Growth inhibition and regression of lung tumors by silibinin: Modulation of angiogenesis by macrophage-associated cytokines and nuclear factor-κB and signal transducers and activators of transcription 3

Cancer Prevention Research

Volumn 2, Issue 1, 2009, Pages 74-83

  Tyagi, Alpna ^a   Singh, Rana P ^a,c   Ramasamy, Kumaraguruparan ^a   Raina, Komal ^a   Redente, Elizabeth F ^a   Dwyer Nield, Lori D ^a   Radcliffe, Richard A ^a   Malkinson, Alvin M ^a,b   Agarwal, Rajesh ^a,b  

^a UNIVERSITY OF COLORADO   (United States)

^b UNIVERSITY OF COLORADO CANCER CENTER   (United States)

^c JAWAHARLAL NEHRU UNIVERSITY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOPOIETIN 2; ANGIOPOIETIN RECEPTOR; HYPOXIA INDUCIBLE FACTOR 1ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 13; NESTIN; SILIBININ; STAT PROTEIN; STAT3 PROTEIN; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN; ANGIOGENESIS INHIBITOR; CYTOKINE; SILYMARIN; STAT3 PROTEIN, MOUSE;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIANGIOGENIC ACTIVITY; ARTICLE; BLOOD VESSEL DIAMETER; CANCER CHEMOTHERAPY; CANCER INHIBITION; CANCER REGRESSION; CARCINOMA CELL; CELL LOSS; CELL NUCLEUS; CELL SUBPOPULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFICACY; DRUG MECHANISM; LUNG ADENOCARCINOMA; LUNG ALVEOLUS MACROPHAGE; MICROVASCULATURE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TISSUE LEVEL; TRANSCRIPTION INITIATION; TREATMENT DURATION; TUMOR ASSOCIATED LEUKOCYTE; TUMOR GROWTH; TUMOR VASCULARIZATION; TUMOR VOLUME; UPREGULATION; ADENOCARCINOMA; ANIMAL; APOPTOSIS; CELL PROLIFERATION; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; LUNG TUMOR; MACROPHAGE; MALE; METABOLISM; NEOVASCULARIZATION (PATHOLOGY); NICK END LABELING;

ADENOCARCINOMA; ANGIOGENESIS INHIBITORS; ANIMALS; APOPTOSIS; CELL PROLIFERATION; CYTOKINES; ENZYME-LINKED IMMUNOSORBENT ASSAY; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; LUNG NEOPLASMS; MACROPHAGES; MALE; MICE; MICROVESSELS; NEOVASCULARIZATION, PATHOLOGIC; NF-KAPPA B; SIGNAL TRANSDUCTION; SILYMARIN; STAT3 TRANSCRIPTION FACTOR;

EID: 62349117597     PISSN: 19406207     EISSN: None     Source Type: Journal    
DOI: 10.1158/1940-6207.CAPR-08-0095     Document Type: Article

References (38)

1. Jemal A, Siegel R, Ward E, Murray T, Xu J, Thun MJ. Cancer statistics 2007. CA Cancer J Clin 2007;57:43-46
2. Karp DD, Tsao AS, Kim ES. Nonsmall-cell lung cancer: chemoprevention studies. Semin Thorac Cardiovasc Surg 2003;15:405-420 (Pubitemid 38100716)
3. Tyagi A, Raina K, Singh RP, et al. Chemopreventive effects of Silymarin and silibinin on N-butyl-N-(4-hydroxybutyl) nitrosamine induced urinary bladder carcinogenesis in male ICR mice. Mol Cancer Ther 2007;6:3248-3255
4. Raina K, Blouin MJ, Singh RP, et al. Dietary feeding of silibinin inhibits prostate tumor growth and progression in transgenic adenocarcinoma of the mouse prostate model. Cancer Res 2007;67:11083-11091 (Pubitemid 350145939)
5. Roy S, Kaur M, Agarwal C, Tecklenburg M, Sclafani RA, Agarwal R. p21 and p27 induction by silibinin is essential for its cell cycle arrest effect in prostate carcinoma cells. Mol Cancer Ther 2007;6:2696-2707
6. Gu M, Singh RP, Dhanalakshmi S, Agarwal C, Agarwal R. Silibinin inhibits inflammatory and angiogenic attributes in photocarcinogenesis in SKH-1 hairless mice. Cancer Res 2007;67:3483-3491 (Pubitemid 46724890)
7. Singh RP, Deep G, Chittezhath M, et al. Effect of silibinin on the growth and progression of primary lung tumors in mice. J Natl Cancer Inst 2006;98:846-855 (Pubitemid 43923441)
8. Singh RP, Agarwal R. Prostate cancer chemoprevention by silibinin: bench to bedside. Mol Carcinog 2006;45:436-442 (Pubitemid 43865852)
9. Sharma G, Singh RP, Chan DC, Agarwal R. Silibinin induces growth inhibition and apoptotic cell death in human lung carcinoma cells. Anticancer Res 2003;23:2649-2655 (Pubitemid 36897139)
10. Chu SC, Chiou HL, Chen PN, Yang SF, Hsieh YS. Silibinin inhibits the invasion of human lung cancer cells via decreased productions of urokinase-plasminogen activator and matrix metalloproteinase-2. Mol Carcinog 2004;40:143-149
11. Chen PN, Hsieh YS, Chiou HL, Chu SC. Silibinin inhibits cell invasion through inactivation of both PI3K-Akt and MAPK signaling pathways. Chem Biol Interact 2005;156:141-150
12. Singh RP, Mallikarjuna GU, Sharma G, et al. Oral silibinin inhibits lung tumor growth in athymic nude mice and forms a novel chemocombination with doxorubicin targeting nuclear factor κB-mediated inducible chemoresistance. Clin Cancer Res 2004;10:8641-8647
13. Folkman J. Angiogenesis. Annu Rev Med 2006;57:1-18.
14. Handsley MM, Edwards DR. Metalloproteinases and their inhibitors in tumor angiogenesis. Int J Cancer 2005;115:849-860 (Pubitemid 40791824)
15. Redente EF, Orlicky DJ, Bouchard RJ, Malkinson AM. Tumor signaling to the bone marrow changes the phenotype of monocytes and pulmonary macrophages during urethane-induced primary lung tumorigenesis in A/J mice. Am J Pathol 2007;170:693-708.
16. Kimura YN, Watari K, Fotovati A, et al. Inflammatory stimuli from macrophages and cancer cells synergistically promote tumor growth and angiogenesis. Cancer Sci 2007;98:2009-2018 (Pubitemid 350002210)
17. Zhao J, Agarwal R. Tissue distribution of silibinin, the major active constituent of silymarin, in mice and its association with enhancement of phase II enzymes: implications in cancer chemoprevention. Carcinogenesis 1999;20:2101-2108 (Pubitemid 29535311)
18. You M, Candrian U, Maronpot RR, Stoner GD, Anderson MW. Activation of the Ki-ras protooncogene in spontaneously occurring and chemically induced lung tumors of the strain A mouse. Proc Natl Acad Sci U S A 1989;86:3070-3074 (Pubitemid 19129560)
19. Malkinson AM. Primary lung tumors in mice as an aid for understanding, preventing, and treating human adenocarcinoma of the lung. Lung Cancer 2001;32:265-279
20. Malkinson AM. Primary lung tumors in mice: an experimentally manipulable model of human adenocarcinoma. Cancer Res 1992;52:2670-6s.
21. Kleeberger W, Bova GS, Nielsen ME, et al. Roles for the stem cell associated intermediate filament nestin in prostate cancer migration and metastasis. Cancer Res 2007;67:9199-9206 (Pubitemid 47535906)
22. Sinha P, Clements VK, Ostrand-Rosenberg S. Interleukin-13-regulated M2 macrophages in combination with myeloid suppressor cells block immune surveillance against metastasis. Cancer Res 2005;65:11743-11751 (Pubitemid 41821736)
23. Singh RP, Agarwal R. Inducible nitric oxide synthase-vascular endothelial growth factor axis: a potential target to inhibit tumor angiogenesis by dietary agents. Curr Cancer Drug Targets 2007;7:475-483 (Pubitemid 47196207)
24. Singh RP, Agarwal R. Tumor angiogenesis: a potential target in cancer control by phytochemicals. Curr Cancer Drug Targets 2003;3:205-217 (Pubitemid 36565762)
25. Kisley LR, Barrett BS, Dwyer-Nield LD, Bauer AK, Thompson DC, Malkinson AM. Genetic ablation of inducible nitric oxide synthase decreases mouse lung tumorigenesis. Cancer Res 2002;62:6850-6856
26. Bauer AK, Dwyer-Nield LD, Malkinson AM. High cyclooxygenase 1 (COX-1) and cyclooxygenase 2 (COX-2) contents in mouse lung tumors. Carcinogenesis 2000;21:543-550
27. Lee K, Roth RA, LaPres JJ. Hypoxia, drug therapy and toxicity. Pharmacol Ther 2007;113:229-246 (Pubitemid 46149044)
28. Van Waes C. Nuclear factor-κB in development, prevention, and therapy of cancer. Clin Cancer Res 2007;13:1076-1082 (Pubitemid 46424045)
29. Baby J, Pickering BF, Vashisht Gopal YN, Van Dyke MW. Constitutive and inducible nuclear factor-κB in immortalized normal human bronchial epithelial and non-small cell lung cancer cell lines. Cancer Lett 2007;255:85-94. (Pubitemid 47212609)
30. Jiang H, Harris MB, Rothman P. IL-4/IL-13 signaling beyond JAK/STAT. J Allergy Clin Immunol 2000;105:1063-1070 (Pubitemid 30418781)
31. Cao Y, Sonveaux P, Liu S, et al. Systemic overexpression of angiopoietin-2 promotes tumor microvessel regression and inhibits angiogenesis and tumor growth. Cancer Res 2007;67:3835-3844 (Pubitemid 46762171)
32. Vukanovic J, Isaacs JT. Linomide inhibits angiogenesis, growth, metastasis, and macrophage infiltration within rat prostatic cancers. Cancer Res 1995;55:1499-1504
33. Koch AE, Burrows JC, Polverini PJ, Cho M, Leibovich SJ. Thiol-containing compounds inhibit the production of monocyte/macrophage-derived angiogenic activity. Agents Actions 1991;34:350-357
34. Stathopoulos GT, Sherrill TP, Cheng DS, et al. Epithelial NF-κB activation promotes urethane-induced lung carcinogenesis. Proc Natl Acad Sci U S A 2007;104:18514-18519
35. Ramer R, Eichele K, Hinz B. Upregulation of tissue inhibitor of matrix metalloproteinases-1 confers the anti-invasive action of cisplatin on human cancer cells. Oncogene 2007;26:5822-5827 (Pubitemid 47312810)
36. Plank MJ, Sleeman BD. Tumor-induced angiogenesis: a review. J Theoretical Med 2003;5:137-153
37. Li XF, Carlin S, Urano M, Russell J, Ling CC, O'Donoghue JA. Visualization of hypoxia in microscopic tumors by immunofluorescent microscopy. Cancer Res 2007;67:7646-7653 (Pubitemid 47281357)
38. Hawighorst T, Skobe M, Streit M, et al. Activation of the tie2 receptor by angiopoietin enhances tumor vessel maturation and impairs squamous cell carcinoma growth. Am J Pathol 2002;160:1381-1392 (Pubitemid 34411642)