Relevance of nonsynonymous CYP2C8 polymorphisms to 13-cis retinoic acid and paclitaxel hydroxylation

Drug Metabolism and Disposition

Volumn 38, Issue 8, 2010, Pages 1261-1266

  Rowbotham, Sophie E ^a   Boddy, Alan V ^a   Redfern, Chris P F ^a   Veal, Gareth J ^a   Daly, Ann K ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; CYTOCHROME P450 2C8; PACLITAXEL; RECOMBINANT ENZYME; RETINOIC ACID;

ARTICLE; DRUG HYDROXYLATION; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME KINETICS; ESCHERICHIA COLI; HUMAN; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MICHAELIS MENTEN KINETICS; NONHUMAN; NUCLEOTIDE SEQUENCE; PLASMID; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; STATISTICAL SIGNIFICANCE;

AMINO ACID SUBSTITUTION; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; ARYL HYDROCARBON HYDROXYLASES; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME ACTIVATION; ESCHERICHIA COLI; HUMANS; ISOTRETINOIN; PACLITAXEL; POLYMORPHISM, SINGLE NUCLEOTIDE; TRANSFECTION;

ESCHERICHIA COLI;

EID: 77954896186     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.109.030866     Document Type: Article

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