메뉴 건너뛰기




Volumn 19, Issue 2, 2014, Pages 2497-2522

Effects of honey and its mechanisms of action on the development and progression of cancer

Author keywords

Anticancer; Antimetastatic; Antiproliferative; Antitumor; Cancer; Honey

Indexed keywords

ANTIOXIDANT;

EID: 84894633874     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules19022497     Document Type: Review
Times cited : (143)

References (156)
  • 2
    • 84872853140 scopus 로고    scopus 로고
    • Global estimates of cancer prevalence for 27 sites in the adult population in 2008
    • Bray, F.; Ren, J.S.; Masuyer, E.; Ferlay, J. Global estimates of cancer prevalence for 27 sites in the adult population in 2008. Int. J. Cancer 2013, 132, 1133-1145.
    • (2013) Int. J. Cancer , vol.132 , pp. 1133-1145
    • Bray, F.1    Ren, J.S.2    Masuyer, E.3    Ferlay, J.4
  • 3
    • 33745594629 scopus 로고    scopus 로고
    • The rising burden of cancer in the developing world
    • Kanavos, P. The rising burden of cancer in the developing world. Ann. Oncol. 2006, 17, viii15-viii23.
    • (2006) Ann. Oncol. , vol.17
    • Kanavos, P.1
  • 4
    • 84863693584 scopus 로고    scopus 로고
    • Honey and cancer: Sustainable inverse relationship particularly for developing nations-A review
    • doi:10.1155/2012/410406
    • Othman, N.H. Honey and cancer: Sustainable inverse relationship particularly for developing nations-A review. Evid. Based Complement. Altern. Med. 2012, 2012, doi:10.1155/2012/410406.
    • (2012) Evid. Based Complement. Altern. Med. , vol.2012
    • Othman, N.H.1
  • 5
    • 0027274815 scopus 로고
    • The molecular biology of carcinogenesis
    • Pitot, H.C. The molecular biology of carcinogenesis. Cancer 1993, 72, 962-970.
    • (1993) Cancer , vol.72 , pp. 962-970
    • Pitot, H.C.1
  • 6
    • 0031603858 scopus 로고    scopus 로고
    • Carcinogenesis: From epidemiology to molecular biology
    • Tubiana, M. Carcinogenesis: From epidemiology to molecular biology. Bull. Acad. Natl. Med. 1998, 182, 19-29.
    • (1998) Bull. Acad. Natl. Med. , vol.182 , pp. 19-29
    • Tubiana, M.1
  • 7
    • 79951806556 scopus 로고    scopus 로고
    • Nanotherapeutics to overcome conventional cancer chemotherapy limitations
    • Chidambaram, M.; Manavalan, R.; Kathiresan, K. Nanotherapeutics to overcome conventional cancer chemotherapy limitations. J. Pharm. Pharm. Sci. 2011, 14, 67-77.
    • (2011) J. Pharm. Pharm. Sci. , vol.14 , pp. 67-77
    • Chidambaram, M.1    Manavalan, R.2    Kathiresan, K.3
  • 8
    • 77951497771 scopus 로고    scopus 로고
    • Chances and limitations of chemotherapy in elderly patients
    • doi:10.1007/s00108-010-2601-x
    • Wedding, U. Chances and limitations of chemotherapy in elderly patients. Internist 2010, 51, doi:10.1007/s00108-010-2601-x.
    • (2010) Internist , vol.51
    • Wedding, U.1
  • 9
    • 59849093878 scopus 로고    scopus 로고
    • Evidenced based medicine. Benefits, limitations and issues for complementary and alternative medicine
    • Mendel, J. Evidenced based medicine. Benefits, limitations and issues for complementary and alternative medicine. Aust. J. Holist. Nurs. 2004, 11, 21-29.
    • (2004) Aust. J. Holist. Nurs. , vol.11 , pp. 21-29
    • Mendel, J.1
  • 10
    • 14044279801 scopus 로고    scopus 로고
    • Defining complementary and alternative medicine in allergies and asthma: Benefits and risks
    • Heimall, J.; Bielory, L. Defining complementary and alternative medicine in allergies and asthma: Benefits and risks. Clin. Rev. Allergy Immunol. 2004, 27, 93-103.
    • (2004) Clin. Rev. Allergy Immunol. , vol.27 , pp. 93-103
    • Heimall, J.1    Bielory, L.2
  • 11
    • 78649775124 scopus 로고    scopus 로고
    • The use and perceived benefits resulting from the use of complementary and alternative medicine by cancer patients in Australia
    • Oh, B.; Butow, P.; Mullan, B.; Beale, P.; Pavlakis, N.; Rosenthal, D.; Clarke, S. The use and perceived benefits resulting from the use of complementary and alternative medicine by cancer patients in Australia. Asia Pac. J. Clin. Oncol. 2010, 6, 342-349.
    • (2010) Asia Pac. J. Clin. Oncol. , vol.6 , pp. 342-349
    • Oh, B.1    Butow, P.2    Mullan, B.3    Beale, P.4    Pavlakis, N.5    Rosenthal, D.6    Clarke, S.7
  • 14
    • 84858328733 scopus 로고    scopus 로고
    • Honey supplementation in spontaneously hypertensive rats elicits antihypertensive effect via amelioration of renal oxidative stress
    • Erejuwa, O.O.; Sulaiman, S.A.; Ab Wahab, M.S.; Sirajudeen, K.N.; Salleh, S.; Gurtu, S. Honey supplementation in spontaneously hypertensive rats elicits antihypertensive effect via amelioration of renal oxidative stress. Oxid. Med. Cell. Longev. 2012, 2012, 374037.
    • (2012) Oxid. Med. Cell. Longev. , vol.2012 , pp. 374037
    • Erejuwa, O.O.1    Sulaiman, S.A.2    Ab Wahab, M.S.3    Sirajudeen, K.N.4    Salleh, S.5    Gurtu, S.6
  • 15
    • 77957660708 scopus 로고    scopus 로고
    • Ellagic acid, phenolic acids, and flavonoids in Malaysian honey extracts demonstrate in vitro anti-inflammatory activity
    • Kassim, M.; Achoui, M.; Mustafa, M.R.; Mohd, M.A.; Yusoff, K.M. Ellagic acid, phenolic acids, and flavonoids in Malaysian honey extracts demonstrate in vitro anti-inflammatory activity. Nutr. Res. 2010, 30, 650-659.
    • (2010) Nutr. Res. , vol.30 , pp. 650-659
    • Kassim, M.1    Achoui, M.2    Mustafa, M.R.3    Mohd, M.A.4    Yusoff, K.M.5
  • 18
    • 84877273439 scopus 로고    scopus 로고
    • Honey as a source of dietary antioxidants: Structures, bioavailability and evidence of protective effects against human chronic diseases
    • Alvarez-Suarez, J.M.; Giampieri, F.; Battino, M. Honey as a source of dietary antioxidants: Structures, bioavailability and evidence of protective effects against human chronic diseases. Curr. Med. Chem. 2013, 20, 621-638.
    • (2013) Curr. Med. Chem. , vol.20 , pp. 621-638
    • Alvarez-Suarez, J.M.1    Giampieri, F.2    Battino, M.3
  • 20
    • 0043123040 scopus 로고    scopus 로고
    • Free amino acid composition and botanical origin of honey
    • Hermosin, I.; Chicón, R.M.; Dolores Cabezudo, M. Free amino acid composition and botanical origin of honey. Food Chem. 2003, 83, 263-268.
    • (2003) Food Chem. , vol.83 , pp. 263-268
    • Hermosin, I.1    Chicón, R.M.2    Dolores Cabezudo, M.3
  • 21
    • 84883672012 scopus 로고    scopus 로고
    • Characterisation of honeys according to their content of phenolic compounds using high performance liquid chromatography/tandem mass spectrometry
    • Sergiel, I.; Pohl, P.; Biesaga, M. Characterisation of honeys according to their content of phenolic compounds using high performance liquid chromatography/tandem mass spectrometry. Food Chem. 2014, 145, 404-408.
    • (2014) Food Chem. , vol.145 , pp. 404-408
    • Sergiel, I.1    Pohl, P.2    Biesaga, M.3
  • 22
    • 84879044608 scopus 로고    scopus 로고
    • Analysis of the flavonoid component of bioactive New Zealand manuka (Leptospermum scoparium) honey and the isolation, characterisation and synthesis of an unusual pyrrole
    • Chan, C.W.; Deadman, B.J.; Manley-Harris, M.; Wilkins, A.L.; Alber, D.G.; Harry, E. Analysis of the flavonoid component of bioactive New Zealand manuka (Leptospermum scoparium) honey and the isolation, characterisation and synthesis of an unusual pyrrole. Food Chem. 2013, 141, 1772-1781.
    • (2013) Food Chem. , vol.141 , pp. 1772-1781
    • Chan, C.W.1    Deadman, B.J.2    Manley-Harris, M.3    Wilkins, A.L.4    Alber, D.G.5    Harry, E.6
  • 24
    • 84886508466 scopus 로고    scopus 로고
    • Kaempferol promotes apoptosis in human bladder cancer cells by inducing the tumor suppressor, PTEN
    • Xie, F.; Su, M.; Qiu, W.; Zhang, M.; Guo, Z.; Su, B.; Liu, J.; Li, X.; Zhou, L. Kaempferol promotes apoptosis in human bladder cancer cells by inducing the tumor suppressor, PTEN. Int. J. Mol. Sci. 2013, 14, 21215-21226.
    • (2013) Int. J. Mol. Sci. , vol.14 , pp. 21215-21226
    • Xie, F.1    Su, M.2    Qiu, W.3    Zhang, M.4    Guo, Z.5    Su, B.6    Liu, J.7    Li, X.8    Zhou, L.9
  • 25
    • 84861056087 scopus 로고    scopus 로고
    • Growth inhibition by caffeic acid, one of the phenolic constituents of honey, in HCT 15 colon cancer cells
    • doi:10.1100/2012/372345
    • Jaganathan, S.K. Growth inhibition by caffeic acid, one of the phenolic constituents of honey, in HCT 15 colon cancer cells. Sci. World J. 2012, 2012, doi:10.1100/2012/372345.
    • (2012) Sci. World J. , vol.2012
    • Jaganathan, S.K.1
  • 26
    • 79961160763 scopus 로고    scopus 로고
    • Chrysin reduces proliferation and induces apoptosis in the human prostate cancer cell line pc-3
    • Samarghandian, S.; Afshari, J.T.; Davoodi, S. Chrysin reduces proliferation and induces apoptosis in the human prostate cancer cell line pc-3. Clinics 2011, 66, 1073-1079.
    • (2011) Clinics , vol.66 , pp. 1073-1079
    • Samarghandian, S.1    Afshari, J.T.2    Davoodi, S.3
  • 28
    • 84857021782 scopus 로고    scopus 로고
    • Toxicological aspects of the use of phenolic compounds in disease prevention
    • Kyselova, Z. Toxicological aspects of the use of phenolic compounds in disease prevention. Interdiscip. Toxicol. 2011, 4, 173-183.
    • (2011) Interdiscip. Toxicol. , vol.4 , pp. 173-183
    • Kyselova, Z.1
  • 29
    • 0036654441 scopus 로고    scopus 로고
    • Relationship between estrogen receptor-binding and estrogenic activities of environmental estrogens and suppression by flavonoids
    • Han, D.H.; Denison, M.S.; Tachibana, H.; Yamada, K. Relationship between estrogen receptor-binding and estrogenic activities of environmental estrogens and suppression by flavonoids. Biosci. Biotechnol. Biochem. 2002, 66, 1479-1487.
    • (2002) Biosci. Biotechnol. Biochem. , vol.66 , pp. 1479-1487
    • Han, D.H.1    Denison, M.S.2    Tachibana, H.3    Yamada, K.4
  • 30
    • 80052196450 scopus 로고    scopus 로고
    • Estrogen carcinogenesis in breast cancer
    • Germain, D. Estrogen carcinogenesis in breast cancer. Endocrinol. Metab Clin North. Am. 2011, 40, 473-484.
    • (2011) Endocrinol. Metab Clin North. Am. , vol.40 , pp. 473-484
    • Germain, D.1
  • 31
    • 67349237894 scopus 로고    scopus 로고
    • Bioactivity of Greek honey extracts on breast cancer (MCF-7), prostate cancer (PC-3) and endometrial cancer (Ishikawa) cells: Profile analysis of extracts
    • Tsiapara, A.V.; Jaakkola, M.; Chinou, I.; Graikou, K.; Tolonen, T.; Virtanen, V.; Moutsatsou, P. Bioactivity of Greek honey extracts on breast cancer (MCF-7), prostate cancer (PC-3) and endometrial cancer (Ishikawa) cells: Profile analysis of extracts. Food Chem. 2009, 116, 702-708.
    • (2009) Food Chem. , vol.116 , pp. 702-708
    • Tsiapara, A.V.1    Jaakkola, M.2    Chinou, I.3    Graikou, K.4    Tolonen, T.5    Virtanen, V.6    Moutsatsou, P.7
  • 33
    • 1342264764 scopus 로고    scopus 로고
    • Phytoestrogens and breast cancer
    • Ziegler, R.G. Phytoestrogens and breast cancer. Am. J. Clin. Nutr. 2004, 79, 183-184.
    • (2004) Am. J. Clin. Nutr. , vol.79 , pp. 183-184
    • Ziegler, R.G.1
  • 34
    • 84856185031 scopus 로고    scopus 로고
    • The pro-apoptotic effect of quercetin in cancer cell lines requires ERbeta-dependent signals
    • Bulzomi, P.; Galluzzo, P.; Bolli, A.; Leone, S.; Acconcia, F.; Marino, M. The pro-apoptotic effect of quercetin in cancer cell lines requires ERbeta-dependent signals. J. Cell. Physiol. 2012, 227, 1891-1898.
    • (2012) J. Cell. Physiol. , vol.227 , pp. 1891-1898
    • Bulzomi, P.1    Galluzzo, P.2    Bolli, A.3    Leone, S.4    Acconcia, F.5    Marino, M.6
  • 35
    • 67651091566 scopus 로고    scopus 로고
    • Quercetin-induced apoptotic cascade in cancer cells: Antioxidant versus estrogen receptor alpha-dependent mechanisms
    • Galluzzo, P.; Martini, C.; Bulzomi, P.; Leone, S.; Bolli, A.; Pallottini, V.; Marino, M. Quercetin-induced apoptotic cascade in cancer cells: Antioxidant versus estrogen receptor alpha-dependent mechanisms. Mol. Nutr. Food Res. 2009, 53, 699-708.
    • (2009) Mol. Nutr. Food Res. , vol.53 , pp. 699-708
    • Galluzzo, P.1    Martini, C.2    Bulzomi, P.3    Leone, S.4    Bolli, A.5    Pallottini, V.6    Marino, M.7
  • 36
    • 79952451695 scopus 로고    scopus 로고
    • Tualang honey induces apoptosis and disrupts the mitochondrial membrane potential of human breast and cervical cancer cell lines
    • Fauzi, A.N.; Norazmi, M.N.; Yaacob, N.S. Tualang honey induces apoptosis and disrupts the mitochondrial membrane potential of human breast and cervical cancer cell lines. Food Chem. Toxicol. 2011, 49, 871-878.
    • (2011) Food Chem. Toxicol. , vol.49 , pp. 871-878
    • Fauzi, A.N.1    Norazmi, M.N.2    Yaacob, N.S.3
  • 37
    • 84874866273 scopus 로고    scopus 로고
    • Tualang honey promotes apoptotic cell death induced by tamoxifen in breast cancer cell lines
    • doi:10.1155/2013/989841
    • Yaacob, N.S.; Nengsih, A.; Norazmi, M.N. Tualang honey promotes apoptotic cell death induced by tamoxifen in breast cancer cell lines. Evid. Based Complement. Altern. Med. 2013, 2013, doi:10.1155/2013/989841.
    • (2013) Evid. Based Complement. Altern. Med. , vol.2013
    • Yaacob, N.S.1    Nengsih, A.2    Norazmi, M.N.3
  • 38
    • 77956261170 scopus 로고    scopus 로고
    • Studies on the phenolic profiling, anti-oxidant and cytotoxic activity of Indian honey: In vitro evaluation
    • Jaganathan, S.K.; Mandal, S.M.; Jana, S.K.; Das, S.; Mandal, M. Studies on the phenolic profiling, anti-oxidant and cytotoxic activity of Indian honey: In vitro evaluation. Nat. Prod. Res. 2010, 24, 1295-1306.
    • (2010) Nat. Prod. Res. , vol.24 , pp. 1295-1306
    • Jaganathan, S.K.1    Mandal, S.M.2    Jana, S.K.3    Das, S.4    Mandal, M.5
  • 41
    • 84886789491 scopus 로고    scopus 로고
    • Chrysin inhibits metastatic potential of human triple-negative breast cancer cells by modulating matrix metalloproteinase-10, epithelial to mesenchymal transition, and PI3K/Akt signaling pathway
    • doi:10.1002/jat.2941
    • Yang, B.; Huang, J.; Xiang, T.; Yin, X.; Luo, X.; Luo, F.; Li, H.; Ren, G. Chrysin inhibits metastatic potential of human triple-negative breast cancer cells by modulating matrix metalloproteinase-10, epithelial to mesenchymal transition, and PI3K/Akt signaling pathway. J. Appl. Toxicol. 2013, 2013, doi:10.1002/jat.2941.
    • (2013) J. Appl. Toxicol. , vol.2013
    • Yang, B.1    Huang, J.2    Xiang, T.3    Yin, X.4    Luo, X.5    Luo, F.6    Li, H.7    Ren, G.8
  • 42
    • 77951694575 scopus 로고    scopus 로고
    • Effect of honey and eugenol on Ehrlich ascites and solid carcinoma
    • doi:10.1155/2010/989163
    • Jaganathan, S.K.; Mondhe, D.; Wani, Z.A.; Pal, H.C.; Mandal, M. Effect of honey and eugenol on Ehrlich ascites and solid carcinoma. J. Biomed. Biotechnol. 2010, 2010, doi:10.1155/2010/989163.
    • J. Biomed. Biotechnol. , vol.2010 , pp. 2010
    • Jaganathan, S.K.1    Mondhe, D.2    Wani, Z.A.3    Pal, H.C.4    Mandal, M.5
  • 43
    • 79953196894 scopus 로고    scopus 로고
    • Oral administration of aloe vera and honey reduces walker tumour growth by decreasing cell proliferation and increasing apoptosis in tumour tissue
    • Tomasin, R.; Gomes-Marcondes, M.C. Oral administration of aloe vera and honey reduces walker tumour growth by decreasing cell proliferation and increasing apoptosis in tumour tissue. Phytother. Res. 2011, 25, 619-623.
    • (2011) Phytother. Res. , vol.25 , pp. 619-623
    • Tomasin, R.1    Gomes-Marcondes, M.C.2
  • 44
    • 84880262394 scopus 로고    scopus 로고
    • Inhibitory effects of tualang honey on experimental breast cancer in rats: A preliminary study
    • Kadir, E.A.; Sulaiman, S.A.; Yahya, N.K.; Othman, N.H. Inhibitory effects of tualang honey on experimental breast cancer in rats: A preliminary study. Asian Pac. J. Cancer Prev. 2013, 14, 2249-2254.
    • (2013) Asian Pac. J. Cancer Prev. , vol.14 , pp. 2249-2254
    • Kadir, E.A.1    Sulaiman, S.A.2    Yahya, N.K.3    Othman, N.H.4
  • 46
    • 79952277505 scopus 로고    scopus 로고
    • The incidence and epidemiology of hepatocellular carcinoma: A global and regional perspective
    • Venook, A.P.; Papandreou, C.; Furuse, J.; de Guevara, L.L. The incidence and epidemiology of hepatocellular carcinoma: A global and regional perspective. Oncologist 2010, 15, 5-13.
    • (2010) Oncologist , vol.15 , pp. 5-13
    • Venook, A.P.1    Papandreou, C.2    Furuse, J.3    De Guevara, L.L.4
  • 47
    • 84869446702 scopus 로고    scopus 로고
    • Antineoplastic effects of bee honey and Nigella sativa on hepatocellular carcinoma cells
    • Hassan, M.I.; Mabrouk, G.M.; Shehata, H.H.; Aboelhussein, M.M. Antineoplastic effects of bee honey and Nigella sativa on hepatocellular carcinoma cells. Integr. Cancer Ther. 2012, 11, 354-363.
    • (2012) Integr. Cancer Ther. , vol.11 , pp. 354-363
    • Hassan, M.I.1    Mabrouk, G.M.2    Shehata, H.H.3    Aboelhussein, M.M.4
  • 48
    • 0033600791 scopus 로고    scopus 로고
    • Growth stimulation versus induction of cell quiescence by hydrogen peroxide in prostate tumor spheroids is encoded by the duration of the Ca2+ response
    • Wartenberg, M.; Diedershagen, H.; Hescheler, J.; Sauer, H. Growth stimulation versus induction of cell quiescence by hydrogen peroxide in prostate tumor spheroids is encoded by the duration of the Ca2+ response. J. Biol. Chem. 1999, 274, 27759-27767.
    • (1999) J. Biol. Chem. , vol.274 , pp. 27759-27767
    • Wartenberg, M.1    Diedershagen, H.2    Hescheler, J.3    Sauer, H.4
  • 49
    • 0026515446 scopus 로고
    • Active oxygen species stimulate vascular smooth muscle cell growth and proto-oncogene expression
    • Rao, G.N.; Berk, B.C. Active oxygen species stimulate vascular smooth muscle cell growth and proto-oncogene expression. Circ. Res. 1992, 70, 593-599.
    • (1992) Circ. Res. , vol.70 , pp. 593-599
    • Rao, G.N.1    Berk, B.C.2
  • 50
    • 84894612787 scopus 로고    scopus 로고
    • Antiproliferative activity and apoptosis induction by gelam honey on liver cancer cell line
    • Jubri, Z.; Narayanan, N.N.N.; Karim, N.A.; Ngah, W.Z.W. Antiproliferative activity and apoptosis induction by gelam honey on liver cancer cell line. Int. J. Appl. Sci. Technol. 2012, 2, 135-141.
    • (2012) Int. J. Appl. Sci. Technol. , vol.2 , pp. 135-141
    • Jubri, Z.1    Narayanan, N.N.N.2    Karim, N.A.3    Ngah, W.Z.W.4
  • 51
    • 84894640129 scopus 로고    scopus 로고
    • Insulin sensitivity enhancement of the mixture of Tinospora crispa and gelam (Melaleuca cajuputi) honey and its antiproliferative activity on hepatocellular carcinoma, HepG2: A preliminary study
    • Ismail, W.I.W.; Abu, M.N.; Salleh, M.A.M.; Radzman, N.H.M.; Yusof, R.M.; Hassan, H.F. Insulin sensitivity enhancement of the mixture of Tinospora crispa and gelam (Melaleuca cajuputi) honey and its antiproliferative activity on hepatocellular carcinoma, HepG2: A preliminary study. J. Med. Res. Dev. 2013, 2, 48-54.
    • (2013) J. Med. Res. Dev. , vol.2 , pp. 48-54
    • Ismail, W.I.W.1    Abu, M.N.2    Salleh, M.A.M.3    Radzman, N.H.M.4    Yusof, R.M.5    Hassan, H.F.6
  • 53
    • 77952254729 scopus 로고    scopus 로고
    • Effect of some honey bee extracts on the proliferation, proteolytic and gelatinolytic activities of the hepatocellular carcinoma Hepg2 cell line
    • Abdel Aziz, A.; Rady, H.; Amer, M.; Kiwan, H. Effect of some honey bee extracts on the proliferation, proteolytic and gelatinolytic activities of the hepatocellular carcinoma Hepg2 cell line. Aust. J. Basic Appl. Sci. 2009, 3, 2754-2769.
    • (2009) Aust. J. Basic Appl. Sci. , vol.3 , pp. 2754-2769
    • Abdel Aziz, A.1    Rady, H.2    Amer, M.3    Kiwan, H.4
  • 54
    • 33748708193 scopus 로고    scopus 로고
    • Free radical production and quenching in honeys with wound healing potential
    • Henriques, A.; Jackson, S.; Cooper, R.; Burton, N. Free radical production and quenching in honeys with wound healing potential. J. Antimicrob. Chemother. 2006, 58, 773-777.
    • (2006) J. Antimicrob. Chemother. , vol.58 , pp. 773-777
    • Henriques, A.1    Jackson, S.2    Cooper, R.3    Burton, N.4
  • 55
    • 84872377728 scopus 로고    scopus 로고
    • Enhancement of the antitumor effect of honey and some of its extracts using adiponectin hormone
    • Hanaa, M.; Shaymaa, M. Enhancement of the antitumor effect of honey and some of its extracts using adiponectin hormone. Aust. J. Basic Appl. Sci. 2011, 5, 100-108.
    • (2011) Aust. J. Basic Appl. Sci. , vol.5 , pp. 100-108
    • Hanaa, M.1    Shaymaa, M.2
  • 56
    • 84880971950 scopus 로고    scopus 로고
    • Spanish honeys protect against food mutagen-induced DNA damage
    • Haza, A.I.; Morales, P. Spanish honeys protect against food mutagen-induced DNA damage. J. Sci. Food Agric. 2013, 93, 2995-3000.
    • (2013) J. Sci. Food Agric. , vol.93 , pp. 2995-3000
    • Haza, A.I.1    Morales, P.2
  • 57
    • 84864109881 scopus 로고    scopus 로고
    • Anti-tumor effects of bee honey on PCNA and P53 expression in the rat hepatocarcinogenesis
    • El-kott, A.F.; Kandeel, A.A.; El-Aziz, S.F.A.; Ribea, H.M. Anti-tumor effects of bee honey on PCNA and P53 expression in the rat hepatocarcinogenesis. Int. J. Cancer Res. 2012, 8, 130-139.
    • (2012) Int. J. Cancer Res. , vol.8 , pp. 130-139
    • El-Kott, A.F.1    Kandeel, A.A.2    El-Aziz, S.F.A.3    Ribea, H.M.4
  • 58
    • 0034734896 scopus 로고    scopus 로고
    • ABC of colorectal cancer: Epidemiology
    • Boyle, P.; Langman, J.S. ABC of colorectal cancer: Epidemiology. BMJ 2000, 321, 805-808.
    • (2000) BMJ , vol.321 , pp. 805-808
    • Boyle, P.1    Langman, J.S.2
  • 60
    • 0036031826 scopus 로고    scopus 로고
    • Epidemiology of colorectal cancer
    • Boyle, P.; Leon, M.E. Epidemiology of colorectal cancer. Br. Med. Bull. 2002, 64, 1-25.
    • (2002) Br. Med. Bull. , vol.64 , pp. 1-25
    • Boyle, P.1    Leon, M.E.2
  • 61
    • 0034638641 scopus 로고    scopus 로고
    • ABC of colorectal cancer: Adjuvant therapy
    • Midgley, R.S.; Kerr, D.J. ABC of colorectal cancer: Adjuvant therapy. BMJ 2000, 321, 1208-1211.
    • (2000) BMJ , vol.321 , pp. 1208-1211
    • Midgley, R.S.1    Kerr, D.J.2
  • 62
    • 84870721115 scopus 로고    scopus 로고
    • Gelam and Nenas honeys inhibit proliferation of HT 29 colon cancer cells by inducing DNA damage and apoptosis while suppressing inflammation
    • Wen, C.T.; Hussein, S.Z.; Abdullah, S.; Karim, N.A.; Makpol, S.; Mohd, Y.A. Gelam and Nenas honeys inhibit proliferation of HT 29 colon cancer cells by inducing DNA damage and apoptosis while suppressing inflammation. Asian Pac. J. Cancer Prev. 2012, 13, 1605-1610.
    • (2012) Asian Pac. J. Cancer Prev. , vol.13 , pp. 1605-1610
    • Wen, C.T.1    Hussein, S.Z.2    Abdullah, S.3    Karim, N.A.4    Makpol, S.5    Mohd, Y.A.6
  • 63
    • 68949146535 scopus 로고    scopus 로고
    • Honey constituents and its apoptotic effect in colon cancer cells
    • Jaganathan, S.; Mandal, M. Honey constituents and its apoptotic effect in colon cancer cells. J. Apiprod. Apimed. Sci. 2009, 1, 29-36.
    • (2009) J. Apiprod. Apimed. Sci. , vol.1 , pp. 29-36
    • Jaganathan, S.1    Mandal, M.2
  • 64
    • 77956058693 scopus 로고    scopus 로고
    • Involvement of non-protein thiols, mitochondrial dysfunction, reactive oxygen species and p53 in honey-induced apoptosis
    • Jaganathan, S.K.; Mandal, M. Involvement of non-protein thiols, mitochondrial dysfunction, reactive oxygen species and p53 in honey-induced apoptosis. Investig. N. Drugs 2010, 28, 624-633.
    • (2010) Investig. N. Drugs , vol.28 , pp. 624-633
    • Jaganathan, S.K.1    Mandal, M.2
  • 65
    • 13444250126 scopus 로고    scopus 로고
    • Honey-bee products in prevention and/or therapy of murine transplantable tumours
    • Oršolić, N.; Terzić, S.; Šver, L.; Bašić, I. Honey-bee products in prevention and/or therapy of murine transplantable tumours. J. Sci. Food Agric. 2005, 85, 363-370.
    • (2005) J. Sci. Food Agric. , vol.85 , pp. 363-370
    • Oršolić, N.1    Terzić, S.2    Šver, L.3    Bašić, I.4
  • 66
    • 11244279886 scopus 로고    scopus 로고
    • Honey as a cancer-preventive agent
    • Orsolic, N.; Basic, I. Honey as a cancer-preventive agent. Period. Biol. 2004, 106, 397-401.
    • (2004) Period. Biol. , vol.106 , pp. 397-401
    • Orsolic, N.1    Basic, I.2
  • 67
    • 0036736903 scopus 로고    scopus 로고
    • Inhibition of methylnitrosourea (MNU) induced oxidative stress and carcinogenesis by orally administered bee honey and Nigella grains in Sprague Dawely rats
    • Mabrouk, G.M.; Moselhy, S.S.; Zohny, S.F.; Ali, E.M.; Helal, T.E.; Amin, A.A.; Khalifa, A.A. Inhibition of methylnitrosourea (MNU) induced oxidative stress and carcinogenesis by orally administered bee honey and Nigella grains in Sprague Dawely rats. J. Exp. Clin. Cancer Res. 2002, 21, 341-346.
    • (2002) J. Exp. Clin. Cancer Res. , vol.21 , pp. 341-346
    • Mabrouk, G.M.1    Moselhy, S.S.2    Zohny, S.F.3    Ali, E.M.4    Helal, T.E.5    Amin, A.A.6    Khalifa, A.A.7
  • 68
    • 0038146982 scopus 로고    scopus 로고
    • Antineoplastic activity of honey in an experimental bladder cancer implantation model: In vivo and in vitro studies
    • Swellam, T.; Miyanaga, N.; Onozawa, M.; Hattori, K.; Kawai, K.; Shimazui, T.; Akaza, H. Antineoplastic activity of honey in an experimental bladder cancer implantation model: In vivo and in vitro studies. Int. J. Urol. 2003, 10, 213-219.
    • (2003) Int. J. Urol. , vol.10 , pp. 213-219
    • Swellam, T.1    Miyanaga, N.2    Onozawa, M.3    Hattori, K.4    Kawai, K.5    Shimazui, T.6    Akaza, H.7
  • 70
    • 77956542382 scopus 로고    scopus 로고
    • Acacia honey and chrysin reduce proliferation of melanoma cells through alterations in cell cycle progression
    • Pichichero, E.; Cicconi, R.; Mattei, M.; Muzi, M.G.; Canini, A. Acacia honey and chrysin reduce proliferation of melanoma cells through alterations in cell cycle progression. Int. J. Oncol. 2010, 37, 973-981.
    • (2010) Int. J. Oncol. , vol.37 , pp. 973-981
    • Pichichero, E.1    Cicconi, R.2    Mattei, M.3    Muzi, M.G.4    Canini, A.5
  • 72
    • 77956461244 scopus 로고    scopus 로고
    • Antiproliferative effect of tualang honey on oral squamous cell carcinoma and osteosarcoma cell lines
    • Ghashm, A.A.; Othman, N.H.; Khattak, M.N.; Ismail, N.M.; Saini, R. Antiproliferative effect of tualang honey on oral squamous cell carcinoma and osteosarcoma cell lines. BMC Complement. Altern. Med. 2010, 10, 49.
    • (2010) BMC Complement. Altern. Med. , vol.10 , pp. 49
    • Ghashm, A.A.1    Othman, N.H.2    Khattak, M.N.3    Ismail, N.M.4    Saini, R.5
  • 73
    • 84879656951 scopus 로고    scopus 로고
    • Antiproliferative and apoptotic effects of spanish honeys
    • Morales, P.; Haza, A.I. Antiproliferative and apoptotic effects of spanish honeys. Pharmacogn. Mag. 2013, 9, 231-237.
    • (2013) Pharmacogn. Mag. , vol.9 , pp. 231-237
    • Morales, P.1    Haza, A.I.2
  • 75
    • 84873606729 scopus 로고    scopus 로고
    • Intravenous administration of manuka honey inhibits tumor growth and improves host survival when used in combination with chemotherapy in a melanoma mouse model
    • Fernandez-Cabezudo, M.J.; El-Kharrag, R.; Torab, F.; Bashir, G.; George, J.A.; El-Taji, H.; Al-Ramadi, B.K. Intravenous administration of manuka honey inhibits tumor growth and improves host survival when used in combination with chemotherapy in a melanoma mouse model. PLoS One 2013, 8, e55993.
    • (2013) PLoS One , vol.8
    • Fernandez-Cabezudo, M.J.1    El-Kharrag, R.2    Torab, F.3    Bashir, G.4    George, J.A.5    El-Taji, H.6    Al-Ramadi, B.K.7
  • 76
    • 82755177826 scopus 로고    scopus 로고
    • The cell cycle and cancer
    • Williams, G.H.; Stoeber, K. The cell cycle and cancer. J. Pathol. 2012, 226, 352-364.
    • (2012) J. Pathol. , vol.226 , pp. 352-364
    • Williams, G.H.1    Stoeber, K.2
  • 77
    • 0028171292 scopus 로고
    • G1 phase progression: Cycling on cue
    • Sherr, C.J. G1 phase progression: Cycling on cue. Cell 1994, 79, 551-555.
    • (1994) Cell , vol.79 , pp. 551-555
    • Sherr, C.J.1
  • 80
    • 78049294193 scopus 로고    scopus 로고
    • The flavonoid quercetin induces cell cycle arrest and mitochondria-mediated apoptosis in human cervical cancer (HeLa) cells through p53 induction and NF-kappaB inhibition
    • Vidya Priyadarsini, R.; Senthil Murugan, R.; Maitreyi, S.; Ramalingam, K.; Karunagaran, D.; Nagini, S. The flavonoid quercetin induces cell cycle arrest and mitochondria-mediated apoptosis in human cervical cancer (HeLa) cells through p53 induction and NF-kappaB inhibition. Eur. J. Pharmacol. 2010, 649, 84-91.
    • (2010) Eur. J. Pharmacol. , vol.649 , pp. 84-91
    • Vidya Priyadarsini, R.1    Senthil Murugan, R.2    Maitreyi, S.3    Ramalingam, K.4    Karunagaran, D.5    Nagini, S.6
  • 81
    • 42749088247 scopus 로고    scopus 로고
    • Flavones and flavonols exert cytotoxic effects on a human oesophageal adenocarcinoma cell line (OE33) by causing G2/M arrest and inducing apoptosis
    • Zhang, Q.; Zhao, X.H.; Wang, Z.J. Flavones and flavonols exert cytotoxic effects on a human oesophageal adenocarcinoma cell line (OE33) by causing G2/M arrest and inducing apoptosis. Food Chem. Toxicol. 2008, 46, 2042-2053.
    • (2008) Food Chem. Toxicol. , vol.46 , pp. 2042-2053
    • Zhang, Q.1    Zhao, X.H.2    Wang, Z.J.3
  • 82
    • 34250338494 scopus 로고    scopus 로고
    • Quercetin induces cell cycle G1 arrest through elevating Cdk inhibitors p21 and p27 in human hepatoma cell line (HepG2)
    • Mu, C.; Jia, P.; Yan, Z.; Liu, X.; Li, X.; Liu, H. Quercetin induces cell cycle G1 arrest through elevating Cdk inhibitors p21 and p27 in human hepatoma cell line (HepG2). Methods Find. Exp. Clin. Pharmacol. 2007, 29, 179-183.
    • (2007) Methods Find. Exp. Clin. Pharmacol. , vol.29 , pp. 179-183
    • Mu, C.1    Jia, P.2    Yan, Z.3    Liu, X.4    Li, X.5    Liu, H.6
  • 83
    • 84896691526 scopus 로고    scopus 로고
    • Kaempferol induces cell cycle arrest and apoptosis in renal cell carcinoma through EGFR/p38 signaling
    • Song, W.; Dang, Q.; Xu, D.; Chen, Y.; Zhu, G.; Wu, K.; Zeng, J.; Long, Q.; Wang, X.; He, D.; et al. Kaempferol induces cell cycle arrest and apoptosis in renal cell carcinoma through EGFR/p38 signaling. Oncol. Rep. 2014, 31, 1350-1356.
    • (2014) Oncol. Rep. , vol.31 , pp. 1350-1356
    • Song, W.1    Dang, Q.2    Xu, D.3    Chen, Y.4    Zhu, G.5    Wu, K.6    Zeng, J.7    Long, Q.8    Wang, X.9    He, D.10
  • 84
    • 3442886811 scopus 로고    scopus 로고
    • The pathophysiology of mitochondrial cell death
    • Green, D.R.; Kroemer, G. The pathophysiology of mitochondrial cell death. Science 2004, 305, 626-629.
    • (2004) Science , vol.305 , pp. 626-629
    • Green, D.R.1    Kroemer, G.2
  • 85
    • 8844235617 scopus 로고    scopus 로고
    • The mitochondrial death pathway and cardiac myocyte apoptosis
    • Crow, M.T.; Mani, K.; Nam, Y.J.; Kitsis, R.N. The mitochondrial death pathway and cardiac myocyte apoptosis. Circ. Res. 2004, 95, 957-970.
    • (2004) Circ. Res. , vol.95 , pp. 957-970
    • Crow, M.T.1    Mani, K.2    Nam, Y.J.3    Kitsis, R.N.4
  • 86
    • 33745591102 scopus 로고    scopus 로고
    • Multiple pathways of cytochrome c release from mitochondria in apoptosis
    • Gogvadze, V.; Orrenius, S.; Zhivotovsky, B. Multiple pathways of cytochrome c release from mitochondria in apoptosis. Biochim. Biophys. Acta 2006, 1757, 639-647.
    • (2006) Biochim. Biophys. Acta , vol.1757 , pp. 639-647
    • Gogvadze, V.1    Orrenius, S.2    Zhivotovsky, B.3
  • 87
    • 0037051715 scopus 로고    scopus 로고
    • Food-derived polyphenols inhibit pancreatic cancer growth through mitochondrial cytochrome C release and apoptosis
    • Mouria, M.; Gukovskaya, A.S.; Jung, Y.; Buechler, P.; Hines, O.J.; Reber, H.A.; Pandol, S.J. Food-derived polyphenols inhibit pancreatic cancer growth through mitochondrial cytochrome C release and apoptosis. Int. J. Cancer 2002, 98, 761-769.
    • (2002) Int. J. Cancer , vol.98 , pp. 761-769
    • Mouria, M.1    Gukovskaya, A.S.2    Jung, Y.3    Buechler, P.4    Hines, O.J.5    Reber, H.A.6    Pandol, S.J.7
  • 88
    • 84866443277 scopus 로고    scopus 로고
    • Induction of apoptosis by 7-piperazinethylchrysin in HCT-116 human colon cancer cells
    • Ren, J.; Cheng, H.; Xin, W.Q.; Chen, X.; Hu, K. Induction of apoptosis by 7-piperazinethylchrysin in HCT-116 human colon cancer cells. Oncol. Rep. 2012, 28, 1719-1726.
    • (2012) Oncol. Rep. , vol.28 , pp. 1719-1726
    • Ren, J.1    Cheng, H.2    Xin, W.Q.3    Chen, X.4    Hu, K.5
  • 89
    • 33745950626 scopus 로고    scopus 로고
    • Mitochondrial outer membrane permeabilization during apoptosis: The innocent bystander scenario
    • Chipuk, J.E.; Bouchier-Hayes, L.; Green, D.R. Mitochondrial outer membrane permeabilization during apoptosis: The innocent bystander scenario. Cell Death Differ. 2006, 13, 1396-1402.
    • (2006) Cell Death Differ. , vol.13 , pp. 1396-1402
    • Chipuk, J.E.1    Bouchier-Hayes, L.2    Green, D.R.3
  • 90
    • 70349680622 scopus 로고    scopus 로고
    • Quercetin-induced apoptosis acts through mitochondrial- and caspase-3-dependent pathways in human breast cancer MDA-MB-231 cells
    • Chien, S.Y.; Wu, Y.C.; Chung, J.G.; Yang, J.S.; Lu, H.F.; Tsou, M.F.; Wood, W.G.; Kuo, S.J.; Chen, D.R. Quercetin-induced apoptosis acts through mitochondrial- and caspase-3-dependent pathways in human breast cancer MDA-MB-231 cells. Hum. Exp. Toxicol. 2009, 28, 493-503.
    • (2009) Hum. Exp. Toxicol. , vol.28 , pp. 493-503
    • Chien, S.Y.1    Wu, Y.C.2    Chung, J.G.3    Yang, J.S.4    Lu, H.F.5    Tsou, M.F.6    Wood, W.G.7    Kuo, S.J.8    Chen, D.R.9
  • 91
    • 28244442462 scopus 로고    scopus 로고
    • Apoptosis: A basic biological phenomenon with wide-ranging implications in human disease
    • Fadeel, B.; Orrenius, S. Apoptosis: A basic biological phenomenon with wide-ranging implications in human disease. J. Intern. Med. 2005, 258, 479-517.
    • (2005) J. Intern. Med. , vol.258 , pp. 479-517
    • Fadeel, B.1    Orrenius, S.2
  • 92
    • 84894640291 scopus 로고    scopus 로고
    • Apoptosis: From biology to therapeutic targeting
    • O'Connor, O. Apoptosis: From biology to therapeutic targeting. Ann. Oncol. 2011, 22, iv76-iv79.
    • (2011) Ann. Oncol. , vol.22
    • O'Connor, O.1
  • 94
    • 77956095537 scopus 로고    scopus 로고
    • Mitochondria and cell death: Outer membrane permeabilization and beyond
    • Tait, S.W.; Green, D.R. Mitochondria and cell death: Outer membrane permeabilization and beyond. Nat. Rev. Mol. Cell Biol. 2010, 11, 621-632.
    • (2010) Nat. Rev. Mol. Cell Biol. , vol.11 , pp. 621-632
    • Tait, S.W.1    Green, D.R.2
  • 96
    • 84863412840 scopus 로고    scopus 로고
    • Suppression of error prone pathway is responsible for antimutagenic activity of honey
    • Saxena, S.; Gautam, S.; Maru, G.; Kawle, D.; Sharma, A. Suppression of error prone pathway is responsible for antimutagenic activity of honey. Food Chem. Toxicol. 2012, 50, 625-633.
    • (2012) Food Chem. Toxicol. , vol.50 , pp. 625-633
    • Saxena, S.1    Gautam, S.2    Maru, G.3    Kawle, D.4    Sharma, A.5
  • 97
    • 79952699255 scopus 로고    scopus 로고
    • P53: The most frequently altered gene in human cancers
    • Vogelstein, B.; Sur, S.; Prives, C. p53: The most frequently altered gene in human cancers. Nat. Educ. 2010, 3, 6.
    • (2010) Nat. Educ. , vol.3 , pp. 6
    • Vogelstein, B.1    Sur, S.2    Prives, C.3
  • 98
    • 80053039210 scopus 로고    scopus 로고
    • Mutations in the p53 tumor suppressor gene: Important milestones at the various steps of tumorigenesis
    • Rivlin, N.; Brosh, R.; Oren, M.; Rotter, V. Mutations in the p53 tumor suppressor gene: Important milestones at the various steps of tumorigenesis. Genes Cancer 2011, 2, 466-474.
    • (2011) Genes Cancer , vol.2 , pp. 466-474
    • Rivlin, N.1    Brosh, R.2    Oren, M.3    Rotter, V.4
  • 101
    • 84860719243 scopus 로고    scopus 로고
    • Quercetin inhibits human breast cancer cell proliferation and induces apoptosis via Bcl-2 and Bax regulation
    • Duo, J.; Ying, G.G.; Wang, G.W.; Zhang, L. Quercetin inhibits human breast cancer cell proliferation and induces apoptosis via Bcl-2 and Bax regulation. Mol. Med. Rep. 2012, 5, 1453-1456.
    • (2012) Mol. Med. Rep. , vol.5 , pp. 1453-1456
    • Duo, J.1    Ying, G.G.2    Wang, G.W.3    Zhang, L.4
  • 102
    • 78651249051 scopus 로고    scopus 로고
    • Chrysin-induced apoptosis is mediated through p38 and Bax activation in B16-F1 and A375 melanoma cells
    • Pichichero, E.; Cicconi, R.; Mattei, M.; Canini, A. Chrysin-induced apoptosis is mediated through p38 and Bax activation in B16-F1 and A375 melanoma cells. Int. J. Oncol. 2011, 38, 473-483.
    • (2011) Int. J. Oncol. , vol.38 , pp. 473-483
    • Pichichero, E.1    Cicconi, R.2    Mattei, M.3    Canini, A.4
  • 103
    • 79953719297 scopus 로고    scopus 로고
    • A survey of the anti-apoptotic Bcl-2 subfamily expression in cancer types provides a platform to predict the efficacy of Bcl-2 antagonists in cancer therapy
    • Placzek, W.J.; Wei, J.; Kitada, S.; Zhai, D.; Reed, J.C.; Pellecchia, M. A survey of the anti-apoptotic Bcl-2 subfamily expression in cancer types provides a platform to predict the efficacy of Bcl-2 antagonists in cancer therapy. Cell Death Dis. 2010, 1, e40.
    • (2010) Cell Death Dis. , vol.1
    • Placzek, W.J.1    Wei, J.2    Kitada, S.3    Zhai, D.4    Reed, J.C.5    Pellecchia, M.6
  • 104
    • 0032877668 scopus 로고    scopus 로고
    • Dysregulation of apoptosis in cancer
    • Reed, J.C. Dysregulation of apoptosis in cancer. J. Clin. Oncol. 1999, 17, 2941-2953.
    • (1999) J. Clin. Oncol. , vol.17 , pp. 2941-2953
    • Reed, J.C.1
  • 105
    • 0034873185 scopus 로고    scopus 로고
    • Reactive oxygen species as intracellular messengers during cell growth and differentiation
    • Sauer, H.; Wartenberg, M.; Hescheler, J. Reactive oxygen species as intracellular messengers during cell growth and differentiation. Cell. Physiol. Biochem. 2001, 11, 173-186.
    • (2001) Cell. Physiol. Biochem. , vol.11 , pp. 173-186
    • Sauer, H.1    Wartenberg, M.2    Hescheler, J.3
  • 107
    • 84855723034 scopus 로고    scopus 로고
    • Interplay between membrane lipid peroxidation, transglutaminase activity, and cyclooxygenase 2 expression in the tissue adjoining to breast cancer
    • Balestrieri, M.L.; Dicitore, A.; Benevento, R.; di Maio, M.; Santoriello, A.; Canonico, S.; Giordano, A.; Stiuso, P. Interplay between membrane lipid peroxidation, transglutaminase activity, and cyclooxygenase 2 expression in the tissue adjoining to breast cancer. J. Cell. Physiol. 2012, 227, 1577-1582.
    • (2012) J. Cell. Physiol. , vol.227 , pp. 1577-1582
    • Balestrieri, M.L.1    Dicitore, A.2    Benevento, R.3    Di Maio, M.4    Santoriello, A.5    Canonico, S.6    Giordano, A.7    Stiuso, P.8
  • 108
    • 84860358440 scopus 로고    scopus 로고
    • Assessment of 8-oxo-7, 8-dihydro-2'-deoxyguanosine and malondialdehyde levels as oxidative stress markers and antioxidant status in non-small cell lung cancer
    • Peddireddy, V.; Siva Prasad, B.; Gundimeda, S.D.; Penagaluru, P.R.; Mundluru, H.P. Assessment of 8-oxo-7, 8-dihydro-2'-deoxyguanosine and malondialdehyde levels as oxidative stress markers and antioxidant status in non-small cell lung cancer. Biomarkers 2012, 17, 261-268.
    • (2012) Biomarkers , vol.17 , pp. 261-268
    • Peddireddy, V.1    Siva Prasad, B.2    Gundimeda, S.D.3    Penagaluru, P.R.4    Mundluru, H.P.5
  • 110
  • 111
    • 84883415498 scopus 로고    scopus 로고
    • Reactive oxygen species in cancer biology and anticancer therapy
    • Yang, Y.; Karakhanova, S.; Werner, J.; Bazhin, A.V. Reactive oxygen species in cancer biology and anticancer therapy. Curr. Med. Chem. 2013, 20, 3677-3692.
    • (2013) Curr. Med. Chem. , vol.20 , pp. 3677-3692
    • Yang, Y.1    Karakhanova, S.2    Werner, J.3    Bazhin, A.V.4
  • 112
    • 84893872939 scopus 로고    scopus 로고
    • Evidence in support of potential applications of lipid peroxidation products in cancer treatment
    • Erejuwa, O.O.; Sulaiman, S.A.; Wahab, M.S. Evidence in support of potential applications of lipid peroxidation products in cancer treatment. Oxid. Med. Cell. Longev. 2013, 2013, 931251.
    • (2013) Oxid. Med. Cell. Longev. , vol.2013 , pp. 931251
    • Erejuwa, O.O.1    Sulaiman, S.A.2    Wahab, M.S.3
  • 114
    • 84872042914 scopus 로고    scopus 로고
    • Evaluation of the antioxidant activity of three varieties of honey from different botanical and geographical origins
    • Alzahrani, H.A.; Boukraa, L.; Bellik, Y.; Abdellah, F.; Bakhotmah, B.A.; Kolayli, S.; Sahin, H. Evaluation of the antioxidant activity of three varieties of honey from different botanical and geographical origins. Glob. J. Health Sci. 2012, 4, 191-196.
    • (2012) Glob. J. Health Sci. , vol.4 , pp. 191-196
    • Alzahrani, H.A.1    Boukraa, L.2    Bellik, Y.3    Abdellah, F.4    Bakhotmah, B.A.5    Kolayli, S.6    Sahin, H.7
  • 115
    • 77953435397 scopus 로고    scopus 로고
    • Antioxidant protective effect of glibenclamide and metformin in combination with honey in pancreas of streptozotocin-induced diabetic rats
    • Erejuwa, O.O.; Sulaiman, S.A.; Wahab, M.S.; Salam, S.K.; Salleh, M.S.; Gurtu, S. Antioxidant protective effect of glibenclamide and metformin in combination with honey in pancreas of streptozotocin-induced diabetic rats. Int. J. Mol. Sci. 2010, 11, 2056-2066.
    • (2010) Int. J. Mol. Sci. , vol.11 , pp. 2056-2066
    • Erejuwa, O.O.1    Sulaiman, S.A.2    Wahab, M.S.3    Salam, S.K.4    Salleh, M.S.5    Gurtu, S.6
  • 116
    • 77956232225 scopus 로고    scopus 로고
    • Antioxidant protection of Malaysian tualang honey in pancreas of normal and streptozotocin-induced diabetic rats
    • Erejuwa, O.O.; Sulaiman, S.A.; Wahab, M.S.; Sirajudeen, K.N.; Salleh, M.S.; Gurtu, S. Antioxidant protection of Malaysian tualang honey in pancreas of normal and streptozotocin-induced diabetic rats. Ann. Endocrinol. (Paris) 2010, 71, 291-296.
    • (2010) Ann. Endocrinol. (Paris) , vol.71 , pp. 291-296
    • Erejuwa, O.O.1    Sulaiman, S.A.2    Wahab, M.S.3    Sirajudeen, K.N.4    Salleh, M.S.5    Gurtu, S.6
  • 117
    • 33745200514 scopus 로고    scopus 로고
    • Prevention of the deterioration of polyphenol-rich beverages
    • Aoshima, H.; Ayabe, S. Prevention of the deterioration of polyphenol-rich beverages. Food Chem. 2007, 100, 350-355.
    • (2007) Food Chem. , vol.100 , pp. 350-355
    • Aoshima, H.1    Ayabe, S.2
  • 118
    • 84879621492 scopus 로고    scopus 로고
    • Redox cycling of endogenous copper by thymoquinone leads to ROS-mediated DNA breakage and consequent cell death: Putative anticancer mechanism of antioxidants
    • Zubair, H.; Khan, H.Y.; Sohail, A.; Azim, S.; Ullah, M.F.; Ahmad, A.; Sarkar, F.H.; Hadi, S.M. Redox cycling of endogenous copper by thymoquinone leads to ROS-mediated DNA breakage and consequent cell death: Putative anticancer mechanism of antioxidants. Cell Death Dis. 2013, 4, e660.
    • (2013) Cell Death Dis. , vol.4
    • Zubair, H.1    Khan, H.Y.2    Sohail, A.3    Azim, S.4    Ullah, M.F.5    Ahmad, A.6    Sarkar, F.H.7    Hadi, S.M.8
  • 119
    • 30644475948 scopus 로고    scopus 로고
    • Plant polyphenols mobilize endogenous copper in human peripheral lymphocytes leading to oxidative DNA breakage: A putative mechanism for anticancer properties
    • Azmi, A.S.; Bhat, S.H.; Hanif, S.; Hadi, S.M. Plant polyphenols mobilize endogenous copper in human peripheral lymphocytes leading to oxidative DNA breakage: A putative mechanism for anticancer properties. FEBS Lett. 2006, 580, 533-538.
    • (2006) FEBS Lett. , vol.580 , pp. 533-538
    • Azmi, A.S.1    Bhat, S.H.2    Hanif, S.3    Hadi, S.M.4
  • 120
    • 84875292654 scopus 로고    scopus 로고
    • Quercetin induces cytochrome-c release and ROS accumulation to promote apoptosis and arrest the cell cycle in G2/M, in cervical carcinoma: Signal cascade and drug-DNA interaction
    • Bishayee, K.; Ghosh, S.; Mukherjee, A.; Sadhukhan, R.; Mondal, J.; Khuda-Bukhsh, A.R. Quercetin induces cytochrome-c release and ROS accumulation to promote apoptosis and arrest the cell cycle in G2/M, in cervical carcinoma: Signal cascade and drug-DNA interaction. Cell Prolif. 2013, 46, 153-163.
    • (2013) Cell Prolif. , vol.46 , pp. 153-163
    • Bishayee, K.1    Ghosh, S.2    Mukherjee, A.3    Sadhukhan, R.4    Mondal, J.5    Khuda-Bukhsh, A.R.6
  • 121
    • 69249161777 scopus 로고    scopus 로고
    • Colorectal cancer and inflammatory bowel disease: Epidemiology, risk factors, mechanisms of carcinogenesis and prevention strategies
    • Triantafillidis, J.K.; Nasioulas, G.; Kosmidis, P.A. Colorectal cancer and inflammatory bowel disease: Epidemiology, risk factors, mechanisms of carcinogenesis and prevention strategies. Anticancer Res. 2009, 29, 2727-2737.
    • (2009) Anticancer Res. , vol.29 , pp. 2727-2737
    • Triantafillidis, J.K.1    Nasioulas, G.2    Kosmidis, P.A.3
  • 122
    • 84869774895 scopus 로고    scopus 로고
    • Bladder cancer and schistosomiasis
    • Zaghloul, M.S. Bladder cancer and schistosomiasis. J. Egypt. Natl. Cancer Inst. 2012, 24, 151-159.
    • (2012) J. Egypt. Natl. Cancer Inst. , vol.24 , pp. 151-159
    • Zaghloul, M.S.1
  • 123
    • 80052025654 scopus 로고    scopus 로고
    • The increasing clinical relevance of human papillomavirus type 16 (HPV-16) infection in oropharyngeal cancer
    • Shaw, R.; Robinson, M. The increasing clinical relevance of human papillomavirus type 16 (HPV-16) infection in oropharyngeal cancer. Br. J. Oral Maxillofac. Surg. 2011, 49, 423-429.
    • (2011) Br. J. Oral Maxillofac. Surg. , vol.49 , pp. 423-429
    • Shaw, R.1    Robinson, M.2
  • 124
    • 0036093865 scopus 로고    scopus 로고
    • Inflammation and the development of pancreatic cancer
    • Farrow, B.; Evers, B.M. Inflammation and the development of pancreatic cancer. Surg. Oncol. 2002, 10, 153-169.
    • (2002) Surg. Oncol. , vol.10 , pp. 153-169
    • Farrow, B.1    Evers, B.M.2
  • 125
    • 84888344830 scopus 로고    scopus 로고
    • The immune system and inflammation in breast cancer
    • Jiang, X.; Shapiro, D.J. The immune system and inflammation in breast cancer. Mol. Cell. Endocrinol. 2014, 382, 673-682.
    • (2014) Mol. Cell. Endocrinol. , vol.382 , pp. 673-682
    • Jiang, X.1    Shapiro, D.J.2
  • 126
    • 79954428532 scopus 로고    scopus 로고
    • Effect of NF-kappaB signaling on apoptosis in chronic inflammation-associated carcinogenesis
    • Wang, H.; Cho, C.H. Effect of NF-kappaB signaling on apoptosis in chronic inflammation-associated carcinogenesis. Curr. Cancer Drug Targets 2010, 10, 593-599.
    • (2010) Curr. Cancer Drug Targets , vol.10 , pp. 593-599
    • Wang, H.1    Cho, C.H.2
  • 128
    • 78651276266 scopus 로고    scopus 로고
    • Proinflammatory cytokines in breast cancer: Mechanisms of action and potential targets for therapeutics
    • Goldberg, J.E.; Schwertfeger, K.L. Proinflammatory cytokines in breast cancer: Mechanisms of action and potential targets for therapeutics. Curr. Drug Targets 2010, 11, 1133-1146.
    • (2010) Curr. Drug Targets , vol.11 , pp. 1133-1146
    • Goldberg, J.E.1    Schwertfeger, K.L.2
  • 130
    • 84890078551 scopus 로고    scopus 로고
    • Effect of gelam honey on the oxidative stress-induced signaling pathways in pancreatic hamster cells
    • doi:10.1155/2013/367312
    • Batumalaie, K.; Zaman Safi, S.; Mohd Yusof, K.; Shah Ismail, I.; Devi Sekaran, S.; Qvist, R. Effect of gelam honey on the oxidative stress-induced signaling pathways in pancreatic hamster cells. Int. J. Endocrinol. 2013, 2013, doi:10.1155/2013/367312.
    • (2013) Int. J. Endocrinol. , vol.2013
    • Batumalaie, K.1    Zaman Safi, S.2    Mohd Yusof, K.3    Shah Ismail, I.4    Devi Sekaran, S.5    Qvist, R.6
  • 131
    • 79952037283 scopus 로고    scopus 로고
    • Chrysin promotes tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) induced apoptosis in human cancer cell lines
    • Li, X.; Wang, J.N.; Huang, J.M.; Xiong, X.K.; Chen, M.F.; Ong, C.N.; Shen, H.M.; Yang, X.F. Chrysin promotes tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) induced apoptosis in human cancer cell lines. Toxicol. In Vitro 2011, 25, 630-635.
    • (2011) Toxicol. in Vitro , vol.25 , pp. 630-635
    • Li, X.1    Wang, J.N.2    Huang, J.M.3    Xiong, X.K.4    Chen, M.F.5    Ong, C.N.6    Shen, H.M.7    Yang, X.F.8
  • 132
    • 84861558613 scopus 로고    scopus 로고
    • Indigenous New Zealand honeys exhibit multiple anti-inflammatory activities
    • Leong, A.G.; Herst, P.M.; Harper, J.L. Indigenous New Zealand honeys exhibit multiple anti-inflammatory activities. Innate Immun. 2012, 18, 459-466.
    • (2012) Innate Immun. , vol.18 , pp. 459-466
    • Leong, A.G.1    Herst, P.M.2    Harper, J.L.3
  • 133
    • 84865044901 scopus 로고    scopus 로고
    • Gelam honey inhibits the production of proinflammatory, mediators NO, PGE(2), TNF-alpha, and IL-6 in carrageenan-induced acute paw edema in rats
    • Hussein, S.Z.; Mohd Yusoff, K.; Makpol, S.; Mohd Yusof, Y.A. Gelam honey inhibits the production of proinflammatory, mediators NO, PGE(2), TNF-alpha, and IL-6 in carrageenan-induced acute paw edema in rats. Evid.-Based Complement. Altern. Med. 2012, 2012, 109636.
    • (2012) Evid.-Based Complement. Altern. Med. , vol.2012 , pp. 109636
    • Hussein, S.Z.1    Mohd Yusoff, K.2    Makpol, S.3    Mohd Yusof, Y.A.4
  • 134
    • 84883187610 scopus 로고    scopus 로고
    • Gelam honey attenuates carrageenan-induced rat paw inflammation via NF-kappaB pathway
    • Hussein, S.Z.; Mohd Yusoff, K.; Makpol, S.; Mohd Yusof, Y.A. Gelam honey attenuates carrageenan-induced rat paw inflammation via NF-kappaB pathway. PLoS One 2013, 8, e72365.
    • (2013) PLoS One , vol.8
    • Hussein, S.Z.1    Mohd Yusoff, K.2    Makpol, S.3    Mohd Yusof, Y.A.4
  • 135
    • 84870686605 scopus 로고    scopus 로고
    • A review of molecular mechanisms of the anti-leukemic effects of phenolic compounds in honey
    • Abubakar, M.B.; Abdullah, W.Z.; Sulaiman, S.A.; Suen, A.B. A review of molecular mechanisms of the anti-leukemic effects of phenolic compounds in honey. Int. J. Mol. Sci. 2012, 13, 15054-15073.
    • (2012) Int. J. Mol. Sci. , vol.13 , pp. 15054-15073
    • Abubakar, M.B.1    Abdullah, W.Z.2    Sulaiman, S.A.3    Suen, A.B.4
  • 136
    • 0027880285 scopus 로고
    • Inhibitory effect of caffeic acid esters on azoxymethane-induced biochemical changes and aberrant crypt foci formation in rat colon
    • Rao, C.V.; Desai, D.; Simi, B.; Kulkarni, N.; Amin, S.; Reddy, B.S. Inhibitory effect of caffeic acid esters on azoxymethane-induced biochemical changes and aberrant crypt foci formation in rat colon. Cancer Res. 1993, 53, 4182-4188.
    • (1993) Cancer Res. , vol.53 , pp. 4182-4188
    • Rao, C.V.1    Desai, D.2    Simi, B.3    Kulkarni, N.4    Amin, S.5    Reddy, B.S.6
  • 137
    • 2942520997 scopus 로고    scopus 로고
    • Diabetes mellitus as a predictor of cancer mortality in a large cohort of US adults
    • Coughlin, S.S.; Calle, E.E.; Teras, L.R.; Petrelli, J.; Thun, M.J. Diabetes mellitus as a predictor of cancer mortality in a large cohort of US adults. Am. J. Epidemiol. 2004, 159, 1160-1167.
    • (2004) Am. J. Epidemiol. , vol.159 , pp. 1160-1167
    • Coughlin, S.S.1    Calle, E.E.2    Teras, L.R.3    Petrelli, J.4    Thun, M.J.5
  • 141
    • 84879491317 scopus 로고    scopus 로고
    • Targeting non-small cell lung cancer cells by dual inhibition of the insulin receptor and the insulin-like growth factor-1 receptor
    • Vincent, E.E.; Elder, D.J.; Curwen, J.; Kilgour, E.; Hers, I.; Tavare, J.M. Targeting non-small cell lung cancer cells by dual inhibition of the insulin receptor and the insulin-like growth factor-1 receptor. PLoS One 2013, 8, e66963.
    • (2013) PLoS One , vol.8
    • Vincent, E.E.1    Elder, D.J.2    Curwen, J.3    Kilgour, E.4    Hers, I.5    Tavare, J.M.6
  • 143
    • 33745684527 scopus 로고    scopus 로고
    • Metastasis: A question of life or death
    • Mehlen, P.; Puisieux, A. Metastasis: A question of life or death. Nat. Rev. Cancer 2006, 6, 449-458.
    • (2006) Nat. Rev. Cancer , vol.6 , pp. 449-458
    • Mehlen, P.1    Puisieux, A.2
  • 144
    • 84887444879 scopus 로고    scopus 로고
    • Microenvironmental regulation of tumor progression and metastasis
    • Quail, D.F.; Joyce, J.A. Microenvironmental regulation of tumor progression and metastasis. Nat. Med. 2013, 19, 1423-1437.
    • (2013) Nat. Med. , vol.19 , pp. 1423-1437
    • Quail, D.F.1    Joyce, J.A.2
  • 145
    • 84865408903 scopus 로고    scopus 로고
    • Role of angiogenesis in the pathogenesis of cancer
    • Hoff, P.M.; Machado, K.K. Role of angiogenesis in the pathogenesis of cancer. Cancer Treat. Rev. 2012, 38, 825-833.
    • (2012) Cancer Treat. Rev. , vol.38 , pp. 825-833
    • Hoff, P.M.1    Machado, K.K.2
  • 146
    • 84879654537 scopus 로고    scopus 로고
    • Targeting angiogenesis for treatment of human cancer
    • Somani, R.R.; Bhanushali, U.V. Targeting angiogenesis for treatment of human cancer. Indian J. Pharm. Sci. 2013, 75, 3-10.
    • (2013) Indian J. Pharm. Sci. , vol.75 , pp. 3-10
    • Somani, R.R.1    Bhanushali, U.V.2
  • 147
    • 78049397322 scopus 로고    scopus 로고
    • Honey promotes angiogeneic activity in the rat aortic ring assay
    • Rossiter, K.; Cooper, A.J.; Voegeli, D.; Lwaleed, B.A. Honey promotes angiogeneic activity in the rat aortic ring assay. J. Wound Care 2010, 19, 442-446.
    • (2010) J. Wound Care , vol.19 , pp. 442-446
    • Rossiter, K.1    Cooper, A.J.2    Voegeli, D.3    Lwaleed, B.A.4
  • 148
    • 79955655735 scopus 로고    scopus 로고
    • Honey for wound healing, ulcers, and burns; Data supporting its use in clinical practice
    • Al-Waili, N.; Salom, K.; Al-Ghamdi, A.A. Honey for wound healing, ulcers, and burns; data supporting its use in clinical practice. Sci. World J. 2011, 11, 766-787.
    • (2011) Sci. World J. , vol.11 , pp. 766-787
    • Al-Waili, N.1    Salom, K.2    Al-Ghamdi, A.A.3
  • 150
    • 0032545526 scopus 로고    scopus 로고
    • Stimulation of in vitro angiogenesis by hydrogen peroxide and the relation with ETS-1 in endothelial cells
    • Yasuda, M.; Ohzeki, Y.; Shimizu, S.; Naito, S.; Ohtsuru, A.; Yamamoto, T.; Kuroiwa, Y. Stimulation of in vitro angiogenesis by hydrogen peroxide and the relation with ETS-1 in endothelial cells. Life Sci. 1999, 64, 249-258.
    • (1999) Life Sci. , vol.64 , pp. 249-258
    • Yasuda, M.1    Ohzeki, Y.2    Shimizu, S.3    Naito, S.4    Ohtsuru, A.5    Yamamoto, T.6    Kuroiwa, Y.7
  • 151
    • 11144237662 scopus 로고    scopus 로고
    • Antiangiogenic properties of natural polyphenols from red wine and green tea
    • Oak, M.H.; El Bedoui, J.; Schini-Kerth, V.B. Antiangiogenic properties of natural polyphenols from red wine and green tea. J. Nutr. Biochem. 2005, 16, 1-8.
    • (2005) J. Nutr. Biochem. , vol.16 , pp. 1-8
    • Oak, M.H.1    El Bedoui, J.2    Schini-Kerth, V.B.3
  • 153
    • 84866433129 scopus 로고    scopus 로고
    • Natural-derived polyphenols as potential anticancer agents
    • Spatafora, C.; Tringali, C. Natural-derived polyphenols as potential anticancer agents. Anticancer Agents Med. Chem. 2012, 12, 902-918.
    • (2012) Anticancer Agents Med. Chem. , vol.12 , pp. 902-918
    • Spatafora, C.1    Tringali, C.2
  • 155
    • 34249339750 scopus 로고    scopus 로고
    • Suppression of tumor-induced angiogenesis by Brazilian propolis: Major component artepillin C inhibits in vitro tube formation and endothelial cell proliferation
    • Ahn, M.R.; Kunimasa, K.; Ohta, T.; Kumazawa, S.; Kamihira, M.; Kaji, K.; Uto, Y.; Hori, H.; Nagasawa, H.; Nakayama, T. Suppression of tumor-induced angiogenesis by Brazilian propolis: Major component artepillin C inhibits in vitro tube formation and endothelial cell proliferation. Cancer Lett. 2007, 252, 235-243.
    • (2007) Cancer Lett. , vol.252 , pp. 235-243
    • Ahn, M.R.1    Kunimasa, K.2    Ohta, T.3    Kumazawa, S.4    Kamihira, M.5    Kaji, K.6    Uto, Y.7    Hori, H.8    Nagasawa, H.9    Nakayama, T.10
  • 156
    • 33646085333 scopus 로고    scopus 로고
    • Inhibitory effects of caffeic acid phenethyl ester on cancer cell metastasis mediated by the down-regulation of matrix metalloproteinase expression in human HT1080 fibrosarcoma cells
    • Hwang, H.J.; Park, H.J.; Chung, H.J.; Min, H.Y.; Park, E.J.; Hong, J.Y.; Lee, S.K. Inhibitory effects of caffeic acid phenethyl ester on cancer cell metastasis mediated by the down-regulation of matrix metalloproteinase expression in human HT1080 fibrosarcoma cells. J. Nutr. Biochem. 2006, 17, 356-362.
    • (2006) J. Nutr. Biochem. , vol.17 , pp. 356-362
    • Hwang, H.J.1    Park, H.J.2    Chung, H.J.3    Min, H.Y.4    Park, E.J.5    Hong, J.Y.6    Lee, S.K.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.