-
1
-
-
67449147595
-
Interleukin-23/Th17 pathways and inflammatory bowel disease
-
Abraham C, Cho J (2009). Interleukin-23/Th17 pathways and inflammatory bowel disease. Inflamm Bowel Dis, 15, 1090-100.
-
(2009)
Inflamm Bowel Dis
, vol.15
, pp. 1090-1100
-
-
Abraham, C.1
Cho, J.2
-
2
-
-
59449085264
-
Targeting inflammatory pathways for prevention and therapy of cancer: short-term friend, long-term foe
-
Aggarwal BB, Vijayalekshmi RV, Sung B (2009). Targeting inflammatory pathways for prevention and therapy of cancer: short-term friend, long-term foe. Clin Cancer Res, 15, 425-30.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 425-430
-
-
Aggarwal, B.B.1
Vijayalekshmi, R.V.2
Sung, B.3
-
3
-
-
77956082214
-
STAT3 upregulates the protein expression and transcriptional activity of beta-catenin in breast cancer
-
Armanious H, Gelebart P, Mackey J, et al (2010). STAT3 upregulates the protein expression and transcriptional activity of beta-catenin in breast cancer. Int J Clin Exp Pathol, 3, 654-64.
-
(2010)
Int J Clin Exp Pathol
, vol.3
, pp. 654-664
-
-
Armanious, H.1
Gelebart, P.2
Mackey, J.3
-
4
-
-
54149090600
-
Protective role of luteolin on the status of lipid peroxidation and antioxidant defense against azoxymethane-induced experimental colon carcinogenesis
-
Ashokkumar P, Sudhandiran G (2008). Protective role of luteolin on the status of lipid peroxidation and antioxidant defense against azoxymethane-induced experimental colon carcinogenesis. Biomed Pharmacother, 62, 590-7.
-
(2008)
Biomed Pharmacother
, vol.62
, pp. 590-597
-
-
Ashokkumar, P.1
Sudhandiran, G.2
-
5
-
-
79957473480
-
Luteolin inhibits cell proliferation during Azoxymethane-induced experimental colon carcinogenesis via Wnt/ beta-catenin pathway
-
Ashokkumar P, Sudhandiran G (2011). Luteolin inhibits cell proliferation during Azoxymethane-induced experimental colon carcinogenesis via Wnt/ beta-catenin pathway. Invest New Drugs, 29, 273-84.
-
(2011)
Invest New Drugs
, vol.29
, pp. 273-284
-
-
Ashokkumar, P.1
Sudhandiran, G.2
-
6
-
-
18344410191
-
Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in crohn disease and experimental colitis in vivo
-
Atreya R, Mudter J, Finotto S, et al (2000). Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in crohn disease and experimental colitis in vivo. Nat Med, 6, 583-8.
-
(2000)
Nat Med
, vol.6
, pp. 583-588
-
-
Atreya, R.1
Mudter, J.2
Finotto, S.3
-
7
-
-
44949130806
-
Signaling molecules: the pathogenic role of the IL-6/STAT-3 trans signaling pathway in intestinal inflammation and in colonic cancer
-
Atreya R, Neurath MF (2008). Signaling molecules: the pathogenic role of the IL-6/STAT-3 trans signaling pathway in intestinal inflammation and in colonic cancer. Curr Drug Targets, 9, 369-74.
-
(2008)
Curr Drug Targets
, vol.9
, pp. 369-374
-
-
Atreya, R.1
Neurath, M.F.2
-
8
-
-
0347444723
-
MicroRNAs: genomics, biogenesis, mechanism, and function
-
Bartel DP (2004). MicroRNAs: genomics, biogenesis, mechanism, and function. Cell, 116, 281-97.
-
(2004)
Cell
, vol.116
, pp. 281-297
-
-
Bartel, D.P.1
-
10
-
-
5644252874
-
TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling
-
Becker C, Fantini MC, Schramm C, et al (2004). TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling. Immunity, 21, 491-501.
-
(2004)
Immunity
, vol.21
, pp. 491-501
-
-
Becker, C.1
Fantini, M.C.2
Schramm, C.3
-
11
-
-
23644436122
-
IL-6 signaling promotes tumor growth in colorectal cancer
-
Becker C, Fantini MC, Wirtz S, et al (2005). IL-6 signaling promotes tumor growth in colorectal cancer. Cell Cycle, 4, 217-20.
-
(2005)
Cell Cycle
, vol.4
, pp. 217-220
-
-
Becker, C.1
Fantini, M.C.2
Wirtz, S.3
-
12
-
-
0035865012
-
Cancer risk in patients with inflammatory bowel disease: a population-based study
-
Bernstein CN, Blanchard JF, Kliewer E, et al (2001). Cancer risk in patients with inflammatory bowel disease: a population-based study. Cancer, 91, 854-62.
-
(2001)
Cancer
, vol.91
, pp. 854-862
-
-
Bernstein, C.N.1
Blanchard, J.F.2
Kliewer, E.3
-
13
-
-
58649101347
-
gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis
-
Bollrath J, Phesse TJ, von Burstin VA, et al (2009). gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis. Cancer Cell, 15, 91-102.
-
(2009)
Cancer Cell
, vol.15
, pp. 91-102
-
-
Bollrath, J.1
Phesse, T.J.2
von Burstin, V.A.3
-
14
-
-
67650224449
-
Crohn's disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease
-
Brand S (2009). Crohn's disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease. Gut, 58, 1152-67.
-
(2009)
Gut
, vol.58
, pp. 1152-1167
-
-
Brand, S.1
-
15
-
-
33747623018
-
Notch signalling: a simple pathway becomes complex
-
Bray SJ (2006). Notch signalling: a simple pathway becomes complex. Nat Rev Mol Cell Biol, 7, 678-89.
-
(2006)
Nat Rev Mol Cell Biol
, vol.7
, pp. 678-689
-
-
Bray, S.J.1
-
16
-
-
0033529704
-
Stat3 as an oncogene
-
Bromberg JF, Wrzeszczynska MH, Devgan G, et al (1999). Stat3 as an oncogene. Cell, 98, 295-303.
-
(1999)
Cell
, vol.98
, pp. 295-303
-
-
Bromberg, J.F.1
Wrzeszczynska, M.H.2
Devgan, G.3
-
17
-
-
0036554816
-
Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention
-
Buettner R, Mora LB, Jove R (2002). Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention. Clin Cancer Res, 8, 945-54.
-
(2002)
Clin Cancer Res
, vol.8
, pp. 945-954
-
-
Buettner, R.1
Mora, L.B.2
Jove, R.3
-
18
-
-
40749123066
-
Autocrine regulation of IL-21 production in human T lymphocytes
-
Caprioli F, Sarra M, Caruso R, et al (2008). Autocrine regulation of IL-21 production in human T lymphocytes. J Immunol, 180, 1800-7.
-
(2008)
J Immunol
, vol.180
, pp. 1800-1807
-
-
Caprioli, F.1
Sarra, M.2
Caruso, R.3
-
19
-
-
33644857025
-
Gene regulation by microRNAs
-
Carthew RW (2006). Gene regulation by microRNAs. Curr Opin Genet Dev, 16, 203-8.
-
(2006)
Curr Opin Genet Dev
, vol.16
, pp. 203-208
-
-
Carthew, R.W.1
-
20
-
-
0032984589
-
Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells
-
Catlett-Falcone R, Landowski TH, Oshiro MM, et al (1999). Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells. Immunity, 10, 105-15.
-
(1999)
Immunity
, vol.10
, pp. 105-115
-
-
Catlett-Falcone, R.1
Landowski, T.H.2
Oshiro, M.M.3
-
21
-
-
84865304885
-
Inducible microRNA-223 down-regulation promotes TLR-triggered IL-6 and IL-1beta production in macrophages by targeting STAT3
-
Chen Q, Wang H, Liu Y, et al (2012). Inducible microRNA-223 down-regulation promotes TLR-triggered IL-6 and IL-1beta production in macrophages by targeting STAT3. PLoS ONE, 7, 42971.
-
(2012)
PLoS ONE
, vol.7
, pp. 42971
-
-
Chen, Q.1
Wang, H.2
Liu, Y.3
-
22
-
-
22044437986
-
Persistent STAT3 activation in colon cancer is associated with enhanced cell proliferation and tumor growth
-
Corvinus FM, Orth C, Moriggl R, et al (2005). Persistent STAT3 activation in colon cancer is associated with enhanced cell proliferation and tumor growth. Neoplasia, 7, 545-55.
-
(2005)
Neoplasia
, vol.7
, pp. 545-555
-
-
Corvinus, F.M.1
Orth, C.2
Moriggl, R.3
-
23
-
-
0037180757
-
Inflammation and cancer
-
Coussens LM, Werb Z (2002). Inflammation and cancer. Nature, 420, 860-7.
-
(2002)
Nature
, vol.420
, pp. 860-867
-
-
Coussens, L.M.1
Werb, Z.2
-
24
-
-
77953479589
-
Inflammatory bowel disease and intestinal cancer: a paradigm of the Yin-Yang interplay between inflammation and cancer
-
Danese S, Mantovani A (2010). Inflammatory bowel disease and intestinal cancer: a paradigm of the Yin-Yang interplay between inflammation and cancer. Oncogene, 29, 3313-23.
-
(2010)
Oncogene
, vol.29
, pp. 3313-3323
-
-
Danese, S.1
Mantovani, A.2
-
25
-
-
0036782706
-
Transcription factors as targets for cancer therapy
-
Darnell JE, Jr (2002). Transcription factors as targets for cancer therapy. Nat Rev Cancer, 2, 740-9.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 740-749
-
-
Darnell Jr., J.E.1
-
26
-
-
0032521538
-
High frequency of beta-catenin (ctnnb1) mutations in the colon tumors induced by two heterocyclic amines in the F344 rat
-
Dashwood RH, Suzui M, Nakagama H, et al (1998). High frequency of beta-catenin (ctnnb1) mutations in the colon tumors induced by two heterocyclic amines in the F344 rat. Cancer Res, 58, 1127-9.
-
(1998)
Cancer Res
, vol.58
, pp. 1127-1129
-
-
Dashwood, R.H.1
Suzui, M.2
Nakagama, H.3
-
27
-
-
77955726401
-
Interleukin-21 triggers effector cell responses in the gut
-
De Nitto D, Sarra M, Pallone F, et al (2010). Interleukin-21 triggers effector cell responses in the gut. World J Gastroenterol, 16, 3638-41.
-
(2010)
World J Gastroenterol
, vol.16
, pp. 3638-3641
-
-
De Nitto, D.1
Sarra, M.2
Pallone, F.3
-
28
-
-
76149117809
-
A novel mouse model of inflammatory bowel disease links mammalian target of rapamycin-dependent hyperproliferation of colonic epithelium to inflammation-associated tumorigenesis
-
Deng L, Zhou JF, Sellers RS, et al (2010). A novel mouse model of inflammatory bowel disease links mammalian target of rapamycin-dependent hyperproliferation of colonic epithelium to inflammation-associated tumorigenesis. Am J Pathol, 176, 952-67.
-
(2010)
Am J Pathol
, vol.176
, pp. 952-967
-
-
Deng, L.1
Zhou, J.F.2
Sellers, R.S.3
-
29
-
-
84876145364
-
Constitutive Notch2 signaling induces hepatic tumors in mice
-
Dill MT, Tornillo L, Fritzius T, et al (2013). Constitutive Notch2 signaling induces hepatic tumors in mice. Hepatology, 57, 1607-19.
-
(2013)
Hepatology
, vol.57
, pp. 1607-1619
-
-
Dill, M.T.1
Tornillo, L.2
Fritzius, T.3
-
30
-
-
18944375734
-
Role of Notch signaling in cell-fate determination of human mammary stem/progenitor cells
-
Dontu G, Jackson KW, McNicholas E, et al (2004). Role of Notch signaling in cell-fate determination of human mammary stem/progenitor cells. Breast Cancer Res, 6, 605-15.
-
(2004)
Breast Cancer Res
, vol.6
, pp. 605-615
-
-
Dontu, G.1
Jackson, K.W.2
McNicholas, E.3
-
31
-
-
0023554422
-
Effects of chronic dietary ethanol on in vivo and in vitro metabolism of methylazoxymethanol and on methylazoxymethanol-induced DNA methylation in rat colon and liver
-
Fiala ES, Sohn OS, Hamilton SR (1987). Effects of chronic dietary ethanol on in vivo and in vitro metabolism of methylazoxymethanol and on methylazoxymethanol-induced DNA methylation in rat colon and liver. Cancer Res, 47, 5939-43.
-
(1987)
Cancer Res
, vol.47
, pp. 5939-5943
-
-
Fiala, E.S.1
Sohn, O.S.2
Hamilton, S.R.3
-
32
-
-
41349121555
-
Regulation of gut inflammation and th17 cell response by interleukin-21
-
Fina D, Sarra M, Fantini MC, et al (2008). Regulation of gut inflammation and th17 cell response by interleukin-21. Gastroenterology, 134, 1038-48.
-
(2008)
Gastroenterology
, vol.134
, pp. 1038-1048
-
-
Fina, D.1
Sarra, M.2
Fantini, M.C.3
-
33
-
-
65549086537
-
Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestine
-
Fre S, Pallavi SK, Huyghe M, et al (2009). Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestine. Proc Natl Acad Sci U S A, 106, 6309-14.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 6309-6314
-
-
Fre, S.1
Pallavi, S.K.2
Huyghe, M.3
-
34
-
-
60149095444
-
Most mammalian mRNAs are conserved targets of microRNAs
-
Friedman RC, Farh KK, Burge CB, et al (2009). Most mammalian mRNAs are conserved targets of microRNAs. Genome Res, 19, 92-105.
-
(2009)
Genome Res
, vol.19
, pp. 92-105
-
-
Friedman, R.C.1
Farh, K.K.2
Burge, C.B.3
-
35
-
-
0037216498
-
Increased expression of interleukin 17 in inflammatory bowel disease
-
Fujino S, Andoh A, Bamba S, et al (2003). Increased expression of interleukin 17 in inflammatory bowel disease. Gut, 52, 65-70.
-
(2003)
Gut
, vol.52
, pp. 65-70
-
-
Fujino, S.1
Andoh, A.2
Bamba, S.3
-
36
-
-
76549092128
-
Matrix metalloproteinase-9 functions as a tumor suppressor in colitis-associated cancer
-
Garg P, Sarma D, Jeppsson S, et al (2010). Matrix metalloproteinase-9 functions as a tumor suppressor in colitis-associated cancer. Cancer Res, 70, 792-801.
-
(2010)
Cancer Res
, vol.70
, pp. 792-801
-
-
Garg, P.1
Sarma, D.2
Jeppsson, S.3
-
37
-
-
0037405713
-
The gastritis connection: prevention and early detection of gastric neoplasms
-
Genta RM (2003). The gastritis connection: prevention and early detection of gastric neoplasms. J Clin Gastroenterol, 36, 61-2.
-
(2003)
J Clin Gastroenterol
, vol.36
, pp. 61-62
-
-
Genta, R.M.1
-
38
-
-
17444423289
-
Wnt signaling in the intestinal epithelium: from endoderm to cancer
-
Gregorieff A, Clevers H (2005). Wnt signaling in the intestinal epithelium: from endoderm to cancer. Genes Dev, 19, 877-90.
-
(2005)
Genes Dev
, vol.19
, pp. 877-890
-
-
Gregorieff, A.1
Clevers, H.2
-
39
-
-
58649108302
-
IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer
-
Grivennikov S, Karin E, Terzic J, et al (2009). IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer. Cancer Cell, 15, 103-13.
-
(2009)
Cancer Cell
, vol.15
, pp. 103-113
-
-
Grivennikov, S.1
Karin, E.2
Terzic, J.3
-
40
-
-
37349098725
-
Autocrine IL-6 signaling: a key event in tumorigenesis?
-
Grivennikov S, Karin M (2008). Autocrine IL-6 signaling: a key event in tumorigenesis? Cancer Cell, 13, 7-9.
-
(2008)
Cancer Cell
, vol.13
, pp. 7-9
-
-
Grivennikov, S.1
Karin, M.2
-
41
-
-
37749021324
-
Cutting edge: An in vivo requirement for STAT3 signaling in TH17 development and TH17-dependent autoimmunity
-
Harris TJ, Grosso JF, Yen HR, et al (2007). Cutting edge: An in vivo requirement for STAT3 signaling in TH17 development and TH17-dependent autoimmunity. J Immunol, 179, 4313-7.
-
(2007)
J Immunol
, vol.179
, pp. 4313-4317
-
-
Harris, T.J.1
Grosso, J.F.2
Yen, H.R.3
-
42
-
-
78650859531
-
NF-kappaB and STAT3-key players in liver inflammation and cancer
-
He G, Karin M (2011). NF-kappaB and STAT3-key players in liver inflammation and cancer. Cell Res, 21, 159-68.
-
(2011)
Cell Res
, vol.21
, pp. 159-168
-
-
He, G.1
Karin, M.2
-
43
-
-
0032483439
-
Identification of c-MYC as a target of the APC pathway
-
He TC, Sparks AB, Rago C, et al (1998). Identification of c-MYC as a target of the APC pathway. Science, 281, 1509-12.
-
(1998)
Science
, vol.281
, pp. 1509-1512
-
-
He, T.C.1
Sparks, A.B.2
Rago, C.3
-
44
-
-
42649129014
-
Systematic review of the association between circulating interleukin-6 (IL-6) and cancer
-
Heikkila K, Ebrahim S, Lawlor DA (2008). Systematic review of the association between circulating interleukin-6 (IL-6) and cancer. Eur J Cancer, 44, 937-945.
-
(2008)
Eur J Cancer
, vol.44
, pp. 937-945
-
-
Heikkila, K.1
Ebrahim, S.2
Lawlor, D.A.3
-
45
-
-
0030044345
-
Genes of the Enhancer of split and achaete-scute complexes are required for a regulatory loop between Notch and Delta during lateral signalling in Drosophila
-
Heitzler P, Bourouis M, Ruel L, et al (1996). Genes of the Enhancer of split and achaete-scute complexes are required for a regulatory loop between Notch and Delta during lateral signalling in Drosophila. Development, 122, 161-71.
-
(1996)
Development
, vol.122
, pp. 161-171
-
-
Heitzler, P.1
Bourouis, M.2
Ruel, L.3
-
46
-
-
78649689761
-
Signal transduction pathways and transcriptional regulation in Th17 cell differentiation
-
Hirahara K, Ghoreschi K, Laurence A, et al (2010). Signal transduction pathways and transcriptional regulation in Th17 cell differentiation. Cytokine Growth Factor Rev, 21, 425-34.
-
(2010)
Cytokine Growth Factor Rev
, vol.21
, pp. 425-434
-
-
Hirahara, K.1
Ghoreschi, K.2
Laurence, A.3
-
47
-
-
84859602743
-
Role of IL-17A in the development of colitis-associated cancer
-
Hyun YS, Han DS, Lee AR, et al (2012). Role of IL-17A in the development of colitis-associated cancer. Carcinogenesis, 33, 931-6.
-
(2012)
Carcinogenesis
, vol.33
, pp. 931-936
-
-
Hyun, Y.S.1
Han, D.S.2
Lee, A.R.3
-
48
-
-
77955992756
-
STAT3 activation of miR-21 and miR-181b-1 via PTEN and CYLD are part of the epigenetic switch linking inflammation to cancer
-
Iliopoulos D, Jaeger SA, Hirsch HA, et al (2010). STAT3 activation of miR-21 and miR-181b-1 via PTEN and CYLD are part of the epigenetic switch linking inflammation to cancer. Mol Cell, 39, 493-506.
-
(2010)
Mol Cell
, vol.39
, pp. 493-506
-
-
Iliopoulos, D.1
Jaeger, S.A.2
Hirsch, H.A.3
-
49
-
-
3042599473
-
Inflammation and cancer IV. Colorectal cancer in inflammatory bowel disease: the role of inflammation
-
Itzkowitz SH, Yio X (2004). Inflammation and cancer IV. Colorectal cancer in inflammatory bowel disease: the role of inflammation. Am J Physiol Gastrointest Liver Physiol, 287, 7-17.
-
(2004)
Am J Physiol Gastrointest Liver Physiol
, vol.287
, pp. 7-17
-
-
Itzkowitz, S.H.1
Yio, X.2
-
50
-
-
33748588423
-
The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells
-
Ivanov, II, McKenzie BS, Zhou L, et al (2006). The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell, 126, 1121-33.
-
(2006)
Cell
, vol.126
, pp. 1121-1133
-
-
Ivanov, I.I.1
McKenzie, B.S.2
Zhou, L.3
-
51
-
-
18544404101
-
Control of endodermal endocrine development by Hes-1
-
Jensen J, Pedersen EE, Galante P, et al (2000). Control of endodermal endocrine development by Hes-1. Nat Genet, 24, 36-44.
-
(2000)
Nat Genet
, vol.24
, pp. 36-44
-
-
Jensen, J.1
Pedersen, E.E.2
Galante, P.3
-
52
-
-
84885599457
-
Non-canonical Notch signaling activates IL-6/JAK/STAT signaling in breast tumor cells and is controlled by p53 and IKKalpha/IKKbeta
-
Jin S, Mutvei AP, Chivukula IV, et al (2012). Non-canonical Notch signaling activates IL-6/JAK/STAT signaling in breast tumor cells and is controlled by p53 and IKKalpha/IKKbeta. Oncogene, 26, 517.
-
(2012)
Oncogene
, vol.26
, pp. 517
-
-
Jin, S.1
Mutvei, A.P.2
Chivukula, I.V.3
-
53
-
-
44149095198
-
Radiosensitization of melanoma cells through combined inhibition of protein regulators of cell survival
-
Johnson GE, Ivanov VN, Hei TK (2008). Radiosensitization of melanoma cells through combined inhibition of protein regulators of cell survival. Apoptosis, 13, 790-802.
-
(2008)
Apoptosis
, vol.13
, pp. 790-802
-
-
Johnson, G.E.1
Ivanov, V.N.2
Hei, T.K.3
-
54
-
-
3543093971
-
Mechanisms of natural tolerance in the intestine: implications for inflammatory bowel disease
-
Jump RL, Levine AD (2004). Mechanisms of natural tolerance in the intestine: implications for inflammatory bowel disease. Inflamm Bowel Dis, 10, 462-78.
-
(2004)
Inflamm Bowel Dis
, vol.10
, pp. 462-478
-
-
Jump, R.L.1
Levine, A.D.2
-
55
-
-
68049106295
-
Homeostatic (IL-7) and effector (IL-17) cytokines as distinct but complementary target for an optimal therapeutic strategy in inflammatory bowel disease
-
Kanai T, Nemoto Y, Kamada N, et al (2009). Homeostatic (IL-7) and effector (IL-17) cytokines as distinct but complementary target for an optimal therapeutic strategy in inflammatory bowel disease. Curr Opin Gastroenterol, 25, 306-13.
-
(2009)
Curr Opin Gastroenterol
, vol.25
, pp. 306-313
-
-
Kanai, T.1
Nemoto, Y.2
Kamada, N.3
-
56
-
-
84879292123
-
O-1602, an atypical cannabinoid, inhibits tumor growth in colitis-associated colon cancer through multiple mechanisms
-
Kargl J, Haybaeck J, Stancic A, et al (2013). O-1602, an atypical cannabinoid, inhibits tumor growth in colitis-associated colon cancer through multiple mechanisms. J Mol Med, 91, 449-58.
-
(2013)
J Mol Med
, vol.91
, pp. 449-458
-
-
Kargl, J.1
Haybaeck, J.2
Stancic, A.3
-
57
-
-
25844459154
-
NF-kappaB: linking inflammation and immunity to cancer development and progression
-
Karin M, Greten FR (2005). NF-kappaB: linking inflammation and immunity to cancer development and progression. Nat Rev Immunol, 5, 749-759.
-
(2005)
Nat Rev Immunol
, vol.5
, pp. 749-759
-
-
Karin, M.1
Greten, F.R.2
-
58
-
-
84869224215
-
Prohibitin attenuates colitis-associated tumorigenesis in mice by modulating p53 and STAT3 apoptotic responses
-
Kathiria AS, Neumann WL, Rhees J, et al (2012). Prohibitin attenuates colitis-associated tumorigenesis in mice by modulating p53 and STAT3 apoptotic responses. Cancer Res, 72, 5778-89.
-
(2012)
Cancer Res
, vol.72
, pp. 5778-5789
-
-
Kathiria, A.S.1
Neumann, W.L.2
Rhees, J.3
-
59
-
-
77951679964
-
Silibinin suppresses growth of human colorectal carcinoma SW480 cells in culture and xenograft through down-regulation of beta-catenin-dependent signaling
-
Kaur M, Velmurugan B, Tyagi A, et al (2010). Silibinin suppresses growth of human colorectal carcinoma SW480 cells in culture and xenograft through down-regulation of beta-catenin-dependent signaling. Neoplasia, 12, 415-24.
-
(2010)
Neoplasia
, vol.12
, pp. 415-424
-
-
Kaur, M.1
Velmurugan, B.2
Tyagi, A.3
-
60
-
-
33645513412
-
Signal transducers and activators of transcription 3 activation is involved in nuclear accumulation of beta-catenin in colorectal cancer
-
Kawada M, Seno H, Uenoyama Y, Set al (2006). Signal transducers and activators of transcription 3 activation is involved in nuclear accumulation of beta-catenin in colorectal cancer. Cancer Res, 66, 2913-7.
-
(2006)
Cancer Res
, vol.66
, pp. 2913-2917
-
-
Kawada, M.1
Seno, H.2
Uenoyama, Y.S.3
-
61
-
-
33745489431
-
Oxidative and nitrative DNA damage in animals and patients with inflammatory diseases in relation to inflammation-related carcinogenesis
-
Kawanishi S, Hiraku Y, Pinlaor S, et al (2006). Oxidative and nitrative DNA damage in animals and patients with inflammatory diseases in relation to inflammation-related carcinogenesis. Biol Chem, 387, 365-72.
-
(2006)
Biol Chem
, vol.387
, pp. 365-372
-
-
Kawanishi, S.1
Hiraku, Y.2
Pinlaor, S.3
-
62
-
-
38149083478
-
Regulation of interleukin-6-induced hepatic insulin resistance by mammalian target of rapamycin through the STAT3-SOCS3 pathway
-
Kim JH, Kim JE, Liu HY, et al (2008). Regulation of interleukin-6-induced hepatic insulin resistance by mammalian target of rapamycin through the STAT3-SOCS3 pathway. J Biol Chem, 283, 708-15.
-
(2008)
J Biol Chem
, vol.283
, pp. 708-715
-
-
Kim, J.H.1
Kim, J.E.2
Liu, H.Y.3
-
63
-
-
56549104968
-
IL23 differentially regulates the Th1/Th17 balance in ulcerative colitis and Crohn's disease
-
Kobayashi T, Okamoto S, Hisamatsu T, et al (2008). IL23 differentially regulates the Th1/Th17 balance in ulcerative colitis and Crohn's disease. Gut, 57, 1682-9.
-
(2008)
Gut
, vol.57
, pp. 1682-1689
-
-
Kobayashi, T.1
Okamoto, S.2
Hisamatsu, T.3
-
64
-
-
0030975671
-
Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/-colon carcinoma
-
Korinek V, Barker N, Morin PJ, et al (1997). Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/-colon carcinoma. Science, 275, 1784-7.
-
(1997)
Science
, vol.275
, pp. 1784-1787
-
-
Korinek, V.1
Barker, N.2
Morin, P.J.3
-
65
-
-
61949463911
-
IL-17 and Th17 Cells
-
Korn T, Bettelli E, Oukka M, et al (2009). IL-17 and Th17 Cells. Annu Rev Immunol, 27, 485-517.
-
(2009)
Annu Rev Immunol
, vol.27
, pp. 485-517
-
-
Korn, T.1
Bettelli, E.2
Oukka, M.3
-
66
-
-
39449087338
-
Th17 cells: effector T cells with inflammatory properties
-
Korn T, Oukka M, Kuchroo V, et al (2007). Th17 cells: effector T cells with inflammatory properties. Semin Immunol, 19, 362-71.
-
(2007)
Semin Immunol
, vol.19
, pp. 362-371
-
-
Korn, T.1
Oukka, M.2
Kuchroo, V.3
-
67
-
-
78651293534
-
miRBase: integrating microRNA annotation and deep-sequencing data
-
Kozomara A, Griffiths-Jones S (2011). miRBase: integrating microRNA annotation and deep-sequencing data. Nucleic Acids Res, 39, 30.
-
(2011)
Nucleic Acids Res
, vol.39
, pp. 30
-
-
Kozomara, A.1
Griffiths-Jones, S.2
-
68
-
-
47849098044
-
Inflammation: gearing the journey to cancer
-
Kundu JK, Surh YJ (2008). Inflammation: gearing the journey to cancer. Mutat Res, 659, 15-30.
-
(2008)
Mutat Res
, vol.659
, pp. 15-30
-
-
Kundu, J.K.1
Surh, Y.J.2
-
69
-
-
23444452377
-
Expression of p-STAT3 in human colorectal adenocarcinoma and adenoma; correlation with clinicopathological factors
-
Kusaba T, Nakayama T, Yamazumi K, et al (2005). Expression of p-STAT3 in human colorectal adenocarcinoma and adenoma; correlation with clinicopathological factors. J Clin Pathol, 58, 833-8.
-
(2005)
J Clin Pathol
, vol.58
, pp. 833-838
-
-
Kusaba, T.1
Nakayama, T.2
Yamazumi, K.3
-
70
-
-
33847406439
-
Activation of STAT3 is a marker of poor prognosis in human colorectal cancer
-
Kusaba T, Nakayama T, Yamazumi K, et al (2006). Activation of STAT3 is a marker of poor prognosis in human colorectal cancer. Oncol Rep, 15, 1445-51.
-
(2006)
Oncol Rep
, vol.15
, pp. 1445-1451
-
-
Kusaba, T.1
Nakayama, T.2
Yamazumi, K.3
-
71
-
-
53449086211
-
Risk for colorectal cancer in ulcerative colitis: changes, causes and management strategies
-
Lakatos PL, Lakatos L (2008). Risk for colorectal cancer in ulcerative colitis: changes, causes and management strategies. World J Gastroenterol, 14, 3937-47.
-
(2008)
World J Gastroenterol
, vol.14
, pp. 3937-3947
-
-
Lakatos, P.L.1
Lakatos, L.2
-
72
-
-
33846981871
-
STAT3 mRNA and protein expression in colorectal cancer: effects on STAT3-inducible targets linked to cell survival and proliferation
-
Lassmann S, Schuster I, Walch A, et al (2007). STAT3 mRNA and protein expression in colorectal cancer: effects on STAT3-inducible targets linked to cell survival and proliferation. J Clin Pathol, 60, 173-9.
-
(2007)
J Clin Pathol
, vol.60
, pp. 173-179
-
-
Lassmann, S.1
Schuster, I.2
Walch, A.3
-
73
-
-
63249092765
-
Persistently activated Stat3 maintains constitutive NF-kappaB activity in tumors
-
Lee H, Herrmann A, Deng JH, et al (2009). Persistently activated Stat3 maintains constitutive NF-kappaB activity in tumors. Cancer Cell, 15, 283-93.
-
(2009)
Cancer Cell
, vol.15
, pp. 283-293
-
-
Lee, H.1
Herrmann, A.2
Deng, J.H.3
-
74
-
-
78650686123
-
MicroRNA regulation of core apoptosis pathways in cancer
-
Lima RT, Busacca S, Almeida GM, et al (2011). MicroRNA regulation of core apoptosis pathways in cancer. Eur J Cancer, 47, 163-74.
-
(2011)
Eur J Cancer
, vol.47
, pp. 163-174
-
-
Lima, R.T.1
Busacca, S.2
Almeida, G.M.3
-
75
-
-
77955520465
-
A novel small molecule inhibits STAT3 phosphorylation and DNA binding activity and exhibits potent growth suppressive activity in human cancer cells
-
Lin L, Deangelis S, Foust E, et al (2010). A novel small molecule inhibits STAT3 phosphorylation and DNA binding activity and exhibits potent growth suppressive activity in human cancer cells. Mol Cancer, 9, 217.
-
(2010)
Mol Cancer
, vol.9
, pp. 217
-
-
Lin, L.1
Deangelis, S.2
Foust, E.3
-
76
-
-
84855876635
-
STAT3 signaling pathway is necessary for cell survival and tumorsphere forming capacity in ALDH(+)/CD133(+) stem cell-like human colon cancer cells
-
Lin L, Fuchs J, Li C, et al (2011). STAT3 signaling pathway is necessary for cell survival and tumorsphere forming capacity in ALDH(+)/CD133(+) stem cell-like human colon cancer cells. Biochem Biophys Res Commun, 416, 246-51.
-
(2011)
Biochem Biophys Res Commun
, vol.416
, pp. 246-251
-
-
Lin, L.1
Fuchs, J.2
Li, C.3
-
77
-
-
13944249521
-
Cytokine overexpression and constitutive NFkappaB in cancer
-
Lu T, Stark GR (2004). Cytokine overexpression and constitutive NFkappaB in cancer. Cell Cycle, 3, 1114-7.
-
(2004)
Cell Cycle
, vol.3
, pp. 1114-1117
-
-
Lu, T.1
Stark, G.R.2
-
78
-
-
47949096781
-
Cancer-related inflammation
-
Mantovani A, Allavena P, Sica A, et al (2008). Cancer-related inflammation. Nature, 454, 436-44.
-
(2008)
Nature
, vol.454
, pp. 436-444
-
-
Mantovani, A.1
Allavena, P.2
Sica, A.3
-
79
-
-
70049105092
-
Intestinal effector T cells in health and disease
-
Maynard CL, Weaver CT (2009). Intestinal effector T cells in health and disease. Immunity, 31, 389-400.
-
(2009)
Immunity
, vol.31
, pp. 389-400
-
-
Maynard, C.L.1
Weaver, C.T.2
-
80
-
-
41549134361
-
Th17 cell differentiation: the long and winding road
-
McGeachy MJ, Cua DJ (2008). Th17 cell differentiation: the long and winding road. Immunity, 28, 445-53.
-
(2008)
Immunity
, vol.28
, pp. 445-453
-
-
McGeachy, M.J.1
Cua, D.J.2
-
82
-
-
0028796711
-
Soluble interleukin-6 receptors in inflammatory bowel disease: relation to circulating interleukin-6
-
Mitsuyama K, Toyonaga A, Sasaki E, et al (1995). Soluble interleukin-6 receptors in inflammatory bowel disease: relation to circulating interleukin-6. Gut, 36, 45-9.
-
(1995)
Gut
, vol.36
, pp. 45-49
-
-
Mitsuyama, K.1
Toyonaga, A.2
Sasaki, E.3
-
83
-
-
15744390341
-
Interleukin-21 enhances T-helper cell type I signaling and interferon-gamma production in Crohn's disease
-
Monteleone G, Monteleone I, Fina D, et al (2005). Interleukin-21 enhances T-helper cell type I signaling and interferon-gamma production in Crohn's disease. Gastroenterology, 128, 687-94.
-
(2005)
Gastroenterology
, vol.128
, pp. 687-694
-
-
Monteleone, G.1
Monteleone, I.2
Fina, D.3
-
84
-
-
34548190038
-
IL-6 signaling in inflammatory bowel disease: pathophysiological role and clinical relevance
-
Mudter J, Neurath MF (2007). IL-6 signaling in inflammatory bowel disease: pathophysiological role and clinical relevance. Inflamm Bowel Dis, 13, 1016-23.
-
(2007)
Inflamm Bowel Dis
, vol.13
, pp. 1016-1023
-
-
Mudter, J.1
Neurath, M.F.2
-
85
-
-
33947301294
-
Immune dysfunction in inflammatory bowel disease
-
Neuman MG (2007). Immune dysfunction in inflammatory bowel disease. Transl Res, 149, 173-86.
-
(2007)
Transl Res
, vol.149
, pp. 173-186
-
-
Neuman, M.G.1
-
86
-
-
79958270237
-
miRNA expression in colon polyps provides evidence for a multihit model of colon cancer
-
Oberg AL, French AJ, Sarver AL, et al (2011). miRNA expression in colon polyps provides evidence for a multihit model of colon cancer. PLoS ONE, 6, 620465.
-
(2011)
PLoS ONE
, vol.6
, pp. 620465
-
-
Oberg, A.L.1
French, A.J.2
Sarver, A.L.3
-
87
-
-
55049118394
-
Interleukin-17 promotes autoimmunity by triggering a positive-feedback loop via interleukin-6 induction
-
Ogura H, Murakami M, Okuyama Y, et al (2008). Interleukin-17 promotes autoimmunity by triggering a positive-feedback loop via interleukin-6 induction. Immunity, 29, 628-36.
-
(2008)
Immunity
, vol.29
, pp. 628-636
-
-
Ogura, H.1
Murakami, M.2
Okuyama, Y.3
-
88
-
-
0029942998
-
Promotion of colorectal neoplasia in experimental murine ulcerative colitis
-
Okayasu I, Ohkusa T, Kajiura K, et al (1996). Promotion of colorectal neoplasia in experimental murine ulcerative colitis. Gut, 39, 87-92.
-
(1996)
Gut
, vol.39
, pp. 87-92
-
-
Okayasu, I.1
Ohkusa, T.2
Kajiura, K.3
-
89
-
-
84880255103
-
Potential Targets for Prevention of Colorectal Cancer: a Focus on PI3K/Akt/mTOR and Wnt Pathways
-
Pandurangan AK (2013). Potential Targets for Prevention of Colorectal Cancer: a Focus on PI3K/Akt/mTOR and Wnt Pathways. Asian Pac J Cancer Prev, 14, 2201-5.
-
(2013)
Asian Pac J Cancer Prev
, vol.14
, pp. 2201-2205
-
-
Pandurangan, A.K.1
-
90
-
-
84890331521
-
Luteolin, a bioflavonoid inhibits Azoxymethane-induced colorectal cancer through Nrf2 signaling
-
Pandurangan AK, Ananda Sadagopan SK, Dharmalingam P et al (2013). Luteolin, a bioflavonoid inhibits Azoxymethane-induced colorectal cancer through Nrf2 signaling. Toxicol Mech Methods, 24, 13-20.
-
(2013)
Toxicol Mech Methods
, vol.24
, pp. 13-20
-
-
Pandurangan, A.K.1
Ananda Sadagopan, S.K.2
Dharmalingam, P.3
-
91
-
-
84873027164
-
Effect of luteolin on the levels of glycoproteins during azoxymethane-induced colon carcinogenesis in mice
-
Pandurangan AK, Dharmalingam P, Ananda Sadagopan SK, et al (2012). Effect of luteolin on the levels of glycoproteins during azoxymethane-induced colon carcinogenesis in mice. Asian Pac J Cancer Prev, 13, 1569-73.
-
(2012)
Asian Pac J Cancer Prev
, vol.13
, pp. 1569-1573
-
-
Pandurangan, A.K.1
Dharmalingam, P.2
Ananda Sadagopan, S.K.3
-
92
-
-
31444434449
-
mTOR signaling: implications for cancer and anticancer therapy
-
Petroulakis E, Mamane Y, Le Bacquer O,et al (2006). mTOR signaling: implications for cancer and anticancer therapy. Br J Cancer, 94, 195-9.
-
(2006)
Br J Cancer
, vol.94
, pp. 195-199
-
-
Petroulakis, E.1
Mamane, Y.2
Le Bacquer, O.3
-
93
-
-
4644324186
-
NF-kappaB functions as a tumour promoter in inflammation-associated cancer
-
Pikarsky E, Porat RM, Stein I, et al (2004). NF-kappaB functions as a tumour promoter in inflammation-associated cancer. Nature, 431, 461-6.
-
(2004)
Nature
, vol.431
, pp. 461-466
-
-
Pikarsky, E.1
Porat, R.M.2
Stein, I.3
-
94
-
-
3242804439
-
Studies with the azoxymethane-rat preclinical model for assessing colon tumor development and chemoprevention
-
Reddy BS (2004). Studies with the azoxymethane-rat preclinical model for assessing colon tumor development and chemoprevention. Environ Mol Mutagen, 44, 26-35.
-
(2004)
Environ Mol Mutagen
, vol.44
, pp. 26-35
-
-
Reddy, B.S.1
-
95
-
-
59049088446
-
Activation of Notch signaling in human colon adenocarcinoma
-
Reedijk M, Odorcic S, Zhang H, et al (2008). Activation of Notch signaling in human colon adenocarcinoma. Int J Oncol, 33, 1223-9.
-
(2008)
Int J Oncol
, vol.33
, pp. 1223-1229
-
-
Reedijk, M.1
Odorcic, S.2
Zhang, H.3
-
96
-
-
33745260930
-
AKT activation in human glioblastomas enhances proliferation via TSC2 and S6 kinase signaling
-
Riemenschneider MJ, Betensky RA, Pasedag SM, et al (2006). AKT activation in human glioblastomas enhances proliferation via TSC2 and S6 kinase signaling. Cancer Res, 66, 5618-23.
-
(2006)
Cancer Res
, vol.66
, pp. 5618-5623
-
-
Riemenschneider, M.J.1
Betensky, R.A.2
Pasedag, S.M.3
-
97
-
-
21544483506
-
Functional and therapeutic significance of Akt deregulation in malignant melanoma
-
Robertson GP (2005). Functional and therapeutic significance of Akt deregulation in malignant melanoma. Cancer Metastasis Rev, 24, 273-85.
-
(2005)
Cancer Metastasis Rev
, vol.24
, pp. 273-285
-
-
Robertson, G.P.1
-
98
-
-
68449085757
-
Interleukin-6 trans-signaling and colonic cancer associated with inflammatory bowel disease
-
Rose-John S, Mitsuyama K, Matsumoto S, et al (2009). Interleukin-6 trans-signaling and colonic cancer associated with inflammatory bowel disease. Curr Pharm Des, 15, 2095-103.
-
(2009)
Curr Pharm Des
, vol.15
, pp. 2095-2103
-
-
Rose-John, S.1
Mitsuyama, K.2
Matsumoto, S.3
-
99
-
-
34848813857
-
Correlation of IL-8 with induction, progression and metastatic potential of colorectal cancer
-
Rubie C, Frick VO, Pfeil S, et al (2007). Correlation of IL-8 with induction, progression and metastatic potential of colorectal cancer. World J Gastroenterol, 13, 4996-5002.
-
(2007)
World J Gastroenterol
, vol.13
, pp. 4996-5002
-
-
Rubie, C.1
Frick, V.O.2
Pfeil, S.3
-
100
-
-
65249141108
-
Constitutive NF-kappaB activation in colorectal carcinoma plays a key role in angiogenesis, promoting tumor growth
-
Sakamoto K, Maeda S, Hikiba Y, et al (2009). Constitutive NF-kappaB activation in colorectal carcinoma plays a key role in angiogenesis, promoting tumor growth. Clin Cancer Res, 15, 2248-58.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 2248-2258
-
-
Sakamoto, K.1
Maeda, S.2
Hikiba, Y.3
-
101
-
-
33745775434
-
Mechanisms of disease: pathogenesis of Crohn's disease and ulcerative colitis
-
Sartor RB (2006). Mechanisms of disease: pathogenesis of Crohn's disease and ulcerative colitis. Nat Clin Pract Gastroenterol Hepatol, 3, 390-407.
-
(2006)
Nat Clin Pract Gastroenterol Hepatol
, vol.3
, pp. 390-407
-
-
Sartor, R.B.1
-
102
-
-
71549125896
-
Human colon cancer profiles show differential microRNA expression depending on mismatch repair status and are characteristic of undifferentiated proliferative states
-
Sarver AL, French AJ, Borralho PM, et al (2009). Human colon cancer profiles show differential microRNA expression depending on mismatch repair status and are characteristic of undifferentiated proliferative states. BMC Cancer, 9, 401.
-
(2009)
BMC Cancer
, vol.9
, pp. 401
-
-
Sarver, A.L.1
French, A.J.2
Borralho, P.M.3
-
103
-
-
0037862006
-
Unravelling the activation mechanisms of protein kinase B/Akt
-
Scheid MP, Woodgett JR (2003). Unravelling the activation mechanisms of protein kinase B/Akt. FEBS Lett, 546, 108-12.
-
(2003)
FEBS Lett
, vol.546
, pp. 108-112
-
-
Scheid, M.P.1
Woodgett, J.R.2
-
104
-
-
33646228126
-
Interleukin-6 trans-signalling in chronic inflammation and cancer
-
Scheller J, Ohnesorge N, Rose-John S (2006). Interleukin-6 trans-signalling in chronic inflammation and cancer. Scand J Immunol, 63, 321-9.
-
(2006)
Scand J Immunol
, vol.63
, pp. 321-329
-
-
Scheller, J.1
Ohnesorge, N.2
Rose-John, S.3
-
105
-
-
33645939916
-
Cytokines, NF-kappaB, microenvironment, intestinal inflammation and cancer
-
Schottelius AJ, Dinter H (2006). Cytokines, NF-kappaB, microenvironment, intestinal inflammation and cancer. Cancer Treat Res, 130, 67-87.
-
(2006)
Cancer Treat Res
, vol.130
, pp. 67-87
-
-
Schottelius, A.J.1
Dinter, H.2
-
106
-
-
0032574993
-
Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain
-
Schroeter EH, Kisslinger JA, Kopan Rn (1998). Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain. Nature, 393, 382-6.
-
(1998)
Nature
, vol.393
, pp. 382-386
-
-
Schroeter, E.H.1
Kisslinger, J.A.2
Kopan, R.N.3
-
107
-
-
15744378607
-
Continuous cytokine exposure of colonic epithelial cells induces DNA damage
-
Seidelin JB, Nielsen OH (2005). Continuous cytokine exposure of colonic epithelial cells induces DNA damage. Eur J Gastroenterol Hepatol, 17, 363-9.
-
(2005)
Eur J Gastroenterol Hepatol
, vol.17
, pp. 363-369
-
-
Seidelin, J.B.1
Nielsen, O.H.2
-
108
-
-
84862016307
-
Apigenin induces apoptosis via extrinsic pathway, inducing p53 and inhibiting STAT3 and NFkappaB signaling in HER2-overexpressing breast cancer cells
-
Seo HS, Choi HS, Kim SR, et al (2012). Apigenin induces apoptosis via extrinsic pathway, inducing p53 and inhibiting STAT3 and NFkappaB signaling in HER2-overexpressing breast cancer cells. Mol Cell Biochem, 366, 319-34.
-
(2012)
Mol Cell Biochem
, vol.366
, pp. 319-334
-
-
Seo, H.S.1
Choi, H.S.2
Kim, S.R.3
-
109
-
-
84887444153
-
Prophylactic Inositol Hexaphosphate (IP6) inhibits colon cancer through involvement of Wnt/β-catenin and COX-2 pathway
-
Shafie NH, Mohd Esa N, Ithnin H, et al (2013). Prophylactic Inositol Hexaphosphate (IP6) inhibits colon cancer through involvement of Wnt/β-catenin and COX-2 pathway. BioMed Res Int, 2013, 681027.
-
(2013)
BioMed Res Int
, vol.2013
, pp. 681027
-
-
Shafie, N.H.1
Mohd Esa, N.2
Ithnin, H.3
-
110
-
-
79960009770
-
Ursolic acid inhibits multiple cell survival pathways leading to suppression of growth of prostate cancer xenograft in nude mice
-
Shanmugam MK, Rajendran P, Li F, et al (2011). Ursolic acid inhibits multiple cell survival pathways leading to suppression of growth of prostate cancer xenograft in nude mice. J Mol Med, 89, 713-27.
-
(2011)
J Mol Med
, vol.89
, pp. 713-727
-
-
Shanmugam, M.K.1
Rajendran, P.2
Li, F.3
-
111
-
-
0031868440
-
Nuclear translocation of beta-catenin in hereditary and carcinogen-induced intestinal adenomas
-
Sheng H, Shao J, Williams CS, et al (1998). Nuclear translocation of beta-catenin in hereditary and carcinogen-induced intestinal adenomas. Carcinogenesis, 19, 543-9.
-
(1998)
Carcinogenesis
, vol.19
, pp. 543-549
-
-
Sheng, H.1
Shao, J.2
Williams, C.S.3
-
112
-
-
0026082126
-
Metabolism of azoxymethane, methylazoxymethanol and N-nitrosodimethylamine by cytochrome P450IIE1
-
Sohn OS, Ishizaki H, Yang CS, et al (1991). Metabolism of azoxymethane, methylazoxymethanol and N-nitrosodimethylamine by cytochrome P450IIE1. Carcinogenesis, 12, 127-31.
-
(1991)
Carcinogenesis
, vol.12
, pp. 127-131
-
-
Sohn, O.S.1
Ishizaki, H.2
Yang, C.S.3
-
113
-
-
77954565039
-
Inflammation-mediated promotion of invasion and metastasis
-
Solinas G, Marchesi F, Garlanda C, et al (2010). Inflammation-mediated promotion of invasion and metastasis. Cancer Metastasis Rev, 29, 243-8.
-
(2010)
Cancer Metastasis Rev
, vol.29
, pp. 243-248
-
-
Solinas, G.1
Marchesi, F.2
Garlanda, C.3
-
114
-
-
0032521433
-
Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer
-
Sparks AB, Morin PJ, Vogelstein B, et al (1998). Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer. Cancer Res, 58, 1130-4.
-
(1998)
Cancer Res
, vol.58
, pp. 1130-1134
-
-
Sparks, A.B.1
Morin, P.J.2
Vogelstein, B.3
-
115
-
-
33846966636
-
A brief history of T(H)17, the first major revision in the T(H)1/T(H)2 hypothesis of T cell-mediated tissue damage
-
Steinman L (2007). A brief history of T(H)17, the first major revision in the T(H)1/T(H)2 hypothesis of T cell-mediated tissue damage. Nat Med, 13, 139-45.
-
(2007)
Nat Med
, vol.13
, pp. 139-145
-
-
Steinman, L.1
-
116
-
-
80055105733
-
Involvement of interleukin-21 in the regulation of colitis-associated colon cancer
-
Stolfi C, Rizzo A, Franze E, et al (2011). Involvement of interleukin-21 in the regulation of colitis-associated colon cancer. J Exp Med, 208, 2279-90.
-
(2011)
J Exp Med
, vol.208
, pp. 2279-2290
-
-
Stolfi, C.1
Rizzo, A.2
Franze, E.3
-
117
-
-
0032958592
-
Frequent mutations of the rat beta-catenin gene in colon cancers induced by methylazoxymethanol acetate plus 1-hydroxyanthraquinone
-
Suzui M, Ushijima T, Dashwood RH, et al (1999). Frequent mutations of the rat beta-catenin gene in colon cancers induced by methylazoxymethanol acetate plus 1-hydroxyanthraquinone. Mol Carcinog, 24, 232-7.
-
(1999)
Mol Carcinog
, vol.24
, pp. 232-237
-
-
Suzui, M.1
Ushijima, T.2
Dashwood, R.H.3
-
118
-
-
0035910753
-
CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestinal inflammation
-
Suzuki A, Hanada T, Mitsuyama K, et al (2001). CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestinal inflammation. J Exp Med, 193, 471-81.
-
(2001)
J Exp Med
, vol.193
, pp. 471-481
-
-
Suzuki, A.1
Hanada, T.2
Mitsuyama, K.3
-
119
-
-
0031984227
-
Beta-catenin is frequently mutated and demonstrates altered cellular location in azoxymethane-induced rat colon tumors
-
Takahashi M, Fukuda K, Sugimura T, et al (1998). Beta-catenin is frequently mutated and demonstrates altered cellular location in azoxymethane-induced rat colon tumors. Cancer Res, 58, 42-6.
-
(1998)
Cancer Res
, vol.58
, pp. 42-46
-
-
Takahashi, M.1
Fukuda, K.2
Sugimura, T.3
-
120
-
-
67349245787
-
New insights into the aetiology of colorectal cancer from genome-wide association studies
-
Tenesa A, Dunlop MG (2009). New insights into the aetiology of colorectal cancer from genome-wide association studies. Nat Rev Genet, 10, 353-8.
-
(2009)
Nat Rev Genet
, vol.10
, pp. 353-358
-
-
Tenesa, A.1
Dunlop, M.G.2
-
121
-
-
0033119801
-
Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells
-
Tetsu O, McCormick F (1999). Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature, 398, 422-6.
-
(1999)
Nature
, vol.398
, pp. 422-426
-
-
Tetsu, O.1
McCormick, F.2
-
122
-
-
84873328655
-
mTORC1 inhibition restricts inflammation-associated gastrointestinal tumorigenesis in mice
-
Thiem S, Pierce TP, Palmieri M, et al (2013). mTORC1 inhibition restricts inflammation-associated gastrointestinal tumorigenesis in mice. J Clin Invest, 123, 767-81.
-
(2013)
J Clin Invest
, vol.123
, pp. 767-781
-
-
Thiem, S.1
Pierce, T.P.2
Palmieri, M.3
-
123
-
-
78751574129
-
Aspirin promotes apoptosis in a murine model of colorectal cancer by mechanisms involving downregulation of IL-6-STAT3 signaling pathway
-
Tian Y, Ye Y, Gao W, et al (2011). Aspirin promotes apoptosis in a murine model of colorectal cancer by mechanisms involving downregulation of IL-6-STAT3 signaling pathway. Int J Colorectal Dis, 26, 13-22.
-
(2011)
Int J Colorectal Dis
, vol.26
, pp. 13-22
-
-
Tian, Y.1
Ye, Y.2
Gao, W.3
-
124
-
-
62349117597
-
Growth inhibition and regression of lung tumors by silibinin: modulation of angiogenesis by macrophage-associated cytokines and nuclear factor-kappaB and signal transducers and activators of transcription 3
-
Tyagi A, Singh RP, Ramasamy K, et al (2009). Growth inhibition and regression of lung tumors by silibinin: modulation of angiogenesis by macrophage-associated cytokines and nuclear factor-kappaB and signal transducers and activators of transcription 3. Cancer Prev Res, 2, 74-83.
-
(2009)
Cancer Prev Res
, vol.2
, pp. 74-83
-
-
Tyagi, A.1
Singh, R.P.2
Ramasamy, K.3
-
125
-
-
79955564023
-
Intestinal inflammation and cancer
-
Ullman TA, Itzkowitz SH (2011). Intestinal inflammation and cancer. Gastroenterology, 140, 1807-16.
-
(2011)
Gastroenterology
, vol.140
, pp. 1807-1816
-
-
Ullman, T.A.1
Itzkowitz, S.H.2
-
126
-
-
0033835921
-
Frequently relapsing Crohn's disease is characterized by persistent elevation in interleukin-6 and soluble interleukin-2 receptor serum levels during remission
-
Van Kemseke C, Belaiche J, Louis E (2000). Frequently relapsing Crohn's disease is characterized by persistent elevation in interleukin-6 and soluble interleukin-2 receptor serum levels during remission. Int J Colorectal Dis, 15, 206-10.
-
(2000)
Int J Colorectal Dis
, vol.15
, pp. 206-210
-
-
Van Kemseke, C.1
Belaiche, J.2
Louis, E.3
-
127
-
-
84869774410
-
Notch signaling is activated in human hepatocellular carcinoma and induces tumor formation in mice
-
Villanueva A, Alsinet C, Yanger K, et al (2012). Notch signaling is activated in human hepatocellular carcinoma and induces tumor formation in mice. Gastroenterology, 143, 1660-9.
-
(2012)
Gastroenterology
, vol.143
, pp. 1660-1669
-
-
Villanueva, A.1
Alsinet, C.2
Yanger, K.3
-
128
-
-
46649087778
-
Nogo-66 promotes the differentiation of neural progenitors into astroglial lineage cells through mTOR-STAT3 pathway
-
Wang B, Xiao Z, Chen B, et al (2008). Nogo-66 promotes the differentiation of neural progenitors into astroglial lineage cells through mTOR-STAT3 pathway. PLoS ONE, 3, 1856.
-
(2008)
PLoS ONE
, vol.3
, pp. 1856
-
-
Wang, B.1
Xiao, Z.2
Chen, B.3
-
129
-
-
70350743112
-
Triptolide downregulates Rac1 and the JAK/STAT3 pathway and inhibits colitis-related colon cancer progression
-
Wang Z, Jin H, Xu R, et al (2009). Triptolide downregulates Rac1 and the JAK/STAT3 pathway and inhibits colitis-related colon cancer progression. Exp Mol Med, 41, 717-27.
-
(2009)
Exp Mol Med
, vol.41
, pp. 717-727
-
-
Wang, Z.1
Jin, H.2
Xu, R.3
-
130
-
-
0016374178
-
Morphogenesis of chemically induced neoplasms of the colon and small intestine in rats
-
Ward JM (1974). Morphogenesis of chemically induced neoplasms of the colon and small intestine in rats. Lab Invest, 30, 505-13.
-
(1974)
Lab Invest
, vol.30
, pp. 505-513
-
-
Ward, J.M.1
-
131
-
-
0032406715
-
Mechanisms of Wnt signaling in development
-
Wodarz A, Nusse R (1998). Mechanisms of Wnt signaling in development. Annu Rev Cell Dev Biol, 14, 59-88.
-
(1998)
Annu Rev Cell Dev Biol
, vol.14
, pp. 59-88
-
-
Wodarz, A.1
Nusse, R.2
-
132
-
-
53249127054
-
beta-Catenin/TCF pathway upregulates STAT3 expression in human esophageal squamous cell carcinoma
-
Yan S, Zhou C, Zhang W, et al (2008). beta-Catenin/TCF pathway upregulates STAT3 expression in human esophageal squamous cell carcinoma. Cancer Lett, 271, 85-97.
-
(2008)
Cancer Lett
, vol.271
, pp. 85-97
-
-
Yan, S.1
Zhou, C.2
Zhang, W.3
-
133
-
-
84877077775
-
Pterostilbene Exerts Antitumor Activity via the Notch1 Signaling Pathway in Human Lung Adenocarcinoma Cells
-
Yang Y, Yan X, Duan W, et al (2013). Pterostilbene Exerts Antitumor Activity via the Notch1 Signaling Pathway in Human Lung Adenocarcinoma Cells. PLoS ONE, 8, 62652.
-
(2013)
PLoS ONE
, vol.8
, pp. 62652
-
-
Yang, Y.1
Yan, X.2
Duan, W.3
-
134
-
-
1042302005
-
The STATs of cancer-new molecular targets come of age
-
Yu H, Jove R (2004). The STATs of cancer-new molecular targets come of age. Nat Rev Cancer, 4, 97-105.
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 97-105
-
-
Yu, H.1
Jove, R.2
-
135
-
-
33845865825
-
Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment
-
Yu H, Kortylewski M, Pardoll D (2007). Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment. Nat Rev Immunol, 7, 41-51.
-
(2007)
Nat Rev Immunol
, vol.7
, pp. 41-51
-
-
Yu, H.1
Kortylewski, M.2
Pardoll, D.3
-
136
-
-
70350500225
-
STATs in cancer inflammation and immunity: a leading role for STAT3
-
Yu H, Pardoll D, Jove R (2009). STATs in cancer inflammation and immunity: a leading role for STAT3. Nat Rev Cancer, 9, 798-809.
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 798-809
-
-
Yu, H.1
Pardoll, D.2
Jove, R.3
-
137
-
-
59549100166
-
Esophageal adenocarcinoma arising in Barrett esophagus
-
Zhang HY, Spechler SJ, Souza RF (2009). Esophageal adenocarcinoma arising in Barrett esophagus. Cancer Lett, 275, 170-7.
-
(2009)
Cancer Lett
, vol.275
, pp. 170-177
-
-
Zhang, H.Y.1
Spechler, S.J.2
Souza, R.F.3
-
138
-
-
0028349735
-
Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6
-
Zhong Z, Wen Z, Darnell JE, Jr (1994). Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6. Science, 264, 95-8.
-
(1994)
Science
, vol.264
, pp. 95-98
-
-
Zhong, Z.1
Wen, Z.2
Darnell Jr., J.E.3
-
139
-
-
36048963331
-
Activation of the PTEN/mTOR/STAT3 pathway in breast cancer stem-like cells is required for viability and maintenance
-
Zhou J, Wulfkuhle J, Zhang H, et al (2007). Activation of the PTEN/mTOR/STAT3 pathway in breast cancer stem-like cells is required for viability and maintenance. Proc Natl Acad Sci U S A, 104, 16158-63.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 16158-16163
-
-
Zhou, J.1
Wulfkuhle, J.2
Zhang, H.3
-
140
-
-
84877018113
-
Elevated Jagged-1 and Notch-1 expression in high grade and metastatic prostate cancers
-
Zhu H, Zhou X, Redfield S, et al (2013). Elevated Jagged-1 and Notch-1 expression in high grade and metastatic prostate cancers. Am J Transl Res, 5, 368-78.
-
(2013)
Am J Transl Res
, vol.5
, pp. 368-378
-
-
Zhu, H.1
Zhou, X.2
Redfield, S.3
|