammi J, Niemi M, Neuvonen PJ, Backman JT. Gemfibrozil is a strong inactivator of CYP2C8 in very small multiple doses. Clin Pharmacol Ther 2012; 91:846-855.
    • (2012) Clin Pharmacol Ther , vol.91 , pp. 846-855
    • Honkalammi, J.1    Niemi, M.2    Neuvonen, P.J.3    Backman, J.T.4
  • 51
    • 79952984332 scopus 로고    scopus 로고
    • Mechanism-based inactivation of CYP2C8 by gemfibrozil occurs rapidly in humans
    • Honkalammi J, Niemi M, Neuvonen PJ, Backman JT. Mechanism-based inactivation of CYP2C8 by gemfibrozil occurs rapidly in humans. Clin Pharmacol Ther 2011; 89:579-586.
    • (2011) Clin Pharmacol Ther , vol.89 , pp. 579-586
    • Honkalammi, J.1    Niemi, M.2    Neuvonen, P.J.3    Backman, J.T.4
  • 53
    • 19144370649 scopus 로고    scopus 로고
    • Effects of gemfibrozil, itraconazole, and their combination on the pharmacokinetics of pioglitazone
    • Jaakkola T, Backman JT, Neuvonen M, Neuvonen PJ. Effects of gemfibrozil, itraconazole, and their combination on the pharmacokinetics of pioglitazone. Clin Pharmacol Ther 2005; 77:404-414.
    • (2005) Clin Pharmacol Ther , vol.77 , pp. 404-414
    • Jaakkola, T.1    Backman, J.T.2    Neuvonen, M.3    Neuvonen, P.J.4
  • 54
    • 28344441475 scopus 로고    scopus 로고
    • Effect of gemfibrozil on the pharmacokinetics of pioglitazone
    • Deng LJ, Wang F, Li HD. Effect of gemfibrozil on the pharmacokinetics of pioglitazone. Eur J Clin Pharmacol 2005; 61:831-836.
    • (2005) Eur J Clin Pharmacol , vol.61 , pp. 831-836
    • Deng, L.J.1    Wang, F.2    Li, H.D.3
  • 55
    • 0037627707 scopus 로고    scopus 로고
    • Effects of gemfibrozil, itraconazole, and their combination on the pharmacokinetics and pharmacodynamics of repaglinide: Potentially hazardous interaction between gemfibrozil and repaglinide
    • Niemi M, Backman JT, Neuvonen M, Neuvonen PJ. Effects of gemfibrozil, itraconazole, and their combination on the pharmacokinetics and pharmacodynamics of repaglinide: potentially hazardous interaction between gemfibrozil and repaglinide. Diabetologia 2003; 46:347-351.
    • (2003) Diabetologia , vol.46 , pp. 347-351
    • Niemi, M.1    Backman, J.T.2    Neuvonen, M.3    Neuvonen, P.J.4
  • 56
    • 49949093994 scopus 로고    scopus 로고
    • The effect of gemfibrozil on repaglinide pharmacokinetics persists for at least 12 h after the dose: Evidence for mechanism-based inhibition of CYP2C8 in vivo
    • Tornio A, Niemi M, Neuvonen M, Laitila J, Kalliokoski A, Neuvonen PJ, et al. The effect of gemfibrozil on repaglinide pharmacokinetics persists for at least 12 h after the dose: evidence for mechanism-based inhibition of CYP2C8 in vivo. Clin Pharmacol Ther 2008; 84:403-411.
    • (2008) Clin Pharmacol Ther , vol.84 , pp. 403-411
    • Tornio, A.1    Niemi, M.2    Neuvonen, M.3    Laitila, J.4    Kalliokoski, A.5    Neuvonen, P.J.6
  • 57
    • 80053146805 scopus 로고    scopus 로고
    • Dose-dependent interaction between gemfibrozil and repaglinide in humans: Strong inhibition of CYP2C8 with subtherapeutic gemfibrozil doses
    • Honkalammi J, Niemi M, Neuvonen PJ, Backman JT. Dose-dependent interaction between gemfibrozil and repaglinide in humans: strong inhibition of CYP2C8 with subtherapeutic gemfibrozil doses. Drug Metab Dispos 2011; 39:1977-1986.
    • (2011) Drug Metab Dispos , vol.39 , pp. 1977-1986
    • Honkalammi, J.1    Niemi, M.2    Neuvonen, P.J.3    Backman, J.T.4
  • 60
    • 34147190117 scopus 로고    scopus 로고
    • Stereoselective interaction between the CYP2C8 inhibitor gemfibrozil and racemic ibuprofen
    • Tornio A, Niemi M, Neuvonen PJ, Backman JT. Stereoselective interaction between the CYP2C8 inhibitor gemfibrozil and racemic ibuprofen. Eur J Clin Pharmacol 2007; 63:463-469.
    • (2007) Eur J Clin Pharmacol , vol.63 , pp. 463-469
    • Tornio, A.1    Niemi, M.2    Neuvonen, P.J.3    Backman, J.T.4
  • 61
    • 77954887450 scopus 로고    scopus 로고
    • Gemfibrozil markedly increases the plasma concentrations of montelukast: A previously unrecognized role for CYP2C8 in the metabolism of montelukast
    • Karonen T, Filppula A, Laitila J, Niemi M, Neuvonen PJ, Backman JT. Gemfibrozil markedly increases the plasma concentrations of montelukast: a previously unrecognized role for CYP2C8 in the metabolism of montelukast. Clin Pharmacol Ther 2010; 88:223-230.
    • (2010) Clin Pharmacol Ther , vol.88 , pp. 223-230
    • Karonen, T.1    Filppula, A.2    Laitila, J.3    Niemi, M.4    Neuvonen, P.J.5    Backman, J.T.6
  • 62
    • 84883201944 scopus 로고    scopus 로고
    • Gemfibrozil impairs imatinib absorption and inhibits the CYP2C8-mediated formation of its main metabolite
    • doi: 10.1038/clpt.2013.92. [Epub ahead of print]
    • Filppula AM, Tornio A, Niemi M, Neuvonen PJ, Backman JT. Gemfibrozil impairs imatinib absorption and inhibits the CYP2C8-mediated formation of its main metabolite. Clin Pharmacol Ther 2013. doi: 10.1038/clpt.2013.92. [Epub ahead of print].
    • (2013) Clin Pharmacol Ther
    • Filppula, A.M.1    Tornio, A.2    Niemi, M.3    Neuvonen, P.J.4    Backman, J.T.5
  • 63
    • 23944516070 scopus 로고    scopus 로고
    • Human CYP2C8 is transcriptionally regulated by the nuclear receptors constitutive androstane receptor, pregnane X receptor, glucocorticoid receptor, and hepatic nuclear factor 4alpha
    • Ferguson SS, Chen Y, LeCluyse EL, Negishi M, Goldstein JA. Human CYP2C8 is transcriptionally regulated by the nuclear receptors constitutive androstane receptor, pregnane X receptor, glucocorticoid receptor, and hepatic nuclear factor 4alpha. Mol Pharmacol 2005; 68:747-757.
    • (2005) Mol Pharmacol , vol.68 , pp. 747-757
    • Ferguson, S.S.1    Chen, Y.2    Lecluyse, E.L.3    Negishi, M.4    Goldstein, J.A.5
  • 64
    • 70450157394 scopus 로고    scopus 로고
    • The transcriptional regulation of the human CYP2C genes
    • Chen Y, Goldstein JA. The transcriptional regulation of the human CYP2C genes. Curr Drug Metab 2009; 10:567-578.
    • (2009) Curr Drug Metab , vol.10 , pp. 567-578
    • Chen, Y.1    Goldstein, J.A.2
  • 66
    • 0035201366 scopus 로고    scopus 로고
    • Rifampin is a selective, pleiotropic inducer of drug metabolism genes in human hepatocytes: Studies with cDNA and oligonucleotide expression arrays
    • Rae JM, Johnson MD, Lippman ME, Flockhart DA. Rifampin is a selective, pleiotropic inducer of drug metabolism genes in human hepatocytes: studies with cDNA and oligonucleotide expression arrays. J Pharmacol Exp Ther 2001; 299:849-857.
    • (2001) J Pharmacol Exp Ther , vol.299 , pp. 849-857
    • Rae, J.M.1    Johnson, M.D.2    Lippman, M.E.3    Flockhart, D.A.4
  • 68
    • 0037379409 scopus 로고    scopus 로고
    • Effects of prototypical microsomal enzyme inducers on cytochrome P450 expression in cultured human hepatocytes
    • Madan A, Graham RA, Carroll KM, Mudra DR, Burton LA, Krueger LA, et al. Effects of prototypical microsomal enzyme inducers on cytochrome P450 expression in cultured human hepatocytes. Drug Metab Dispos 2003; 31:421-431.
    • (2003) Drug Metab Dispos , vol.31 , pp. 421-431
    • Madan, A.1    Graham, R.A.2    Carroll, K.M.3    Mudra, D.R.4    Burton, L.A.5    Krueger, L.A.6
  • 69
    • 4544349505 scopus 로고    scopus 로고
    • Effects of trimethoprim and rifampin on the pharmacokinetics of the cytochrome P450 2C8 substrate rosiglitazone
    • Niemi M, Backman JT, Neuvonen PJ. Effects of trimethoprim and rifampin on the pharmacokinetics of the cytochrome P450 2C8 substrate rosiglitazone. Clin Pharmacol Ther 2004; 76:239-249.
    • (2004) Clin Pharmacol Ther , vol.76 , pp. 239-249
    • Niemi, M.1    Backman, J.T.2    Neuvonen, P.J.3
  • 70
    • 1542286164 scopus 로고    scopus 로고
    • Effect of rifampin on the pharmacokinetics of rosiglitazone in healthy subjects
    • Park JY, Kim KA, Kang MH, Kim SL, Shin JG. Effect of rifampin on the pharmacokinetics of rosiglitazone in healthy subjects. Clin Pharmacol Ther 2004; 75:157-162.
    • (2004) Clin Pharmacol Ther , vol.75 , pp. 157-162
    • Park, J.Y.1    Kim, K.A.2    Kang, M.H.3    Kim, S.L.4    Shin, J.G.5
  • 74
    • 0028068016 scopus 로고
    • Fluorescence in situ hybridization analysis of chromosomal localization of three human cytochrome P450 2C genes (CYP2C8, 2C9, and 2C10) at 10q24.1
    • Inoue K, Inazawa J, Suzuki Y, Shimada T, Yamazaki H, Guengerich FP, et al. Fluorescence in situ hybridization analysis of chromosomal localization of three human cytochrome P450 2C genes (CYP2C8, 2C9, and 2C10) at 10q24.1. Jpn J Hum Genet 1994; 39:337-343.
    • (1994) Jpn J Hum Genet , vol.39 , pp. 337-343
    • Inoue, K.1    Inazawa, J.2    Suzuki, Y.3    Shimada, T.4    Yamazaki, H.5    Guengerich, F.P.6
  • 75
    • 0029122980 scopus 로고
    • A 2.4-megabase physical map spanning the CYP2C gene cluster on chromosome 10q24
    • Gray IC, Nobile C, Muresu R, Ford S, Spurr NK. A 2.4-megabase physical map spanning the CYP2C gene cluster on chromosome 10q24. Genomics 1995; 28:328-332.
    • (1995) Genomics , vol.28 , pp. 328-332
    • Gray, I.C.1    Nobile, C.2    Muresu, R.3    Ford, S.4    Spurr, N.K.5
  • 79
    • 0036889666 scopus 로고    scopus 로고
    • CYP2C8 polymorphisms in caucasians and their relationship with paclitaxel 6alpha-hydroxylase activity in human liver microsomes
    • Bahadur N, Leathart JB, Mutch E, Steimel-Crespi D, Dunn SA, Gilissen R, et al. CYP2C8 polymorphisms in Caucasians and their relationship with paclitaxel 6alpha-hydroxylase activity in human liver microsomes. Biochem Pharmacol 2002; 64:1579-1589.
    • (2002) Biochem Pharmacol , vol.64 , pp. 1579-1589
    • Bahadur, N.1    Leathart, J.B.2    Mutch, E.3    Steimel-Crespi, D.4    Dunn, S.A.5    Gilissen, R.6
  • 81
    • 0034791777 scopus 로고    scopus 로고
    • Polymorphisms in human CYP2C8 decrease metabolism of the anticancer drug paclitaxel and arachidonic acid
    • Dai D, Zeldin DC, Blaisdell JA, Chanas B, Coulter SJ, Ghanayem BI, et al. Polymorphisms in human CYP2C8 decrease metabolism of the anticancer drug paclitaxel and arachidonic acid. Pharmacogenetics 2001; 11:597-607.
    • (2001) Pharmacogenetics , vol.11 , pp. 597-607
    • Dai, D.1    Zeldin, D.C.2    Blaisdell, J.A.3    Chanas, B.4    Coulter, S.J.5    Ghanayem, B.I.6
  • 82
    • 34447569316 scopus 로고    scopus 로고
    • Amodiaquine metabolism is impaired by common polymorphisms in CYP2C8: Implications for malaria treatment in Africa
    • Parikh S, Ouedraogo JB, Goldstein JA, Rosenthal PJ, Kroetz DL. Amodiaquine metabolism is impaired by common polymorphisms in CYP2C8: implications for malaria treatment in Africa. Clin Pharmacol Ther 2007; 82:197-203.
    • (2007) Clin Pharmacol Ther , vol.82 , pp. 197-203
    • Parikh, S.1    Ouedraogo, J.B.2    Goldstein, J.A.3    Rosenthal, P.J.4    Kroetz, D.L.5
  • 83
    • 77953594273 scopus 로고    scopus 로고
    • Functional characterization of five CYP2C8 variants and prediction of CYP2C8 genotype-dependent effects on in vitro and in vivo drug-drug interactions
    • Gao Y, Liu D, Wang H, Zhu J, Chen C. Functional characterization of five CYP2C8 variants and prediction of CYP2C8 genotype-dependent effects on in vitro and in vivo drug-drug interactions. Xenobiotica 2010; 40:467-475.
    • (2010) Xenobiotica , vol.40 , pp. 467-475
    • Gao, Y.1    Liu, D.2    Wang, H.3    Zhu, J.4    Chen, C.5
  • 84
    • 84879846126 scopus 로고    scopus 로고
    • Influence of CYP2C8 polymorphisms on the hydroxylation metabolism of paclitaxel, repaglinide, and ibuprofen enantiomers in vitro
    • Yu L, Shi D, Ma L, Zhou Q, Zeng S. Influence of CYP2C8 polymorphisms on the hydroxylation metabolism of paclitaxel, repaglinide, and ibuprofen enantiomers in vitro. Biopharm Drug Dispos 2013; 34:278-287.
    • (2013) Biopharm Drug Dispos , vol.34 , pp. 278-287
    • Yu, L.1    Shi, D.2    Ma, L.3    Zhou, Q.4    Zeng, S.5
  • 85
    • 0035214173 scopus 로고    scopus 로고
    • Non-synonymous single nucleotide alterations found in the CYP2C8 gene result in reduced in vitro paclitaxel metabolism
    • Soyama A, Saito Y, Hanioka N, Murayama N, Nakajima O, Katori N, et al. Non-synonymous single nucleotide alterations found in the CYP2C8 gene result in reduced in vitro paclitaxel metabolism. Biol Pharm Bull 2001; 24:1427-1430.
    • (2001) Biol Pharm Bull , vol.24 , pp. 1427-1430
    • Soyama, A.1    Saito, Y.2    Hanioka, N.3    Murayama, N.4    Nakajima, O.5    Katori, N.6
  • 87
    • 14644401778 scopus 로고    scopus 로고
    • Utilization of human liver microsomes to explain individual differences in paclitaxel metabolism by CYP2C8 and CYP3A4
    • Taniguchi R, Kumai T, Matsumoto N,Watanabe M, Kamio K, Suzuki S, et al. Utilization of human liver microsomes to explain individual differences in paclitaxel metabolism by CYP2C8 and CYP3A4. J Pharmacol Sci 2005; 97:83-90.
    • (2005) J Pharmacol Sci , vol.97 , pp. 83-90
    • Taniguchi, R.1    Kumai, T.2    Matsumoto, N.3    Watanabe, M.4    Kamio, K.5    Suzuki, S.6
  • 88
    • 77954896186 scopus 로고    scopus 로고
    • Relevance of nonsynonymous CYP2C8 polymorphisms to 13-cis retinoic acid and paclitaxel hydroxylation
    • Rowbotham SE, Boddy AV, Redfern CP, Veal GJ, Daly AK. Relevance of nonsynonymous CYP2C8 polymorphisms to 13-cis retinoic acid and paclitaxel hydroxylation. Drug Metab Dispos 2010; 38:1261-1266.
    • (2010) Drug Metab Dispos , vol.38 , pp. 1261-1266
    • Rowbotham, S.E.1    Boddy, A.V.2    Redfern, C.P.3    Veal, G.J.4    Daly, A.K.5
  • 91
    • 80051544848 scopus 로고    scopus 로고
    • Drug metabolism by CYP2C8.3 is determined by substrate dependent interactions with cytochrome P450 reductase and cytochrome b5
    • Kaspera R, Naraharisetti SB, Evangelista EA, Marciante KD, Psaty BM, Totah RA. Drug metabolism by CYP2C8.3 is determined by substrate dependent interactions with cytochrome P450 reductase and cytochrome b5. Biochem Pharmacol 2011; 82:681-691.
    • (2011) Biochem Pharmacol , vol.82 , pp. 681-691
    • Kaspera, R.1    Naraharisetti, S.B.2    Evangelista, E.A.3    Marciante, K.D.4    Psaty, B.M.5    Totah, R.A.6
  • 92
    • 85011913445 scopus 로고    scopus 로고
    • Five novel single nucleotide polymorphisms in the CYP2C8 gene, one of which induces a frame-shift
    • Soyama A, Saito Y, Komamura K, Ueno K, Kamakura S, Ozawa S, et al. Five novel single nucleotide polymorphisms in the CYP2C8 gene, one of which induces a frame-shift. Drug Metab Pharmacokinet 2002; 17:374- 377.
    • (2002) Drug Metab Pharmacokinet , vol.17 , pp. 374-377
    • Soyama, A.1    Saito, Y.2    Komamura, K.3    Ueno, K.4    Kamakura, S.5    Ozawa, S.6
  • 93
    • 48849098300 scopus 로고    scopus 로고
    • Functional role of Ile264 in CYP2C8: Mutations affect haem incorporation and catalytic activity
    • Singh R, Ting JG, Pan Y, Teh LK, Ismail R, Ong CE. Functional role of Ile264 in CYP2C8: mutations affect haem incorporation and catalytic activity. Drug Metab Pharmacokinet 2008; 23:165-174.
    • (2008) Drug Metab Pharmacokinet , vol.23 , pp. 165-174
    • Singh, R.1    Ting, J.G.2    Pan, Y.3    Teh, L.K.4    Ismail, R.5    Ong, C.E.6
  • 94
    • 79954436517 scopus 로고    scopus 로고
    • Structural and functional insights into polymorphic enzymes of cytochrome P450 2C8
    • Jiang H, Zhong F, Sun L, Feng W, Huang ZX, Tan X. Structural and functional insights into polymorphic enzymes of cytochrome P450 2C8. Amino Acids 2011; 40:1195-1204.
    • (2011) Amino Acids , vol.40 , pp. 1195-1204
    • Jiang, H.1    Zhong, F.2    Sun, L.3    Feng, W.4    Huang, Z.X.5    Tan, X.6
  • 96
    • 34250173817 scopus 로고    scopus 로고
    • CYP2C8 haplotype structures and their influence on pharmacokinetics of paclitaxel in a Japanese population
    • Saito Y, Katori N, Soyama A, Nakajima Y, Yoshitani T, Kim SR, et al. CYP2C8 haplotype structures and their influence on pharmacokinetics of paclitaxel in a Japanese population. Pharmacogenet Genomics 2007; 17:461-471.
    • (2007) Pharmacogenet Genomics , vol.17 , pp. 461-471
    • Saito, Y.1    Katori, N.2    Soyama, A.3    Nakajima, Y.4    Yoshitani, T.5    Kim, S.R.6
  • 97
    • 8644235696 scopus 로고    scopus 로고
    • A frameshift variant of CYP2C8 was identified in a patient who suffered from rhabdomyolysis after administration of cerivastatin
    • Ishikawa C, Ozaki H, Nakajima T, Ishii T, Kanai S, Anjo S, et al. A frameshift variant of CYP2C8 was identified in a patient who suffered from rhabdomyolysis after administration of cerivastatin. J Hum Genet 2004; 49:582-585.
    • (2004) J Hum Genet , vol.49 , pp. 582-585
    • Ishikawa, C.1    Ozaki, H.2    Nakajima, T.3    Ishii, T.4    Kanai, S.5    Anjo, S.6
  • 98
    • 20944438107 scopus 로고    scopus 로고
    • Functional characterization of five novel CYP2C8 variants, G171S, R186X, R186G, K247R, and K383N, found in a Japanese population
    • Hichiya H, Tanaka-Kagawa T, Soyama A, Jinno H, Koyano S, Katori N, et al. Functional characterization of five novel CYP2C8 variants, G171S, R186X, R186G, K247R, and K383N, found in a Japanese population. Drug Metab Dispos 2005; 33:630-636.
    • (2005) Drug Metab Dispos , vol.33 , pp. 630-636
    • Hichiya, H.1    Tanaka-Kagawa, T.2    Soyama, A.3    Jinno, H.4    Koyano, S.5    Katori, N.6
  • 99
    • 79952837092 scopus 로고    scopus 로고
    • Discovery of a novel allelic variant of CYP2C8, CYP2C8*11, in asian populations and its clinical effect on the rosiglitazone disposition in vivo
    • Yeo CW, Lee SJ, Lee SS, Bae SK, Kim EY, Shon JH, et al. Discovery of a novel allelic variant of CYP2C8, CYP2C8*11, in Asian populations and its clinical effect on the rosiglitazone disposition in vivo. Drug Metab Dispos 2011; 39:711-716.
    • (2011) Drug Metab Dispos , vol.39 , pp. 711-716
    • Yeo, C.W.1    Lee, S.J.2    Lee, S.S.3    Bae, S.K.4    Kim, E.Y.5    Shon, J.H.6
  • 100
    • 77953838981 scopus 로고    scopus 로고
    • Functional characterization of CYP2C8.13 and CYP2C8.14: Catalytic activities toward paclitaxel
    • Hanioka N, Matsumoto K, Saito Y, Narimatsu S. Functional characterization of CYP2C8.13 and CYP2C8.14: catalytic activities toward paclitaxel. Basic Clin Pharmacol Toxicol 2010; 107:565-569.
    • (2010) Basic Clin Pharmacol Toxicol , vol.107 , pp. 565-569
    • Hanioka, N.1    Matsumoto, K.2    Saito, Y.3    Narimatsu, S.4
  • 102
    • 33746677973 scopus 로고    scopus 로고
    • Impact of the haplotype CYP3A4*16B harboring the Thr185Ser substitution on paclitaxel metabolism in Japanese patients with cancer
    • Nakajima Y, Yoshitani T, Fukushima-Uesaka H, Saito Y, Kaniwa N, Kurose K, et al. Impact of the haplotype CYP3A4*16B harboring the Thr185Ser substitution on paclitaxel metabolism in Japanese patients with cancer. Clin Pharmacol Ther 2006; 80:179-191.
    • (2006) Clin Pharmacol Ther , vol.80 , pp. 179-191
    • Nakajima, Y.1    Yoshitani, T.2    Fukushima-Uesaka, H.3    Saito, Y.4    Kaniwa, N.5    Kurose, K.6
  • 103
    • 0036797540 scopus 로고    scopus 로고
    • Amiodarone N-deethylation by CYP2C8 and its variants, CYP2C8*3 and CYP2C8 P404A
    • Soyama A, Hanioka N, Saito Y, Murayama N, Ando M, Ozawa S, et al. Amiodarone N-deethylation by CYP2C8 and its variants, CYP2C8*3 and CYP2C8 P404A. Pharmacol Toxicol 2002; 91:174-178.
    • (2002) Pharmacol Toxicol , vol.91 , pp. 174-178
    • Soyama, A.1    Hanioka, N.2    Saito, Y.3    Murayama, N.4    Ando, M.5    Ozawa, S.6
  • 104
    • 27744475863 scopus 로고    scopus 로고
    • Genetic polymorphism of CYP2C8 in three Malaysian ethnics: CYP2C8*2 and CYP2C8*3 are found in Malaysian Indians
    • Muthiah YD, Lee WL, Teh LK, Ong CE, Ismail R. Genetic polymorphism of CYP2C8 in three Malaysian ethnics: CYP2C8*2 and CYP2C8*3 are found in Malaysian Indians. J Clin Pharm Ther 2005; 30:487-490.
    • (2005) J Clin Pharm Ther , vol.30 , pp. 487-490
    • Muthiah, Y.D.1    Lee, W.L.2    Teh, L.K.3    Ong, C.E.4    Ismail, R.5
  • 106
    • 78649317664 scopus 로고    scopus 로고
    • Linkage disequilibrium between the CYP2C19*17 allele and wildtype CYP2C8 and CYP2C9 alleles: Identification of CYP2C haplotypes in healthy nordic populations
    • Pedersen RS, Brasch-Andersen C, Sim SC, Bergmann TK, Halling J, Petersen MS, et al. Linkage disequilibrium between the CYP2C19*17 allele and wildtype CYP2C8 and CYP2C9 alleles: identification of CYP2C haplotypes in healthy Nordic populations. Eur J Clin Pharmacol 2010; 66:1199-1205.
    • (2010) Eur J Clin Pharmacol , vol.66 , pp. 1199-1205
    • Pedersen, R.S.1    Brasch-Andersen, C.2    Sim, S.C.3    Bergmann, T.K.4    Halling, J.5    Petersen, M.S.6
  • 108
    • 19944429040 scopus 로고    scopus 로고
    • A single-nucleotide polymorphism tagging set for human drug metabolism and transport
    • Ahmadi KR, Weale ME, Xue ZY, Soranzo N, Yarnall DP, Briley JD, et al. A single-nucleotide polymorphism tagging set for human drug metabolism and transport. Nat Genet 2005; 37:84-89.
    • (2005) Nat Genet , vol.37 , pp. 84-89
    • Ahmadi, K.R.1    Weale, M.E.2    Xue, Z.Y.3    Soranzo, N.4    Yarnall, D.P.5    Briley, J.D.6
  • 109
    • 84861458604 scopus 로고    scopus 로고
    • Global pharmacogenomics: Impact of population diversity on the distribution of polymorphisms in the CYP2C cluster among Brazilians
    • Suarez-Kurtz G, Genro JP, de Moraes MO, Ojopi EB, Pena SD, Perini JA, et al. Global pharmacogenomics: impact of population diversity on the distribution of polymorphisms in the CYP2C cluster among Brazilians. Pharmacogenomics J 2012; 12:267-276.
    • (2012) Pharmacogenomics J , vol.12 , pp. 267-276
    • Suarez-Kurtz, G.1    Genro, J.P.2    De Moraes, M.O.3    Ojopi, E.B.4    Pena, S.D.5    Perini, J.A.6
  • 110
    • 84866604283 scopus 로고    scopus 로고
    • Linkage disequilibrium between the CYP2C19*17 allele and other clinically important CYP2C allelic variants in a healthy Scandinavian population
    • Pedersen RS, Christensen MM, Brosen K. Linkage disequilibrium between the CYP2C19*17 allele and other clinically important CYP2C allelic variants in a healthy Scandinavian population. Eur J Clin Pharmacol 2012; 68:1463-1464.
    • (2012) Eur J Clin Pharmacol , vol.68 , pp. 1463-1464
    • Pedersen, R.S.1    Christensen, M.M.2    Brosen, K.3
  • 112
    • 37549040583 scopus 로고    scopus 로고
    • Trimethoprim and the CYP2C8*3 allele have opposite effects on the pharmacokinetics of pioglitazone
    • Tornio A, Niemi M, Neuvonen PJ, Backman JT. Trimethoprim and the CYP2C8*3 allele have opposite effects on the pharmacokinetics of pioglitazone. Drug Metab Dispos 2008; 36:73-80.
    • (2008) Drug Metab Dispos , vol.36 , pp. 73-80
    • Tornio, A.1    Niemi, M.2    Neuvonen, P.J.3    Backman, J.T.4
  • 114
    • 63449139904 scopus 로고    scopus 로고
    • Influence of SLCO1B1 and CYP2C8 gene polymorphisms on rosiglitazone pharmacokinetics in healthy volunteers
    • Aquilante CL, Bushman LR, Knutsen SD, Burt LE, Rome LC, Kosmiski LA. Influence of SLCO1B1 and CYP2C8 gene polymorphisms on rosiglitazone pharmacokinetics in healthy volunteers. Hum Genomics 2008; 3:7-16.
    • (2008) Hum Genomics , vol.3 , pp. 7-16
    • Aquilante, C.L.1    Bushman, L.R.2    Knutsen, S.D.3    Burt, L.E.4    Rome, L.C.5    Kosmiski, L.A.6
  • 116
    • 84874090211 scopus 로고    scopus 로고
    • Effect of cytochrome P450 2C8*3 on the population pharmacokinetics of pioglitazone in healthy caucasian volunteers
    • Kadam R, Bourne D, Kompella U, Aquilante C. Effect of cytochrome P450 2C8*3 on the population pharmacokinetics of pioglitazone in healthy Caucasian volunteers. Biol Pharm Bull 2013; 36:245-251.
    • (2013) Biol Pharm Bull , vol.36 , pp. 245-251
    • Kadam, R.1    Bourne, D.2    Kompella, U.3    Aquilante, C.4
  • 117
    • 84885333492 scopus 로고    scopus 로고
    • Influence of CYP2C8*2 on the pharmacokinetics of pioglitazone in healthy African-American volunteers
    • doi: 10.1002/phar.1292. [Epub ahead of print]
    • Aquilante CL, Wempe MF, Spencer SH, Kosmiski LA, Predhomme JA, Sidhom MS. Influence of CYP2C8*2 on the pharmacokinetics of pioglitazone in healthy African-American volunteers. Pharmacotherapy 2013. doi: 10.1002/phar.1292. [Epub ahead of print].
    • (2013) Pharmacotherapy
    • Aquilante, C.L.1    Wempe, M.F.2    Spencer, S.H.3    Kosmiski, L.A.4    Predhomme, J.A.5    Sidhom, M.S.6
  • 118
    • 84874945128 scopus 로고    scopus 로고
    • The role of genetic variants in CYP2C8, LPIN1, PPARGC1A and PPARgamma on the trough steady-state plasma concentrations of rosiglitazone and on glycosylated haemoglobin A1c in type 2 diabetes
    • Stage TB, Christensen MM, Feddersen S, Beck-Nielsen H, Brosen K. The role of genetic variants in CYP2C8, LPIN1, PPARGC1A and PPARgamma on the trough steady-state plasma concentrations of rosiglitazone and on glycosylated haemoglobin A1c in type 2 diabetes. Pharmacogenet Genomics 2013; 23:219-227.
    • (2013) Pharmacogenet Genomics , vol.23 , pp. 219-227
    • Stage, T.B.1    Christensen, M.M.2    Feddersen, S.3    Beck-Nielsen, H.4    Brosen, K.5
  • 119
    • 20444466590 scopus 로고    scopus 로고
    • Polymorphic organic anion transporting polypeptide 1B1 is a major determinant of repaglinide pharmacokinetics
    • Niemi M, Backman JT, Kajosaari LI, Leathart JB, Neuvonen M, Daly AK, et al. Polymorphic organic anion transporting polypeptide 1B1 is a major determinant of repaglinide pharmacokinetics. Clin Pharmacol Ther 2005; 77:468-478.
    • (2005) Clin Pharmacol Ther , vol.77 , pp. 468-478
    • Niemi, M.1    Backman, J.T.2    Kajosaari, L.I.3    Leathart, J.B.4    Neuvonen, M.5    Daly, A.K.6
  • 123
    • 28144461394 scopus 로고    scopus 로고
    • Association of CYP2C8, CYP3A4, CYP3A5, and ABCB1 polymorphisms with the pharmacokinetics of paclitaxel
    • Henningsson A, Marsh S, Loos WJ, Karlsson MO, Garsa A, Mross K, et al. Association of CYP2C8, CYP3A4, CYP3A5, and ABCB1 polymorphisms with the pharmacokinetics of paclitaxel. Clin Cancer Res 2005; 11:8097-8104.
    • (2005) Clin Cancer Res , vol.11 , pp. 8097-8104
    • Henningsson, A.1    Marsh, S.2    Loos, W.J.3    Karlsson, M.O.4    Garsa, A.5    Mross, K.6
  • 124
    • 34548081331 scopus 로고    scopus 로고
    • Pharmacogenetic analysis of paclitaxel transport and metabolism genes in breast cancer
    • Marsh S, Somlo G, Li X, Frankel P, King CR, Shannon WD, et al. Pharmacogenetic analysis of paclitaxel transport and metabolism genes in breast cancer. Pharmacogenomics J 2007; 7:362-365.
    • (2007) Pharmacogenomics J , vol.7 , pp. 362-365
    • Marsh, S.1    Somlo, G.2    Li, X.3    Frankel, P.4    King, C.R.5    Shannon, W.D.6
  • 125
    • 35648997048 scopus 로고    scopus 로고
    • Pharmacogenetic assessment of toxicity and outcome after platinum plus taxane chemotherapy in ovarian cancer: The scottish randomised trial in ovarian cancer
    • Marsh S, Paul J, King CR, Gifford G, McLeod HL, Brown R. Pharmacogenetic assessment of toxicity and outcome after platinum plus taxane chemotherapy in ovarian cancer: the Scottish Randomised Trial in Ovarian Cancer. J Clin Oncol 2007; 25:4528-4535.
    • (2007) J Clin Oncol , vol.25 , pp. 4528-4535
    • Marsh, S.1    Paul, J.2    King, C.R.3    Gifford, G.4    McLeod, H.L.5    Brown, R.6
  • 127
    • 79953048086 scopus 로고    scopus 로고
    • Impact of CYP2C8*3 on paclitaxel clearance: A population pharmacokinetic and pharmacogenomic study in 93 patients with ovarian cancer
    • Bergmann TK, Brasch-Andersen C, Green H, Mirza M, Pedersen RS, Nielsen F, et al. Impact of CYP2C8*3 on paclitaxel clearance: a population pharmacokinetic and pharmacogenomic study in 93 patients with ovarian cancer. Pharmacogenomics J 2011; 11:113-120.
    • (2011) Pharmacogenomics J , vol.11 , pp. 113-120
    • Bergmann, T.K.1    Brasch-Andersen, C.2    Green, H.3    Mirza, M.4    Pedersen, R.S.5    Nielsen, F.6
  • 128
    • 84870824777 scopus 로고    scopus 로고
    • Pharmacogenetics of taxanes: Impact of gene polymorphisms of drug transporters on pharmacokinetics and toxicity
    • Jabir RS, Naidu R, Annuar MA, Ho GF, Munisamy M, Stanslas J. Pharmacogenetics of taxanes: impact of gene polymorphisms of drug transporters on pharmacokinetics and toxicity. Pharmacogenomics 2012; 13:1979-1988.
    • (2012) Pharmacogenomics , vol.13 , pp. 1979-1988
    • Jabir, R.S.1    Naidu, R.2    Annuar, M.A.3    Ho, G.F.4    Munisamy, M.5    Stanslas, J.6
  • 129
    • 27644562207 scopus 로고    scopus 로고
    • Association of paclitaxel pharmacokinetics with the development of peripheral neuropathy in patients with advanced cancer
    • Mielke S, Sparreboom A, Steinberg SM, Gelderblom H, Unger C, Behringer D, et al. Association of paclitaxel pharmacokinetics with the development of peripheral neuropathy in patients with advanced cancer. Clin Cancer Res 2005; 11:4843-4850.
    • (2005) Clin Cancer Res , vol.11 , pp. 4843-4850
    • Mielke, S.1    Sparreboom, A.2    Steinberg, S.M.3    Gelderblom, H.4    Unger, C.5    Behringer, D.6
  • 132
    • 84875940168 scopus 로고    scopus 로고
    • CYP2C8*3 increases risk of neuropathy in breast cancer patients treated with paclitaxel
    • Hertz DL, Roy S, Motsinger-Reif AA, Drobish A, Clark LS, McLeod HL, et al. CYP2C8*3 increases risk of neuropathy in breast cancer patients treated with paclitaxel. Ann Oncol 2013; 24:1472-1478.
    • (2013) Ann Oncol , vol.24 , pp. 1472-1478
    • Hertz, D.L.1    Roy, S.2    Motsinger-Reif, A.A.3    Drobish, A.4    Clark, L.S.5    McLeod, H.L.6
  • 133
    • 0037075262 scopus 로고    scopus 로고
    • Cerivastatin and reports of fatal rhabdomyolysis
    • Staffa JA, Chang J, Green L. Cerivastatin and reports of fatal rhabdomyolysis. N Engl J Med 2002; 346:539-540.
    • (2002) N Engl J Med , vol.346 , pp. 539-540
    • Staffa, J.A.1    Chang, J.2    Green, L.3
  • 134
    • 0042627731 scopus 로고    scopus 로고
    • Influence of CYP2C9 polymorphisms on the pharmacokinetics and cholesterol-lowering activity of (-)-3S,5R-fluvastatin and (+)-3R,5S-fluvastatin in healthy volunteers
    • Kirchheiner J, Kudlicz D, Meisel C, Bauer S, Meineke I, Roots I, et al. Influence of CYP2C9 polymorphisms on the pharmacokinetics and cholesterol-lowering activity of (-)-3S,5R-fluvastatin and (+)-3R,5S-fluvastatin in healthy volunteers. Clin Pharmacol Ther 2003; 74:186-194.
    • (2003) Clin Pharmacol Ther , vol.74 , pp. 186-194
    • Kirchheiner, J.1    Kudlicz, D.2    Meisel, C.3    Bauer, S.4    Meineke, I.5    Roots, I.6
  • 136
    • 80155194178 scopus 로고    scopus 로고
    • Human genetic variation is associated with plasmodium falciparum drug resistance
    • Paganotti GM, Gallo BC, Verra F, Sirima BS, Nebie I, Diarra A, et al. Human genetic variation is associated with Plasmodium falciparum drug resistance. J Infect Dis 2011; 204:1772-1778.
    • (2011) J Infect Dis , vol.204 , pp. 1772-1778
    • Paganotti, G.M.1    Gallo, B.C.2    Verra, F.3    Sirima, B.S.4    Nebie, I.5    Diarra, A.6
  • 137
    • 84876079888 scopus 로고    scopus 로고
    • CYP2C8 status of patients with malaria influences selection of plasmodium falciparum pfmdr1 alleles after amodiaquine-artesunate treatment
    • Cavaco I, Martensson A, Froberg G, Msellem M, Bjorkman A, Gil JP. CYP2C8 status of patients with malaria influences selection of Plasmodium falciparum pfmdr1 alleles after amodiaquine-artesunate treatment. J Infect Dis 2013; 207:687-688.
    • (2013) J Infect Dis , vol.207 , pp. 687-688
    • Cavaco, I.1    Martensson, A.2    Froberg, G.3    Msellem, M.4    Bjorkman, A.5    Gil, J.P.6
  • 138
    • 3543012028 scopus 로고    scopus 로고
    • Interindividual variability in ibuprofen pharmacokinetics is related to interaction of cytochrome P450 2C8 and 2C9 amino acid polymorphisms
    • Garcia-Martin E, Martinez C, Tabares B, Frias J, Agundez JA. Interindividual variability in ibuprofen pharmacokinetics is related to interaction of cytochrome P450 2C8 and 2C9 amino acid polymorphisms. Clin Pharmacol Ther 2004; 76:119-127.
    • (2004) Clin Pharmacol Ther , vol.76 , pp. 119-127
    • Garcia-Martin, E.1    Martinez, C.2    Tabares, B.3    Frias, J.4    Agundez, J.A.5
  • 139
    • 11144300168 scopus 로고    scopus 로고
    • The effect of the cytochrome P450 CYP2C8 polymorphism on the disposition of (R)-ibuprofen enantiomer in healthy subjects
    • Martinez C, Garcia-Martin E, Blanco G, Gamito FJ, Ladero JM, Agundez JA. The effect of the cytochrome P450 CYP2C8 polymorphism on the disposition of (R)-ibuprofen enantiomer in healthy subjects. Br J Clin Pharmacol 2005; 59:62-69.
    • (2005) Br J Clin Pharmacol , vol.59 , pp. 62-69
    • Martinez, C.1    Garcia-Martin, E.2    Blanco, G.3    Gamito, F.J.4    Ladero, J.M.5    Agundez, J.A.6
  • 140
    • 50649086561 scopus 로고    scopus 로고
    • Influence of CYP2C8 and CYP2C9 polymorphisms on pharmacokinetic and pharmacodynamic parameters of racemic and enantiomeric forms of ibuprofen in healthy volunteers
    • Lopez-Rodriguez R, Novalbos J, Gallego-Sandin S, Roman-Martinez M, Torrado J, Gisbert JP, et al. Influence of CYP2C8 and CYP2C9 polymorphisms on pharmacokinetic and pharmacodynamic parameters of racemic and enantiomeric forms of ibuprofen in healthy volunteers. Pharmacol Res 2008; 58:77-84.
    • (2008) Pharmacol Res , vol.58 , pp. 77-84
    • Lopez-Rodriguez, R.1    Novalbos, J.2    Gallego-Sandin, S.3    Roman-Martinez, M.4    Torrado, J.5    Gisbert, J.P.6
  • 141
    • 69249203743 scopus 로고    scopus 로고
    • Pharmacokinetic studies of enantiomers of ibuprofen and its chiral metabolites in humans with different variants of genes coding CYP2C8 and CYP2C9 isoenzymes
    • Karazniewicz-Lada M, Luczak M, Glowka F. Pharmacokinetic studies of enantiomers of ibuprofen and its chiral metabolites in humans with different variants of genes coding CYP2C8 and CYP2C9 isoenzymes. Xenobiotica 2009; 39:476-485.
    • (2009) Xenobiotica , vol.39 , pp. 476-485
    • Karazniewicz-Lada, M.1    Luczak, M.2    Glowka, F.3
  • 142
    • 38949134846 scopus 로고    scopus 로고
    • Interaction of CYP2C8 and CYP2C9 genotypes modifies the risk for nonsteroidal anti-inflammatory drugs-related acute gastrointestinal bleeding
    • Blanco G, Martinez C, Ladero JM, Garcia-Martin E, Taxonera C, Gamito FG, et al. Interaction of CYP2C8 and CYP2C9 genotypes modifies the risk for nonsteroidal anti-inflammatory drugs-related acute gastrointestinal bleeding. Pharmacogenet Genomics 2008; 18:37-43.
    • (2008) Pharmacogenet Genomics , vol.18 , pp. 37-43
    • Blanco, G.1    Martinez, C.2    Ladero, J.M.3    Garcia-Martin, E.4    Taxonera, C.5    Gamito, F.G.6
  • 143
    • 67649416267 scopus 로고    scopus 로고
    • Genetically based impairment in CYP2C8- and CYP2C9-dependent NSAID metabolism as a risk factor for gastrointestinal bleeding: Is a combination of pharmacogenomics and metabolomics required to improve personalized medicine?
    • Agundez JA, Garcia-Martin E, Martinez C. Genetically based impairment in CYP2C8- and CYP2C9-dependent NSAID metabolism as a risk factor for gastrointestinal bleeding: is a combination of pharmacogenomics and metabolomics required to improve personalized medicine? Expert Opin Drug Metab Toxicol 2009; 5:607-620.
    • (2009) Expert Opin Drug Metab Toxicol , vol.5 , pp. 607-620
    • Agundez, J.A.1    Garcia-Martin, E.2    Martinez, C.3
  • 144
    • 53449093633 scopus 로고    scopus 로고
    • Bisphosphonate-related osteonecrosis of the jaw is associated with polymorphisms of the cytochrome P450 CYP2C8 in multiple myeloma: A genome-wide single nucleotide polymorphism analysis
    • Sarasquete ME, Garcia-Sanz R, Marin L, Alcoceba M, Chillon MC, Balanzategui A, et al. Bisphosphonate-related osteonecrosis of the jaw is associated with polymorphisms of the cytochrome P450 CYP2C8 in multiple myeloma: a genome-wide single nucleotide polymorphism analysis. Blood 2008; 112:2709-2712.
    • (2008) Blood , vol.112 , pp. 2709-2712
    • Sarasquete, M.E.1    Garcia-Sanz, R.2    Marin, L.3    Alcoceba, M.4    Chillon, M.C.5    Balanzategui, A.6
  • 145
    • 84155171431 scopus 로고    scopus 로고
    • A SNP in CYP2C8 is not associated with the development of bisphosphonate-related osteonecrosis of the jaw in men with castrate-resistant prostate cancer
    • English BC, Baum CE, Adelberg DE, Sissung TM, Kluetz PG, Dahut WL, et al. A SNP in CYP2C8 is not associated with the development of bisphosphonate- related osteonecrosis of the jaw in men with castrate-resistant prostate cancer. Ther Clin Risk Manag 2010; 6:579-583.
    • (2010) Ther Clin Risk Manag , vol.6 , pp. 579-583
    • English, B.C.1    Baum, C.E.2    Adelberg, D.E.3    Sissung, T.M.4    Kluetz, P.G.5    Dahut, W.L.6
  • 146
    • 80053624145 scopus 로고    scopus 로고
    • CYP2C8 gene polymorphism and bisphosphonate-related osteonecrosis of the jaw in patients with multiple myeloma
    • Such E, Cervera J, Terpos E, Bagan JV, Avaria A, Gomez I, et al. CYP2C8 gene polymorphism and bisphosphonate-related osteonecrosis of the jaw in patients with multiple myeloma. Haematologica 2011; 96:1557-1559.
    • (2011) Haematologica , vol.96 , pp. 1557-1559
    • Such, E.1    Cervera, J.2    Terpos, E.3    Bagan, J.V.4    Avaria, A.5    Gomez, I.6
  • 147
    • 79956286289 scopus 로고    scopus 로고
    • Genetic polymorphisms and other risk factors associated with bisphosphonate induced osteonecrosis of the jaw
    • Katz J, Gong Y, Salmasinia D, Hou W, Burkley B, Ferreira P, et al. Genetic polymorphisms and other risk factors associated with bisphosphonate induced osteonecrosis of the jaw. Int J Oral Maxillofac Surg 2011; 40:605-611.
    • (2011) Int J Oral Maxillofac Surg , vol.40 , pp. 605-611
    • Katz, J.1    Gong, Y.2    Salmasinia, D.3    Hou, W.4    Burkley, B.5    Ferreira, P.6
  • 148
    • 84877860571 scopus 로고    scopus 로고
    • CYP2C8*3 polymorphism and donor age are associated with allograft dysfunction in kidney transplant recipients treated with calcineurin inhibitors
    • Gervasini G, Garcia M, Macias RM, Benitez J, Caravaca F, Cubero JJ. CYP2C8*3 polymorphism and donor age are associated with allograft dysfunction in kidney transplant recipients treated with calcineurin inhibitors. J Clin Pharmacol 2013; 53:427-434.
    • (2013) J Clin Pharmacol , vol.53 , pp. 427-434
    • Gervasini, G.1    Garcia, M.2    Macias, R.M.3    Benitez, J.4    Caravaca, F.5    Cubero, J.J.6
  • 149
    • 79951512755 scopus 로고    scopus 로고
    • Genetic determinants of mycophenolate-related anemia and leukopenia after transplantation
    • Jacobson PA, Schladt D, Oetting WS, Leduc R, Guan W, Matas AJ, et al. Genetic determinants of mycophenolate-related anemia and leukopenia after transplantation. Transplantation 2011; 91:309-316.
    • (2011) Transplantation , vol.91 , pp. 309-316
    • Jacobson, P.A.1    Schladt, D.2    Oetting, W.S.3    Leduc, R.4    Guan, W.5    Matas, A.J.6
  • 150
    • 84861043247 scopus 로고    scopus 로고
    • Mycophenolic acid-related anemia and leucopenia in renal transplant recipients are related to genetic polymorphisms in CYP2C8
    • 93e39-e40 author reply
    • Bouamar R, Elens L, Shuker N, van Schaik RH,Weimar W, Hesselink DA, et al. Mycophenolic acid-related anemia and leucopenia in renal transplant recipients are related to genetic polymorphisms in CYP2C8. Transplantation 2012; 93:e39-e40, author reply e41-e32.
    • (2012) Transplantation
    • Bouamar, R.1    Elens, L.2    Shuker, N.3    Van Schaik, R.H.4    Weimar, W.5    Hesselink, D.A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.