Quercetin induces cytochrome-c release and ROS accumulation to promote apoptosis and arrest the cell cycle in G2/M, In cervical carcinoma: Signal cascade and drug-DNA interaction

Cell Proliferation

Volumn 46, Issue 2, 2013, Pages 153-163

  Bishayee, K ^a   Ghosh, S ^a   Mukherjee, A ^a   Sadhukhan, R ^a   Mondal, J ^a   Khuda Bukhsh, A R ^a  

^a UNIVERSITY OF KALYANI   (India)

Author keywords

[No Author keywords available]

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; CASPASE 3; CYTOCHROME C; PROTEIN BCL 2; PROTEIN KINASE B; PROTEIN P53; QUERCETIN; REACTIVE OXYGEN METABOLITE;

APOPTOSIS; ARTICLE; ASSAY; CELL MIGRATION; CELL PROLIFERATION; CIRCULAR DICHROISM; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DNA INTERACTION; FLUORESCENCE ACTIVATED CELL SORTING; G2 PHASE CELL CYCLE CHECKPOINT; GENE EXPRESSION; HELA CELL; HUMAN; HUMAN CELL; INTERCALATION COMPLEX; MEMBRANE DEPOLARIZATION; MITOCHONDRIAL MEMBRANE POTENTIAL; PROTEIN SECRETION; THYMOCYTE; UPREGULATION; UTERINE CERVIX CARCINOMA;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CASPASE 3; CELL MOVEMENT; CELL PROLIFERATION; CELL SURVIVAL; CIRCULAR DICHROISM; CYTOCHROMES C; DNA; DNA FRAGMENTATION; DNA, NEOPLASM; FEMALE; FLOW CYTOMETRY; G2 PHASE CELL CYCLE CHECKPOINTS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, BCL-2; HELA CELLS; HUMANS; M PHASE CELL CYCLE CHECKPOINTS; MEMBRANE POTENTIAL, MITOCHONDRIAL; NUCLEOSOMES; QUERCETIN; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TRANSCRIPTOME; TUMOR SUPPRESSOR PROTEIN P53; UTERINE CERVICAL NEOPLASMS;

EID: 84875292654     PISSN: 09607722     EISSN: 13652184     Source Type: Journal    
DOI: 10.1111/cpr.12017     Document Type: Article

References (26)

1. Neuhouser ML (2004) Dietary flavonoids and cancer risk: evidence from human population studies. Nutr. Cancer 50, 1-7.
2. Häkkinen SH, Kärenlampi SO, Heinonen IM, Mykkänen HM, Törrönen AR (1999) Content of the flavonols quercetin, myricetin, and kaempferol in 25 edible berries. J. Agric. Food Chem. 47, 2274-2279.
3. Nöthlings U, Murphy SP, Wilkens LR, Henderson BE, Kolonel LN (2007) Flavonols and pancreatic cancer risk: the multiethnic cohort study. Am. J. Epidemiol. 166, 924-931.
4. Paliwal S, Sundaram J, Mitragotri S (2005) Induction of cancer-specific cytotoxicity towards human prostate and skin cells using quercetin and ultrasound. Br. J. Cancer 92, 499-502.
5. Zhang W, Zhang F (2009) Effects of quercetin on proliferation, apoptosis, adhesion and migration, and invasion of HeLa cells. Eur. J. Gynaecol. Oncol. 30, 60-64.
6. Huang LQ, Zhang W, Yang Y, Tao L (2009) Effects and its mechanism of quercetin on cervical cancer HeLa cells. Zhonghua Fu Chan Ke Za Zhi. 44, 436-439.
7. Priyadarsini RV, Murugan RS, Maitreyi S, Ramalingam K, Karunagaran D, Nagini S (2010) The flavonoid quercetin induces cell cycle arrest and mitochondria-mediated apoptosis in human cervical cancer (HeLa) cells through p53 induction and NF-κB inhibition. Eur. J. Pharmacol. 649, 84-91.
8. Green JA (2001) Clinical trials in cancer. Br. J. Cancer 104, 1521-1522.
9. Swenson DH, Li LH, Hurley LH, Rokem JS, Petzold GL, Dayton BD et al. (1982) Mechanism of Interaction of CC-1065 (NSC 298223) with DNA. Cancer Res. 42, 2821-2828.
10. Palumbo M, Capasso L, Palù G, Marcianimagno G (1985) Conformational aspects of drug-DNA interactions: studies on anthracycline antibiotics and psoralen derivatives. J. Biosci. 8, 689-697.
11. Gottlieb TM, Leal JML, Seger R, Tay Y, Oren M (2002) Cross-talk between Akt, p53 and Mdm2: possible implications for the regulation of apoptosis. Oncogene 21, 1299-1303.
12. Bishayee K, Mukherjee A, Paul A, Khuda-Bukhsh AR (2012) Homeopathic mother tincture of Conium initiates reactive oxygen species mediated DNA damage and makes HeLa cells prone to apoptosis. Int. J. Genuine Traditional Med. 2, e26. doi: 10.5667/tang.2012.0018.
13. Garbett NC, Patricia A, Ragazzon PA, Chaires JB (2007) Circular dichroism to determine binding mode and affinity of ligand-DNA interactions. Nat. Protoc. 2, 3166-3172.
14. Liang CC, Park AY, Guan JL (2007) In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro. Nat. Protoc. 2, 329-333.
15. Paul A, Bishayee K, Ghosh S, Mukherjee A, Sikdar S, Chakraborty D et al. (2012) Chelidonine isolated from ethanolic extract of Chelidonium majus promotes apoptosis in HeLa cells through p38-p53 and PI3K/AKT signalling pathways. Zhong Xi Yi Jie He Xue Bao. 10, 1025-1038.
16. Chakraborty D, Bishayee K, Ghosh S, Biswas R, Mandal SK, Khuda-Bukhsh AR (2012) [6]-gingerol induces caspase 3 dependent apoptosis and autophagy in cancer cells: Drug-DNA interaction and expression of certain signal genes in HeLa cells. Eur. J. Pharmacol. 694, 20-29.
17. Chakraborty D, Mukherjee A, Sikdar S, Paul A, Ghosh S, Khuda-Bukhsh AR (2012) [6]-Gingerol isolated from ginger attenuates sodium arsenite induced oxidative stress and plays a corrective role in improving insulin signalling in mice. Toxicol. Lett. 210, 34-43.
18. Mandal SK, Biswas R, Bhattacharyya SS, Paul S, Dutta S, Pathak S et al. (2010) Lycopodin from Licopodium clavatumextract inhibits proliferation on HeLa cells through induction of apoptosis via caspase-3 activation. Eur. J. Pharmacol. 626, 115-122.
19. Fulda S, Debatin KM (2006) Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy. Oncogene 25, 4798-4811.
20. Shahabuddin MS, Gopal M, Raghavan SC (2007) Intercalating cytotoxic, antitumour activity of 8-chloro and 4-morpholinopyrimido [4', 5':4, 5]thieno(2, 3-b)quinoline. J. Photochem. Photobiol. B 3, 139-146.
21. Atlantea A, Calissano P, Bobba A, Azzariti A, Marra E, Passarella S (2000) Cytochrome c is released from mitochondria in a reactive oxygen species (ROS)-dependent fashion and can operate as a ROS scavenger and as a respiratory substrate in cerebellar neurons undergoing excitotoxic death. J. Biol. Chem. 275, 37159-37166.
22. Gottlieb TM, Leal JFM, Seger R, Taya Y, Oren M (2002) Cross-talk between Akt, p53 and Mdm2: possible implications for the regulation of apoptosis. Oncogene 21, 1299-1303.
23. Tsuruta F, Masuyama N, Gotoh Y (2002) The phosphatidylinositol 3-kinase (PI3K)-Akt pathway suppress Bax translocation to mitochondria. J. Biol. Chem. 277, 14040-14047.
24. Vento MT, Zazzu VZ, Loffreda A, Cross JR, Downward J, Stoppelli MP et al. (2010) Praf2 is a novel Bcl-xL/Bcl-2 interacting protein with the ability to modulate survival of cancer cells. PLoS One 5, 1-13.
25. Tsujimoto Y, Shimizu S (2000) Bcl-2 family: life-or-death switch. FEBS Lett. 466, 6-10.
26. Mantena SK, Sharma SD, Katiyar SK (2006) Berberine, a natural product, induces G1-phase cell cycle arrest and caspase-3-dependent apoptosis in human prostate carcinoma cells. Mol. Cancer Ther. 5, 296-308.