Reactive oxygen species as intracellular messengers during cell growth and differentiation

Cellular Physiology and Biochemistry

Volumn 11, Issue 4, 2001, Pages 173-186

  Sauer, Heinrich ^a   Wartenberg, Maria ^a   Hescheler, Juergen ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

Author keywords

Antioxidative defence; NADPH oxidase; Reactive oxygen species; Second messenger; Signal transduction

Indexed keywords

ANTIOXIDANT; PHOSPHOPROTEIN PHOSPHATASE; PROTEIN KINASE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; TRANSCRIPTION FACTOR;

CALCIUM CELL LEVEL; CALCIUM SIGNALING; CELL CYCLE; CELL DEATH; CELL DIFFERENTIATION; CELL GROWTH; CELL MEMBRANE; CELL NUCLEUS; ENZYME KINETICS; LIGAND BINDING; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; REVIEW; SECOND MESSENGER; SIGNAL TRANSDUCTION;

EID: 0034873185     PISSN: 10158987     EISSN: None     Source Type: Journal    
DOI: 10.1159/000047804     Document Type: Review

References (128)

1. Free radicals and the regulation of mammalian cell proliferation
2. Roles of reactive oxygen species: Signaling and regulation of cellular functions
3. Superoxide and hydrogen peroxide in relation to mammalian cell proliferation
4. Oxygen radicals and signaling
5. Oxidants, oxidative stress and the biology of ageing
6. Role of reactive oxygen species in the regulation of physiological functions
7. Oxidants as stimulators of signal transduction
8. Reactive oxygen species in cell signaling
9. Redox regulatory mechanisms of cellular signal transduction
10. Redox regulation of cellular signalling
11. Active oxygen species stimulate vascular smooth muscle cell growth and proto-oncogene expression
12. Superoxide anion increases intracellular pH, intracellular free calcium, and arachidonate release in human amnion cells
13. 2+ response
14. Reactive oxygen species induce proliferation of bovine aortic endothelial cells
15. Oxidative stress involvement in chemically induced differentiation of K562 cells
16. Hydroxyl radicals as an early signal involved in phorbol ester-induced monocytic differentiation of HL60 cells
17. Hyperoxia induces the neuronal differentiated phenotype of PC12 cells via a sustained activity of mitogen-activated protein kinase induced by Bcl-2
18. Involvement of hydrogen peroxide in the differentiation of clonal HD- 11EM cells into osteoclast-like cells
19. Effects of electrical fields on cardiomyocyte differentiation of embryonic stem cells
20. Overexpression of human catalase inhibits proliferation and promotes apoptosis in vascular smooth muscle cells
21. Inhibition of cell growth and sensitization to oxidative damage by overexpression of manganese superoxide dismutase in rat glioma cells
22. Oxidative influence on development and differentiation: An overview of a free radical theory of development
23. Normal prion protein has an activity like that of superoxide dismutase
24. Redox-regulation of intrinsic prion expression in multicellular prostate tumor spheroids
25. Production of large amounts of hydrogen peroxide by human tumor cells
26. Reactive oxygen species and proinflammatory cytokine signaling in endothelial cells: Effect of selenium supplementation
27. Methotrexate suppresses the interleukin-6 induced generation of reactive oxygen species in the synoviocytes of rheumatoid arthritis
28. Hemato-poietic growth factors signal through the formation of reactive oxygen species
29. Interleukin 1-alpha and tumor necrosis factor-alpha induce oxygen radical production in mesangial cells
30. 2 induced vascular hypertrophy
31. Reactive oxygen species mediate the activation of Akt/protein kinase B by angiotensin II in vascular smooth muscle cells
32. 2 for platelet-derived growth factor signal transduction
33. Nerve growth factor-induced neuronal differentiation requires generation of Rac1-regulated reactive oxygen species
34. 2 release from bovine pulmonary artery endothelial cells induced by TGF-beta 1
35. 2+ channels
36. Reactive oxygen species and calcium homeostasis in cultured human intestinal smooth muscle cells
37. 2+ changes in endothelial cells induced by low doses of reactive oxygen species: Role of hydrogen peroxide
38. Hydrogen peroxide induced responses of cat tracheal smooth muscle cells
39. Hydrogen peroxide increases the intracellular calcium activity in rat mesangial cells in primary culture
40. Calcium signals and protein tyrosine kinases are required for the induction of c-jun in Jurkat cells stimulated by the T cell-receptor complex and oxidative signals
41. Calcium-dependence of hydrogen peroxide-induced c-fos expression and growth stimulation of multicellular prostate tumor spheroids
42. 2+ channels expressed in Xenopus oocytes
43. Redox control of ion channel activity in vascular endothelial cells by glutathione
44. Purified reconstituted inositol 1,4,5-trisphosphate receptors. Thiol reagents act directly on receptor protein
45. Spontaneous calcium release from inositol trisphosphate-sensitive calcium stores
46. 2 functions
47. 2+ stores to inositol 1,4,5-trisphosphate in human endothelial cells
48. 2+ -pump isoform SERCA3a is more resistant to superoxide damage than SERCA2b
49. 2+ exchange in ventricular myocytes
50. (2) modulates the ability to activate the plasma membrane Ca-ATPase
51. Reactive oxygen species and nitric oxide mediate plasticity of neuronal calcium signaling
52. 2 : Senescence- like growth arrest or apoptosis?
53. The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen
54. Mitochondrial respiratory chain-dependent generation of superoxide anion and its release into the intermembrane space
55. Hydroperoxide metabolism in mammalian organs
56. Oxidative damage in chemical teratogenesis
57. Thalidomide inhibits angiogenesis in embryoid bodies by the generation of hydroxyl radicals
58. Endothelium-derived hyperpolarizing factor synthase (Cytochrome P450 2C9) is a functionally significant source of reactive oxygen species in coronary arteries
59. 2 production and S-thiolation
60. Hydrogen peroxide produced during gamma-glutamyl transpeptidase activity is involved in prevention of apoptosis and maintainance of proliferation in U937 cells
61. Function of wild-type or mutant Rac2 and Rap1a GTPases in differentiated HL60 cell NADPH oxidase activation
62. Targeting of rac1 to the phagocyte membrane is sufficient for the induction of NADPH oxidase assembly
63. Stimulation of a vascular smooth muscle cell NAD(P)H oxidase by thrombin. Evidence that p47(phox) may participate in forming this oxidase in vitro and in vivo
64. Detection of protein and mRNA of various components of the NADPH oxidase complex in an immortalized human chondrocyte line
65. NADPH oxidase activity is required for endothelial cell proliferation and migration
66. A gp91phox containing NADPH oxidase selectively expressed in endothelial cells is a major source of oxygen radical generation in the arterial wall
67. Down-regulation of intrinsic P-glycoprotein expression in multicellular prostate tumor spheroids by reactive oxygen species
68. p22phox is a critical component of the superoxide-generating NADH/NADPH oxidase system and regulates angiotensin II-induced hypertrophy in vascular smooth muscle cells
69. The expression of NADPH oxidase components in human glomerular mesangial cells: Detection of protein and mRNA for p47phox, p67phox, and p22phox
70. 2
71. NADH oxidoreductase is a major source of superoxide anion in bovine coronary artery endothelium
72. 2 mice lacking the gp91 phox subunit of NADPH oxidase
73. Rac1, and not Rac2, is involved in the regulation of the intracellular hydrogen peroxide level in HepG2 cells
74. A Rac1 effector site controlling mitogenesis through superoxide production
75. (2) production requires the activation of phosphatidylinositol 3-kinase
76. Role of reactive oxygen species and phosphatidylinositol 3-kinase in cardiomyocyte differentiation of embryonic stem cells
77. Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts
78. Regulation of reactive-oxygen-species generation in fibroblasts by Rac1
79. Ras-dependent and -independent regulation of reactive oxygen species by mitogenic growth factors and TGF-beta1 [In Process Citation]
80. Cell transformation by the superoxide-generating oxidase Mox1
81. Hydrogen peroxide mediates the cell growth and transformation caused by the mitogenic oxidase Nox1
82. A new superoxide-generating oxidase in murine osteoclasts
83. A novel superoxide-producing NAD(P)H oxidase in kidney
84. Human fibroblasts release reactive oxygen species in response to interleukin-1 or tumour necrosis factor-alpha
85. Secretion of MCP-1 and IL-6 by cytokine stimulated production of reactive oxygen species in endothelial cells
86. Oxygen radicals as second messengers for expression of the monocyte chemoattractant protein, JE/MCP-1, and the monocyte colony-stimulating factor, CSF-1, in response to tumor necrosis factor-alpha and immunoglobulin G. Evidence for involvement of reduced nicotinamide adenine dinucleotide phosphate (NADPH)-dependent oxidase
87. Antioxidant defenses in the TNF-treated MCF-7 cells: Selective increase in MnSOD
88. Linoleic acid and tumor necrosis factor-alpha increase manganese superoxide dismutase activity in intestinal cells
89. Overexpression of manganese superoxide dismutase suppresses tumor necrosis factor-induced apoptosis and activation of nuclear transcription factor-kappaB and activated protein-1
90. Overexpression of manganese-containing superoxide dismutase confers resistance to the cytotoxicity of tumor necrosis factor alpha and/or hyperthermia
91. Anti-death properties of TNF against metabolic poisoning: Mitochondrial stabilization by MnSOD
92. 2 proteins as early responses of cell cycle-dependent inhibition of DNA synthesis by transforming growth factor beta 1
93. Activation of an H2O2-generating NADH oxidase in human lung fibroblasts by transforming growth factor beta 1
94. Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells
95. Angiotensin II stimulates endothelial vascular cell adhesion molecule-1 via nuclear factor-kappaB activation induced by intracellular oxidative stress
96. Kip1 and induction of cellular hypertrophy in renal tubular cells depend on the generation of oxygen radicals
97. Angiotensin II induces superoxide anion production by mesangial cells
98. Negative feedback regulation of reactive oxygen species on AT1 receptor gene expression
99. Endothelin-1 and smooth muscle cells: Induction of jun amino-terminal kinase through an oxygen radical-sensitive mechanism
100. Role of reactive oxygen species in bradykinin-induced mitogen-activated protein kinase and c-fos induction in vascular cells
101. c-Jun triggers apoptosis in human vascular endothelial cells
102. Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis
103. p38 mitogen-activated protein kinase inhibition attenuates intercellular adhesion molecule-1 up-regulation on human pulmonary microvascular endothelial cells
104. p21ras as a common signaling target of reactive free radicals and cellular redox stress
105. Fyn and JAK2 mediate Ras activation by reactive oxygen species
106. Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway
107. Reactive oxygen species activate p90 ribosomal S6 kinase via Fyn and Ras
108. Hydrogen peroxide activates p70(S6k) signaling pathway
109. Src and Cas mediate JNK activation but not ERK1/2 and p38 kinases by reactive oxygen species
110. c-Src is required for oxidative stress-mediated activation of big mitogen-activated protein kinase 1
111. Selective inhibition of protein tyrosine phosphatase activities by H2O2 and vanadate in vitro
112. Nuclear factor kappa B: An oxidative stress-responsive transcription factor of eukaryotic cells (a review)
113. Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1
114. Redox regulation of fos and jun DNA-binding activity in vitro
115. Escape from redox regulation enhances the transforming activity of Fos
116. Physical and functional sensitivity of zinc finger transcription factors to redox change
117. Reduction of a conserved Cys is essential for Myb DNA-binding
118. Role of cysteine residues in regulation of p53 function
119. Functional activation of the egr-1 (early growth response-1) gene by hydrogen peroxide
120. Effect of altered redox states on expression and DNA-binding activity of hypoxia-inducible factor 1
121. rac1 regulates a cytokine-stimulated, redox-dependent pathway necessary for NF-kappaB activation
122. Activation of the nuclear factor-kappaB by Rho, CDC42, and Rac-1 proteins
123. Nitrosation and oxidation in the regulation of gene expression
124. Oxidation-reduction and the molecular mechanism of a regulatory RNA-protein interaction
125. Identification and characterization of Ref-1, a nuclear protein that facilitates AP-1 DNA-binding activity
126. Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzyme
127. AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1
128. Caloric restriction and aging: An update