Pioglitazone is metabolised by CYP2C8 and CYP3A4 in vitro: Potential for interactions with CYP2C8 inhibitors

Basic and Clinical Pharmacology and Toxicology

Volumn 99, Issue 1, 2006, Pages 44-51

  Jaakkola, Tiina ^a   Laitila, Jouko ^a   Neuvonen, Pertti J ^a   Backman, Janne T ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

CLOPIDOGREL; CYTOCHROME P450 1A2; CYTOCHROME P450 2B6; CYTOCHROME P450 2C19; CYTOCHROME P450 2C8; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 2E1; CYTOCHROME P450 3A4; CYTOCHROME P450 3A5; CYTOCHROME P450 INHIBITOR; DIETHYLDITHIOCARBAMIC ACID; DRUG METABOLITE; FURAFYLLINE; GEMFIBROZIL; ITRACONAZOLE; KETOCONAZOLE; MONTELUKAST; OMEPRAZOLE; PIOGLITAZONE; QUINIDINE; RIFAMPICIN; SULFAPHENAZOLE; TRIMETHOPRIM; TROLEANDOMYCIN; ZAFIRLUKAST;

ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG ELIMINATION; DRUG METABOLISM; DRUG POTENCY; DRUG STRUCTURE; HUMAN; HUMAN TISSUE; IC 50; IN VITRO STUDY; LIVER MICROSOME; PRIORITY JOURNAL;

ARYL HYDROCARBON HYDROXYLASES; CYTOCHROME P-450 CYP3A; CYTOCHROME P-450 ENZYME SYSTEM; DRUG INTERACTIONS; ENZYME INHIBITORS; HUMANS; HYPOGLYCEMIC AGENTS; MICROSOMES, LIVER; NADP; THIAZOLIDINEDIONES;

EID: 33745703773     PISSN: 17427835     EISSN: 17427843     Source Type: Journal    
DOI: 10.1111/j.1742-7843.2006.pto_437.x     Document Type: Article

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