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Volumn 13, Issue 4, 2013, Pages 369-377

Multi-ethnic distribution of clinically relevant CYP2C genotypes and haplotypes

Author keywords

Clinical pharmacogenetics; CYP2C19; CYP2C8; CYP2C9; Haplotype; Linkage disequilibrium

Indexed keywords

CYTOCHROME P450 2C19; CYTOCHROME P450 2C8; CYTOCHROME P450 2C9;

EID: 84881126177     PISSN: 1470269X     EISSN: 14731150     Source Type: Journal    
DOI: 10.1038/tpj.2012.10     Document Type: Article
Times cited : (92)

References (68)
  • 1
    • 10644241977 scopus 로고    scopus 로고
    • Pharmacogenetics of the cytochromes P450
    • Daly AK. Pharmacogenetics of the cytochromes P450. Curr Top Med Chem 2004; 4: 1733-1744.
    • (2004) Curr Top Med Chem , vol.4 , pp. 1733-1744
    • Daly, A.K.1
  • 2
    • 0029122980 scopus 로고
    • A 2.4-megabase physical map spanning the CYP2C gene cluster on chromosome 10q24
    • Gray IC, Nobile C, Muresu R, Ford S, Spurr NK. A 2.4-megabase physical map spanning the CYP2C gene cluster on chromosome 10q24. Genomics 1995; 28: 328-332.
    • (1995) Genomics , vol.28 , pp. 328-332
    • Gray, I.C.1    Nobile, C.2    Muresu, R.3    Ford, S.4    Spurr, N.K.5
  • 3
    • 0034792584 scopus 로고    scopus 로고
    • Clinical relevance of genetic polymorphisms in the human CYP2C subfamily
    • Goldstein JA. Clinical relevance of genetic polymorphisms in the human CYP2C subfamily. Br J Clin Pharmacol 2001; 52: 349-355.
    • (2001) Br J Clin Pharmacol , vol.52 , pp. 349-355
    • Goldstein, J.A.1
  • 4
    • 70450157394 scopus 로고    scopus 로고
    • The transcriptional regulation of the human CYP2C genes
    • Chen Y, Goldstein JA. The transcriptional regulation of the human CYP2C genes. Curr Drug Metab 2009; 10: 567-578.
    • (2009) Curr Drug Metab , vol.10 , pp. 567-578
    • Chen, Y.1    Goldstein, J.A.2
  • 5
    • 0036394942 scopus 로고    scopus 로고
    • Clinical significance of the cytochrome P450 2C19 genetic polymorphism
    • Desta Z, Zhao X, Shin JG, Flockhart DA. Clinical significance of the cytochrome P450 2C19 genetic polymorphism. Clin Pharmacokinet 2002; 41: 913-958.
    • (2002) Clin Pharmacokinet , vol.41 , pp. 913-958
    • Desta, Z.1    Zhao, X.2    Shin, J.G.3    Flockhart, D.A.4
  • 6
    • 79957673659 scopus 로고    scopus 로고
    • The influence of CYP2C19 polymorphisms on the pharmacokinetics, pharmacodynamics, and clinical effectiveness of P2Y(12) inhibitors
    • Price MJ, Tantry US, Gurbel PA. The influence of CYP2C19 polymorphisms on the pharmacokinetics, pharmacodynamics, and clinical effectiveness of P2Y(12) inhibitors. Rev Cardiovasc Med 2011; 12: 1-12.
    • (2011) Rev Cardiovasc Med , vol.12 , pp. 1-12
    • Price, M.J.1    Tantry, U.S.2    Gurbel, P.A.3
  • 7
    • 84855953171 scopus 로고    scopus 로고
    • Pharm GKB summary: Very important pharmacogene information for cytochrome P450, family 2, subfamily C, polypeptide 19
    • Scott SA, Sangkuhl K, Shuldiner AR, Hulot JS, Thorn CF, Altman RB et al. Pharm GKB summary: very important pharmacogene information for cytochrome P450, family 2, subfamily C, polypeptide 19. Pharmacogenet Genomics 2011; 22: 159-165.
    • (2011) Pharmacogenet Genomics , vol.22 , pp. 159-165
    • Scott, S.A.1    Sangkuhl, K.2    Shuldiner, A.R.3    Hulot, J.S.4    Thorn, C.F.5    Altman, R.B.6
  • 8
    • 0031841377 scopus 로고    scopus 로고
    • Cytochrome P4502C9: An enzyme of major importance in human drug metabolism
    • Miners JO, Birkett DJ. Cytochrome P4502C9: an enzyme of major importance in human drug metabolism. Br J Clin Pharmacol 1998; 45: 525-538.
    • (1998) Br J Clin Pharmacol , vol.45 , pp. 525-538
    • Miners, J.O.1    Birkett, D.J.2
  • 10
    • 76749094018 scopus 로고    scopus 로고
    • Human CYP2C8: Structure, substrate specificity, inhibitor selectivity, inducers and polymorphisms
    • Lai XS, Yang LP, Li XT, Liu JP, Zhou ZW, Zhou SF. Human CYP2C8: structure, substrate specificity, inhibitor selectivity, inducers and polymorphisms. Curr Drug Metab 2009; 10: 1009-1047.
    • (2009) Curr Drug Metab , vol.10 , pp. 1009-1047
    • Lai, X.S.1    Yang, L.P.2    Li, X.T.3    Liu, J.P.4    Zhou, Z.W.5    Zhou, S.F.6
  • 11
    • 0029865596 scopus 로고    scopus 로고
    • Genetic analysis of the cytochrome P-45OIIC18 (CYP2C18) gene and a novel member of the CYP2C subfamily
    • Tsuneoka Y, Matsuo Y, Okuyama E, Watanabe Y, Ichikawa Y. Genetic analysis of the cytochrome P-45OIIC18 (CYP2C18) gene and a novel member of the CYP2C subfamily. FEBS Lett 1996; 384: 281-284.
    • (1996) FEBS Lett , vol.384 , pp. 281-284
    • Tsuneoka, Y.1    Matsuo, Y.2    Okuyama, E.3    Watanabe, Y.4    Ichikawa, Y.5
  • 12
    • 0029868939 scopus 로고    scopus 로고
    • Identification of a new non-functional CYP2C18 allele in Japanese: Substitution of T204 to A in exon2 generates a premature stop codon
    • Komai K, Sumida K, Kaneko H, Nakatsuka I. Identification of a new non-functional CYP2C18 allele in Japanese: substitution of T204 to A in exon2 generates a premature stop codon. Pharmacogenetics 1996; 6: 117-119.
    • (1996) Pharmacogenetics , vol.6 , pp. 117-119
    • Komai, K.1    Sumida, K.2    Kaneko, H.3    Nakatsuka, I.4
  • 13
    • 85027954420 scopus 로고    scopus 로고
    • The Human Cytochrome P450 (CYP) Allele Nomenclature website: A peer-reviewed database of CYP variants and their associated effects
    • Sim SC, Ingelman-Sundberg M. The Human Cytochrome P450 (CYP) Allele Nomenclature website: a peer-reviewed database of CYP variants and their associated effects. Hum Genomics 2010; 4: 278-281.
    • (2010) Hum Genomics , vol.4 , pp. 278-281
    • Sim, S.C.1    Ingelman-Sundberg, M.2
  • 14
    • 0037131892 scopus 로고    scopus 로고
    • CYP2C9 allelic variants: Ethnic distribution and functional significance
    • Xie HG, Prasad HC, Kim RB, Stein CM. CYP2C9 allelic variants: ethnic distribution and functional significance. Adv Drug Deliv Rev 2002; 54: 1257-1270.
    • (2002) Adv Drug Deliv Rev , vol.54 , pp. 1257-1270
    • Xie, H.G.1    Prasad, H.C.2    Kim, R.B.3    Stein, C.M.4
  • 15
    • 77957295385 scopus 로고    scopus 로고
    • Worldwide allele frequency distribution of four polymorphisms associated with warfarin dose requirements
    • Ross KA, Bigham AW, Edwards M, Gozdzik A, Suarez-Kurtz G, Parra EJ. Worldwide allele frequency distribution of four polymorphisms associated with warfarin dose requirements. J Hum Genet 2010; 55: 582-589.
    • (2010) J Hum Genet , vol.55 , pp. 582-589
    • Ross, K.A.1    Bigham, A.W.2    Edwards, M.3    Gozdzik, A.4    Suarez-Kurtz, G.5    Parra, E.J.6
  • 18
    • 19944429040 scopus 로고    scopus 로고
    • A singlenucleotide polymorphism tagging set for human drug metabolism and transport
    • Ahmadi KR, Weale ME, Xue ZY, Soranzo N, Yarnall DP, Briley JD et al. A singlenucleotide polymorphism tagging set for human drug metabolism and transport. Nat Genet 2005; 37: 84-89.
    • (2005) Nat Genet , vol.37 , pp. 84-89
    • Ahmadi, K.R.1    Weale, M.E.2    Xue, Z.Y.3    Soranzo, N.4    Yarnall, D.P.5    Briley, J.D.6
  • 19
    • 25144502503 scopus 로고    scopus 로고
    • Haplotype block structure of the cytochrome P450 CYP2C gene cluster on chromosome 10
    • author reply 916
    • Walton R, Kimber M, Rockett K, Trafford C, Kwiatkowski D, Sirugo G. Haplotype block structure of the cytochrome P450 CYP2C gene cluster on chromosome 10. Nat Genet 2005; 37: 915-916, author reply 916.
    • (2005) Nat Genet , vol.37 , pp. 915-916
    • Walton, R.1    Kimber, M.2    Rockett, K.3    Trafford, C.4    Kwiatkowski, D.5    Sirugo, G.6
  • 22
    • 78649317664 scopus 로고    scopus 로고
    • Linkage disequilibrium between the CYP2C19 17 allele and wildtype CYP2C8 and CYP2C9 alleles: Identification of CYP2C haplotypes in healthy Nordic populations
    • Pedersen RS, Brasch-Andersen C, Sim SC, Bergmann TK, Halling J, Petersen MS et al. Linkage disequilibrium between the CYP2C1917 allele and wildtype CYP2C8 and CYP2C9 alleles: identification of CYP2C haplotypes in healthy Nordic populations. Eur J Clin Pharmacol 2010; 66: 1199-1205.
    • (2010) Eur J Clin Pharmacol , vol.66 , pp. 1199-1205
    • Pedersen, R.S.1    Brasch-Andersen, C.2    Sim, S.C.3    Bergmann, T.K.4    Halling, J.5    Petersen, M.S.6
  • 23
    • 84861458604 scopus 로고    scopus 로고
    • Global pharmacogenomics: Impact of population diversity on the distribution of polymorphisms in the CYP2C cluster among Brazilians
    • in press
    • Suarez-Kurtz G, Genro JP, de Moraes MO, Ojopi EB, Pena SD, Perini JA et al. Global pharmacogenomics: impact of population diversity on the distribution of polymorphisms in the CYP2C cluster among Brazilians. Pharmacogenomics J 2012 (in press).
    • (2012) Pharmacogenomics J
    • Suarez-Kurtz, G.1    Genro, J.P.2    De Moraes, M.O.3    Ojopi, E.B.4    Pena, S.D.5    Perini, J.A.6
  • 24
    • 79151474312 scopus 로고    scopus 로고
    • Linkage disequilibrium between the CYP2C1917 and CYP2C8 2 alleles in populations of African descent
    • Suarez-Kurtz G. Linkage disequilibrium between the CYP2C1917 and CYP2C82 alleles in populations of African descent. Eur J Clin Pharmacol 2011; 67: 211-212.
    • (2011) Eur J Clin Pharmacol , vol.67 , pp. 211-212
    • Suarez-Kurtz, G.1
  • 26
    • 84864348920 scopus 로고    scopus 로고
    • Identification of CYP2C19 4B: Pharmacogenetic implications for drug metabolism including clopidogrel responsiveness
    • in press
    • Scott SA, Martis S, Peter I, Kasai Y, Kornreich R, Desnick RJ. Identification of CYP2C194B: pharmacogenetic implications for drug metabolism including clopidogrel responsiveness. Pharmacogenomics J 2012 (in press).
    • (2012) Pharmacogenomics J
    • Scott, S.A.1    Martis, S.2    Peter, I.3    Kasai, Y.4    Kornreich, R.5    Desnick, R.J.6
  • 28
    • 77955638355 scopus 로고    scopus 로고
    • ACCF/AHA clopidogrel clinical alert: Approaches to the FDA 00boxed warning00: A report of the American College of Cardiology Foundation Task Force on clinical expert consensus documents and the American Heart Association endorsed by the Society for Cardiovascular Angiography and Interventions and the Society of Thoracic Surgeons
    • Holmes Jr DR, Dehmer GJ, Kaul S, Leifer D, O'Gara PT, Stein CM. ACCF/AHA clopidogrel clinical alert: approaches to the FDA 00boxed warning00: a report of the American College of Cardiology Foundation Task Force on clinical expert consensus documents and the American Heart Association endorsed by the Society for Cardiovascular Angiography and Interventions and the Society of Thoracic Surgeons. J Am Coll Cardiol 2010; 56: 321-341.
    • (2010) J Am Coll Cardiol , vol.56 , pp. 321-341
    • Holmes Jr., D.R.1    Dehmer, G.J.2    Kaul, S.3    Leifer, D.4    O'Gara, P.T.5    Stein, C.M.6
  • 30
    • 79960613122 scopus 로고    scopus 로고
    • Clinical pharmacogenetics implementation consortium guidelines for Cytochrome P450-2C19 (CYP2C19) genotype and clopidogrel therapy
    • Scott SA, Sangkuhl K, Gardner EE, Stein CM, Hulot JS, Johnson JA et al. Clinical pharmacogenetics implementation consortium guidelines for Cytochrome P450-2C19 (CYP2C19) genotype and clopidogrel therapy. Clin Pharmacol Ther 2011; 90: 328-332.
    • (2011) Clin Pharmacol Ther , vol.90 , pp. 328-332
    • Scott, S.A.1    Sangkuhl, K.2    Gardner, E.E.3    Stein, C.M.4    Hulot, J.S.5    Johnson, J.A.6
  • 34
    • 77958105401 scopus 로고    scopus 로고
    • Genetic variants in ABCB1 and CYP2C19 and cardiovascular outcomes after treatment with clopidogrel and prasugrel in the TRITON-TIMI 38 trial: A pharmacogenetic analysis
    • Mega JL, Close SL, Wiviott SD, Shen L, Walker JR, Simon T et al. Genetic variants in ABCB1 and CYP2C19 and cardiovascular outcomes after treatment with clopidogrel and prasugrel in the TRITON-TIMI 38 trial: a pharmacogenetic analysis. Lancet 2010; 376: 1312-1319.
    • (2010) Lancet , vol.376 , pp. 1312-1319
    • Mega, J.L.1    Close, S.L.2    Wiviott, S.D.3    Shen, L.4    Walker, J.R.5    Simon, T.6
  • 35
    • 77958100874 scopus 로고    scopus 로고
    • Effect of CYP2C19 and ABCB1 single nucleotide polymorphisms on outcomes of treatment with ticagrelor versus clopidogrel for acute coronary syndromes: A genetic substudy of the PLATO trial
    • Wallentin L, James S, Storey RF, Armstrong M, Barratt BJ, Horrow J et al. Effect of CYP2C19 and ABCB1 single nucleotide polymorphisms on outcomes of treatment with ticagrelor versus clopidogrel for acute coronary syndromes: a genetic substudy of the PLATO trial. Lancet 2010; 376: 1320-1328.
    • (2010) Lancet , vol.376 , pp. 1320-1328
    • Wallentin, L.1    James, S.2    Storey, R.F.3    Armstrong, M.4    Barratt, B.J.5    Horrow, J.6
  • 36
    • 34548103768 scopus 로고    scopus 로고
    • CYP2C9, CYP2C19 and CYP2D6 allele frequencies in the Ashkenazi Jewish population
    • Scott SA, Edelmann L, Kornreich R, Erazo M, Desnick RJ. CYP2C9, CYP2C19 and CYP2D6 allele frequencies in the Ashkenazi Jewish population. Pharmacogenomics 2007; 8: 721-730.
    • (2007) Pharmacogenomics , vol.8 , pp. 721-730
    • Scott, S.A.1    Edelmann, L.2    Kornreich, R.3    Erazo, M.4    Desnick, R.J.5
  • 37
    • 40749123052 scopus 로고    scopus 로고
    • Warfarin pharmacogenetics: CYP2C9 and VKORC1 genotypes predict different sensitivity and resistance frequencies in the Ashkenazi and Sephardi Jewish populations
    • Scott SA, Edelmann L, Kornreich R, Desnick RJ. Warfarin pharmacogenetics: CYP2C9 and VKORC1 genotypes predict different sensitivity and resistance frequencies in the Ashkenazi and Sephardi Jewish populations. Am J Hum Genet 2008; 82: 495-500.
    • (2008) Am J Hum Genet , vol.82 , pp. 495-500
    • Scott, S.A.1    Edelmann, L.2    Kornreich, R.3    Desnick, R.J.4
  • 38
    • 78049440186 scopus 로고    scopus 로고
    • Experience with carrier screening and prenatal diagnosis for 16 Ashkenazi Jewish genetic diseases
    • Scott SA, Edelmann L, Liu L, Luo M, Desnick RJ, Kornreich R. Experience with carrier screening and prenatal diagnosis for 16 Ashkenazi Jewish genetic diseases. Hum Mutat 2010; 31: 1240-1250.
    • (2010) Hum Mutat , vol.31 , pp. 1240-1250
    • Scott, S.A.1    Edelmann, L.2    Liu, L.3    Luo, M.4    Desnick, R.J.5    Kornreich, R.6
  • 40
    • 36348943475 scopus 로고    scopus 로고
    • Common polymorphisms of CYP2C19 and CYP2C9 affect the pharmacokinetic and pharmacodynamic response to clopidogrel but not prasugrel
    • Brandt JT, Close SL, Iturria SJ, Payne CD, Farid NA, Ernest 2nd CS et al. Common polymorphisms of CYP2C19 and CYP2C9 affect the pharmacokinetic and pharmacodynamic response to clopidogrel but not prasugrel. J Thromb Haemost 2007; 5: 2429-2436.
    • (2007) J Thromb Haemost , vol.5 , pp. 2429-2436
    • Brandt, J.T.1    Close, S.L.2    Iturria, S.J.3    Payne, C.D.4    Farid, N.A.5    Ernest, I.I.C.S.6
  • 41
    • 79955116606 scopus 로고    scopus 로고
    • High doses of clopidogrel to overcome genetic resistance: The randomized crossover CLOVIS-2 (Clopidogrel and response variability investigation study 2)
    • Collet JP, Hulot JS, Anzaha G, Pena A, Chastre T, Caron C et al. High doses of clopidogrel to overcome genetic resistance: the randomized crossover CLOVIS-2 (Clopidogrel and response variability investigation study 2). JACC Cardiovasc Interv 2011; 4: 392-402.
    • (2011) JACC Cardiovasc Interv , vol.4 , pp. 392-402
    • Collet, J.P.1    Hulot, J.S.2    Anzaha, G.3    Pena, A.4    Chastre, T.5    Caron, C.6
  • 42
    • 33749339075 scopus 로고    scopus 로고
    • Cytochrome P450 2C19 loss-of-function polymorphism is a major determinant of clopidogrel responsiveness in healthy subjects
    • Hulot JS, Bura A, Villard E, Azizi M, Remones V, Goyenvalle C et al. Cytochrome P450 2C19 loss-of-function polymorphism is a major determinant of clopidogrel responsiveness in healthy subjects. Blood 2006; 108: 2244-2247.
    • (2006) Blood , vol.108 , pp. 2244-2247
    • Hulot, J.S.1    Bura, A.2    Villard, E.3    Azizi, M.4    Remones, V.5    Goyenvalle, C.6
  • 43
    • 38449103046 scopus 로고    scopus 로고
    • Cytochrome P450 2C19 loss-of-function polymorphism, but not CYP3A4 IVS10 + 12G/A and P2Y12 T744C polymorphisms, is associated with response variability to dual antiplatelet treatment in high-risk vascular patients
    • Giusti B, Gori AM, Marcucci R, Saracini C, Sestini I, Paniccia R et al. Cytochrome P450 2C19 loss-of-function polymorphism, but not CYP3A4 IVS10 + 12G/A and P2Y12 T744C polymorphisms, is associated with response variability to dual antiplatelet treatment in high-risk vascular patients. Pharmacogenet Genomics 2007; 17: 1057-1064.
    • (2007) Pharmacogenet Genomics , vol.17 , pp. 1057-1064
    • Giusti, B.1    Gori, A.M.2    Marcucci, R.3    Saracini, C.4    Sestini, I.5    Paniccia, R.6
  • 45
    • 69249219296 scopus 로고    scopus 로고
    • Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy
    • Shuldiner AR, O'Connell JR, Bliden KP, Gandhi A, Ryan K, Horenstein RB et al. Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy. JAMA 2009; 302: 849-857.
    • (2009) JAMA , vol.302 , pp. 849-857
    • Shuldiner, A.R.1    O'Connell, J.R.2    Bliden, K.P.3    Gandhi, A.4    Ryan, K.5    Horenstein, R.B.6
  • 46
    • 58249135635 scopus 로고    scopus 로고
    • Cytochrome P450 2C19 polymorphism in young patients treated with clopidogrel after myocardial infarction: A cohort study
    • Collet JP, Hulot JS, Pena A, Villard E, Esteve JB, Silvain J et al. Cytochrome P450 2C19 polymorphism in young patients treated with clopidogrel after myocardial infarction: a cohort study. Lancet 2009; 373: 309-317.
    • (2009) Lancet , vol.373 , pp. 309-317
    • Collet, J.P.1    Hulot, J.S.2    Pena, A.3    Villard, E.4    Esteve, J.B.5    Silvain, J.6
  • 47
    • 77953896604 scopus 로고    scopus 로고
    • Cardiovascular risk in clopidogrel-treated patients according to cytochrome P450 2C19 2 loss-of-function allele or proton pump inhibitor coadministration: A systematic meta-analysis
    • Hulot JS, Collet JP, Silvain J, Pena A, Bellemain-Appaix A, Barthelemy O et al. Cardiovascular risk in clopidogrel-treated patients according to cytochrome P450 2C192 loss-of-function allele or proton pump inhibitor coadministration: a systematic meta-analysis. J Am Coll Cardiol 2010; 56: 134-143.
    • (2010) J Am Coll Cardiol , vol.56 , pp. 134-143
    • Hulot, J.S.1    Collet, J.P.2    Silvain, J.3    Pena, A.4    Bellemain-Appaix, A.5    Barthelemy, O.6
  • 48
    • 78049326068 scopus 로고    scopus 로고
    • Reducedfunction CYP2C19 genotype and risk of adverse clinical outcomes among patients treated with clopidogrel predominantly for PCI: A meta-analysis
    • Mega JL, Simon T, Collet JP, Anderson JL, Antman EM, Bliden K et al. Reducedfunction CYP2C19 genotype and risk of adverse clinical outcomes among patients treated with clopidogrel predominantly for PCI: a meta-analysis. JAMA 2010; 304: 1821-1830.
    • (2010) JAMA , vol.304 , pp. 1821-1830
    • Mega, J.L.1    Simon, T.2    Collet, J.P.3    Anderson, J.L.4    Antman, E.M.5    Bliden, K.6
  • 49
    • 77958559512 scopus 로고    scopus 로고
    • Clopidogrel pharmacogenomics: Next steps: A clinical algorithm, gene-gene interactions, and an elusive outcomes trial
    • Gladding P, Panattoni L, Webster M, Cho L, Ellis S. Clopidogrel pharmacogenomics: next steps: a clinical algorithm, gene-gene interactions, and an elusive outcomes trial. JACC Cardiovasc Interv 2010; 3: 995-1000.
    • (2010) JACC Cardiovasc Interv , vol.3 , pp. 995-1000
    • Gladding, P.1    Panattoni, L.2    Webster, M.3    Cho, L.4    Ellis, S.5
  • 50
    • 77955413903 scopus 로고    scopus 로고
    • Responding to the clopidogrel warning by the US food and drug administration: Real life is complicated
    • Roden DM, Shuldiner AR. Responding to the clopidogrel warning by the US food and drug administration: real life is complicated. Circulation 2010; 122: 445-448.
    • (2010) Circulation , vol.122 , pp. 445-448
    • Roden, D.M.1    Shuldiner, A.R.2
  • 51
    • 84873363486 scopus 로고    scopus 로고
    • Genetic testing for CYP450 polymorphisms to predict response to clopidogrel: Current evidence and test availability. Application: Pharmacogenomics
    • Ned Mmsc Phd RM
    • Ned Mmsc Phd RM. Genetic testing for CYP450 polymorphisms to predict response to clopidogrel: current evidence and test availability. Application: pharmacogenomics. PLoS Curr 2010; 2: RRN1180.
    • (2010) PLoS Curr , vol.2
  • 52
    • 79955014308 scopus 로고    scopus 로고
    • Evaluation of a CYP2C19 genotype panel on the GenMark eSensor(R) platform and the comparison to the Autogenomics Infiniti and Luminex CYP2C19 panels
    • Lee CC, McMillin GA, Babic N, Melis R, Yeo KT. Evaluation of a CYP2C19 genotype panel on the GenMark eSensor(R) platform and the comparison to the Autogenomics Infiniti and Luminex CYP2C19 panels. Clin Chim Acta 2011; 412: 1133-1137.
    • (2011) Clin Chim Acta , vol.412 , pp. 1133-1137
    • Lee, C.C.1    McMillin, G.A.2    Babic, N.3    Melis, R.4    Yeo, K.T.5
  • 53
    • 80054919425 scopus 로고    scopus 로고
    • Clinical, angiographic, and genetic factors associated with early coronary stent thrombosis
    • Cayla G, Hulot JS, O'Connor SA, Pathak A, Scott SA, Gruel Y et al. Clinical, angiographic, and genetic factors associated with early coronary stent thrombosis. JAMA 2011; 306: 1765-1774.
    • (2011) JAMA , vol.306 , pp. 1765-1774
    • Cayla, G.1    Hulot, J.S.2    O'Connor, S.A.3    Pathak, A.4    Scott, S.A.5    Gruel, Y.6
  • 54
    • 0034724324 scopus 로고    scopus 로고
    • Functional polymorphisms of the human multidrug-resistance gene: Multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo
    • Hoffmeyer S, Burk O, von Richter O, Arnold HP, Brockmoller J, Johne A et al. Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo. Proc Natl Acad Sci USA 2000; 97: 3473-3478.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 3473-3478
    • Hoffmeyer, S.1    Burk, O.2    Von Richter, O.3    Arnold, H.P.4    Brockmoller, J.5    Johne, A.6
  • 55
    • 0036224114 scopus 로고    scopus 로고
    • Effect of the mutation (C3435T) at exon 26 of the MDR1 gene on expression level of MDR1 messenger ribonucleic acid in duodenal enterocytes of healthy Japanese subjects
    • Nakamura T, Sakaeda T, Horinouchi M, Tamura T, Aoyama N, Shirakawa T et al. Effect of the mutation (C3435T) at exon 26 of the MDR1 gene on expression level of MDR1 messenger ribonucleic acid in duodenal enterocytes of healthy Japanese subjects. Clin Pharmacol Ther 2002; 71: 297-303.
    • (2002) Clin Pharmacol Ther , vol.71 , pp. 297-303
    • Nakamura, T.1    Sakaeda, T.2    Horinouchi, M.3    Tamura, T.4    Aoyama, N.5    Shirakawa, T.6
  • 56
    • 15244350810 scopus 로고    scopus 로고
    • Relationship between the C3435T and G2677T(A) polymorphisms in the ABCB1 gene and Pglycoprotein expression in human liver
    • Owen A, Goldring C, Morgan P, Chadwick D, Park BK, Pirmohamed M. Relationship between the C3435T and G2677T(A) polymorphisms in the ABCB1 gene and Pglycoprotein expression in human liver. Br J Clin Pharmacol 2005; 59: 365-370.
    • (2005) Br J Clin Pharmacol , vol.59 , pp. 365-370
    • Owen, A.1    Goldring, C.2    Morgan, P.3    Chadwick, D.4    Park, B.K.5    Pirmohamed, M.6
  • 57
    • 0028036727 scopus 로고
    • Selective biotransformation of taxol to 6 alpha-hydroxytaxol by human cytochrome P450 2C8
    • Rahman A, Korzekwa KR, Grogan J, Gonzalez FJ, Harris JW. Selective biotransformation of taxol to 6 alpha-hydroxytaxol by human cytochrome P450 2C8. Cancer Res 1994; 54: 5543-5546.
    • (1994) Cancer Res , vol.54 , pp. 5543-5546
    • Rahman, A.1    Korzekwa, K.R.2    Grogan, J.3    Gonzalez, F.J.4    Harris, J.W.5
  • 58
    • 0034791777 scopus 로고    scopus 로고
    • Polymorphisms in human CYP2C8 decrease metabolism of the anticancer drug paclitaxel and arachidonic acid
    • Dai D, Zeldin DC, Blaisdell JA, Chanas B, Coulter SJ, Ghanayem BI et al. Polymorphisms in human CYP2C8 decrease metabolism of the anticancer drug paclitaxel and arachidonic acid. Pharmacogenetics 2001; 11: 597-607.
    • (2001) Pharmacogenetics , vol.11 , pp. 597-607
    • Dai, D.1    Zeldin, D.C.2    Blaisdell, J.A.3    Chanas, B.4    Coulter, S.J.5    Ghanayem, B.I.6
  • 59
    • 19144368324 scopus 로고    scopus 로고
    • Cytochrome P450 2C8: Substrates, inhibitors, pharmacogenetics, and clinical relevance
    • Totah RA, Rettie AE. Cytochrome P450 2C8: substrates, inhibitors, pharmacogenetics, and clinical relevance. Clin Pharmacol Ther 2005; 77: 341-352.
    • (2005) Clin Pharmacol Ther , vol.77 , pp. 341-352
    • Totah, R.A.1    Rettie, A.E.2
  • 60
    • 70649100416 scopus 로고    scopus 로고
    • Cytochrome P450 2C8 pharmacogenetics: A review of clinical studies
    • Daily EB, Aquilante CL. Cytochrome P450 2C8 pharmacogenetics: a review of clinical studies. Pharmacogenomics 2009; 10: 1489-1510.
    • (2009) Pharmacogenomics , vol.10 , pp. 1489-1510
    • Daily, E.B.1    Aquilante, C.L.2
  • 61
    • 85011913445 scopus 로고    scopus 로고
    • Five novel single nucleotide polymorphisms in the CYP2C8 gene, one of which induces a frame-shift
    • Soyama A, Saito Y, Komamura K, Ueno K, Kamakura S, Ozawa S et al. Five novel single nucleotide polymorphisms in the CYP2C8 gene, one of which induces a frame-shift. Drug Metab Pharmacokinet 2002; 17: 374-377.
    • (2002) Drug Metab Pharmacokinet , vol.17 , pp. 374-377
    • Soyama, A.1    Saito, Y.2    Komamura, K.3    Ueno, K.4    Kamakura, S.5    Ozawa, S.6
  • 62
    • 20944438107 scopus 로고    scopus 로고
    • Functional characterization of five novel CYP2C8 variants, G171S, R186X, R186G, K247R, and K383N, found in a Japanese population
    • Hichiya H, Tanaka-Kagawa T, Soyama A, Jinno H, Koyano S, Katori N et al. Functional characterization of five novel CYP2C8 variants, G171S, R186X, R186G, K247R, and K383N, found in a Japanese population. Drug Metab Dispos 2005; 33: 630-636.
    • (2005) Drug Metab Dispos , vol.33 , pp. 630-636
    • Hichiya, H.1    Tanaka-Kagawa, T.2    Soyama, A.3    Jinno, H.4    Koyano, S.5    Katori, N.6
  • 63
    • 33746677973 scopus 로고    scopus 로고
    • Impact of the haplotype CYP3A4 16B harboring the Thr185Ser substitution on paclitaxel metabolism in Japanese patients with cancer
    • Nakajima Y, Yoshitani T, Fukushima-Uesaka H, Saito Y, Kaniwa N, Kurose K et al. Impact of the haplotype CYP3A416B harboring the Thr185Ser substitution on paclitaxel metabolism in Japanese patients with cancer. Clin Pharmacol Ther 2006; 80: 179-191.
    • (2006) Clin Pharmacol Ther , vol.80 , pp. 179-191
    • Nakajima, Y.1    Yoshitani, T.2    Fukushima-Uesaka, H.3    Saito, Y.4    Kaniwa, N.5    Kurose, K.6
  • 64
    • 34250173817 scopus 로고    scopus 로고
    • CYP2C8 haplotype structures and their influence on pharmacokinetics of paclitaxel in a Japanese population
    • Saito Y, Katori N, Soyama A, Nakajima Y, Yoshitani T, Kim SR et al. CYP2C8 haplotype structures and their influence on pharmacokinetics of paclitaxel in a Japanese population. Pharmacogenet Genomics 2007; 17: 461-471.
    • (2007) Pharmacogenet Genomics , vol.17 , pp. 461-471
    • Saito, Y.1    Katori, N.2    Soyama, A.3    Nakajima, Y.4    Yoshitani, T.5    Kim, S.R.6
  • 66
    • 79951811694 scopus 로고    scopus 로고
    • The missing association: Sequencing-based discovery of novel SNPs in VKORC1 and CYP2C9 that affect warfarin dose in African Americans
    • Perera MA, Gamazon E, Cavallari LH, Patel SR, Poindexter S, Kittles RA et al. The missing association: sequencing-based discovery of novel SNPs in VKORC1 and CYP2C9 that affect warfarin dose in African Americans. Clin Pharmacol Ther 2011; 89: 408-415.
    • (2011) Clin Pharmacol Ther , vol.89 , pp. 408-415
    • Perera, M.A.1    Gamazon, E.2    Cavallari, L.H.3    Patel, S.R.4    Poindexter, S.5    Kittles, R.A.6
  • 68
    • 76649115043 scopus 로고    scopus 로고
    • Pharmacogenetics of CYP2C19: Functional and clinical implications of a new variant CYP2C19 17
    • Li-Wan-Po A, Girard T, Farndon P, Cooley C, Lithgow J. Pharmacogenetics of CYP2C19: functional and clinical implications of a new variant CYP2C1917. Br J Clin Pharmacol 2010; 69: 222-230.
    • (2010) Br J Clin Pharmacol , vol.69 , pp. 222-230
    • Li-Wan-Po, A.1    Girard, T.2    Farndon, P.3    Cooley, C.4    Lithgow, J.5


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