Bioactivity of Greek honey extracts on breast cancer (MCF-7), prostate cancer (PC-3) and endometrial cancer (Ishikawa) cells: Profile analysis of extracts

Food Chemistry

Volumn 116, Issue 3, 2009, Pages 702-708

  Tsiapara, Anna V ^a   Jaakkola, Mari ^b   Chinou, Ioanna ^c   Graikou, Konstadia ^c   Tolonen, Tiina ^b   Virtanen, Vesa ^b   Moutsatsou, Paraskevi ^a  

^a UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^b UNIVERSITY OF OULU   (Finland)

^c UNIVERSITY OF ATHENS   (Greece)

Author keywords

Honey extracts; Hydroxymethylfurfural; Oestrogenic activity; Total phenolics

Indexed keywords

ANTIESTROGEN; ANTINEOPLASTIC AGENT; FATTY ACID; GREEK HONEY EXTRACT; HYDROXYMETHYL 2 FURALDEHYDE; NATURAL PRODUCT; PHENOL DERIVATIVE; PHENOLIC ACID DERIVATIVE; PINE CONE EXTRACT; SUGAR; THYME OIL; UNCLASSIFIED DRUG; VOLATILE AGENT;

ARTICLE; BEE EXTRACT; BREAST CANCER; CANCER PREVENTION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACTIVITY; ENDOMETRIUM CANCER; ESTROGEN ACTIVITY; FIR HONEY; HONEY; HUMAN; HUMAN CELL; PINE; PROSTATE CANCER; THYME;

ABIES; THYMUS VULGARIS;

EID: 67349237894     PISSN: 03088146     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.foodchem.2009.03.024     Document Type: Article

References (36)

1. Adhami V.M., and Mukhtar H. Polyphenols from green tea and pomegranate for prevention of prostate cancer. Free Radical Research 40 10 (2006) 1095-1104
2. Alissandrakis E., Tarantilis P.A., Harizanis P.C., and Polissiou M. Comparison of the volatile composition in thyme honeys from several origins in Greece. Journal of Agricultural and Food Chemistry 55 20 (2007) 8152-8157
3. Al-Waili N.S., and Haq A. Effect of honey on antibody production against thymus-dependent and thymus-independent antigens in primary and secondary immune responses. Journal of Medicinal Food 7 4 (2004) 491-494
4. Burton J.L., and Wells M. The effect of phytoestrogens on the female genital tract. Journal of Clinical Pathology 55 6 (2002) 401-407
5. Chan J.M., Gann P.H., and Giovannucci E.L. Role of diet in prostate cancer development and progression. Journal of Clinical Oncology 23 32 (2005) 8152-8160
6. Denizot F., and Lang R. Rapid colorimetric assay for cell growth and survival modifications to the tetrazolium dye procedure giving improved sensitivity and reliability. Journal of Immunological Methods 89 2 (1986) 271-277
7. French V.M., Cooper R.A., and Molan P.C. The antibacterial activity of honey against coagulase-negative Staphylococci. Journal of Antimicrobial Chemotherapy 56 1 (2005) 228-231
8. Gheldof N., and Engeseth N.J. Antioxidant capacity of honeys from various floral sources based on the determination of oxygen radical absorbance capacity and inhibition of in vitro lipoprotein oxidation in human serum samples. Journal of Agricultural and Food Chemistry 50 21 (2002) 3050-3055
9. Gomez-Caravaca A.M., Gomez-Romero M., Arraez-Roman D., Segura-Carretero A., and Fernandez-Gutierrez A. Advances in the analysis of phenolic compounds in products derived from bees. Journal of Pharmaceutical and Biomedical Analysis 41 4 (2006) 1220-1234
10. Harris D.M., Besselink E., Henning S.M., Go V.L., and Heber D. Phytoestrogens induce differential estrogen receptor alpha- or beta-mediated responses in transfected breast cancer cells. Experimental Biology and Medicine (Maywood) 230 8 (2005) 558-568
11. Jerkovic I., Mastelic J., and Marijanovic Z. A variety of volatile compounds as markers in unifloral honey from Dalmatian sage (Salvia officinalis L.). Chemistry and Biodiversity 3 12 (2006) 1307-1316
12. Ju Y.H., Carlson K.E., Sun J., Pathak D., Katzenellenbogen B.S., Katzenellenbogen J.A., et al. Estrogenic effects of extracts from cabbage, fermented cabbage, and acidified Brussels sprouts on growth and gene expression of estrogen-dependent human breast cancer (MCF-7) cells. Journal of Agricultural and Food Chemistry 48 10 (2000) 4628-4634
13. Kris-Etherton P.M., Hecker K.D., Bonanome A., Coval S.M., Binkoski A.E., Hilpert K.F., et al. Bioactive compounds in foods: Their role in the prevention of cardiovascular disease and cancer. American Journal of Medicine 113 Suppl. 9B (2002) 71S-88S
14. Mabrouk G.M., Moselhy S.S., Zohny S.F., Ali E.M., Helal T.E., Amin A.A., et al. Inhibition of methylnitrosourea (MNU) induced oxidative stress and carcinogenesis by orally administered bee honey and Nigella grains in Sprague Dawely rats. Journal of Experimental and Clinical Cancer Research 21 3 (2002) 341-346
15. Merken H.M., and Beecher G.R. Measurement of food flavonoids by high-performance liquid chromatography: A review. Journal of Agricultural and Food Chemistry 48 3 (2000) 577-599
16. Michail K., Matzi V., Majer A., Herwig R., Greilberger J., Juan H., et al. Hydroxymethylfurfural: An enemy or a friendly xenobiotic? A bioanalytical approach. Analytical and Bioanalytical Chemistry 387 8 (2007) 2801-2814
17. Molan P.C. The evidence supporting the use of honey as a wound dressing. International Journal of Lower Extremity Wounds 5 1 (2006) 122
18. Moutsatsou P. The spectrum of phytoestrogens in nature: Our knowledge is expanding. Hormones 6 (2007) 173-193
19. Mueller S.O. Overview of in vitro tools to assess the estrogenic and antiestrogenic activity of phytoestrogens. Journal of Chromatography B Analytical Technologies Biomedical Life Sciences 777 1-2 (2002) 155-165
20. Oddo L.P., Heard T.A., Rodriguez-Malaver A., Perez R.A., Fernandez-Muino M., Sancho M.T., et al. Composition and antioxidant activity of Trigona carbonaria honey from Australia. Journal of Medicinal Food 11 4 (2008) 789-794
21. Official Journal of the European Communities. Council Directive 2001/110/EC of 20 December, 2001 relating to honey. Official Journal of the European Communities L 10 (2002) 58-66
22. Prevot M.A., and Gantois M.E. Methode rapide de dosage de l'acide erucique dans les graines de colza in Lipidforum seminar, Goteborg. Blood 4 (1975) 211-222
23. Ross J.A., and Kasum C.M. Dietary flavonoids: Bioavailability, metabolic effects and safety. Annual Review of Nutrition 22 (2002) 19-34
24. Rüdiger W. Ihr Name ist Apis-Kulturgeschichte der biene Ehrenwirth. München (1977) 92-94
25. Sanz M.L., del Castillo M.D., Corzo N., and Olano A. 2-Furoylmethyl amino acids and hydroxymethylfurfural as indicators of honey quality. Journal of Agricultural and Food Chemistry 51 (2003) 4278-4283
26. Schramm D.D., Karim M., Schrader H.R., Holt R.R., Cardetti M., and Keen C.L. Honey with high levels of antioxidants can provide protection to healthy human subjects. Journal of Agricultural and Food Chemistry 51 6 (2003) 1732-1735
27. Skiadas P.K., and Lascaratos J.G. Dietetics in ancient Greek philosophy: Plato's concepts of healthy diet. European Journal of Clinical Nutrition 55 7 (2001) 532-537
28. Swellam T., Miyanaga N., Onozawa M., Hattori K., Kawai K., Shimazui T., et al. Antineoplastic activity of honey in an experimental bladder cancer implantation model: In vivo and in vitro studies. International Journal of Urology 10 4 (2003) 213-219
29. Tonks A., Cooper R.A., Price A.J., Olan P.C., and Jones K.P. Stimulation of TNF-alpha release in monocytes by honey. Cytokine 14 4 (2001) 240-242
30. Von Low E.C., Perabo F.G., Siener R., and Muller S.C. Review. Facts and fiction of phytotherapy for prostate cancer: A critical assessment of preclinical and clinical data. In vivo 21 2 (2007) 189-204
31. Wiseman H. The bioavailability of non-nutrient plant factors: Dietary flavonoids and phyto-oestrogens. Proceedings of the Nutrition Society 58 1 (1999) 139-146
32. Woo K.J., Jeong Y.J., Park J.W., and Kwon T.K. Chrysin-induced apoptosis is mediated through caspase activation and Akt inactivation in U937 leukemia cells. Biochemical and Biophysical Research Communications 325 4 (2004) 1215-1222
33. Wrolstad, R. E., Acree, T. E., Decker, E. A., Penner, M. H., Reid, D. S., Schwartz, S. J., et al. (2005). Handbook of food analytical chemistry (Vol. 2, pp. 459-470). New Jersey: John Wiley and Sons.
34. Yao L., Jiang Y., D'Arcy B., Singanusong R., Datta N., Caffin N., et al. Quantitative high-performance liquid chromatography analyses of flavonoids in Australian Eucalyptus honeys. Journal of Agricultural and Food Chemistry 52 2 (2004) 210-214
35. Yech C.T., Huang S.M., and Yen G.C. Induction of phenolsulfotransferase expression by phenolic acids in human hepatoma HepG2 cells. Journal of Agricultural and Food Chemistry 53 12 (2005) 4766-4773
36. Yech C.T., and Yen G.C. Effect of vegetables on human phenolsulfotransferases in relation to their antioxidant activity and total phenolics. Free Radical Research 39 8 (2005) 893-904