-
1
-
-
33846100356
-
A human colon cancer cell capable of initiating tumour growth in immunodeficient mice
-
O'Brien C.A., Pollett A., Gallinger S., Dick J.E. A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature 2007, 445:106-110.
-
(2007)
Nature
, vol.445
, pp. 106-110
-
-
O'Brien, C.A.1
Pollett, A.2
Gallinger, S.3
Dick, J.E.4
-
2
-
-
33846095137
-
Identification and expansion of human colon-cancer-initiating cells
-
Ricci-Vitiani L., Lombardi D.G., Pilozzi E., Biffoni M., Todaro M., Peschle C., De Maria R. Identification and expansion of human colon-cancer-initiating cells. Nature 2007, 445:111-115.
-
(2007)
Nature
, vol.445
, pp. 111-115
-
-
Ricci-Vitiani, L.1
Lombardi, D.G.2
Pilozzi, E.3
Biffoni, M.4
Todaro, M.5
Peschle, C.6
De Maria, R.7
-
3
-
-
45549085634
-
Human colon cancer stem cells: a new paradigm in gastrointestinal oncology
-
Boman B.M., Huang E. Human colon cancer stem cells: a new paradigm in gastrointestinal oncology. J. Clin. Oncol. 2008, 26:2828-2838.
-
(2008)
J. Clin. Oncol.
, vol.26
, pp. 2828-2838
-
-
Boman, B.M.1
Huang, E.2
-
4
-
-
35548974423
-
Identification of stem cells in small intestine and colon by marker gene Lgr5
-
Barker N., van Es J.H., Kuipers J., Kujala P., van den Born M., Cozijnsen M., Haegebarth A., Korving J., Begthel H., Peters P.J., Clevers H. Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature 2007, 449:1003-1007.
-
(2007)
Nature
, vol.449
, pp. 1003-1007
-
-
Barker, N.1
van Es, J.H.2
Kuipers, J.3
Kujala, P.4
van den Born, M.5
Cozijnsen, M.6
Haegebarth, A.7
Korving, J.8
Begthel, H.9
Peters, P.J.10
Clevers, H.11
-
5
-
-
34247600538
-
STAT3 as a central mediator of neoplastic cellular transformation
-
Frank D.A. STAT3 as a central mediator of neoplastic cellular transformation. Cancer Lett. 2007, 251:199-210.
-
(2007)
Cancer Lett.
, vol.251
, pp. 199-210
-
-
Frank, D.A.1
-
6
-
-
35348893870
-
Targeting the cytoplasmic and nuclear functions of signal transducers and activators of transcription 3 for cancer therapy
-
Germain D., Frank D.A. Targeting the cytoplasmic and nuclear functions of signal transducers and activators of transcription 3 for cancer therapy. Clin. Cancer Res. 2007, 13:5665-5669.
-
(2007)
Clin. Cancer Res.
, vol.13
, pp. 5665-5669
-
-
Germain, D.1
Frank, D.A.2
-
7
-
-
0034722896
-
STAT proteins: novel molecular targets for cancer drug discovery
-
Turkson J., Jove R. STAT proteins: novel molecular targets for cancer drug discovery. Oncogene 2002, 19:6613-6626.
-
(2002)
Oncogene
, vol.19
, pp. 6613-6626
-
-
Turkson, J.1
Jove, R.2
-
8
-
-
0242285719
-
STAT proteins: from normal control of cellular events to tumorigenesis
-
Calo V.V., Migliavacca M., Bazan V., Macaluso M., Buscemi M., Gebbia N. STAT proteins: from normal control of cellular events to tumorigenesis. J. Cell. Physiol. 2003, 197:157-168.
-
(2003)
J. Cell. Physiol.
, vol.197
, pp. 157-168
-
-
Calo, V.V.1
Migliavacca, M.2
Bazan, V.3
Macaluso, M.4
Buscemi, M.5
Gebbia, N.6
-
9
-
-
2942741268
-
Constitutive activation of Stat3 signaling pathway in human colorectal carcinoma
-
Ma X., Wang S., Ye Y., Du R., Cui Z., Somsouk M. Constitutive activation of Stat3 signaling pathway in human colorectal carcinoma. World J. Gastroenterol. 2004, 10:1569-1573.
-
(2004)
World J. Gastroenterol.
, vol.10
, pp. 1569-1573
-
-
Ma, X.1
Wang, S.2
Ye, Y.3
Du, R.4
Cui, Z.5
Somsouk, M.6
-
10
-
-
22044437986
-
Persistent STAT3 activation in colon cancer is associated with enhanced cell proliferation and tumor growth
-
Corvinus F.M., Orth C., Moriggl R., Tsareva S.A., Wagner S., Pfitzner E.B., Baus D., Kaufmann R., Huber L.A., Zatloukal K., Beug H., Ohlschlager P., Schutz A., Halbhuber K.J., Friedrich K. Persistent STAT3 activation in colon cancer is associated with enhanced cell proliferation and tumor growth. Neoplasia 2005, 7:545-555.
-
(2005)
Neoplasia
, vol.7
, pp. 545-555
-
-
Corvinus, F.M.1
Orth, C.2
Moriggl, R.3
Tsareva, S.A.4
Wagner, S.5
Pfitzner, E.B.6
Baus, D.7
Kaufmann, R.8
Huber, L.A.9
Zatloukal, K.10
Beug, H.11
Ohlschlager, P.12
Schutz, A.13
Halbhuber, K.J.14
Friedrich, K.15
-
11
-
-
23444452377
-
Expression of p-STAT3 in human colorectal adenocarcinoma and adenoma; correlation with clinicopathological factors
-
Kusaba T., Nakayama T., Yamazumi K., Yakata Y., Yoshizaki A., Nagayasu T., Sekine I. Expression of p-STAT3 in human colorectal adenocarcinoma and adenoma; correlation with clinicopathological factors. J. Clin. Pathol. 2005, 58:833-838.
-
(2005)
J. Clin. Pathol.
, vol.58
, pp. 833-838
-
-
Kusaba, T.1
Nakayama, T.2
Yamazumi, K.3
Yakata, Y.4
Yoshizaki, A.5
Nagayasu, T.6
Sekine, I.7
-
12
-
-
26244463218
-
Constitutive activation of JAK3/STAT3 in colon carcinoma tumors and cell lines: inhibition of JAK3/STAT3 signaling induces apoptosis and cell cycle arrest of colon carcinoma cells
-
Lin Q., Lai R., Chirieac L.R., Li C., Thomazy V.A., Grammatikakis I., Rassidakis G.Z., Zhang W., Fujio Y., Kunisada K., Hamilton S.R., Amin H.M. Constitutive activation of JAK3/STAT3 in colon carcinoma tumors and cell lines: inhibition of JAK3/STAT3 signaling induces apoptosis and cell cycle arrest of colon carcinoma cells. Am. J. Pathol. 2005, 167:969-980.
-
(2005)
Am. J. Pathol.
, vol.167
, pp. 969-980
-
-
Lin, Q.1
Lai, R.2
Chirieac, L.R.3
Li, C.4
Thomazy, V.A.5
Grammatikakis, I.6
Rassidakis, G.Z.7
Zhang, W.8
Fujio, Y.9
Kunisada, K.10
Hamilton, S.R.11
Amin, H.M.12
-
13
-
-
40149094813
-
Inhibition of JAK1, 2/STAT3 signaling induces apoptosis, cell cycle arrest, and reduces tumor cell invasion in colorectal cancer cells
-
Xiong H., Zhang Z., Tian X., Sun D., Liang Q., Zhang Y., Lu R., Chen Y., Fang J. Inhibition of JAK1, 2/STAT3 signaling induces apoptosis, cell cycle arrest, and reduces tumor cell invasion in colorectal cancer cells. Neoplasia 2008, 10:287-297.
-
(2008)
Neoplasia
, vol.10
, pp. 287-297
-
-
Xiong, H.1
Zhang, Z.2
Tian, X.3
Sun, D.4
Liang, Q.5
Zhang, Y.6
Lu, R.7
Chen, Y.8
Fang, J.9
-
14
-
-
34247281958
-
Signal transducer and activator of transcription 3 activation promotes invasive growth of colon carcinomas through matrix metalloproteinase induction
-
Tsareva S., Moriggl R., Corvinus F., Wiederanders B., Schütz A., Kovacic B., Friedrich K. Signal transducer and activator of transcription 3 activation promotes invasive growth of colon carcinomas through matrix metalloproteinase induction. Neoplasia 2007, 9:279-291.
-
(2007)
Neoplasia
, vol.9
, pp. 279-291
-
-
Tsareva, S.1
Moriggl, R.2
Corvinus, F.3
Wiederanders, B.4
Schütz, A.5
Kovacic, B.6
Friedrich, K.7
-
15
-
-
77957591579
-
Targeting breast cancer stem cells
-
Liu S., Wicha M. Targeting breast cancer stem cells. J. Clin. Oncol. 2010, 28:4006-4012.
-
(2010)
J. Clin. Oncol.
, vol.28
, pp. 4006-4012
-
-
Liu, S.1
Wicha, M.2
-
16
-
-
9244241576
-
Identification of human brain tumour initiating cells
-
Singh S.K., Hawkins C., Clarke I.D., Squire J.A., Bayani J., Hide T., Henkelman R.M., Cusimano M.D., Dirks P.B. Identification of human brain tumour initiating cells. Nature 2004, 432:396-401.
-
(2004)
Nature
, vol.432
, pp. 396-401
-
-
Singh, S.K.1
Hawkins, C.2
Clarke, I.D.3
Squire, J.A.4
Bayani, J.5
Hide, T.6
Henkelman, R.M.7
Cusimano, M.D.8
Dirks, P.B.9
-
17
-
-
45749102020
-
- metastatic colon cancer cells initiate tumors
-
- metastatic colon cancer cells initiate tumors. J. Clin. Invest. 2008, 118:2111-2120.
-
(2008)
J. Clin. Invest.
, vol.118
, pp. 2111-2120
-
-
Shmelkov, S.V.1
Butler, J.M.2
Hooper, A.T.3
Hormigo, A.4
Kushner, J.5
Milde, T.6
St Clair, R.7
Baljevic, M.8
White, I.9
Jin, D.K.10
Chadburn, A.11
Murphy, A.J.12
Valenzuela, D.M.13
Gale, N.W.14
Thurston, G.15
Yancopoulos, G.D.16
D'Angelica, M.17
Kemeny, N.18
Lyden, D.19
Rafii, S.20
more..
-
18
-
-
0030024868
-
Induction of cyclophosphamide-resistance by aldehyde-dehydrogenase gene transfer
-
Magni M., Shammah S., Schiro R., Mellado W., Dalla-Favera R., Gianni A.M. Induction of cyclophosphamide-resistance by aldehyde-dehydrogenase gene transfer. Blood 1996, 87:1097-1103.
-
(1996)
Blood
, vol.87
, pp. 1097-1103
-
-
Magni, M.1
Shammah, S.2
Schiro, R.3
Mellado, W.4
Dalla-Favera, R.5
Gianni, A.M.6
-
19
-
-
0032006030
-
Human aldehyde dehydrogenase gene family
-
Yoshida A., Rzhetsky A., Hsu L.C., Chang C. Human aldehyde dehydrogenase gene family. Eur. J. Biochem. 1998, 251:549-557.
-
(1998)
Eur. J. Biochem.
, vol.251
, pp. 549-557
-
-
Yoshida, A.1
Rzhetsky, A.2
Hsu, L.C.3
Chang, C.4
-
20
-
-
65949112714
-
Aldehyde dehydrogenase 1 is a marker for normal and malignant human colonic stem cells (SC) and tracks SC overpopulation during colon tumorigenesis
-
Huang E.H., Hynes M.J., Zhang T., Ginestier C., Dontu G., Appelman H., Fields J.Z., Wicha M.S., Boman B.M. Aldehyde dehydrogenase 1 is a marker for normal and malignant human colonic stem cells (SC) and tracks SC overpopulation during colon tumorigenesis. Cancer Res. 2009, 69:3382-3389.
-
(2009)
Cancer Res.
, vol.69
, pp. 3382-3389
-
-
Huang, E.H.1
Hynes, M.J.2
Zhang, T.3
Ginestier, C.4
Dontu, G.5
Appelman, H.6
Fields, J.Z.7
Wicha, M.S.8
Boman, B.M.9
-
21
-
-
33646028804
-
Molecular targets of dietary agents for prevention and therapy of cancer
-
Aggarwal B., Shishodia S. Molecular targets of dietary agents for prevention and therapy of cancer. Biochem. Pharmacol. 2006, 71:1397-1421.
-
(2006)
Biochem. Pharmacol.
, vol.71
, pp. 1397-1421
-
-
Aggarwal, B.1
Shishodia, S.2
-
22
-
-
44749093175
-
Curcumin: from ancient medicine to current clinical trials
-
Hatcher H., Planalp R., Cho J., Torti F.M., Torti S.V. Curcumin: from ancient medicine to current clinical trials. Cell. Mol. Life Sci. 2008, 65:1631-1652.
-
(2008)
Cell. Mol. Life Sci.
, vol.65
, pp. 1631-1652
-
-
Hatcher, H.1
Planalp, R.2
Cho, J.3
Torti, F.M.4
Torti, S.V.5
-
23
-
-
77950190311
-
Novel STAT3 phosphorylation inhibitors exhibit potent growth-suppressive activity in pancreatic and breast cancer cells
-
Lin L., Hutzen B., Zuo M., Ball S., Deangelis S., Foust E., Pandit B., Ihnat M.A., Shenoy S.S., Kulp S., Li P.K., Li C., Fuchs J., Lin J. Novel STAT3 phosphorylation inhibitors exhibit potent growth-suppressive activity in pancreatic and breast cancer cells. Cancer Res. 2010, 70:2445-2454.
-
(2010)
Cancer Res.
, vol.70
, pp. 2445-2454
-
-
Lin, L.1
Hutzen, B.2
Zuo, M.3
Ball, S.4
Deangelis, S.5
Foust, E.6
Pandit, B.7
Ihnat, M.A.8
Shenoy, S.S.9
Kulp, S.10
Li, P.K.11
Li, C.12
Fuchs, J.13
Lin, J.14
-
24
-
-
35848955428
-
ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome
-
Ginestier C., Hur M.H., Charafe-Jauffret E., Monville F., Dutcher J., Brown M., Jacquemier J., Viens P., Kleer C.G., Liu S., Schott A., Hayes D., Birnbaum D., Wicha M.S., Dontu G. ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. Cell Stem Cell 2007, 1:555-567.
-
(2007)
Cell Stem Cell
, vol.1
, pp. 555-567
-
-
Ginestier, C.1
Hur, M.H.2
Charafe-Jauffret, E.3
Monville, F.4
Dutcher, J.5
Brown, M.6
Jacquemier, J.7
Viens, P.8
Kleer, C.G.9
Liu, S.10
Schott, A.11
Hayes, D.12
Birnbaum, D.13
Wicha, M.S.14
Dontu, G.15
-
25
-
-
0029960028
-
Dominant negative stat3 mutant inhibits interleukin-6-induced Jak-STAT signal transduction
-
Kaptein A., Paillard V., Saunders M. Dominant negative stat3 mutant inhibits interleukin-6-induced Jak-STAT signal transduction. J. Biol. Chem. 1996, 271:5961-5964.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 5961-5964
-
-
Kaptein, A.1
Paillard, V.2
Saunders, M.3
-
26
-
-
0030611426
-
Functional differences between STAT 3 and STAT 3
-
Schaefer T., Sanders L., Park O., Nathans D. Functional differences between STAT 3 and STAT 3. Mol. Cell. Biol. 1997, 17:5307-5316.
-
(1997)
Mol. Cell. Biol.
, vol.17
, pp. 5307-5316
-
-
Schaefer, T.1
Sanders, L.2
Park, O.3
Nathans, D.4
-
27
-
-
0035979223
-
Rac1 mediates STAT3 activation by autocrine IL-6
-
Faruqi T., Gomez D., Bustelo X., Bar-Sagi D., Reich N. Rac1 mediates STAT3 activation by autocrine IL-6. Proc. Natl. Acad. Sci. USA 2001, 9014-9019.
-
(2001)
Proc. Natl. Acad. Sci. USA
, pp. 9014-9019
-
-
Faruqi, T.1
Gomez, D.2
Bustelo, X.3
Bar-Sagi, D.4
Reich, N.5
-
28
-
-
0033529704
-
Stat3 as an oncogene
-
Bromberg J., Wrzeszczynska M., Devgan G., Zhao Y., Pestell R., Albanese C., Darnell J.J. Stat3 as an oncogene. Cell 1999, 98:295-303.
-
(1999)
Cell
, vol.98
, pp. 295-303
-
-
Bromberg, J.1
Wrzeszczynska, M.2
Devgan, G.3
Zhao, Y.4
Pestell, R.5
Albanese, C.6
Darnell, J.J.7
-
29
-
-
31544458469
-
Persistent activation of stat3 signaling induces survivin gene expression and confers resistance to apoptosis in human breast cancer cells
-
Gritsko T., Williams A., Turkson J., Kaneko S., Bowman T., Huang M., Nam S., Eweis I., Diaz N., Sullivan D., Yoder S., Enkemann S., Eschrich S., Lee J., Beam C., Cheng J., Minton S., Muro-Cacho C., Jove R. Persistent activation of stat3 signaling induces survivin gene expression and confers resistance to apoptosis in human breast cancer cells. Clin. Cancer Res. 2006, 12:11-19.
-
(2006)
Clin. Cancer Res.
, vol.12
, pp. 11-19
-
-
Gritsko, T.1
Williams, A.2
Turkson, J.3
Kaneko, S.4
Bowman, T.5
Huang, M.6
Nam, S.7
Eweis, I.8
Diaz, N.9
Sullivan, D.10
Yoder, S.11
Enkemann, S.12
Eschrich, S.13
Lee, J.14
Beam, C.15
Cheng, J.16
Minton, S.17
Muro-Cacho, C.18
Jove, R.19
-
30
-
-
37349098725
-
Autocrine IL-6 signaling: a key event in tumorigenesis?
-
Grivennikov S., Karin M. Autocrine IL-6 signaling: a key event in tumorigenesis?. Cancer Cell 2008, 13:7-9.
-
(2008)
Cancer Cell
, vol.13
, pp. 7-9
-
-
Grivennikov, S.1
Karin, M.2
-
31
-
-
18944375734
-
Role of Notch signaling in cell-fate determination of human mammary stem/progenitor cells
-
Dontu G., Jackson K.W., McNicholas E., Kawamura M.J., Abdallah W.M., Wicha M.S. Role of Notch signaling in cell-fate determination of human mammary stem/progenitor cells. Breast Cancer Res. 2004, 6:R605-615.
-
(2004)
Breast Cancer Res.
, vol.6
-
-
Dontu, G.1
Jackson, K.W.2
McNicholas, E.3
Kawamura, M.J.4
Abdallah, W.M.5
Wicha, M.S.6
-
32
-
-
0031460545
-
Curcumin, a natural plant phenolic food additive, inhibits cell proliferation and induces cell cycle changes in colon adenocarcinoma cell lines by a prostaglandin-independent pathway
-
Hanif R., Qiao L., Shiff S.J., Rigas B. Curcumin, a natural plant phenolic food additive, inhibits cell proliferation and induces cell cycle changes in colon adenocarcinoma cell lines by a prostaglandin-independent pathway. J. Lab. Clin. Med. 1997, 130:576-584.
-
(1997)
J. Lab. Clin. Med.
, vol.130
, pp. 576-584
-
-
Hanif, R.1
Qiao, L.2
Shiff, S.J.3
Rigas, B.4
-
33
-
-
0035988602
-
Chemotherapeutic potential of curcumin for colorectal cancer
-
Chauhan D.P. Chemotherapeutic potential of curcumin for colorectal cancer. Curr. Pharm. Des. 2002, 8:1695-1706.
-
(2002)
Curr. Pharm. Des.
, vol.8
, pp. 1695-1706
-
-
Chauhan, D.P.1
-
34
-
-
0033082458
-
Chemopreventive effect of curcumin, a naturally occurring anti-inflammatory agent, during the promotion/progression stages of colon cancer
-
Kawamori T., Lubet R., Steele V.E., Kelloff G.J., Kaskey R.B., Rao C.V., Reddy B.S. Chemopreventive effect of curcumin, a naturally occurring anti-inflammatory agent, during the promotion/progression stages of colon cancer. Cancer Res. 1999, 59:597-601.
-
(1999)
Cancer Res.
, vol.59
, pp. 597-601
-
-
Kawamori, T.1
Lubet, R.2
Steele, V.E.3
Kelloff, G.J.4
Kaskey, R.B.5
Rao, C.V.6
Reddy, B.S.7
-
35
-
-
34547948369
-
Curcumin for chemoprevention of colon cancer
-
Johnson J.J., Mukhtar H. Curcumin for chemoprevention of colon cancer. Cancer Lett. 2007, 255:170-181.
-
(2007)
Cancer Lett.
, vol.255
, pp. 170-181
-
-
Johnson, J.J.1
Mukhtar, H.2
-
36
-
-
0141955061
-
Curcumin (diferuloylmethane) inhibits constitutive and IL-6-inducible STAT3 phosphorylation in human multiple myeloma cells
-
Bharti A., Donato N., Aggarwal B. Curcumin (diferuloylmethane) inhibits constitutive and IL-6-inducible STAT3 phosphorylation in human multiple myeloma cells. J. Immunol. 2003, 171:3863-3871.
-
(2003)
J. Immunol.
, vol.171
, pp. 3863-3871
-
-
Bharti, A.1
Donato, N.2
Aggarwal, B.3
-
37
-
-
33750489699
-
Synthesis and biological analysis of new curcumin analogues bearing an enhanced potential for the medicinal treatment of cancer
-
Ohori H., Yamakoshi H., Tomizawa M., Shibuya M., Kakudo Y., Takahashi A., Takahashi S., Kato S., Suzuki T., Ishioka C., Iwabuchi Y., Shibata H. Synthesis and biological analysis of new curcumin analogues bearing an enhanced potential for the medicinal treatment of cancer. Mol. Cancer Ther. 2006, 5:2563-2571.
-
(2006)
Mol. Cancer Ther.
, vol.5
, pp. 2563-2571
-
-
Ohori, H.1
Yamakoshi, H.2
Tomizawa, M.3
Shibuya, M.4
Kakudo, Y.5
Takahashi, A.6
Takahashi, S.7
Kato, S.8
Suzuki, T.9
Ishioka, C.10
Iwabuchi, Y.11
Shibata, H.12
-
38
-
-
31544460437
-
Activation of stat3 in primary tumors from high-risk breast cancer patients is associated with elevated levels of activated SRC and survivin expression
-
Diaz N., Minton S., Cox C., Bowman T., Gritsko T., Garcia R., Eweis I., Wloch M., Livingston S., Seijo E., Cantor A., Lee J.H., Beam C.A., Sullivan D., Jove R., Muro-Cacho C.A. Activation of stat3 in primary tumors from high-risk breast cancer patients is associated with elevated levels of activated SRC and survivin expression. Clin. Cancer Res. 2006, 12:20-28.
-
(2006)
Clin. Cancer Res.
, vol.12
, pp. 20-28
-
-
Diaz, N.1
Minton, S.2
Cox, C.3
Bowman, T.4
Gritsko, T.5
Garcia, R.6
Eweis, I.7
Wloch, M.8
Livingston, S.9
Seijo, E.10
Cantor, A.11
Lee, J.H.12
Beam, C.A.13
Sullivan, D.14
Jove, R.15
Muro-Cacho, C.A.16
|