Structural and functional insights into polymorphic enzymes of cytochrome P450 2C8

Amino Acids

Volumn 40, Issue 4, 2011, Pages 1195-1204

  Jiang, Hualin ^a   Zhong, Fangfang ^a   Sun, Lu ^a   Feng, Weiyue ^b   Huang, Zhong Xian ^a   Tan, Xiangshi ^a  

^a FUDAN UNIVERSITY   (China)

^b INSTITUTE OF HIGH ENERGY PHYSICS   (China)

Author keywords

CYP2C8; Drug metabolism; Individualized medication; Polymorphism; Structure function relationship

Indexed keywords

CYTOCHROME P450 2C8; HEME; PACLITAXEL;

ARTICLE; BINDING AFFINITY; BINDING SITE; CATALYSIS; CONTROLLED STUDY; DRUG METABOLISM; ELECTRON TRANSPORT; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME POLYMORPHISM; ENZYME SUBSTRATE COMPLEX; PRIORITY JOURNAL; PROTEIN SECONDARY STRUCTURE; STRUCTURE ACTIVITY RELATION; THERMOSTABILITY;

ANTINEOPLASTIC AGENTS; ARYL HYDROCARBON HYDROXYLASES; BINDING SITES; CATALYTIC DOMAIN; ESCHERICHIA COLI; GENE EXPRESSION; HEME; HUMANS; INDIVIDUALIZED MEDICINE; ISOENZYMES; KINETICS; METABOLIC DETOXICATION, PHASE I; MICROSOMES, LIVER; MODELS, MOLECULAR; PACLITAXEL; POLYMORPHISM, GENETIC; PROTEIN BINDING; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RECOMBINANT PROTEINS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SUBSTRATE SPECIFICITY;

EID: 79954436517     PISSN: 09394451     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00726-010-0743-8     Document Type: Article

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