Inhibition of methylnitrosourea (MNU) induced oxidative stress and carcinogenesis by orally administered bee honey and nigella grains in sprague dawely rats

Journal of Experimental and Clinical Cancer Research

Volumn 21, Issue 3, 2002, Pages 341-346

  Mabrouk, Gamal M ^a   Moselhy, S S ^a   Zohny, S F ^a   Ali, E M M ^a   Helal, T E A ^a   Amin, A A ^a   Khalifa, A A ^a  

^a AIN SHAMS UNIVERSITY   (Egypt)

Author keywords

Honey; MNU; Nigella sativa; Nutraceuticals; Oxidative stress

Indexed keywords

MALONALDEHYDE; METHYLNITROSOUREA; NATURAL PRODUCT; NITRIC OXIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; COLON CARCINOMA; CONTROLLED STUDY; DIET SUPPLEMENTATION; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; FOOD INTAKE; GRAIN; HONEYBEE; INFLAMMATION; LUNG CARCINOMA; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; SKIN CARCINOMA;

ADENOCARCINOMA; ADMINISTRATION, ORAL; ALKYLATING AGENTS; ANIMALS; COLONIC NEOPLASMS; FEMALE; HONEY; MALONDIALDEHYDE; METHYLNITROSOUREA; NEOPLASMS, EXPERIMENTAL; NIGELLA SATIVA; NITRIC OXIDE; OXIDATIVE STRESS; PHYTOTHERAPY; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0036736903     PISSN: 03929078     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Ip C., Singh M., Thompson H.J., Scimeca J.A.: Conjugated linoleic acid suppresses mammary carcinogenesis and proliferative activity of the mammary gland in the rat. Cancer Res. 51: 1212-1215, 1994.
2. Anzano M A., Smith J.M., Uskokvic M.R., et al.: 1a, 25-Dihydroxy-16-ene-23-yne-26,27-hexaflourocholecalciferol (Ro245531), a new deltanoid (vitamin D Analogue) for prevention of breast cancer in the rat. Cancer Res. 54(7): 1653-1656, 1994.
3. Jang M., Cai L., Udeani G.O., et al.: Cancer chemopreventive activity of resveratrol, a natural product deprived from grapes. Science 275: 218-220, 1997.
4. Yamane T., Nakatani H., Kikuoka N., et al.: Inhibitory effects and toxicity of green tea polyphenols for gastrointestinal carcinogenesis. Cancer 77 (8): 1662-1667, 1996.
5. Ip C., Lisk D.J.: Efficacy of cancer prevention by high-selenium garlic is primarily dependent on the actin of selenium. Carcinogenesis (England) 16 (11): 2649-2652, 1995.
6. Anzana M.A., Byers S.W., Smith J.M., et al.: Prevention of breast cancer in the rat with 9-cis-retinoic acid as a single agent and in combination with tamoxifen. Cancer Res. 54: 4614-4617, 1994.
7. Overvad K., Gron P., Langhoff O., Foldspang A., Thorling E.B.: Selenium in human mammary carcinogenesis: a case-referent study. Eur. J. Cancer Prev. (England). 1(1): 27-30, 1991.
8. Mizumoto Y., Nakae D., Yoshiji H., et al.: Inhibitory effects of 2-O-octadecylascorbic acid and other vitamin C and E derivatives on the induction of enzyme-altered putative preneoplastic lesions in the livers of rats fed a choline-deficient, L-amino acid-defined diet. Carcinogenesis 15(2): 241-246, 1994.
9. Fukuda A., Osawa T., Oda H., Toyokuni S., Satoh K., Uchida K.: Oxidative stress response un iron-induced renal carcinogenesis: acute nephrotoxicity mediates the enhanced expression of glutathoine S-transferase Yp isozyme. Arch. Biochem. Biophys. 15(2): 111-125, 1995.
10. Sarkar A., Bishayee A., Chatterjee M.: Beta-carotene prevents lipid peroxidation and red blood cell membrane protein damage in experimental hepatocarcinogenesis. Cancer Biochem. Biophys. 329(1): 39-49, 1996.
11. Bachowski S., Xu Y., Baker T.K., Stevenson D.E., Walborg E. F. Jr., Kalunig J.E.: The potential role of oxidative stress in nongenotoxic carcinogenesis in the mouse liver. Prog. Clin. Biol. Res. 391: 385-396, 1995.
12. Block G., Patterson B., Subar A.: Fruit, vegetables and cancer prevention: A review of the epidemiological evidence. Nutrition and Cancer 18: 1-29, 1992.
13. Salomi N.J., Nair S.C., Jayawardhanan K.K., Varghese CD., Panikkar K.R.: Antitumor principles from Nigella sativa seeds. Cancer Letters 63: 41-46, 1992.
14. Salomi M.J., Nair S.C., Panikkar K.R.: Inhibitory effects of Nigella sativa and Saffron (Crocus Sativus) on chemical carcinogenesis in mice. Nutrition and Cancer 16(1): 67-72, 1991.
15. Sharma R.A., Hill K.A., Ireson C.R., et al.: Curcuminoids inhibit cycloxygenase-mediated prostaglandin E2 production and COX-2 expression in human blood. Proceeding of American Association for Cancer Research 22nd annual meeting. Volume 42, Abstract No 93, 2001.
16. Hur S.K., Kim S., Jung S., Oh O., Kim S.S., Lee S.K.: Inhibition of of inducible nitric oxide synthase activity mediated by resveratol analogs. Proceeding of American Association for Cancer Research 22nd annual meeting. Volume 42, Abstract No 98, 2001.
17. Joe A.K., Liu J., Vural M.E., Xiao D., Beer D.G., Ting W., Weinstein B.: Resveratol inhibits growth, induces arrest at the S/G2 transition and apoptosis in several human cancer cell lines. Proceeding of American association for Cancer Research 22nd annual meeting. Volume 42, Abstract No 102, 2001.
18. Su Z.Z., Lin J., Grunberger D., Fisher P.B.: Growth suppression and toxicity induced by caffeic acid phenethyl ester (CAPE) in type 5 adenovirus-transformed progression. Cancer Res. 54(7): 1865-1870, 1994.
19. Huang M.T., Ma W., Yen P., et al.: Inhibitory effects of caffeic acid phenethyl ester (CAPE) on 12-O-tetradecanoylphorbol-13-acetate- induced tumor promotion in mouse skin and the synthesis of DNA, RNA and protein in HeLa cells. Carcinogenesis 17(4): 761-765, 1996.
20. Guarini L., Su Z.Z., Zucker S., Lin J., Grunberger D., Fisher P.B.: Growth inhibition and modulation of antigenic phenotype in human melanoma and glioblastoma multiforme cells by caffeic acid phenethyl ester (CAPE). Cell Mol. Biol. 38(5): 513-527, 1992.
21. Na H.K., Wilson M.R., Kang K.S., Chang C.C., Grunberger D., Trosko J.E.: Restoration of gap junctional intercellular communication by caffeic acis phenephyl ester (CAPE) in a ras-transformed rat liver epithelial cell line. Cancer Lett. 157(1): 31-38, 2000.
22. Mabrouk G.M., Nasser H., Mady E.: Honey bee proteins some biochemical properties. Egypt. J. Biochem. 13(1): 55-62, 1995.
23. Vodovotz Y.: Modified microassay for serum nitrite and nitrate. BioTechniques 20(3): 390-394, 1996.
24. Zima T., Stipek S., Crkovska J., Platenik J.: Measurement of Lipid peroxidation product-malondialdehyde in biological samples by spectrophotometric and HPLC assay. Klin. Bioch. Metab. 3(24): 98-102, 1995.
25. Mabrouk G.M., Shaheen M.M.A., Abou El-Magd M.A., El-Okby M.A.: A study on essential fatty acids and IgE in plasma of atopic dermatitis patients (AD): Correlation between their level and disease status. Egypt. J. Biochem. 14(1): 71-80, 1996.
26. Catignani G.L., Bieri J.G.: Simultaneous determination of retinol and alpha-tocopherol in serum or plasma by liquid chromatography. Clin. Chem. 29(4): 708-712, 1983.
27. Thompson H.J., McGinley J.N., Rothhammer K., Singh M.: Rapid induction of mammary intraductal proliferations, ductal carcinoma in situ and carcinomas by the injection of sexually immature female rats with 1-methyl-1-nitrosourea. Carcinogenesis (England). 16(10): 2407-2411, 1995.
28. Thordarson G., Jin E., Guzman R.C., Swanson S.M., Nandi S., Talamantes E: Refractoriness to mammary tumorigenesis in parous rats: is it caused by persistent changes in the hormonal environment or permanent biochemical alterations in the mammary epithelia? Carcinogenesis (England) 16(11): 2847-2853, 1995.
29. Pape M.E., Kim K.H.: Transcriptional regulation of acetyl coenzyme A carboxylase gene expression by tumor necrosis factor in 30A-5 preadipocytes. Mol. Cell. Biol. 9: 974-982, 1989.
30. Thomsen L.L., Lawton F.G., Knowles R.G., Beesley J.E., Riveros-Moreno V., Moncada S.: Nitric oxide synthase activity in human gynecological cancer. Cancer Res. 54(5): 1352-1354, 1994.
31. Thomsen L.L., Miles D.W., Happerfield L., Bobrow L.G., Knowles R.G., Moncada S.: Nitric oxide synthase activity in human breast cancer. Br. J. Cancer 72(1): 41-44, 1995.
32. Mabrouk G.M.: Nitric oxide and essential fatty acids profile in sera of patients with prostatic cancer and senile hyperplasia. Egypt. J. Biochem. 14(2): 139-147, 1996.
33. Sagar P.S., Das U.N., Karatkar R., Ramesh G., Padma M., Kumar G.S.: Cytotoxic action of cis-unsaturated fatty acids on human cervical carcinoma (HeLa) cells: relationship to free radicals and lipid peroxidation and its modulation by calmodulin antagonists. Cancer Lett. 63(3): 189-198, 1992.
34. Shultz T.D., Chew B.P., Seaman W.R., Luedecke L.O.: The inhibitory effect of conjugated dienoic derivatives of linoleic acid and beta-carotene on the in vitro growth of human cancer cells. Cancer Lett. 63(2): 125-133, 1992.
35. Chaudry A., McClinton S., Moffat L.E., Whale K.W.: Essential fatty acid distribution in the plasma and tissue phosphlipids of patients with benign and malignant prostatic disease. Br. J. Cancer 64(6): 1157-1160, 1991.
36. Fischer S.M., Leyton J., Lee M.L., et al.: Differential effects of dietary linoleic acid on mouse skin-tumor promotion and mammary carcinogenesis. Cancer Res. 52 (7 Suppl): 2049s-2054s, 1992.