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Volumn 176, Issue 2, 2010, Pages 952-967

A novel mouse model of inflammatory bowel disease links mammalian target of rapamycin-dependent hyperproliferation of colonic epithelium to inflammation-associated tumorigenesis

Author keywords

[No Author keywords available]

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN; STAT3 PROTEIN;

EID: 76149117809     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.2353/ajpath.2010.090622     Document Type: Article
Times cited : (192)

References (90)
  • 1
    • 3042599473 scopus 로고    scopus 로고
    • Inflammation and cancer IV. Colorectal cancer in inflammatory bowel disease: The role of inflammation
    • Itzkowitz SH, Yio X: Inflammation and cancer IV. Colorectal cancer in inflammatory bowel disease: the role of inflammation. Am J Physiol Gastrointest Liver Physiol 2004, 287:G7-G17
    • (2004) Am J Physiol Gastrointest Liver Physiol , vol.287
    • Itzkowitz, S.H.1    Yio, X.2
  • 2
    • 33847381116 scopus 로고    scopus 로고
    • The fundamental basis of inflammatory bowel disease
    • Strober W, Fuss I, Mannon P: The fundamental basis of inflammatory bowel disease. J Clin Invest 2007, 117:514-521
    • (2007) J Clin Invest , vol.117 , pp. 514-521
    • Strober, W.1    Fuss, I.2    Mannon, P.3
  • 3
    • 35348982262 scopus 로고    scopus 로고
    • Mouse models of inflammatory bowel disease
    • Wirtz S, Neurath MF: Mouse models of inflammatory bowel disease. Adv Drug Deliv Rev 2007, 59:1073-1083
    • (2007) Adv Drug Deliv Rev , vol.59 , pp. 1073-1083
    • Wirtz, S.1    Neurath, M.F.2
  • 4
    • 35648937573 scopus 로고    scopus 로고
    • Insights from advances in research of chemically induced experimental models of human inflammatory bowel disease
    • Kawada M, Arihiro A, Mizoguchi E: Insights from advances in research of chemically induced experimental models of human inflammatory bowel disease. World J Gastroenterol 2007, 13:5581-5593
    • (2007) World J Gastroenterol , vol.13 , pp. 5581-5593
    • Kawada, M.1    Arihiro, A.2    Mizoguchi, E.3
  • 8
    • 70350453460 scopus 로고    scopus 로고
    • IL-10 and TNF-α promoter haplotypes are associated with childhood Crohn's disease location
    • Sanchez R, Levy E, Costea F, Sinnett D: IL-10 and TNF-α promoter haplotypes are associated with childhood Crohn's disease location. World J Gastroenterol 2009, 15:3776-3782
    • (2009) World J Gastroenterol , vol.15 , pp. 3776-3782
    • Sanchez, R.1    Levy, E.2    Costea, F.3    Sinnett, D.4
  • 10
    • 22644446255 scopus 로고    scopus 로고
    • Tuning of macrophage responses by Stat3-inducing cytokines: Molecular mechanisms and consequences in infection
    • Lang R: Tuning of macrophage responses by Stat3-inducing cytokines: molecular mechanisms and consequences in infection. Immunobiology 2005, 210:63-76
    • (2005) Immunobiology , vol.210 , pp. 63-76
    • Lang, R.1
  • 12
    • 0033034365 scopus 로고    scopus 로고
    • Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils
    • Takeda K, Clausen BE, Kaisho T, Tsujimura T, Terada N, Forster I, Akira S: Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils. Immunity 1999, 10:39-49
    • (1999) Immunity , vol.10 , pp. 39-49
    • Takeda, K.1    Clausen, B.E.2    Kaisho, T.3    Tsujimura, T.4    Terada, N.5    Forster, I.6    Akira, S.7
  • 14
    • 0032213273 scopus 로고    scopus 로고
    • Stat3 activation is responsible for IL-6-dependent T cell proliferation through preventing apoptosis: Generation and characterization of T cell-specific Stat3-deficient mice
    • Takeda K, Kaisho T, Yoshida N, Takeda J, Kishimoto T, Akira S: Stat3 activation is responsible for IL-6-dependent T cell proliferation through preventing apoptosis: generation and characterization of T cell-specific Stat3-deficient mice. J Immunol 1998, 161:4652-4660
    • (1998) J Immunol , vol.161 , pp. 4652-4660
    • Takeda, K.1    Kaisho, T.2    Yoshida, N.3    Takeda, J.4    Kishimoto, T.5    Akira, S.6
  • 15
    • 34347405754 scopus 로고    scopus 로고
    • Mouse neutrophilic granulocytes express mRNA encoding the macrophage colony-stimulating factor receptor (CSF-1R) as well as many other macrophage-specific transcripts and can transdifferentiate into macrophages in vitro in response to CSF-1
    • Sasmono RT, Ehrnsperger A, Cronau SL, Ravasi T, Kandane R, Hickey MJ, Cook AD, Himes SR, Hamilton JA, Hume DA: Mouse neutrophilic granulocytes express mRNA encoding the macrophage colony-stimulating factor receptor (CSF-1R) as well as many other macrophage-specific transcripts and can transdifferentiate into macrophages in vitro in response to CSF-1. J Leukoc Biol 2007, 82:111-123
    • (2007) J Leukoc Biol , vol.82 , pp. 111-123
    • Sasmono, R.T.1    Ehrnsperger, A.2    Cronau, S.L.3    Ravasi, T.4    Kandane, R.5    Hickey, M.J.6    Cook, A.D.7    Himes, S.R.8    Hamilton, J.A.9    Hume, D.A.10
  • 16
    • 0037307026 scopus 로고    scopus 로고
    • A macrophage colony-stimulating factor receptor-green fluorescent protein transgene is expressed throughout the mononuclear phagocyte system of the mouse
    • Sasmono RT, Oceandy D, Pollard JW, Tong W, Pavli P, Wainwright BJ, Ostrowski MC, Himes SR, Hume DA: A macrophage colony-stimulating factor receptor-green fluorescent protein transgene is expressed throughout the mononuclear phagocyte system of the mouse. Blood 2003, 101:1155-1163
    • (2003) Blood , vol.101 , pp. 1155-1163
    • Sasmono, R.T.1    Oceandy, D.2    Pollard, J.W.3    Tong, W.4    Pavli, P.5    Wainwright, B.J.6    Ostrowski, M.C.7    Himes, S.R.8    Hume, D.A.9
  • 19
    • 0027326012 scopus 로고
    • Characterization of A1, a novel hemopoietic-specific early-response gene with sequence similarity to bcl-2
    • Lin EY, Orlofsky A, Berger MS, Prystowsky MB: Characterization of A1, a novel hemopoietic-specific early-response gene with sequence similarity to bcl-2. J Immunol 1993, 151:1979-1988
    • (1993) J Immunol , vol.151 , pp. 1979-1988
    • Lin, E.Y.1    Orlofsky, A.2    Berger, M.S.3    Prystowsky, M.B.4
  • 23
    • 0037394905 scopus 로고    scopus 로고
    • Diagnostic problems and advances in inflammatory bowel disease
    • Odze R: Diagnostic problems and advances in inflammatory bowel disease. Mod Pathol 2003, 16:347-358
    • (2003) Mod Pathol , vol.16 , pp. 347-358
    • Odze, R.1
  • 24
    • 0019379322 scopus 로고
    • Dysplasia-associated lesion or mass (DALM) detected by colonoscopy in long-standing ulcerative colitis: An indication for colectomy
    • Blackstone MO, Riddell RH, Rogers BH, Levin B: Dysplasia-associated lesion or mass (DALM) detected by colonoscopy in long-standing ulcerative colitis: an indication for colectomy. Gastroenterology 1981, 80:366-374
    • (1981) Gastroenterology , vol.80 , pp. 366-374
    • Blackstone, M.O.1    Riddell, R.H.2    Rogers, B.H.3    Levin, B.4
  • 25
    • 38849124333 scopus 로고    scopus 로고
    • Commensal bacteria and epithelial cross talk in the developing intestine
    • Rautava S, Walker WA: Commensal bacteria and epithelial cross talk in the developing intestine. Curr Gastroenterol Rep 2007, 9:385-392
    • (2007) Curr Gastroenterol Rep , vol.9 , pp. 385-392
    • Rautava, S.1    Walker, W.A.2
  • 26
    • 40049097245 scopus 로고    scopus 로고
    • What's new in inflammatory bowel disease in 2008?
    • Baumgart DC: What's new in inflammatory bowel disease in 2008? World J Gastroenterol 2008, 14:329-330
    • (2008) World J Gastroenterol , vol.14 , pp. 329-330
    • Baumgart, D.C.1
  • 30
    • 33845865825 scopus 로고    scopus 로고
    • Crosstalk between cancer and immune cells: Role of STAT3 in the tumour microenvironment
    • Yu H, Kortylewski M, Pardoll D: Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment. Nat Rev Immunol 2007, 7:41-51
    • (2007) Nat Rev Immunol , vol.7 , pp. 41-51
    • Yu, H.1    Kortylewski, M.2    Pardoll, D.3
  • 31
    • 52649172153 scopus 로고    scopus 로고
    • Survivin: Key regulator of mitosis and apoptosis and novel target for cancer therapeutics
    • Mita AC, Mita MM, Nawrocki ST, Giles FJ: Survivin: key regulator of mitosis and apoptosis and novel target for cancer therapeutics. Clin Cancer Res 2008, 14:5000-5005
    • (2008) Clin Cancer Res , vol.14 , pp. 5000-5005
    • Mita, A.C.1    Mita, M.M.2    Nawrocki, S.T.3    Giles, F.J.4
  • 32
    • 37549036729 scopus 로고    scopus 로고
    • Survivin, cancer networks and pathway-directed drug discovery
    • Altieri DC: Survivin, cancer networks and pathway-directed drug discovery. Nat Rev Cancer 2008, 8:61-70
    • (2008) Nat Rev Cancer , vol.8 , pp. 61-70
    • Altieri, D.C.1
  • 35
    • 0029117304 scopus 로고
    • Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation
    • Wen Z, Zhong Z, Darnell JE Jr: Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation. Cell 1995, 82:241-250
    • (1995) Cell , vol.82 , pp. 241-250
    • Wen, Z.1    Zhong, Z.2    Darnell Jr, J.E.3
  • 36
    • 0033968596 scopus 로고    scopus 로고
    • Serine phosphorylation and maximal activation of STAT3 during CNTF signaling is mediated by the rapamycin target mTOR
    • Yokogami K, Wakisaka S, Avruch J, Reeves SA: Serine phosphorylation and maximal activation of STAT3 during CNTF signaling is mediated by the rapamycin target mTOR. Curr Biol 2000, 10:47-50
    • (2000) Curr Biol , vol.10 , pp. 47-50
    • Yokogami, K.1    Wakisaka, S.2    Avruch, J.3    Reeves, S.A.4
  • 37
    • 0037043658 scopus 로고    scopus 로고
    • Inflammatory bowel disease
    • Podolsky DK: Inflammatory bowel disease. N Engl J Med 2002, 347:417-429
    • (2002) N Engl J Med , vol.347 , pp. 417-429
    • Podolsky, D.K.1
  • 38
    • 48349136889 scopus 로고    scopus 로고
    • Barrett JC, Hansoul S, Nicolae DL, Cho JH, Duerr RH, Rioux JD, Brant SR, Silverberg MS, Taylor KD, Barmada MM, Bitton A, Dassopoulos T, Datta LW, Green T, Griffiths AM, Kistner EO, Murtha MT, Regueiro MD, Rotter JI, Schumm LP, Steinhart AH, Targan SR, Xavier RJ, Libioulle C, Sandor C, Lathrop M, Belaiche J, Dewit O, Gut I, Heath S, Laukens D, Mni M, Rutgeerts P, Van Gossum A, Zelenika D, Franchimont D, Hugot JP, de Vos M, Vermeire S, Louis E, Cardon LR, Anderson CA, Drummond H, Nimmo E, Ahmad T, Prescott NJ, Onnie CM, Fisher SA, Marchini J, Ghori J, Bumpstead S, Gwilliam R, Tremelling M, Deloukas P, Mansfield J, Jewell D, Satsangi J, Mathew CG, Parkes M, Georges M, Daly MJ: Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet 2008, 40:955-962
    • Barrett JC, Hansoul S, Nicolae DL, Cho JH, Duerr RH, Rioux JD, Brant SR, Silverberg MS, Taylor KD, Barmada MM, Bitton A, Dassopoulos T, Datta LW, Green T, Griffiths AM, Kistner EO, Murtha MT, Regueiro MD, Rotter JI, Schumm LP, Steinhart AH, Targan SR, Xavier RJ, Libioulle C, Sandor C, Lathrop M, Belaiche J, Dewit O, Gut I, Heath S, Laukens D, Mni M, Rutgeerts P, Van Gossum A, Zelenika D, Franchimont D, Hugot JP, de Vos M, Vermeire S, Louis E, Cardon LR, Anderson CA, Drummond H, Nimmo E, Ahmad T, Prescott NJ, Onnie CM, Fisher SA, Marchini J, Ghori J, Bumpstead S, Gwilliam R, Tremelling M, Deloukas P, Mansfield J, Jewell D, Satsangi J, Mathew CG, Parkes M, Georges M, Daly MJ: Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet 2008, 40:955-962
  • 39
    • 58949097704 scopus 로고    scopus 로고
    • Anderson CA, Massey DC, Barrett JC, Prescott NJ, Tremelling M, Fisher SA, Gwilliam R, Jacob J, Nimmo ER, Drummond H, Lees CW, Onnie CM, Hanson C, Blaszczyk K, Ravindrarajah R, Hunt S, Varma D, Hammond N, Lewis G, Attlesey H, Watkins N, Ouwehand W, Strachan D, McArdle W, Lewis CM, Lobo A, Sanderson J, Jewell DP, Deloukas P, Mansfield JC, Mathew CG, Satsangi J, Parkes M: Investigation of Crohn's disease risk loci in ulcerative colitis further defines their molecular relationship. Gastroenterology 2009, 136:523-529
    • Anderson CA, Massey DC, Barrett JC, Prescott NJ, Tremelling M, Fisher SA, Gwilliam R, Jacob J, Nimmo ER, Drummond H, Lees CW, Onnie CM, Hanson C, Blaszczyk K, Ravindrarajah R, Hunt S, Varma D, Hammond N, Lewis G, Attlesey H, Watkins N, Ouwehand W, Strachan D, McArdle W, Lewis CM, Lobo A, Sanderson J, Jewell DP, Deloukas P, Mansfield JC, Mathew CG, Satsangi J, Parkes M: Investigation of Crohn's disease risk loci in ulcerative colitis further defines their molecular relationship. Gastroenterology 2009, 136:523-529
  • 40
    • 58149232723 scopus 로고    scopus 로고
    • Role of STAT3 in inflammatory bowel disease
    • Sugimoto K: Role of STAT3 in inflammatory bowel disease. World J Gastroenterol 2008, 14:5110-5114
    • (2008) World J Gastroenterol , vol.14 , pp. 5110-5114
    • Sugimoto, K.1
  • 41
    • 32644474195 scopus 로고    scopus 로고
    • STAT3 in immune responses and inflammatory bowel diseases
    • Fu XY: STAT3 in immune responses and inflammatory bowel diseases. Cell Res 2006, 16:214-219
    • (2006) Cell Res , vol.16 , pp. 214-219
    • Fu, X.Y.1
  • 42
    • 0037799912 scopus 로고    scopus 로고
    • Toll-like receptor-dependent production of IL-12p40 causes chronic enterocolitis in myeloid cell-specific Stat3-deficient mice
    • Kobayashi M, Kweon MN, Kuwata H, Schreiber RD, Kiyono H, Takeda K, Akira S: Toll-like receptor-dependent production of IL-12p40 causes chronic enterocolitis in myeloid cell-specific Stat3-deficient mice. J Clin Invest 2003, 111:1297-1308
    • (2003) J Clin Invest , vol.111 , pp. 1297-1308
    • Kobayashi, M.1    Kweon, M.N.2    Kuwata, H.3    Schreiber, R.D.4    Kiyono, H.5    Takeda, K.6    Akira, S.7
  • 43
    • 0037180757 scopus 로고    scopus 로고
    • Inflammation and cancer
    • Coussens LM, Werb Z: Inflammation and cancer. Nature 2002, 420:860-867
    • (2002) Nature , vol.420 , pp. 860-867
    • Coussens, L.M.1    Werb, Z.2
  • 45
    • 0009785235 scopus 로고
    • Mouse lysozyme M gene: Isolation, characterization, and expression studies
    • Cross M, Mangelsdorf I, Wedel A, Renkawitz R: Mouse lysozyme M gene: isolation, characterization, and expression studies. Proc Natl Acad Sci USA: 1988, 85:6232-6236
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 6232-6236
    • Cross, M.1    Mangelsdorf, I.2    Wedel, A.3    Renkawitz, R.4
  • 46
    • 0034662159 scopus 로고    scopus 로고
    • Insertion of enhanced green fluorescent protein into the lysozyme gene creates mice with green fluorescent granulocytes and macrophages
    • Faust N, Varas F, Kelly LM, Heck S, Graf T: Insertion of enhanced green fluorescent protein into the lysozyme gene creates mice with green fluorescent granulocytes and macrophages. Blood 2000, 96:719-726
    • (2000) Blood , vol.96 , pp. 719-726
    • Faust, N.1    Varas, F.2    Kelly, L.M.3    Heck, S.4    Graf, T.5
  • 47
    • 67649922571 scopus 로고    scopus 로고
    • A transgenic mouse model of inducible macrophage depletion: Effects of diphtheria toxin-driven lysozyme M-specific cell lineage ablation on wound inflammatory, angiogenic, and contractive processes
    • Goren I, Allmann N, Yogev N, Schurmann C, Linke A, Holdener M, Waisman A, Pfeilschifter J, Frank S: A transgenic mouse model of inducible macrophage depletion: effects of diphtheria toxin-driven lysozyme M-specific cell lineage ablation on wound inflammatory, angiogenic, and contractive processes. Am J Pathol 2009, 175:132-147
    • (2009) Am J Pathol , vol.175 , pp. 132-147
    • Goren, I.1    Allmann, N.2    Yogev, N.3    Schurmann, C.4    Linke, A.5    Holdener, M.6    Waisman, A.7    Pfeilschifter, J.8    Frank, S.9
  • 48
    • 21044452305 scopus 로고    scopus 로고
    • Musso A, Dentelli P, Carlino A, Chiusa L, Repici A, Sturm A, Fiocchi C, Rizzetto M, Pegoraro L, Sategna-Guidetti C, Brizzi MF: Signal transducers and activators of transcription 3 signaling pathway: an essential mediator of inflammatory bowel disease and other forms of intestinal inflammation. Inflamm Bowel Dis 2005, 11:91-98
    • Musso A, Dentelli P, Carlino A, Chiusa L, Repici A, Sturm A, Fiocchi C, Rizzetto M, Pegoraro L, Sategna-Guidetti C, Brizzi MF: Signal transducers and activators of transcription 3 signaling pathway: an essential mediator of inflammatory bowel disease and other forms of intestinal inflammation. Inflamm Bowel Dis 2005, 11:91-98
  • 49
  • 51
    • 50149092873 scopus 로고    scopus 로고
    • IL-23 and Th17 cytokines in intestinal homeostasis
    • Maloy KJ, Kullberg MC: IL-23 and Th17 cytokines in intestinal homeostasis. Mucosal Immunol 2008, 1:339-349
    • (2008) Mucosal Immunol , vol.1 , pp. 339-349
    • Maloy, K.J.1    Kullberg, M.C.2
  • 52
    • 41549135632 scopus 로고    scopus 로고
    • The biological functions of T helper 17 cell effector cytokines in inflammation
    • Ouyang W, Kolls JK, Zheng Y: The biological functions of T helper 17 cell effector cytokines in inflammation. Immunity 2008, 28:454-467
    • (2008) Immunity , vol.28 , pp. 454-467
    • Ouyang, W.1    Kolls, J.K.2    Zheng, Y.3
  • 53
    • 40449130509 scopus 로고    scopus 로고
    • Interleukin-22: A sheep in wolf's clothing
    • Laurence A, O'Shea JJ, Watford WT: Interleukin-22: a sheep in wolf's clothing. Nat Med 2008, 14:247-249
    • (2008) Nat Med , vol.14 , pp. 247-249
    • Laurence, A.1    O'Shea, J.J.2    Watford, W.T.3
  • 54
    • 33847351136 scopus 로고    scopus 로고
    • The JAK-STAT signaling pathway: Input and output integration
    • Murray PJ: The JAK-STAT signaling pathway: input and output integration. J Immunol 2007, 178:2623-2629
    • (2007) J Immunol , vol.178 , pp. 2623-2629
    • Murray, P.J.1
  • 55
    • 38849113431 scopus 로고    scopus 로고
    • Colitis and cancer: A tale of inflammatory cells and their cytokines
    • Burstein E, Fearon ER: Colitis and cancer: a tale of inflammatory cells and their cytokines. J Clin Invest 2008, 118:464-467
    • (2008) J Clin Invest , vol.118 , pp. 464-467
    • Burstein, E.1    Fearon, E.R.2
  • 56
    • 40049091475 scopus 로고    scopus 로고
    • Cancer in inflammatory bowel disease
    • Xie J, Itzkowitz SH: Cancer in inflammatory bowel disease. World J Gastroenterol 2008, 14:378-389
    • (2008) World J Gastroenterol , vol.14 , pp. 378-389
    • Xie, J.1    Itzkowitz, S.H.2
  • 57
    • 33748139379 scopus 로고    scopus 로고
    • Chemoprevention: Risk reduction with medical therapy of inflammatory bowel disease
    • Chan EP, Lichtenstein GR: Chemoprevention: risk reduction with medical therapy of inflammatory bowel disease. Gastroenterol Clin North Am 2006, 35:675-712
    • (2006) Gastroenterol Clin North Am , vol.35 , pp. 675-712
    • Chan, E.P.1    Lichtenstein, G.R.2
  • 59
    • 0025181580 scopus 로고
    • A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice
    • Okayasu I, Hatakeyama S, Yamada M, Ohkusa T, Inagaki Y, Nakaya R: A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice. Gastroenterology 1990, 98:694-702
    • (1990) Gastroenterology , vol.98 , pp. 694-702
    • Okayasu, I.1    Hatakeyama, S.2    Yamada, M.3    Ohkusa, T.4    Inagaki, Y.5    Nakaya, R.6
  • 60
    • 0032538915 scopus 로고    scopus 로고
    • Oxazolone colitis: A murine model of T helper cell type 2 colitis treatable with antibodies to interleukin 4
    • Boirivant M, Fuss IJ, Chu A, Strober W: Oxazolone colitis: a murine model of T helper cell type 2 colitis treatable with antibodies to interleukin 4. J Exp Med 1998, 188:1929-1939
    • (1998) J Exp Med , vol.188 , pp. 1929-1939
    • Boirivant, M.1    Fuss, I.J.2    Chu, A.3    Strober, W.4
  • 61
    • 0036865725 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory drugs and their colonic effects: More interesting than irritating?
    • Mulcahy HE, O'Donoghue D: Nonsteroidal anti-inflammatory drugs and their colonic effects: more interesting than irritating?. Eur J Gastroenterol Hepatol 2002, 14:1177-1178
    • (2002) Eur J Gastroenterol Hepatol , vol.14 , pp. 1177-1178
    • Mulcahy, H.E.1    O'Donoghue, D.2
  • 62
    • 0034665122 scopus 로고    scopus 로고
    • The cyclooxygenase-2 inhibitor celecoxib is a potent preventive and therapeutic agent in the min mouse model of adenomatous polyposis
    • Jacoby RF, Seibert K, Cole CE, Kelloff G, Lubet RA: The cyclooxygenase-2 inhibitor celecoxib is a potent preventive and therapeutic agent in the min mouse model of adenomatous polyposis. Cancer Res 2000, 60:5040-5044
    • (2000) Cancer Res , vol.60 , pp. 5040-5044
    • Jacoby, R.F.1    Seibert, K.2    Cole, C.E.3    Kelloff, G.4    Lubet, R.A.5
  • 63
    • 4544224979 scopus 로고    scopus 로고
    • Inhibition of NF-κB in cancer cells converts inflammation- induced tumor growth mediated by TNFα to TRAIL-mediated tumor regression
    • Luo JL, Maeda S, Hsu LC, Yagita H, Karin M: Inhibition of NF-κB in cancer cells converts inflammation- induced tumor growth mediated by TNFα to TRAIL-mediated tumor regression. Cancer Cell 2004, 6:297-305
    • (2004) Cancer Cell , vol.6 , pp. 297-305
    • Luo, J.L.1    Maeda, S.2    Hsu, L.C.3    Yagita, H.4    Karin, M.5
  • 66
    • 62849087103 scopus 로고    scopus 로고
    • Impact of EGFR immunoexpression on STAT3 activation and association with proinflammatory/regulatory cytokine pattern in laryngeal squamous cell carcinoma
    • Starska K, Brys M, Forma E, Glowacka E, Lewy-Trenda I, Stasikowska O, Krajewska WM, Lukomski M: Impact of EGFR immunoexpression on STAT3 activation and association with proinflammatory/regulatory cytokine pattern in laryngeal squamous cell carcinoma. Oncol Rep 2009, 21:539-548
    • (2009) Oncol Rep , vol.21 , pp. 539-548
    • Starska, K.1    Brys, M.2    Forma, E.3    Glowacka, E.4    Lewy-Trenda, I.5    Stasikowska, O.6    Krajewska, W.M.7    Lukomski, M.8
  • 68
    • 23944476094 scopus 로고    scopus 로고
    • Involvement of IL-6 in the pathogenesis of inflammatory bowel disease and colon cancer
    • Atreya R, Neurath MF: Involvement of IL-6 in the pathogenesis of inflammatory bowel disease and colon cancer. Clin Rev Allergy Immunol 2005, 28:187-196
    • (2005) Clin Rev Allergy Immunol , vol.28 , pp. 187-196
    • Atreya, R.1    Neurath, M.F.2
  • 69
    • 44449096726 scopus 로고    scopus 로고
    • IL-10: The master regulator of immunity to infection
    • Couper KN, Blount DG, Riley EM: IL-10: the master regulator of immunity to infection. J Immunol 2008, 180:5771-5777
    • (2008) J Immunol , vol.180 , pp. 5771-5777
    • Couper, K.N.1    Blount, D.G.2    Riley, E.M.3
  • 70
    • 50149097975 scopus 로고    scopus 로고
    • IL-22 in mucosal immunity
    • Ouyang W, Valdez P: IL-22 in mucosal immunity. Mucosal Immunol 2008, 1:335-338
    • (2008) Mucosal Immunol , vol.1 , pp. 335-338
    • Ouyang, W.1    Valdez, P.2
  • 72
    • 33847328289 scopus 로고    scopus 로고
    • The Bcl-2 apoptotic switch in cancer development and therapy
    • Adams JM, Cory S: The Bcl-2 apoptotic switch in cancer development and therapy. Oncogene 2007, 26:1324-1337
    • (2007) Oncogene , vol.26 , pp. 1324-1337
    • Adams, J.M.1    Cory, S.2
  • 73
    • 34247149015 scopus 로고    scopus 로고
    • The regulation of cyclin D1 degradation: Roles in cancer development and the potential for therapeutic invention
    • Alao JP: The regulation of cyclin D1 degradation: roles in cancer development and the potential for therapeutic invention. Mol Cancer 2007, 6:24
    • (2007) Mol Cancer , vol.6 , pp. 24
    • Alao, J.P.1
  • 76
    • 65349191756 scopus 로고    scopus 로고
    • New approaches to target the androgen receptor and STAT3 for prostate cancer treatments
    • He M, Young CY: New approaches to target the androgen receptor and STAT3 for prostate cancer treatments. Mini Rev Med Chem 2009, 9:395-400
    • (2009) Mini Rev Med Chem , vol.9 , pp. 395-400
    • He, M.1    Young, C.Y.2
  • 77
    • 58149145889 scopus 로고    scopus 로고
    • Small molecular inhibitors of p-STAT3: Novel agents for treatment of primary and metastatic CNS cancers
    • Heimberger AB, Priebe W: Small molecular inhibitors of p-STAT3: novel agents for treatment of primary and metastatic CNS cancers. Recent Pat CNS Drug Discov 2008, 3:179-188
    • (2008) Recent Pat CNS Drug Discov , vol.3 , pp. 179-188
    • Heimberger, A.B.1    Priebe, W.2
  • 78
    • 44349087591 scopus 로고    scopus 로고
    • STAT 3 as a target for cancer drug discovery
    • Costantino L, Barlocco D: STAT 3 as a target for cancer drug discovery. Curr Med Chem 2008, 15:834-843
    • (2008) Curr Med Chem , vol.15 , pp. 834-843
    • Costantino, L.1    Barlocco, D.2
  • 79
    • 34249679614 scopus 로고    scopus 로고
    • mTOR Complex1-S6K1 signaling: At the crossroads of obesity, diabetes and cancer
    • Dann SG, Selvaraj A, Thomas G: mTOR Complex1-S6K1 signaling: at the crossroads of obesity, diabetes and cancer. Trends Mol Med 2007, 13:252-259
    • (2007) Trends Mol Med , vol.13 , pp. 252-259
    • Dann, S.G.1    Selvaraj, A.2    Thomas, G.3
  • 80
    • 53849125004 scopus 로고    scopus 로고
    • mTORC1 inhibitors: Is temsirolimus in renal cancer telling us how they really work?
    • Le Tourneau C, Faivre S, Serova M, Raymond E: mTORC1 inhibitors: is temsirolimus in renal cancer telling us how they really work? Br J Cancer 2008, 99:1197-1203
    • (2008) Br J Cancer , vol.99 , pp. 1197-1203
    • Le Tourneau, C.1    Faivre, S.2    Serova, M.3    Raymond, E.4
  • 81
    • 33746637660 scopus 로고    scopus 로고
    • Current development of mTOR inhibitors as anticancer agents
    • Faivre S, Kroemer G, Raymond E: Current development of mTOR inhibitors as anticancer agents. Nat Rev Drug Discov 2006, 5:671-688
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 671-688
    • Faivre, S.1    Kroemer, G.2    Raymond, E.3
  • 82
    • 60549096247 scopus 로고    scopus 로고
    • Akt-dependent and -independent mechanisms of mTOR regulation in cancer
    • Memmott RM, Dennis PA: Akt-dependent and -independent mechanisms of mTOR regulation in cancer. Cell Signal 2009, 21:656-664
    • (2009) Cell Signal , vol.21 , pp. 656-664
    • Memmott, R.M.1    Dennis, P.A.2
  • 83
    • 17444431201 scopus 로고    scopus 로고
    • Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis
    • Ma L, Chen Z, Erdjument-Bromage H, Tempst P, Pandolfi PP: Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis. Cell 2005, 121:179-193
    • (2005) Cell , vol.121 , pp. 179-193
    • Ma, L.1    Chen, Z.2    Erdjument-Bromage, H.3    Tempst, P.4    Pandolfi, P.P.5
  • 84
    • 0037093877 scopus 로고    scopus 로고
    • p38 mitogen-activated protein kinase is activated and linked to TNF-α signaling in inflammatory bowel disease
    • Waetzig GH, Seegert D, Rosenstiel P, Nikolaus S, Schreiber S: p38 mitogen-activated protein kinase is activated and linked to TNF-α signaling in inflammatory bowel disease. J Immunol 2002, 168:5342-5351
    • (2002) J Immunol , vol.168 , pp. 5342-5351
    • Waetzig, G.H.1    Seegert, D.2    Rosenstiel, P.3    Nikolaus, S.4    Schreiber, S.5
  • 85
    • 46649087778 scopus 로고    scopus 로고
    • Nogo-66 promotes the differentiation of neural progenitors into astroglial lineage cells through mTOR-STAT3 pathway
    • Wang B, Xiao Z, Chen B, Han J, Gao Y, Zhang J, Zhao W, Wang X, Dai J: Nogo-66 promotes the differentiation of neural progenitors into astroglial lineage cells through mTOR-STAT3 pathway. PLoS ONE 2008, 3:e1856
    • (2008) PLoS ONE , vol.3
    • Wang, B.1    Xiao, Z.2    Chen, B.3    Han, J.4    Gao, Y.5    Zhang, J.6    Zhao, W.7    Wang, X.8    Dai, J.9
  • 87
    • 33745260930 scopus 로고    scopus 로고
    • AKT activation in human glioblastomas enhances proliferation via TSC2 and S6 kinase signaling
    • Riemenschneider MJ, Betensky RA, Pasedag SM, Louis DN: AKT activation in human glioblastomas enhances proliferation via TSC2 and S6 kinase signaling. Cancer Res 2006, 66:5618-5623
    • (2006) Cancer Res , vol.66 , pp. 5618-5623
    • Riemenschneider, M.J.1    Betensky, R.A.2    Pasedag, S.M.3    Louis, D.N.4
  • 88
    • 38149083478 scopus 로고    scopus 로고
    • Regulation of interleukin-6- induced hepatic insulin resistance by mammalian target of rapamycin through the STAT3-SOCS3 pathway
    • Kim JH, Kim JE, Liu HY, Cao W, Chen J: Regulation of interleukin-6- induced hepatic insulin resistance by mammalian target of rapamycin through the STAT3-SOCS3 pathway. J Biol Chem 2008, 283:708-715
    • (2008) J Biol Chem , vol.283 , pp. 708-715
    • Kim, J.H.1    Kim, J.E.2    Liu, H.Y.3    Cao, W.4    Chen, J.5
  • 89
    • 33847632044 scopus 로고    scopus 로고
    • Inflammatory bowel disease: Past, present, and future
    • Sands BE: Inflammatory bowel disease: past, present, and future. J Gastroenterol 2007, 42:16-25
    • (2007) J Gastroenterol , vol.42 , pp. 16-25
    • Sands, B.E.1
  • 90
    • 34547176642 scopus 로고    scopus 로고
    • Unravelling the pathogenesis of inflammatory bowel disease
    • Xavier RJ, Podolsky DK: Unravelling the pathogenesis of inflammatory bowel disease. Nature 2007, 448:427-434
    • (2007) Nature , vol.448 , pp. 427-434
    • Xavier, R.J.1    Podolsky, D.K.2


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