The impact of CYP2C8 polymorphism and grapefruit juice on the pharmacokinetics of repaglinide

British Journal of Clinical Pharmacology

Volumn 61, Issue 1, 2006, Pages 49-57

  Bidstrup, Tanja Busk ^a   Damkier, Per ^b   Olsen, Anette Kristensen ^c   Ekblom, Marianne ^c   Karlsson, Anders ^c   Brøsen, Kim ^a  

^a UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^b ODENSE UNIVERSITY HOSPITAL   (Denmark)

^c NOVO NORDISK A S   (Denmark)

Author keywords

CYP2C8 polymorphism; Grapefruit juice; Repaglinide

Indexed keywords

3 HYDROXYQUINIDINE; CYTOCHROME P450 2C8; CYTOCHROME P450 3A4; DRINKING WATER; GLUCOSE; QUINIDINE; REPAGLINIDE;

ADULT; ALLELE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DIETARY INTAKE; DNA POLYMORPHISM; DOSE RESPONSE; DRUG METABOLISM; ENZYME ACTIVITY; GENE MUTATION; GENOTYPE; GLUCOSE BLOOD LEVEL; GRAPEFRUIT JUICE; HUMAN; HUMAN EXPERIMENT; LOW DRUG DOSE; MALE; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZATION; STATISTICAL SIGNIFICANCE; WILD TYPE;

ADMINISTRATION, ORAL; ADULT; AREA UNDER CURVE; ARYL HYDROCARBON HYDROXYLASES; BEVERAGES; BLOOD GLUCOSE; CARBAMATES; CITRUS PARADISI; CROSS-OVER STUDIES; GENOTYPE; HUMANS; HYPOGLYCEMIC AGENTS; MALE; PIPERIDINES; POLYMORPHISM, GENETIC; QUINIDINE;

EID: 33644905905     PISSN: 03065251     EISSN: 13652125     Source Type: Journal    
DOI: 10.1111/j.1365-2125.2005.02516.x     Document Type: Article

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