Utilization of human liver microsomes to explain individual differences in paclitaxel metabolism by CYP2C8 and CYP3A4

Journal of Pharmacological Sciences

Volumn 97, Issue 1, 2005, Pages 83-90

  Taniguchi, Ryoko ^a   Kumai, Toshio ^a   Matsumoto, Naoki ^a   Watanabe, Minoru ^a   Kamio, Koji ^a   Suzuki, Satoshi ^b   Kobayashi, Shinichi ^a  

^a ST MARIANNA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b Non Profit Org Hum Anim B   (Japan)

Author keywords

CYP; Individual difference; Liver; Paclitaxel; Polymorphism

Indexed keywords

3' HYDROXYPACLITAXEL; 6ALPHA HYDROXYPACLITAXEL; CYTOCHROME P450 2C8; CYTOCHROME P450 3A4; DRUG METABOLITE; MESSENGER RNA; PACLITAXEL; UNCLASSIFIED DRUG;

ARTICLE; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME POLYMORPHISM; GENE FREQUENCY; HUMAN; HUMAN TISSUE; LIVER MICROSOME METABOLISM; PROTEIN EXPRESSION;

EID: 14644401778     PISSN: 13478613     EISSN: None     Source Type: Journal    
DOI: 10.1254/jphs.FP0040603     Document Type: Article

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