Structural and functional characterization of hemp seed (Cannabis sativa L.) protein-derived antioxidant and antihypertensive peptides

Journal of Functional Foods

Volumn 6, Issue 1, 2014, Pages 384-394

  Girgih, Abraham T ^a   He, Rong ^a,c   Malomo, Sunday ^a   Offengenden, Marina ^b   Wu, Jianping ^b   Aluko, Rotimi E ^a  

^a UNIVERSITY OF MANITOBA   (Canada)

^b UNIVERSITY OF ALBERTA   (Canada)

^c NANJING UNIVERSITY OF FINANCE AND ECONOMICS   (China)

Author keywords

Angiotensin converting enzyme; Antihypertensive peptides; Antioxidant peptides; Hemp seed; Renin; Spontaneously hypertensive rats

Indexed keywords

EID: 84895072632     PISSN: 17564646     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jff.2013.11.005     Document Type: Article

References (45)

1. Aluko R.E., Monu E. Functional and bioactive properties of quinoa seed protein hydrolysates. Journal of Food Science 2003, 68:1254-1258.
2. Bains M., Hall E.D. Antioxidant therapies in traumatic brain and spinal cord injury. Biochimica et Biophysica Acta - Molecular Basis of Disease 2012, 1822:675-684.
3. Barkia A., Bougatef A., Khaled H.B., Nasri M. Antioxidant activities of sardinelle heads and/or viscera protein hydrolysates prepared by enzymatic treatment. Journal of Food Biochemistry 2010, 34(SUPPL. 1):303-320.
4. Centenaro G.S., Mellado M.S., Prentice-Hernández C. Antioxidant activity of protein hydrolysates of fish and chicken bones. Advance Journal of Food Science and Technology 2011, 3:280-288.
5. Cumby N., Zhong Y., Naczk M., Shahidi F. Antioxidant activity and water-holding capacity of canola protein hydrolysates. Food Chemistry 2007, 109:144-148.
6. Fujita H., Yokoyama K., Yoshikawa M. Classification and antihypertensive activity of angiotensin I-converting enzyme inhibitory peptides derived from food proteins. Journal of Food Science 2000, 65:564-569.
7. Gao D., Cao Y., Li H. Antioxidant activity of peptide fractions derived from cottonseed protein hydrolysate. Journal of the Science of Food and Agriculture 2010, 90:1855-1860.
8. Ghassem M., Arihara K., Babji A.S. Isolation, purification and characterisation of angiotensin I-converting enzyme-inhibitory peptides derived from catfish (Clarias batrachus) muscle protein thermolysin hydrolysates. International Journal of Food Science and Technology 2012, 47:2444-2451.
9. Girgih A.T., Udenigwe C.C., Aluko R.E. In vitro antioxidant properties of hemp seed (Cannabis sativa L.) protein hydrolysate fractions. Journal of the American Oil Chemists Society 2011, 88:381-389.
10. Girgih A.T., Udenigwe C.C., Aluko R.E. Reverse-phase HPLC separation of hemp seed (Cannabis sativa L.) protein hydrolysate produced peptide fractions with enhanced antioxidant capacity. Plant Foods for Human Nutrition 2013, 68:39-46.
11. Girgih A.T., Udenigwe C.C., Li H., Adebiyi A.P., Aluko R.E. Kinetics of enzyme inhibition and antihypertensive effects of hemp seed (Cannabis sativa L.) protein hydrolysates. Journal of the American Oil Chemists' Society 2011, 88:1767-1774.
12. He R., Girgih A.T., Malomo S.A., Ju X., Aluko R.E. Antioxidant activities of enzymatic rapeseed protein hydrolysates and the membrane ultrafiltration fractions. Journal of Functional Foods 2013, 5:219-227.
13. He R., Malomo S.A., Alashi A., Girgih A.T., Ju X., Aluko R.E. Purification and hypotensive activity of rapeseed protein-derived renin and angiotensin converting enzyme inhibitory peptides. Journal of Functional Foods 2013, 5:781-789.
14. Huang G.J., Lu T.L., Chiu C.S., Chen H.J., Wu C.H., Lin Y.C., Hsieh W.T., Liao J.C., Sheu M.J., Lin Y.H. Sweet potato storage root defensin and its tryptic hydrolysates exhibited angiotensin converting enzyme inhibitory activity in vitro. Botanical Studies 2011, 52:257-264.
15. Ishida Y., Shibata Y., Fukuhara I., Yano Y., Takehara I., Kaneko K. Effect of an excess intake of casein hydrolysate containing Val-Pro-Pro and Ile-Pro-Pro in subjects with normal blood pressure, high-normal blood pressure, or mild hypertension. Bioscience, Biotechnology, and Biochemistry 2011, 75:427-433.
16. Kobayashi Y., Yamauchi T., Katsuda T., Yamaji H., Katoh S. Angiotensin-I converting enzyme (ACE) inhibitory mechanism of tripeptides containing aromatic residues. Journal of Bioscience and Bioengineering 2008, 106:310-312.
17. Li H., Aluko R.E. Identification and inhibitory properties of multifunctional peptides from pea protein hydrolysate. Journal of Agricultural and Food Chemistry 2010, 58:11471-11476.
18. Li G.H., Qu M.R., Wan J.Z., You J.M. Antihypertensive effect of rice protein hydrolysate with in vitro angiotensin I-converting enzyme inhibitory activity in spontaneously hypertensive rats. Asia Pacific Journal of Clinical Nutrition 2007, 16(Suppl. 1):275-280.
19. Liu Q., Kong B., Xiong Y.L., Xia X. Antioxidant activity and functional properties of porcine plasma protein hydrolysate as influenced by the degree of hydrolysis. Food Chemistry 2010, 118:403-410.
20. Lu R.R., Qian P., Sun Z., Zhou X.H., Chen T.P., He J.F., Zhang H., Wu J. Hempseed protein derived antioxidative peptides: Purification, identification and protection from hydrogen peroxide-induced apoptosis in PC12 cells. Food Chemistry 2010, 123:1210-1218.
21. Markwell M.A.K., Haas S.M., Bieber L.L., Tolbert N.E. A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples. Analytical Biochemistry 1978, 87:206-210.
22. Martínez-Maqueda D., Miralles B., Recio I., Hernández-Ledesma B. Antihypertensive peptides from food proteins: A review. Food and Function 2012, 3:350-361.
23. Maulik S.K., Kumar S. Oxidative stress and cardiac hypertrophy: A review. Toxicology Mechanisms and Methods 2012, 22:359-366.
24. Mendis E., Rajapakse N., Kim S.K. Antioxidant properties of a radical-scavenging peptide purified from enzymatically prepared fish skin gelatin hydrolysate. Journal of Agricultural and Food Chemistry 2005, 53:581-587.
25. Ngo D.H., Vo T.S., Ngo D.N., Wijesekara I., Kim S.K. Biological activities and potential health benefits of bioactive peptides derived from marine organisms. International Journal of Biological Macromolecules 2012, 51:378-383.
26. Norris R., Fitzgerald R.J. Antihypertensive peptides from food proteins. Bioactive food peptides in health and disease 2013, 45-72. Intech Publishers Inc, New York. B. Hernandez-Ledesma, C. Hsieh (Eds.).
27. Park S.Y., Lee J.S., Baek H.H., Lee H.G. Purification and characterization of antioxidant peptides from soy protein hydrolysate. Journal of Food Biochemistry 2010, 34(Suppl. 1):120-132.
28. Pihlanto A. Antioxidative peptides derived from milk proteins. International Dairy Journal 2006, 16:1306-1314.
29. Pihlanto A., Mäkinen S. Antihypertensive properties of plant protein derived peptides. Bioactive food peptides in health and disease 2013, 145-182. Intech Publishers Inc, New York. B. Hernandez-Ledesma, C. Hsieh (Eds.).
30. Rajapakse N., Mendis E., Jung W.K., Je J.Y., Kim S.K. Purification of a radical scavenging peptide from fermented mussel sauce and its antioxidant properties. Food Research International 2005, 38:175-182.
31. Ren J., Zhao M., Shi J., Wang J., Jiang Y., Cui C., Kakuda Y., Xue S.J. Purification and identification of antioxidant peptides from grass carp muscle hydrolysates by consecutive chromatography and electrospray ionization-mass spectrometry. Food Chemistry 2008, 108:727-736.
32. Sarmadi B.H., Ismail A. Antioxidative peptides from food proteins: A review. Peptides 2010, 31:1949-1956.
33. Segev A., Badani H., Kapulnik Y., Shomer I., Oren-Shamir M., Galili S. Determination of polyphenols, flavonoids, and antioxidant capacity in colored chickpea (Cicer arietinum L.). Journal of Food Science 2010, 75:S115-S119.
34. Sharma S., Singh R., Rana S. Bioactive peptides: A review. International Journal Bioautomotion 2011, 15:223-250.
35. Tang C.H., Ten Z., Wang X.S., Yang X.Q. Physicochemical and functional properties of hemp (Cannabis sativa L.) protein isolate. Journal of Agricultural and Food Chemistry 2006, 54:8945-8950.
36. Udenigwe C.C., Adebiyi A.P., Doyen A., Li H., Bazinet L., Aluko R.E. Low molecular weight flaxseed protein-derived arginine-containing peptides reduced blood pressure of spontaneously hypertensive rats faster than amino acid form of arginine and native flaxseed protein. Food Chemistry 2012, 132:468-475.
37. Udenigwe C.C., Aluko R.E. Antioxidant and angiotensin converting enzyme-inhibitory properties of a flaxseed protein-derived high fischer ratio peptide mixture. Journal of Agricultural and Food Chemistry 2010, 58:4762-4768.
38. Udenigwe C.C., Aluko R.E. Chemometric analysis of the amino acid requirements of antioxidant food protein Hydrolysates. International Journal of Molecular Sciences 2011, 12:3148-3161.
39. Udenigwe C.C., Lin Y.S., Hou W.C., Aluko R.E. Kinetics of the inhibition of renin and angiotensin I-converting enzyme by flaxseed protein hydrolysate fractions. Journal of Functional Foods 2009, 1:199-207.
40. Wu J., Aluko R.E., Muir A.D. Purification of angiotensin I-converting enzyme-inhibitory peptides from the enzymatic hydrolysate of defatted canola meal. Food Chemistry 2008, 111:942-950.
41. Xie Z., Huang J., Xu X., Jin Z. Antioxidant activity of peptides isolated from alfalfa leaf protein hydrolysate. Food Chemistry 2008, 111:370-376.
42. Yang Y., Guanjun T.A.O., Ping L.I.U., Liu J.I.A. Peptide with angiotensin I-converting enzyme inhibitory activity from hydrolyzed corn gluten meal. Journal of Agricultural and Food Chemistry 2007, 55:7891-7895.
43. Yongvanit P., Pinlaor S., Bartsch H. Oxidative and nitrative DNA damage: Key events in opisthorchiasis-induced carcinogenesis. Parasitology International 2012, 61:130-135.
44. Yuan L., Wu J., Aluko R.E. Size of the aliphatic chain of sodium houttuyfonate analogs determines their affinity for renin and angiotensin I converting enzyme. International Journal of Biological Macromolecules 2007, 41:274-280.
45. Zhou A., Carrell R.W., Murphy M.P., Wei Z., Yan Y., Stanley P.L.D., Stein P.E., Pipkin F.B., Read R.J. A redox switch in angiotensinogen modulates angiotensin release. Nature 2010, 468:108-111.