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Volumn 226, Issue 2, 2012, Pages 352-364

The cell cycle and cancer

Author keywords

biomarker; cancer; cell cycle; DNA replication; geminin; MCM; mitosis; phosphohistone; therapy

Indexed keywords

B RAF KINASE; CISPLATIN; DNA; DOCETAXEL; FLUOROURACIL; GEMCITABINE; GEMININ; HISTONE; IRINOTECAN; METHOTREXATE; MITOGEN ACTIVATED PROTEIN KINASE; PACLITAXEL; PHOSPHATIDYLINOSITOL 3 KINASE; VASCULOTROPIN; VINCRISTINE;

EID: 82755177826     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.3022     Document Type: Review
Times cited : (554)

References (135)
  • 1
    • 0025641727 scopus 로고
    • Stem cells: Attributes, cycles, spirals, pitfalls and uncertainties: Lessons for and from the Crypt
    • Potten CS, Loeffler M,. Stem cells: attributes, cycles, spirals, pitfalls and uncertainties. Lessons for and from the crypt. Development 1990; 110: 1001-1020. (Pubitemid 120009472)
    • (1990) Development , vol.110 , Issue.4 , pp. 1001-1020
    • Potten, C.S.1    Loeffler, M.2
  • 2
    • 0024425529 scopus 로고
    • Stem cells: The generation and maintenance of cellular diversity
    • Hall PA, Watt FM,. Stem cells: the generation and maintenance of cellular diversity. Development 1989; 106: 619-633. (Pubitemid 19221519)
    • (1989) Development , vol.106 , Issue.4 , pp. 619-633
    • Hall, P.A.1    Watt, F.M.2
  • 3
    • 36749082267 scopus 로고    scopus 로고
    • Cell cycle markers in clinical oncology
    • DOI 10.1016/j.ceb.2007.10.005, PII S0955067407001500, Cell Differentiation / Cell Division, Growth and Death
    • Williams GH, Stoeber K,. Cell cycle markers in clinical oncology. Curr Opin Cell Biol 2007; 19: 672-679. (Pubitemid 350216427)
    • (2007) Current Opinion in Cell Biology , vol.19 , Issue.6 , pp. 672-679
    • Williams, G.H.1    Stoeber, K.2
  • 6
    • 30344478587 scopus 로고    scopus 로고
    • Is Cyclin D1-CDK4 kinase a bona fide cancer target?
    • DOI 10.1016/j.ccr.2005.12.026, PII S1535610805004022
    • Malumbres M, Barbacid M,. Is Cyclin D1-CDK4 kinase a bona fide cancer target? Cancer Cell 2006; 9: 2-4. (Pubitemid 43069503)
    • (2006) Cancer Cell , vol.9 , Issue.1 , pp. 2-4
    • Malumbres, M.1    Barbacid, M.2
  • 7
    • 0030657690 scopus 로고    scopus 로고
    • The restriction point and control of cell proliferation
    • DOI 10.1016/S0955-0674(97)80076-2
    • Planas-Silva MD, Weinberg RA,. The restriction point and control of cell proliferation. Curr Opin Cell Biol 1997; 9: 768-772. (Pubitemid 27517264)
    • (1997) Current Opinion in Cell Biology , vol.9 , Issue.6 , pp. 768-772
    • Planas-Silva, M.D.1    Weinberg, R.A.2
  • 8
    • 0035235736 scopus 로고    scopus 로고
    • Mitotic kinases as regulators of cell division and its checkpoints
    • DOI 10.1038/35048096
    • Nigg EA,. Mitotic kinases as regulators of cell division and its checkpoints. Nat Rev Mol Cell Biol 2001; 2: 21-32. (Pubitemid 33676958)
    • (2001) Nature Reviews Molecular Cell Biology , vol.2 , Issue.1 , pp. 21-32
    • Nigg, E.A.1
  • 9
    • 0024425887 scopus 로고
    • Checkpoints: controls that ensure the order of cell cycle events
    • Hartwell LH, Weinert TA,. Checkpoints: controls that ensure the order of cell cycle events. Science 1989; 246: 629-634. (Pubitemid 19283354)
    • (1989) Science , vol.246 , Issue.4930 , pp. 629-634
    • Hartwell, L.H.1    Weinert, T.A.2
  • 11
    • 34247333444 scopus 로고    scopus 로고
    • The spindle-assembly checkpoint in space and time
    • DOI 10.1038/nrm2163, PII NRM2163
    • Musacchio A, Salmon ED,. The spindle-assembly checkpoint in space and time. Nat Rev Mol Cell Biol 2007; 8: 379-393. (Pubitemid 46643240)
    • (2007) Nature Reviews Molecular Cell Biology , vol.8 , Issue.5 , pp. 379-393
    • Musacchio, A.1    Salmon, E.D.2
  • 12
    • 60749109846 scopus 로고    scopus 로고
    • Cell cycle, CDKs and cancer: A changing paradigm
    • Malumbres M, Barbacid M,. Cell cycle, CDKs and cancer: a changing paradigm. Nat Rev Cancer 2009; 9: 153-166.
    • (2009) Nat Rev Cancer , vol.9 , pp. 153-166
    • Malumbres, M.1    Barbacid, M.2
  • 13
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D, Weinberg RA,. Hallmarks of cancer: the next generation. Cell 2011; 144: 646-674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 14
    • 0034306996 scopus 로고    scopus 로고
    • The Rb/E2F pathway: Expanding roles and emerging paradigms
    • Harbour JW, Dean DC,. The Rb/E2F pathway: expanding roles and emerging paradigms. Genes Dev 2000; 14: 2393-2409.
    • (2000) Genes Dev , vol.14 , pp. 2393-2409
    • Harbour, J.W.1    Dean, D.C.2
  • 15
    • 57749188299 scopus 로고    scopus 로고
    • Targeting cancer with small molecule kinase inhibitors
    • Zhang J, Yang PL, Gray NS,. Targeting cancer with small molecule kinase inhibitors. Nat Rev Cancer 2009; 9: 28-39.
    • (2009) Nat Rev Cancer , vol.9 , pp. 28-39
    • Zhang, J.1    Yang, P.L.2    Gray, N.S.3
  • 16
    • 0037444269 scopus 로고    scopus 로고
    • Tissue microarray analysis reveals site-specific prevalence of oncogene amplifications in head and neck squamous cell carcinoma
    • Freier K, Joos S, Flechtenmacher C, et al., Tissue microarray analysis reveals site-specific prevalence of oncogene amplifications in head and neck squamous cell carcinoma. Cancer Res 2003; 63: 1179-1182. (Pubitemid 36348691)
    • (2003) Cancer Research , vol.63 , Issue.6 , pp. 1179-1182
    • Freier, K.1    Joos, S.2    Flechtenmacher, C.3    Devens, F.4    Benner, A.5    Bosch, F.X.6    Lichter, P.7    Hofele, C.8
  • 17
    • 0037148885 scopus 로고    scopus 로고
    • Astrocyte-specific expression of CDK4 is not sufficient for tumor formation, but cooperates with p53 heterozygosity to provide a growth advantage for astrocytes in vivo
    • DOI 10.1038/sj/onc/1205206
    • Huang ZY, Baldwin RL, Hedrick NM, et al., Astrocyte-specific expression of CDK4 is not sufficient for tumor formation, but cooperates with p53 heterozygosity to provide a growth advantage for astrocytes in vivo. Oncogene 2002; 21: 1325-1334. (Pubitemid 34214498)
    • (2002) Oncogene , vol.21 , Issue.9 , pp. 1325-1334
    • Huang, Z.-Y.1    Baldwin, R.L.2    Hedrick, N.M.3    Gutmann, D.H.4
  • 18
    • 0035754080 scopus 로고    scopus 로고
    • To cycle or not to cycle: A critical decision in cancer
    • Malumbres M, Barbacid M,. To cycle or not to cycle: a critical decision in cancer. Nat Rev Cancer 2001; 1: 222-231. (Pubitemid 33741897)
    • (2001) Nature Reviews Cancer , vol.1 , Issue.3 , pp. 222-231
    • Malumbres, M.1    Barbacid, M.2
  • 19
    • 0034680102 scopus 로고    scopus 로고
    • Molecular portraits of human breast tumours
    • Perou CM, Sorlie T, Eisen MB, et al., Molecular portraits of human breast tumours. Nature 2000; 406: 747-752.
    • (2000) Nature , vol.406 , pp. 747-752
    • Perou, C.M.1    Sorlie, T.2    Eisen, M.B.3
  • 21
    • 41649114164 scopus 로고    scopus 로고
    • Enabling personalized cancer medicine through analysis of gene-expression patterns
    • DOI 10.1038/nature06915, PII NATURE06915
    • van't Veer LJ, Bernards R,. Enabling personalized cancer medicine through analysis of gene-expression patterns. Nature 2008; 452: 564-570. (Pubitemid 351483370)
    • (2008) Nature , vol.452 , Issue.7187 , pp. 564-570
    • Van 't Veer, L.J.1    Bernards, R.2
  • 22
    • 13444249852 scopus 로고    scopus 로고
    • Prediction of cancer outcome with microarrays: A multiple random validation strategy
    • DOI 10.1016/S0140-6736(05)17866-0
    • Michiels S, Koscielny S, Hill C,. Prediction of cancer outcome with microarrays: a multiple random validation strategy. Lancet 2005; 365: 488-492. (Pubitemid 40215731)
    • (2005) Lancet , vol.365 , Issue.9458 , pp. 488-492
    • Michiels, S.1    Koscielny, S.2    Hill, C.3
  • 23
    • 33947645465 scopus 로고    scopus 로고
    • Gene expression profiling: Does it add predictive accuracy to clinical characteristics in cancer prognosis?
    • DOI 10.1016/j.ejca.2006.11.018, PII S0959804906010616
    • Dunkler D, Michiels S, Schemper M,. Gene expression profiling: does it add predictive accuracy to clinical characteristics in cancer prognosis? Eur J Cancer 2007; 43: 745-751. (Pubitemid 46502906)
    • (2007) European Journal of Cancer , vol.43 , Issue.4 , pp. 745-751
    • Dunkler, D.1    Michiels, S.2    Schemper, M.3
  • 24
    • 79955391807 scopus 로고    scopus 로고
    • Microarray-based class discovery for molecular classification of breast cancer: Analysis of interobserver agreement
    • Mackay A, Weigelt B, Grigoriadis A, et al., Microarray-based class discovery for molecular classification of breast cancer: analysis of interobserver agreement. J Natl Cancer Inst 2011; 103: 662-673.
    • (2011) J Natl Cancer Inst , vol.103 , pp. 662-673
    • MacKay, A.1    Weigelt, B.2    Grigoriadis, A.3
  • 26
    • 20644447122 scopus 로고    scopus 로고
    • Changes in gene expression associated with response to neoadjuvant chemotherapy in breast cancer
    • Hannemann J, Oosterkamp HM, Bosch CA, et al., Changes in gene expression associated with response to neoadjuvant chemotherapy in breast cancer. J Clin Oncol 2005; 23: 3331-3342.
    • (2005) J Clin Oncol , vol.23 , pp. 3331-3342
    • Hannemann, J.1    Oosterkamp, H.M.2    Bosch, C.A.3
  • 27
    • 34250887474 scopus 로고    scopus 로고
    • Taking gene-expression profiling to the clinic: When will molecular signatures become relevant to patient care?
    • DOI 10.1038/nrc2173, PII NRC2173
    • Sotiriou C, Piccart MJ,. Taking gene-expression profiling to the clinic: when will molecular signatures become relevant to patient care? Nat Rev Cancer 2007; 7: 545-553. (Pubitemid 46985399)
    • (2007) Nature Reviews Cancer , vol.7 , Issue.7 , pp. 545-553
    • Sotiriou, C.1    Piccart, M.J.2
  • 28
    • 33746961739 scopus 로고    scopus 로고
    • Mechanisms of Disease: Oncogene addiction - A rationale for molecular targeting in cancer therapy
    • DOI 10.1038/ncponc0558, PII NCPONC0558
    • Weinstein IB, Joe AK,. Mechanisms of disease: Oncogene addiction-a rationale for molecular targeting in cancer therapy. Nat Clin Pract Oncol 2006; 3: 448-457. (Pubitemid 44203817)
    • (2006) Nature Clinical Practice Oncology , vol.3 , Issue.8 , pp. 448-457
    • Weinstein, I.B.1    Joe, A.K.2
  • 30
    • 77950678272 scopus 로고    scopus 로고
    • Molecular mechanisms of acquired resistance to tyrosine kinase targeted therapy
    • Sierra JR, Cepero V, Giordano S,. Molecular mechanisms of acquired resistance to tyrosine kinase targeted therapy. Mol Cancer 2010; 9: 75.
    • (2010) Mol Cancer , vol.9 , pp. 75
    • Sierra, J.R.1    Cepero, V.2    Giordano, S.3
  • 31
    • 77949891455 scopus 로고    scopus 로고
    • Phase III study of enzastaurin compared with lomustine in the treatment of recurrent intracranial glioblastoma
    • Wick W, Puduvalli VK, Chamberlain MC, et al., Phase III study of enzastaurin compared with lomustine in the treatment of recurrent intracranial glioblastoma. J Clin Oncol 2010; 28: 1168-1174.
    • (2010) J Clin Oncol , vol.28 , pp. 1168-1174
    • Wick, W.1    Puduvalli, V.K.2    Chamberlain, M.C.3
  • 32
    • 30944446883 scopus 로고    scopus 로고
    • Lessons from phase III clinical trials on anti-VEGF therapy for cancer
    • DOI 10.1038/ncponc0403, PII N0403
    • Jain RK, Duda DG, Clark JW, et al., Lessons from Phase III clinical trials on anti-VEGF therapy for cancer. Nat Clin Pract Oncol 2006; 3: 24-40. (Pubitemid 43108832)
    • (2006) Nature Clinical Practice Oncology , vol.3 , Issue.1 , pp. 24-40
    • Jain, R.K.1    Duda, D.G.2    Clark, J.W.3    Loeffler, J.S.4
  • 33
    • 77952318310 scopus 로고    scopus 로고
    • Phase III trial of bevacizumab plus interferon-α versus interferon-α monotherapy in patients with metastatic renal cell carcinoma: Final results of CALGB 90206
    • Rini BI, Halabi S, Rosenberg JE, et al., Phase III trial of bevacizumab plus interferon-α versus interferon-α monotherapy in patients with metastatic renal cell carcinoma: final results of CALGB 90206. J Clin Oncol 2010; 28: 2137-2143.
    • (2010) J Clin Oncol , vol.28 , pp. 2137-2143
    • Rini, B.I.1    Halabi, S.2    Rosenberg, J.E.3
  • 34
    • 80051557189 scopus 로고    scopus 로고
    • The promise of a personalized genomic approach to pancreatic cancer and why targeted therapies have missed the mark
    • Fisher WE,. The promise of a personalized genomic approach to pancreatic cancer and why targeted therapies have missed the mark. World J Surg 2011; 35: 1766-1769.
    • (2011) World J Surg , vol.35 , pp. 1766-1769
    • Fisher, W.E.1
  • 35
    • 79952173475 scopus 로고    scopus 로고
    • The efficacy of cediranib as monotherapy and in combination with lomustine compared to lomustine alone in patients with recurrent glioblastoma: A Phase III randomized study
    • Batchelor T, Mulholland P, Neyns B, et al., The efficacy of cediranib as monotherapy and in combination with lomustine compared to lomustine alone in patients with recurrent glioblastoma: a Phase III randomized study. Neuro-Oncology 2010; 12: iv69-78.
    • (2010) Neuro-Oncology , vol.12
    • Batchelor, T.1    Mulholland, P.2    Neyns, B.3
  • 40
    • 0032794254 scopus 로고    scopus 로고
    • Clinical applications of a novel mammalian cell-free DNA replication system
    • Williams G, Stoeber K,. Clinical applications of a novel mammalian cell-free DNA replication system. Br J Cancer 1999; 80 (suppl 1): 20-24. (Pubitemid 29389602)
    • (1999) British Journal of Cancer , vol.80 , Issue.SUPPL. 1 , pp. 20-24
    • Williams, G.1    Stoeber, K.2
  • 41
    • 13444270648 scopus 로고    scopus 로고
    • Control of DNA replication and its potential clinical exploitation
    • DOI 10.1038/nrc1548
    • Gonzalez MA, Tachibana KE, Laskey RA, et al., Control of DNA replication and its potential clinical exploitation. Nat Rev Cancer 2005; 5: 135-141. (Pubitemid 40215861)
    • (2005) Nature Reviews Cancer , vol.5 , Issue.2 , pp. 135-141
    • Gonzalez, M.A.1    Tachibana, K.-E.K.2    Laskey, R.A.3    Coleman, N.4
  • 42
    • 52549115459 scopus 로고    scopus 로고
    • Replication licensing and cancer-a fatal entanglement?
    • Blow JJ, Gillespie PJ,. Replication licensing and cancer-a fatal entanglement? Nat Rev Cancer 2008; 8: 799-806.
    • (2008) Nat Rev Cancer , vol.8 , pp. 799-806
    • Blow, J.J.1    Gillespie, P.J.2
  • 43
    • 0036470433 scopus 로고    scopus 로고
    • Replication licensing-defining the proliferative state?
    • Blow JJ, Hodgson B,. Replication licensing-defining the proliferative state? Trends Cell Biol 2002; 12: 72-78.
    • (2002) Trends Cell Biol , vol.12 , pp. 72-78
    • Blow, J.J.1    Hodgson, B.2
  • 44
    • 26244431903 scopus 로고    scopus 로고
    • Right place, right time, and only once: Replication initiation in metazoans
    • DOI 10.1016/j.cell.2005.09.019, PII S0092867405009724
    • Machida YJ, Hamlin JL, Dutta A,. Right place, right time, and only once: replication initiation in metazoans. Cell 2005; 123: 13-24. (Pubitemid 41414525)
    • (2005) Cell , vol.123 , Issue.1 , pp. 13-24
    • Machida, Y.J.1    Hamlin, J.L.2    Dutta, A.3
  • 45
    • 77953632048 scopus 로고    scopus 로고
    • Eukaryotic chromosome DNA replication: Where, when, and how?
    • Masai H, Matsumoto S, You Z, et al., Eukaryotic chromosome DNA replication: where, when, and how? Annu Rev Biochem 2010; 79: 89-130.
    • (2010) Annu Rev Biochem , vol.79 , pp. 89-130
    • Masai, H.1    Matsumoto, S.2    You, Z.3
  • 46
    • 40549108563 scopus 로고    scopus 로고
    • Cell cycle regulation of DNA replication
    • Sclafani RA, Holzen TM,. Cell cycle regulation of DNA replication. Annu Rev Genet 2007; 41: 237-280.
    • (2007) Annu Rev Genet , vol.41 , pp. 237-280
    • Sclafani, R.A.1    Holzen, T.M.2
  • 47
    • 0035253410 scopus 로고    scopus 로고
    • Is the MCM2-7 complex the eukaryotic DNA replication fork helicase?
    • DOI 10.1016/S0959-437X(00)00158-1
    • Labib K, Diffley JF,. Is the MCM2-7 complex the eukaryotic DNA replication fork helicase? Curr Opin Genet Dev 2001; 11: 64-70. (Pubitemid 32119280)
    • (2001) Current Opinion in Genetics and Development , vol.11 , Issue.1 , pp. 64-70
    • Labib, K.1    Diffley, J.F.X.2
  • 48
    • 27844564339 scopus 로고    scopus 로고
    • The chromosome cycle: Coordinating replication and segregation
    • DOI 10.1038/sj.embor.7400557, PII 7400557
    • Blow JJ, Tanaka TU,. The chromosome cycle: coordinating replication and segregation. Second in the cycles review series. EMBO Rep 2005; 6: 1028-1034. (Pubitemid 41637646)
    • (2005) EMBO Reports , vol.6 , Issue.11 , pp. 1028-1034
    • Blow, J.J.1    Tanaka, T.U.2
  • 49
    • 0032110626 scopus 로고    scopus 로고
    • Nucleotide-dependent prereplicative complex assembly by Cdc6p, a homolog of eukaryotic and prokaryotic clamp-loaders
    • Perkins G, Diffley JF,. Nucleotide-dependent prereplicative complex assembly by Cdc6p, a homolog of eukaryotic and prokaryotic clamp-loaders. Mol Cell 1998; 2: 23-32. (Pubitemid 128378963)
    • (1998) Molecular Cell , vol.2 , Issue.1 , pp. 23-32
    • Perkins, G.1    Diffley, J.F.X.2
  • 50
    • 77953954908 scopus 로고    scopus 로고
    • How do Cdc7 and cyclin-dependent kinases trigger the initiation of chromosome replication in eukaryotic cells?
    • Labib K,. How do Cdc7 and cyclin-dependent kinases trigger the initiation of chromosome replication in eukaryotic cells? Genes Dev 2010; 24: 1208-1219.
    • (2010) Genes Dev , vol.24 , pp. 1208-1219
    • Labib, K.1
  • 51
    • 33749075373 scopus 로고    scopus 로고
    • Cdc7-Dbf4 Phosphorylates MCM Proteins via a Docking Site-Mediated Mechanism to Promote S Phase Progression
    • DOI 10.1016/j.molcel.2006.07.033, PII S1097276506005351
    • Sheu YJ, Stillman B,. Cdc7-Dbf4 phosphorylates MCM proteins via a docking site-mediated mechanism to promote S phase progression. Mol Cell 2006; 24: 101-113. (Pubitemid 44466677)
    • (2006) Molecular Cell , vol.24 , Issue.1 , pp. 101-113
    • Sheu, Y.-J.1    Stillman, B.2
  • 52
    • 73849129578 scopus 로고    scopus 로고
    • The Dbf4-Cdc7 kinase promotes S phase by alleviating an inhibitory activity in Mcm4
    • Sheu YJ, Stillman B,. The Dbf4-Cdc7 kinase promotes S phase by alleviating an inhibitory activity in Mcm4. Nature 2010; 463: 113-117.
    • (2010) Nature , vol.463 , pp. 113-117
    • Sheu, Y.J.1    Stillman, B.2
  • 54
    • 33645717628 scopus 로고    scopus 로고
    • GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks
    • Gambus A, Jones RC, Sanchez-Diaz A, et al., GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks. Nat Cell Biol 2006; 8: 358-366.
    • (2006) Nat Cell Biol , vol.8 , pp. 358-366
    • Gambus, A.1    Jones, R.C.2    Sanchez-Diaz, A.3
  • 55
    • 34249710254 scopus 로고    scopus 로고
    • A key role for the GINS complex at DNA replication forks
    • DOI 10.1016/j.tcb.2007.04.002, PII S0962892407000852
    • Labib K, Gambus A,. A key role for the GINS complex at DNA replication forks. Trends Cell Biol 2007; 17: 271-278. (Pubitemid 46829847)
    • (2007) Trends in Cell Biology , vol.17 , Issue.6 , pp. 271-278
    • Labib, K.1    Gambus, A.2
  • 57
    • 20344396122 scopus 로고    scopus 로고
    • Preventing re-replication of chromosomal DNA
    • DOI 10.1038/nrm1663
    • Blow JJ, Dutta A,. Preventing re-replication of chromosomal DNA. Nat Rev Mol Cell Biol 2005; 6: 476-486. (Pubitemid 40780559)
    • (2005) Nature Reviews Molecular Cell Biology , vol.6 , Issue.6 , pp. 476-486
    • Blow, J.J.1    Dutta, A.2
  • 58
    • 0043234476 scopus 로고    scopus 로고
    • Skp2 ubiquitin ligase complex interacts with the human replication licensing factor Cdt1 and regulates Cdt1 degradation
    • DOI 10.1074/jbc.C300251200
    • Li X, Zhao Q, Liao R, et al., The SCF(Skp2) ubiquitin ligase complex interacts with the human replication licensing factor Cdt1 and regulates Cdt1 degradation. J Biol Chem 2003; 278: 30854-30858. (Pubitemid 36994595)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.33 , pp. 30854-30858
    • Li, X.1    Zhao, Q.2    Liao, R.3    Sun, P.4    Wu, X.5
  • 59
    • 0035147434 scopus 로고    scopus 로고
    • Repression of origin assembly in metaphase depends on inhibition of RLF-B/Cdt1 by geminin
    • DOI 10.1038/35055000
    • Tada S, Li A, Maiorano D, et al., Repression of origin assembly in metaphase depends on inhibition of RLF-B/Cdt1 by geminin. Nat Cell Biol 2001; 3: 107-113. (Pubitemid 32118362)
    • (2001) Nature Cell Biology , vol.3 , Issue.2 , pp. 107-113
    • Tada, S.1    Li, A.2    Maiorano, D.3    Mechali, M.4    Blow, J.J.5
  • 60
    • 0036313608 scopus 로고    scopus 로고
    • Expression of geminin as a marker of cell proliferation in normal tissues and malignancies
    • Wohlschlegel JA, Kutok JL, Weng AP, et al., Expression of geminin as a marker of cell proliferation in normal tissues and malignancies. Am J Pathol 2002; 161: 267-273. (Pubitemid 34760792)
    • (2002) American Journal of Pathology , vol.161 , Issue.1 , pp. 267-273
    • Wohlschlegel, J.A.1    Kutok, J.L.2    Weng, A.P.3    Dutta, A.4
  • 65
    • 25144525540 scopus 로고    scopus 로고
    • CDKs promote DNA replication origin licensing in human cells by protecting Cdc6 from APC/C-dependent proteolysis
    • DOI 10.1016/j.cell.2005.08.013, PII S0092867405008172
    • Mailand N, Diffley JF,. CDKs promote DNA replication origin licensing in human cells by protecting Cdc6 from APC/C-dependent proteolysis. Cell 2005; 122: 915-926. (Pubitemid 41345208)
    • (2005) Cell , vol.122 , Issue.6 , pp. 915-926
    • Mailand, N.1    Diffley, J.F.X.2
  • 66
    • 34648858645 scopus 로고    scopus 로고
    • Cdc6 is a rate-limiting factor for proliferative capacity during HL60 cell differentiation
    • DOI 10.1016/j.yexcr.2007.07.004, PII S0014482707003187
    • Barkley LR, Hong HK, Kingsbury SR, et al., Cdc6 is a rate-limiting factor for proliferative capacity during HL60 cell differentiation. Exp Cell Res 2007; 313: 3789-3799. (Pubitemid 47464231)
    • (2007) Experimental Cell Research , vol.313 , Issue.17 , pp. 3789-3799
    • Barkley, L.R.1    Hong, H.K.2    Kingsbury, S.R.3    James, M.4    Stoeber, K.5    Williams, G.H.6
  • 67
    • 0031867171 scopus 로고    scopus 로고
    • Stability of the replicative Mcm3 protein in proliferating and differentiating human cells
    • DOI 10.1006/excr.1998.4041
    • Musahl C, Holthoff HP, Lesch R, et al., Stability of the replicative Mcm3 protein in proliferating and differentiating human cells. Exp Cell Res 1998; 241: 260-264. (Pubitemid 28366601)
    • (1998) Experimental Cell Research , vol.241 , Issue.1 , pp. 260-264
    • Musahl, C.1    Holthoff, H.P.2    Lesch, R.3    Knippers, R.4
  • 69
    • 0036179331 scopus 로고    scopus 로고
    • Aberrant expression of minichromosome maintenance proteins 2 and 5, and ki-67 in dysplastic squamous oesophageal epithelium and barrett's mucosa
    • DOI 10.1136/gut.50.3.373
    • Going JJ, Keith WN, Neilson L, et al., Aberrant expression of minichromosome maintenance proteins 2 and 5, and Ki-67 in dysplastic squamous oesophageal epithelium and Barrett's mucosa. Gut 2002; 50: 373-377. (Pubitemid 34161054)
    • (2002) Gut , vol.50 , Issue.3 , pp. 373-377
    • Going, J.J.1    Keith, W.N.2    Neilson, L.3    Stoeber, K.4    Stuart, R.C.5    Williams, G.H.6
  • 70
    • 0036175591 scopus 로고    scopus 로고
    • Minichromosome maintenance (MCM) proteins may be pre-cancer markers
    • DOI 10.1136/gut.50.3.290
    • Alison MR, Hunt T, Forbes SJ,. Minichromosome maintenance (MCM) proteins may be pre-cancer markers. Gut 2002; 50: 290-291. (Pubitemid 34161038)
    • (2002) Gut , vol.50 , Issue.3 , pp. 290-291
    • Alison, M.R.1    Hunt, T.2    Forbes, S.J.3
  • 73
    • 73149113356 scopus 로고    scopus 로고
    • DNA replication licensing factors and aneuploidy are linked to tumor cell cycle state and clinical outcome in penile carcinoma
    • Kayes OJ, Loddo M, Patel N, et al., DNA replication licensing factors and aneuploidy are linked to tumor cell cycle state and clinical outcome in penile carcinoma. Clin Cancer Res 2009; 15: 7335-7344.
    • (2009) Clin Cancer Res , vol.15 , pp. 7335-7344
    • Kayes, O.J.1    Loddo, M.2    Patel, N.3
  • 76
    • 23944515316 scopus 로고    scopus 로고
    • Minichromosome maintenance proteins 2 and 5 expression in muscle-invasive urothelial cancer: A multivariate survival study including proliferation markers and cell cycle regulators
    • DOI 10.1016/j.humpath.2005.06.008, PII S0046817705002856
    • Korkolopoulou P, Givalos N, Saetta A, et al., Minichromosome maintenance proteins 2 and 5 expression in muscle-invasive urothelial cancer: a multivariate survival study including proliferation markers and cell cycle regulators. Hum Pathol 2005; 36: 899-907. (Pubitemid 41187909)
    • (2005) Human Pathology , vol.36 , Issue.8 , pp. 899-907
    • Korkolopoulou, P.1    Givalos, N.2    Saetta, A.3    Goudopoulou, A.4    Gakiopoulou, H.5    Thymara, I.6    Thomas-Tsagli, E.7    Patsouris, E.8
  • 80
    • 2342542322 scopus 로고    scopus 로고
    • Regulation of Geminin and Cdt1 expression by E2F transcription factors
    • DOI 10.1038/sj.onc.1207488
    • Yoshida K, Inoue I,. Regulation of Geminin and Cdt1 expression by E2F transcription factors. Oncogene 2004; 23: 3802-3812. (Pubitemid 38725693)
    • (2004) Oncogene , vol.23 , Issue.21 , pp. 3802-3812
    • Yoshida, K.1    Inoue, I.2
  • 81
    • 0033535590 scopus 로고    scopus 로고
    • Cell growth-regulated expression of mammalian MCM5 and MCM6 genes mediated by the transcription factor E2F
    • Ohtani K, Iwanaga R, Nakamura M, et al., Cell growth-regulated expression of mammalian MCM5 and MCM6 genes mediated by the transcription factor E2F. Oncogene 1999; 18: 2299-2309. (Pubitemid 29192707)
    • (1999) Oncogene , vol.18 , Issue.14 , pp. 2299-2309
    • Ohtani, K.1    Iwanaga, R.2    Nakamura, M.3    Ikeda, M.-A.4    Yabuta, N.5    Tsuruga, H.6    Nojima, H.7
  • 82
    • 4344693869 scopus 로고    scopus 로고
    • Expression of MCM10 and TopBP1 is regulated by cell proliferation and UV irradiation via the E2F transcription factor
    • DOI 10.1038/sj.onc.1207829
    • Yoshida K, Inoue I,. Expression of MCM10 and TopBP1 is regulated by cell proliferation and UV irradiation via the E2F transcription factor. Oncogene 2004; 23: 6250-6260. (Pubitemid 39215295)
    • (2004) Oncogene , vol.23 , Issue.37 , pp. 6250-6260
    • Yoshida, K.1    Inoue, I.2
  • 83
    • 0037008667 scopus 로고    scopus 로고
    • A 63-base pair DNA segment containing an Sp1 site but not a canonical E2F site can confer growth-dependent and E2F-mediated transcriptional stimulation of the human ASK gene encoding the regulatory subunit for human Cdc7-related kinase
    • DOI 10.1074/jbc.M202884200
    • Yamada M, Sato N, Taniyama C, et al., A 63-base pair DNA segment containing an Sp1 site but not a canonical E2F site can confer growth-dependent and E2F-mediated transcriptional stimulation of the human ASK gene encoding the regulatory subunit for human Cdc7-related kinase. J Biol Chem 2002; 277: 27668-27681. (Pubitemid 34966710)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.31 , pp. 27668-27681
    • Yamada, M.1    Sato, N.2    Taniyama, C.3    Ohtani, K.4    Arai, K.-I.5    Masai, H.6
  • 86
    • 33645460360 scopus 로고    scopus 로고
    • Oncogenic activity of Cdc6 through repression of the INK4/ARF locus
    • Gonzalez S, Klatt P, Delgado S, et al., Oncogenic activity of Cdc6 through repression of the INK4/ARF locus. Nature 2006; 440: 702-706.
    • (2006) Nature , vol.440 , pp. 702-706
    • Gonzalez, S.1    Klatt, P.2    Delgado, S.3
  • 87
    • 28744444389 scopus 로고    scopus 로고
    • Cdt1 transgenic mice develop lymphoblastic lymphoma in the absence of p53
    • DOI 10.1038/sj.onc.1208881
    • Seo J, Chung YS, Sharma GG, et al., Cdt1 transgenic mice develop lymphoblastic lymphoma in the absence of p53. Oncogene 2005; 24: 8176-8186. (Pubitemid 41759816)
    • (2005) Oncogene , vol.24 , Issue.55 , pp. 8176-8186
    • Seo, J.1    Chung, Y.S.2    Sharma, G.G.3    Moon, E.4    Burack, W.R.5    Pandita, T.K.6    Choi, K.7
  • 88
    • 33745795112 scopus 로고    scopus 로고
    • Deregulated minichromosomal maintenance protein MCM7 contributes to oncogene driven tumorigenesis
    • DOI 10.1038/sj.onc.1209435, PII 1209435
    • Honeycutt KA, Chen Z, Koster MI, et al., Deregulated minichromosomal maintenance protein MCM7 contributes to oncogene driven tumorigenesis. Oncogene 2006; 25: 4027-4032. (Pubitemid 44024865)
    • (2006) Oncogene , vol.25 , Issue.29 , pp. 4027-4032
    • Honeycutt, K.A.1    Chen, Z.2    Koster, M.I.3    Miers, M.4    Nuchtern, J.5    Hicks, J.6    Roop, D.R.7    Shohet, J.M.8
  • 90
    • 37349025510 scopus 로고    scopus 로고
    • Reduced Mcm2 expression results in severe stem/progenitor cell deficiency and cancer
    • DOI 10.1634/stemcells.2007-0483
    • Pruitt SC, Bailey KJ, Freeland A,. Reduced Mcm2 expression results in severe stem/progenitor cell deficiency and cancer. Stem Cells 2007; 25: 3121-3132. (Pubitemid 350294438)
    • (2007) Stem Cells , vol.25 , Issue.12 , pp. 3121-3132
    • Pruitt, S.C.1    Bailey, K.J.2    Freeland, A.3
  • 91
    • 33846148030 scopus 로고    scopus 로고
    • Detection of cervical high-grade squamous intraepithelial lesions from cytologic samples using a novel immunocytochemical assay (ProEx C)
    • DOI 10.1002/cncr.22288
    • Kelly D, Kincaid E, Fansler Z, et al., Detection of cervical high-grade squamous intraepithelial lesions from cytologic samples using a novel immunocytochemical assay (ProEx C). Cancer 2006; 108: 494-500. (Pubitemid 46076970)
    • (2006) Cancer , vol.108 , Issue.6 , pp. 494-500
    • Kelly, D.1    Kincaid, E.2    Fansler, Z.3    Rosenthal, D.L.4    Clark, D.P.5
  • 92
    • 33750085559 scopus 로고    scopus 로고
    • Validation of a novel immunocytochemical assay for topoisomerase II-; and minichromosome maintenance protein 2 expression in cervical cytology
    • DOI 10.1002/cncr.22171
    • Shroyer KR, Homer P, Heinz D, et al., Validation of a novel immunocytochemical assay for topoisomerase IIα and minichromosome maintenance protein 2 expression in cervical cytology. Cancer 2006; 108: 324-330. (Pubitemid 44583712)
    • (2006) Cancer , vol.108 , Issue.5 , pp. 324-330
    • Shroyer, K.R.1    Homer, P.2    Heinz, D.3    Singh, M.4
  • 95
    • 77955984580 scopus 로고    scopus 로고
    • Diagnosis of prostate cancer by detection of minichromosome maintenance 5 protein in urine sediments
    • Dudderidge TJ, Kelly JD, Wollenschlaeger A, et al., Diagnosis of prostate cancer by detection of minichromosome maintenance 5 protein in urine sediments. Br J Cancer 2010; 103: 701-707.
    • (2010) Br J Cancer , vol.103 , pp. 701-707
    • Dudderidge, T.J.1    Kelly, J.D.2    Wollenschlaeger, A.3
  • 99
    • 78651363414 scopus 로고    scopus 로고
    • ProExC triage of atypical glandular cells on liquid-based cervical cytology specimens
    • Fletcher AH, Barklow TA, Murphy NJ, et al., ProExC triage of atypical glandular cells on liquid-based cervical cytology specimens. J Low Genit Tract Dis 2011; 15: 6-10.
    • (2011) J Low Genit Tract Dis , vol.15 , pp. 6-10
    • Fletcher, A.H.1    Barklow, T.A.2    Murphy, N.J.3
  • 100
    • 45549088905 scopus 로고    scopus 로고
    • Longitudinal clinical evaluation of a novel antibody cocktail for detection of high-grade squamous intraepithelial lesions on cervical cytology specimens
    • Tambouret RH, Misdraji J, Wilbur DC,. Longitudinal clinical evaluation of a novel antibody cocktail for detection of high-grade squamous intraepithelial lesions on cervical cytology specimens. Arch Pathol Lab Med 2008; 132: 918-925. (Pubitemid 351918696)
    • (2008) Archives of Pathology and Laboratory Medicine , vol.132 , Issue.6 , pp. 918-925
    • Tambouret, R.H.1    Misdraji, J.2    Wilbur, D.C.3
  • 101
    • 55249112008 scopus 로고    scopus 로고
    • Detecting high-grade cervical disease on ASC-H cytology: Role of BD ProEx C and Digene Hybrid Capture II HPV DNA testing
    • Siddiqui MT, Cohen C, Nassar A,. Detecting high-grade cervical disease on ASC-H cytology: role of BD ProEx C and Digene Hybrid Capture II HPV DNA testing. Am J Clin Pathol 2008; 130: 765-770.
    • (2008) Am J Clin Pathol , vol.130 , pp. 765-770
    • Siddiqui, M.T.1    Cohen, C.2    Nassar, A.3
  • 102
    • 0026072872 scopus 로고
    • Pathological prognostic factors in breast cancer. I. the value of histological grade in breast cancer: Experience from a large study with long-term follow-up
    • Elston CW, Ellis IO,. Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up. Histopathology 1991; 19: 403-410.
    • (1991) Histopathology , vol.19 , pp. 403-410
    • Elston, C.W.1    Ellis, I.O.2
  • 103
    • 33749457149 scopus 로고    scopus 로고
    • Grading of soft tissue sarcomas: Review and update
    • Coindre JM,. Grading of soft tissue sarcomas: review and update. Arch Pathol Lab Med 2006; 130: 1448-1453.
    • (2006) Arch Pathol Lab Med , vol.130 , pp. 1448-1453
    • Coindre, J.M.1
  • 104
    • 62549091454 scopus 로고    scopus 로고
    • Breast cancer subtypes and response to docetaxel in node-positive breast cancer: Use of an immunohistochemical definition in the BCIRG 001 trial
    • Hugh J, Hanson J, Cheang MC, et al., Breast cancer subtypes and response to docetaxel in node-positive breast cancer: use of an immunohistochemical definition in the BCIRG 001 trial. J Clin Oncol 2009; 27: 1168-1176.
    • (2009) J Clin Oncol , vol.27 , pp. 1168-1176
    • Hugh, J.1    Hanson, J.2    Cheang, M.C.3
  • 105
    • 67649983962 scopus 로고    scopus 로고
    • Ki67 expression and docetaxel efficacy in patients with estrogen receptor-positive breast cancer
    • Penault-Llorca F, Andre F, Sagan C, et al., Ki67 expression and docetaxel efficacy in patients with estrogen receptor-positive breast cancer. J Clin Oncol 2009; 27: 2809-2815.
    • (2009) J Clin Oncol , vol.27 , pp. 2809-2815
    • Penault-Llorca, F.1    Andre, F.2    Sagan, C.3
  • 106
    • 75249083420 scopus 로고    scopus 로고
    • Ki67 in breast cancer: Prognostic and predictive potential
    • Yerushalmi R, Woods R, Ravdin PM, et al., Ki67 in breast cancer: prognostic and predictive potential. Lancet Oncol 2010; 11: 174-183.
    • (2010) Lancet Oncol , vol.11 , pp. 174-183
    • Yerushalmi, R.1    Woods, R.2    Ravdin, P.M.3
  • 107
    • 36749103631 scopus 로고    scopus 로고
    • Mechanisms to control rereplication and implications for cancer
    • DOI 10.1016/j.ceb.2007.10.007, PII S0955067407001524, Cell Differentiation / Cell Division, Growth and Death
    • Hook SS, Lin JJ, Dutta A,. Mechanisms to control rereplication and implications for cancer. Curr Opin Cell Biol 2007; 19: 663-671. (Pubitemid 350216429)
    • (2007) Current Opinion in Cell Biology , vol.19 , Issue.6 , pp. 663-671
    • Hook, S.S.1    Lin, J.J.2    Dutta, A.3
  • 109
    • 0033515426 scopus 로고    scopus 로고
    • Phosphorylation of histone H3 is required for proper chromosome condensation and segregation
    • Wei Y, Yu L, Bowen J, et al., Phosphorylation of histone H3 is required for proper chromosome condensation and segregation. Cell 1999; 97: 99-109. (Pubitemid 29165893)
    • (1999) Cell , vol.97 , Issue.1 , pp. 99-109
    • Wei, Y.1    Yu, L.2    Bowen, J.3    Gorovsky, M.A.4    David Allis, C.5
  • 110
    • 62549147488 scopus 로고    scopus 로고
    • Cell-cycle-phase progression analysis identifies unique phenotypes of major prognostic and predictive significance in breast cancer
    • Loddo M, Kingsbury SR, Rashid M, et al., Cell-cycle-phase progression analysis identifies unique phenotypes of major prognostic and predictive significance in breast cancer. Br J Cancer 2009; 100: 959-970.
    • (2009) Br J Cancer , vol.100 , pp. 959-970
    • Loddo, M.1    Kingsbury, S.R.2    Rashid, M.3
  • 111
    • 77957341219 scopus 로고    scopus 로고
    • Targeting DNA replication before it starts: Cdc7 as a therapeutic target in p53-mutant breast cancers
    • Rodriguez-Acebes S, Proctor I, Loddo M, et al., Targeting DNA replication before it starts: Cdc7 as a therapeutic target in p53-mutant breast cancers. Am J Pathol 2010; 177: 2034-2045.
    • (2010) Am J Pathol , vol.177 , pp. 2034-2045
    • Rodriguez-Acebes, S.1    Proctor, I.2    Loddo, M.3
  • 113
    • 58149330982 scopus 로고    scopus 로고
    • Meta-analysis of gene expression profiles in breast cancer: Toward a unified understanding of breast cancer subtyping and prognosis signatures
    • Wirapati P, Sotiriou C, Kunkel S, et al., Meta-analysis of gene expression profiles in breast cancer: toward a unified understanding of breast cancer subtyping and prognosis signatures. Breast Cancer Res 2008; 10: R65.
    • (2008) Breast Cancer Res , vol.10
    • Wirapati, P.1    Sotiriou, C.2    Kunkel, S.3
  • 116
    • 65549146500 scopus 로고    scopus 로고
    • Sequential docetaxel as adjuvant chemotherapy for early breast cancer (TACT): An open-label, phase III, randomised controlled trial
    • Ellis P, Barrett-Lee P, Johnson L, et al., Sequential docetaxel as adjuvant chemotherapy for early breast cancer (TACT): an open-label, phase III, randomised controlled trial. Lancet 2009; 373: 1681-1692.
    • (2009) Lancet , vol.373 , pp. 1681-1692
    • Ellis, P.1    Barrett-Lee, P.2    Johnson, L.3
  • 117
    • 70350757346 scopus 로고    scopus 로고
    • TAnGo: A randomized Phase III trial of gemcitabine (gem) in paclitaxel-containing, epirubicin/cyclophosphamide-based, adjuvant chemotherapy (CT) for women with early-stage breast cancer (EBC)
    • Abstract 506
    • Poole CJ, Hiller L, Howard HC, et al., tAnGo: a randomized Phase III trial of gemcitabine (gem) in paclitaxel-containing, epirubicin/ cyclophosphamide-based, adjuvant chemotherapy (CT) for women with early-stage breast cancer (EBC). J Clin Oncol 2008; 26:Abstract 506.
    • (2008) J Clin Oncol , vol.26
    • Poole, C.J.1    Hiller, L.2    Howard, H.C.3
  • 118
    • 65249189337 scopus 로고    scopus 로고
    • Cdc7 kinase is a predictor of survival and a novel therapeutic target in epithelial ovarian carcinoma
    • Kulkarni AA, Kingsbury SR, Tudzarova S, et al., Cdc7 kinase is a predictor of survival and a novel therapeutic target in epithelial ovarian carcinoma. Clin Cancer Res 2009; 15: 2417-2425.
    • (2009) Clin Cancer Res , vol.15 , pp. 2417-2425
    • Kulkarni, A.A.1    Kingsbury, S.R.2    Tudzarova, S.3
  • 122
    • 33748093767 scopus 로고    scopus 로고
    • Linking oncogenic pathways with therapeutic opportunities
    • DOI 10.1038/nrc1976, PII NRC1976
    • Bild AH, Potti A, Nevins JR,. Linking oncogenic pathways with therapeutic opportunities. Nat Rev Cancer 2006; 6: 735-741. (Pubitemid 44304232)
    • (2006) Nature Reviews Cancer , vol.6 , Issue.9 , pp. 735-741
    • Bild, A.H.1    Potti, A.2    Nevins, J.R.3
  • 125
    • 0037179866 scopus 로고    scopus 로고
    • Cell type-specific responses of human cells to inhibition of replication licensing
    • DOI 10.1038/sj.onc.1205910
    • Shreeram S, Sparks A, Lane DP, et al., Cell type-specific responses of human cells to inhibition of replication licensing. Oncogene 2002; 21: 6624-6632. (Pubitemid 35177041)
    • (2002) Oncogene , vol.21 , Issue.43 , pp. 6624-6632
    • Shreeram, S.1    Sparks, A.2    Lane, D.P.3    Blow, J.J.4
  • 128
    • 37249025795 scopus 로고    scopus 로고
    • Dormant origins licensed by excess Mcm2-7 are required for human cells to survive replicative stress
    • DOI 10.1101/gad.457807
    • Ge XQ, Jackson DA, Blow JJ,. Dormant origins licensed by excess Mcm2-7 are required for human cells to survive replicative stress. Genes Dev 2007; 21: 3331-3341. (Pubitemid 350277759)
    • (2007) Genes and Development , vol.21 , Issue.24 , pp. 3331-3341
    • Ge, X.Q.1    Jackson, D.A.2    Blow, J.J.3
  • 129
    • 77957809141 scopus 로고    scopus 로고
    • Molecular architecture of the DNA replication origin activation checkpoint
    • Tudzarova S, Trotter MW, Wollenschlaeger A, et al., Molecular architecture of the DNA replication origin activation checkpoint. EMBO J 2010; 29: 3381-3394.
    • (2010) EMBO J , vol.29 , pp. 3381-3394
    • Tudzarova, S.1    Trotter, M.W.2    Wollenschlaeger, A.3
  • 130
    • 71049184413 scopus 로고    scopus 로고
    • Cdc7 kinase-a new target for drug development
    • Swords R, Mahalingam D, O'Dwyer M, et al., Cdc7 kinase-a new target for drug development. Eur J Cancer 2010; 46: 33-40.
    • (2010) Eur J Cancer , vol.46 , pp. 33-40
    • Swords, R.1    Mahalingam, D.2    O'Dwyer, M.3
  • 131
    • 77956713455 scopus 로고    scopus 로고
    • Targeting cell division cycle 7 kinase: A new approach for cancer therapy
    • Montagnoli A, Moll J, Colotta F,. Targeting cell division cycle 7 kinase: a new approach for cancer therapy. Clin Cancer Res 2010; 16: 4503-4508.
    • (2010) Clin Cancer Res , vol.16 , pp. 4503-4508
    • Montagnoli, A.1    Moll, J.2    Colotta, F.3
  • 132
    • 54449087508 scopus 로고    scopus 로고
    • ATR-dependent activation of p38 MAP kinase is responsible for apoptotic cell death in cells depleted of Cdc7
    • Im JS, Lee JK,. ATR-dependent activation of p38 MAP kinase is responsible for apoptotic cell death in cells depleted of Cdc7. J Biol Chem 2008; 283: 25171-25177.
    • (2008) J Biol Chem , vol.283 , pp. 25171-25177
    • Im, J.S.1    Lee, J.K.2
  • 133
    • 44449112225 scopus 로고    scopus 로고
    • Cdc7 kinase mediates Claspin phosphorylation in DNA replication checkpoint
    • DOI 10.1038/sj.onc.1210994, PII 1210994
    • Kim JM, Kakusho N, Yamada M, et al., Cdc7 kinase mediates Claspin phosphorylation in DNA replication checkpoint. Oncogene 2008; 27: 3475-3482. (Pubitemid 351769309)
    • (2008) Oncogene , vol.27 , Issue.24 , pp. 3475-3482
    • Kim, J.M.1    Kakusho, N.2    Yamada, M.3    Kanoh, Y.4    Takemoto, N.5    Masai, H.6
  • 134
    • 78650131158 scopus 로고    scopus 로고
    • Hsk1 kinase and Cdc45 regulate replication stress-induced checkpoint responses in fission yeast
    • Matsumoto S, Shimmoto M, Kakusho N, et al., Hsk1 kinase and Cdc45 regulate replication stress-induced checkpoint responses in fission yeast. Cell Cycle 2010; 9: 4627-4637.
    • (2010) Cell Cycle , vol.9 , pp. 4627-4637
    • Matsumoto, S.1    Shimmoto, M.2    Kakusho, N.3
  • 135
    • 0035359505 scopus 로고    scopus 로고
    • Exploiting cancer cell cycling for selective protection of normal cells
    • Blagosklonny MV, Pardee AB,. Exploiting cancer cell cycling for selective protection of normal cells. Cancer Res 2001; 61: 4301-4305. (Pubitemid 32685747)
    • (2001) Cancer Research , vol.61 , Issue.11 , pp. 4301-4305
    • Blagosklonny, M.V.1    Pardee, A.B.2


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