Genetic polymorphism of CYP2C8 in three Malaysian ethnics: CYP2C8*2 and CYP2C8*3 are found in Malaysian Indians

Journal of Clinical Pharmacy and Therapeutics

Volumn 30, Issue 5, 2005, Pages 487-490

  Muthiah, Y D ^a   Lee, W L ^a   Teh, L K ^a,b   Ong, C E ^c   Ismail, Rusli ^a,d  

^a SCHOOL OF MEDICAL SCIENCES   (Malaysia)

^b UNIVERSITI TEKNOLOGI MARA   (Malaysia)

^c INTERNATIONAL MEDICAL UNIVERSITY   (Malaysia)

^d INSTITUTE FOR RESEARCH IN MOLECULAR MEDICINE INFORMM   (Malaysia)

Author keywords

Allele frequency; CYP2C8; Polymorphism

Indexed keywords

CYTOCHROME P450 2C8; DNA;

ARTICLE; CODON; CONTROLLED STUDY; DNA EXTRACTION; DNA SEQUENCE; ETHNIC GROUP; GENE FREQUENCY; GENE MUTATION; GENETIC POLYMORPHISM; HUMAN; INDIAN; MAJOR CLINICAL STUDY; MALAYSIA; NUCLEOTIDE SEQUENCE;

ALLELES; ARYL HYDROCARBON HYDROXYLASES; CHINA; CODON; DNA; ETHNIC GROUPS; GENE FREQUENCY; HUMANS; INDIA; MALAYSIA; POLYMORPHISM, GENETIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 27744475863     PISSN: 02694727     EISSN: 13652710     Source Type: Journal    
DOI: 10.1111/j.1365-2710.2005.00653.x     Document Type: Article

References (9)

1. Dai D, Zeldin DC, Blasidell JA, Chanas B, Coulter SJ, Ghaneyem BI, Goldstein JA (2001) Polymorphism in human CYP2C8 decrease metabolism of the anticancer drug paclitaxel and arachidonic acid. Pharmacogenetics, 11, 597-607.
2. Rahman A, Korzekwa KR, Grogan J, Gonzalez FJ, Harris JW (1994) Selective biotransformation of taxol to 6-alpha-hydroxytaxol by human cytochrome-P450 2C8. Cancer Research, 54, 5543-5546.
3. Yun CH, Shimada T, Guengerich FP (1992) Roles of human cytochrome P4502C and cytochrome P4503A enzymes in the 3-hydroxylation of benzo(a)pyrene. Cancer Research, 52, 1868-1874.
4. Baldwin SJ, Clarke SE, Chenery RJ (1999) Characterization of the cytochrome P450 enzymes involved in the in vitro metabolism of rosiglitazone. British Journal of Clinical Pharmacology, 48, 424-432.
5. Klose TS, Blaisdell JA, Goldstein JA (1999) Gene structure of CYP2C8 and extrahepatic distribution of the human CYP2Cs. Journal of Biochemical and Molecular Toxicology, 13, 289-295.
6. Bahadur N, Leathart JBS, Mutch E et al. (2002) CYP2C8 polymorphism in Caucasians and their relationship with paclitaxel 6α-hydroxylase activity in human liver microsomes. Biochemical Pharmacology, 64, 1579-1589.
7. Nakajima M, Fujiki Y, Noda K et al. (2003) Genetic polymorphisms of CYP2C8 in Japanese population. Drug Metabolism and Disposition: the Biological Fate of Chemicals, 31, 687-690.
8. Soyama A, Saito Y, Komamura K, Ueno K, Kamamura S, Ozawa S, Sawada J (2002) Five novel single nucleotide polmorphisms in the CYP2C8 gene, one of which induces a frame-shift. Drug Metabolism and Pharmacokinetics, 17, 374-377.
9. Ismail R, Teh LK, Amir J, Alwi Z, Lopez CG (2003) Genetic polymorphism of CYP2D6 in Chinese subjects in Malaysia. Journal of Clinical Pharmacy and Therapeutics, 28, 1-7.