Non-synonymous single nucleotide alterations found in the CYP2C8 gene result in reduced in vitro paclitaxel metabolism

Biological and Pharmaceutical Bulletin

Volumn 24, Issue 12, 2001, Pages 1427-1430

  Soyama, Akiko ^a   Saito, Yoshiro ^a   Hanioka, Nobumitsu ^a   Murayama, Norie ^a   Nakajima, Osamu ^a   Katori, Noriko ^a   Ishida, Seiichi ^a   Sai, Kimie ^a   Ozawa, Shogo ^a   Sawada, Junichi ^a  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

Author keywords

CYP2C8; Metabolism; Paclitaxel; Polymorphism

Indexed keywords

6ALPHA HYDROXY PACLITAXEL; AMINO ACID; COMPLEMENTARY DNA; CYTOCHROME P450; CYTOCHROME P450 2C8; PACLITAXEL; PACLITAXEL DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CELL LINE; CONTROLLED STUDY; DNA SEQUENCE; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG METABOLISM; EXON; GENE CONSTRUCT; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; JAPAN; PROTEIN EXPRESSION; SINGLE NUCLEOTIDE POLYMORPHISM;

AMINO ACID SUBSTITUTION; ANTINEOPLASTIC AGENTS, PHYTOGENIC; ARYL HYDROCARBON HYDROXYLASES; CELL LINE; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME ACTIVATION; HUMANS; PACLITAXEL; POLYMORPHISM, SINGLE NUCLEOTIDE; STEROID 16-ALPHA-HYDROXYLASE; STEROID HYDROXYLASES; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0035214173     PISSN: 09186158     EISSN: None     Source Type: Journal    
DOI: 10.1248/bpb.24.1427     Document Type: Article

References (18)