Honey supplementation in spontaneously hypertensive rats elicits antihypertensive effect via amelioration of renal oxidative stress

Oxidative Medicine and Cellular Longevity

Volumn , Issue , 2012, Pages

  Erejuwa, Omotayo O ^a   Sulaiman, Siti A ^a   Ab Wahab, Mohd S ^a   Sirajudeen, Kuttulebbai N S ^a   Salleh, Salzihan ^a   Gurtu, Sunil ^b  

^a SCHOOL OF MEDICAL SCIENCES   (Malaysia)

^b MONASH UNIVERSITY MALAYSIA   (Malaysia)

Author keywords

[No Author keywords available]

Indexed keywords

2-GROUP; ANTIHYPERTENSIVE EFFECT; DISTILLED WATER; GLUTATHIONE-S-TRANSFERASE; MALONDIALDEHYDE; MRNA EXPRESSION LEVEL; NUCLEAR FACTORS; SPONTANEOUSLY HYPERTENSIVE RATS; SYSTOLIC BLOOD PRESSURE; TOTAL ANTIOXIDANT STATUS; WISTAR-KYOTO RATS;

ALDEHYDES; BLOOD PRESSURE; OXIDATIVE STRESS;

FOOD PRODUCTS;

ANTIHYPERTENSIVE AGENT; CATALASE; GLUTATHIONE DISULFIDE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE; MALONALDEHYDE; MESSENGER RNA; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR NRF2; TUALANG HONEY; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; CONTROLLED STUDY; DIET SUPPLEMENTATION; DOWN REGULATION; ENZYME ACTIVITY; ENZYME INDUCTION; ESSENTIAL HYPERTENSION; HONEY; LIPID PEROXIDATION; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PROTEIN EXPRESSION; RAT; SPONTANEOUSLY HYPERTENSIVE RAT; SYSTOLIC BLOOD PRESSURE; WEIGHT GAIN; WISTAR KYOTO RAT; ANIMAL; DIET THERAPY; DRUG EFFECT; HYPERTENSION; KIDNEY; MALE; METABOLISM; PATHOLOGY; PHYSIOLOGY;

RATTUS;

ANIMALS; ANTIHYPERTENSIVE AGENTS; DIETARY SUPPLEMENTS; HONEY; HYPERTENSION; KIDNEY; MALE; OXIDATIVE STRESS; RATS; RATS, INBRED SHR; RATS, INBRED WKY;

EID: 84858328733     PISSN: 19420900     EISSN: 19420994     Source Type: Journal    
DOI: 10.1155/2012/374037     Document Type: Article

References (79)

1. Poulter N., Ritchie, Global risk of cardiovascular disease Heart 2003 89 2 2 5
2. World Health Organization, The World Health Report 2002. Reducing Risks, Promoting Healthy Life 2002 Geneva, Switzerland WHO
3. Kearney P. M., Whelton M., Reynolds K., Muntner P., Whelton P. K., He J., Global burden of hypertension: analysis of worldwide data The Lancet 2005 365 9455 217 223 (Pubitemid 40138015)
4. Chobanian A. V., Bakris G. L., Black H. R., Cushman W. C., Green L. A., Izzo Jr. J. L., Jones D. W., Materson B. J., Oparil S., Wright Jr. J. T., Roccella E. J., Seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure Hypertension 2003 42 6 1206 1252 (Pubitemid 37553153)
5. Rodrigo R., Gonzlez J., Paoletto F., The role of oxidative stress in the pathophysiology of hypertension Hypertension Research 2011 34 4 431 440
6. Ostrow V., Wu S., Aguilar A., Bonner R., Suarez E., De Luca F., Association between oxidative stress and masked hypertension in a multi-ethnic population of obese children and adolescents Journal of Pediatrics 2010 158 628 633
7. Hirooka Y., Oxidative stress in the cardiovascular center has a pivotal role in the sympathetic activation in hypertension Hypertension Research 2011 34 4 407 412
8. Fanelli C., Zatz R., Linking oxidative stress, the renin-angiotensin system, and hypertension Hypertension 2011 57 3 373 374
9. Banday A. A., Lokhandwala M. F., Oxidative stress causes renal angiotensin II Type 1 receptor upregulation, Na+/H+ exchanger 3 overstimulation, and hypertension Hypertension 2011 57 3 452 459
10. Shull S., Heintz N. H., Periasamy M., Manohar M., Janssen Y. M. W., Marsh J. P., Mossman B. T., Differential regulation of antioxidant enzymes in response to oxidants The Journal of Biological Chemistry 1991 266 36 24398 24403 (Pubitemid 21908955)
11. Rhrdanz E., Kahl R., Alterations of antioxidant enzyme expression in response to hydrogen peroxide Free Radical Biology and Medicine 1998 24 1 27 38 (Pubitemid 28006433)
12. Erejuwa O. O., Sulaiman S. A., Wahab M. S. A., Sirajudeen K. N. S., Salleh M. S. M., Gurtu S., Differential responses to blood pressure and oxidative stress in streptozotocin-induced diabetic wistar-kyoto rats and spontaneously hypertensive rats: effects of antioxidant (Honey) treatment International Journal of Molecular Sciences 2011 12 3 1888 1907
13. Houston M. C., The role of cellular micronutrient analysis, nutraceuticals, vitamins, antioxidants and minerals in the prevention and treatment of hypertension and cardiovascular disease Therapeutic Advances in Cardiovascular Disease 2010 4 3 165 183
14. Kizhakekuttu T. J., Widlansky M. E., Natural antioxidants and hypertension: promise and challenges Cardiovascular Therapeutics 2010 28 4 e20 e32
15. Bogdanov S., Jurendic T., Sieber R., Gallmann P., Honey for nutrition and health: a review Journal of the American College of Nutrition 2008 27 6 677 689
16. Tan H. T., Rahman R. A., Gan S. H., Halim A. S., Hassan S. A., Sulaiman S. A., BS K. K., The antibacterial properties of Malaysian tualang honey against wound and enteric microorganisms in comparison to manuka honey BMC Complementary and Alternative Medicine 2009 9, article 34
17. Ghashm A. A., Othman N. H., Khattak M. N., Ismail N. M., Saini R., Antiproliferative effect of Tualang honey on oral squamous cell carcinoma and osteosarcoma cell lines BMC Complementary and Alternative Medicine 2010 10, article 49
18. Wang X. H., Andrae L., Engeseth N. J., Antimutagenic effect of various honeys and sugars against Trp-p-1 Journal of Agricultural and Food Chemistry 2002 50 23 6923 6928 (Pubitemid 35253194)
19. Al-Waili N. S., Saloom K. Y., Al-Waili T. N., Al-Waili A. N., Akmal M., Al-Waili F. S., Al-Waili H. N., Influence of various diet regimens on deterioration of hepatic function and hematological parameters following carbon tetrachloride: a potential protective role of natural honey Natural Product Research 2006 20 13 1258 1264 (Pubitemid 44824408)
20. Erejuwa O. O., Sulaiman S. A., Wahab M. S., Sirajudeen K. N. S., Salleh M. S. M. D., Gurtu S., Antioxidant protection of Malaysian tualang honey in pancreas of normal and streptozotocin-induced diabetic rats Annales d'Endocrinologie 2010 71 4 291 296
21. Erejuwa O. O., Gurtu S., Sulaiman S. A., Wahab M. S. A., Sirajudeen K. N. S., Salleh M. S. M., Hypoglycemic and antioxidant effects of honey supplementation in streptozotocin-induced diabetic rats International Journal for Vitamin and Nutrition Research 2010 80 1 74 82
22. Rodgers R. L., Depressor effect of diabetes in the spontaneously hypertensive rat: associated changes in heart performance Canadian Journal of Physiology and Pharmacology 1986 64 9 1177 1184 (Pubitemid 17201492)
23. Susic D., Mandal A. K., Jovovic D. J., Radujkovic G., Kentera D., Streptozotocin-induced diabetes mellitus lowers blood pressure in spontaneously hypertensive rat Clinical and Experimental HypertensionPart A 1990 12 6 1021 1035 (Pubitemid 20281370)
24. Davidoff A. J., Pinault F. M., Rodgers R. L., Ventricular relaxation of diabetic spontaneously hypertensive rat Hypertension 1990 15 6 643 651 (Pubitemid 20187610)
25. Touyz R. M., Schiffrin E. L., Reactive oxygen species in vascular biology: implications in hypertension Histochemistry and Cell Biology 2004 122 4 339 352 (Pubitemid 39506592)
26. Xu J. Z., Zhang Y., Wu S. N., Niu W. Q., Zhu D. L., Gao P. J., Impaired endothelial function in hypertensive patients with target organ damage Journal of Human Hypertension 2009 23 11 751 757
27. Tsioufis C., Kordalis A., Flessas D., Pathophysiology of resistant hypertension: the role of sympathetic nervous system International Journal of Hypertension 2011 2011 7
28. Kobori H., Nangaku M., Navar L. G., Nishiyama A., The intrarenal renin-angiotensin system: from physiology to the pathobiology of hypertension and kidney disease Pharmacological Reviews 2007 59 3 251 287 (Pubitemid 47481436)
29. Delano F. A., Schmid-Schnbein G. W., Proteinase activity and receptor cleavage: mechanism for insulin resistance in the spontaneously hypertensive rat Hypertension 2008 52 2 415 423
30. Sowers J. R., Insulin resistance and hypertension American Journal of Physiology 2004 286 5 H1597 H1602 (Pubitemid 38525443)
31. Fridovich I., Superoxide anion radical (O2/- ), superoxide dismutases, and related matters The Journal of Biological Chemistry 1997 272 30 18515 18517 (Pubitemid 27318184)
32. Haber F., Weiss J., The catalytic decomposition of hydrogen peroxide by iron salts Proceedings of the Royal Society 1934 147 332 351
33. Tiedge M., Lortz S., Munday R., Lenzen S., Protection against the co-operative toxicity of nitric oxide and oxygen free radicals by overexpression of antioxidant enzymes in bioengineered insulin-producing RINm5F cells Diabetologia 1999 42 7 849 855 (Pubitemid 29325076)
34. Crawford D. R., Davies K. J. A., Adaptive response and oxidative stress Environmental Health Perspectives 1994 102 10 25 28
35. Gaetani G. F., Galiano S., Canepa L., Ferraris A. M., Kirkman H. N., Catalase and glutathione peroxidase are equally active in detoxification of hydrogen peroxide in human erythrocytes Blood 1989 73 1 334 339 (Pubitemid 19040998)
36. Spolarics Z., Wu J. X. I., Role of glutathione and catalase in H2O2 detoxification in LPS- activated hepatic endothelial and Kupffer cells American Journal of Physiology 1997 273 6 G1304 G1311
37. Cao P., Ito O., Guo Q., Ito D., Muroya Y., Rong R., Mori T., Ito S., Kohzuki M., Endogenous hydrogen peroxide up-regulates the expression of nitric oxide synthase in the kidney of SHR Journal of Hypertension 2011 29 6 1167 1174
38. Bhanja S., Chainy G. B. N., PTU-induced hypothyroidism modulates antioxidant defence status in the developing cerebellum International Journal of Developmental Neuroscience 2010 28 3 251 262
39. Esterbauer H., Schaur R. J., Zollner H., Chemistry and Biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes Free Radical Biology and Medicine 1991 11 1 81 128 (Pubitemid 121003917)
40. Phillis J. W., A radical view of cerebral ischemic injury Progress in Neurobiology 1994 42 4 441 448
41. Hou X., Shen Y. H., Li C., Wang F., Zhang C., Bu P., Zhang Y., PPAR agonist fenofibrate protects the kidney from hypertensive injury in spontaneously hypertensive rats via inhibition of oxidative stress and MAPK activity Biochemical and Biophysical Research Communications 2010 394 3 653 659
42. Redn J., Oliva M. R., Tormos C., Giner V., Chaves J., Iradi A., Sez G. T., Antioxidant activities and oxidative stress byproducts in human hypertension Hypertension 2003 41 5 1096 1101 (Pubitemid 36548609)
43. Sharma R., Yang Y., Sharma A., Awasthi S., Awasthi Y. C., Antioxidant role of glutathione S-transferases: protection against oxidant toxicity and regulation of stress-mediated apoptosis Antioxidants and Redox Signaling 2004 6 2 289 300 (Pubitemid 38332586)
44. Hayes J. D., Strange R. C., Potential contribution of the glutathione S-transferase supergene family to resistance to oxidative stress Free Radical Research 1995 22 3 193 207
45. Mannervik B., The isoenzymes of glutathione transferase Advances in Enzymology and Related Areas of Molecular Biology 1985 57 357 417
46. Derbel M., Igarashi T., Satoh T., Differential induction of glutathione S-transferase subunits by phenobarbital, 3-methylcholanthrene and ethoxyquin in rat liver and kidney Biochimica et Biophysica Acta 1993 1158 2 175 180 (Pubitemid 23291459)
47. Pinkus R., Weiner L. M., Daniel V., Role of oxidants and antioxidants in the induction of AP-1, NF- B, and glutathione S-transferase gene expression The Journal of Biological Chemistry 1996 271 23 13422 13429 (Pubitemid 26185383)
48. Huang J., Tan P. H., Tan B. K., Bay B. H., GST-pi expression correlates with oxidative stress and apoptosis in breast cancer Oncology Reports 2004 12 4 921 925
49. Koo J. R., Liang K. H., Vaziri N. D., Microarray analysis of altered gene expression in kidneys of adult spontaneously hypertensive rats Journal of Applied Research 2004 4 1 111 126 (Pubitemid 39406826)
50. Kim H. J., Vaziri N. D., Contribution of impaired Nrf2-Keap1 pathway to oxidative stress and inflammation in chronic renal failure American Journal of Physiology 2010 298 3 F662 F671
51. Motohashi H., Yamamoto M., Nrf2-Keap1 defines a physiologically important stress response mechanism Trends in Molecular Medicine 2004 10 11 549 557 (Pubitemid 39433824)
52. Kobayashi M., Li L., Iwamoto N., Nakajima-Takagi Y., Kaneko H., Nakayama Y., Eguchi M., Wada Y., Kumagai Y., Yamamoto M., The antioxidant defense system Keap1-Nrf2 comprises a multiple sensing mechanism for responding to a wide range of chemical compounds Molecular and Cellular Biology 2009 29 2 493 502
53. Chanas S. A., Jiang Q., McMahon M., McWalter G. K., McLellan L. I., Elcombe C. R., Henderson C. J., Wolf C. R., Moffat G. J., Itoh K., Yamamoto M., Hayes J. D., Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice Biochemical Journal 2002 365 2 405 416 (Pubitemid 36135312)
54. Reisman S. A., Yeager R. L., Yamamoto M., Klaassen C. D., Increased Nrf2 activation in livers from keap1-knockdown mice Increases expression of cytoprotective genes that detoxify electrophiles more than those that detoxify reactive oxygen species Toxicological Sciences 2009 108 1 35 47
55. Ning J. L., Mo L. W., Lai X. N., Low-and high-dose hydrogen peroxide regulation of transcription factor NF-E2-related factor 2 Chinese Medical Journal 2010 123 8 1063 1069
56. Rojo A. I., Rada P., Egea J., Rosa A. O., Lpez M. G., Cuadrado A., Functional interference between glycogen synthase kinase-3 beta and the transcription factor Nrf2 in protection against kainate-induced hippocampal celldeath Molecular and Cellular Neuroscience 2008 39 1 125 132
57. Erejuwa O. O., Sulaiman S. A., ab Wahab M. S., Salam S. K.N., md Salleh M. S., Gurtu S. G., Comparison of antioxidant effects of honey, glibenclamide, metformin, and their combinations in the kidneys of streptozotocin-induced diabetic rats International Journal of Molecular Sciences 2011 12 1 829 843
58. Binda D., Nicod L., Viollon-Abadie C., Rodriguez S., Berthalot A., Coassolo P., Richert L., Strain difference (WKY, SPRD) in the hepatic antioxidant status in rat and effect of hypertension (SHR, DOCA). Ex vivo and in vitro data Molecular and Cellular Biochemistry 2001 218 1-2 139 146 (Pubitemid 32294144)
59. Kregel K. C., Zhang H. J., An integrated view of oxidative stress in aging: basic mechanisms, functional effects, and pathological considerations American Journal of Physiology 2007 292 1 R18 R36 (Pubitemid 46091599)
60. Gomes P., Simo S., Silva E., Pinto V., Amaral J. S., Afonso J., Serro M. P., Pinho M. J., Soares-Da-Silva P., Aging increases oxidative stress and renal expression of oxidant and antioxidant enzymes that are associated with an increased trend in systolic blood pressure Oxidative Medicine and Cellular Longevity 2009 2 3 138 145
61. Ghosh B., Hanevold C. D., Dobashi K., Orak J. K., Singh I., Tissue differences in antioxidant enzyme gene expression in response to endotoxin Free Radical Biology and Medicine 1996 21 4 533 540 (Pubitemid 26313951)
62. Gygi S. P., Rochon Y., Franza B. R., Aebersold R., Correlation between protein and mRNA abundance in yeast Molecular and Cellular Biology 1999 19 3 1720 1730 (Pubitemid 29098230)
63. Griffin T. J., Gygi S. P., Ideker T., Rist B., Eng J., Hood L., Aebersold R., Complementary profiling of gene expression at the transcriptome and proteome levels in Saccharomyces cerevisiae Molecular Cellular Proteomics 2002 1 4 323 333
64. Garca-Lpez D., Hkkinen K., Cuevas M. J., Lima E., Kauhanen A., Mattila M., Sillanp E., Ahtiainen J. P., Karavirta L., Almar M., Gonzlez-Gallego J., Effects of strength and endurance training on antioxidant enzyme gene expression and activity in middle-aged men Scandinavian Journal of Medicine and Science in Sports 2007 17 5 595 604
65. Arciello M., Capo C. R., D'Annibale S., Cozzolino M., Ferri A., Carr M. T., Rossi L., Copper depletion increases the mitochondrial-associated SOD1 in neuronal cells BioMetals 2010 24 2 269 278
66. Tsan M. F., White J. E., Treanor C., Shaffer J. B., Molecular basis for tumor necrosis factor-induced increase in pulmonary superoxide dismutase activities American Journal of Physiology 1990 259 6 L506 L512
67. Clerch L. B., Massaro D., Tolerance of rats to hyperoxia. Lung antioxidant enzyme gene expression The Journal of Clinical Investigation 1993 91 2 499 508 (Pubitemid 23064134)
68. Ohkawa H., Ohishi N., Yagi K., Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction Analytical Biochemistry 1979 95 2 351 358 (Pubitemid 9194347)
69. Koracevic D., Koracevic G., Djordjevic V., Andrejevic S., Cosic V., Method for the measurement of antioxidant activity in human fluids Journal of Clinical Pathology 2001 54 5 356 361 (Pubitemid 32458132)
70. Goth L., A simple method for determination of serum catalase activity and revision of reference range Clinica Chimica Acta 1991 196 2-3 143 151
71. Goldberg D. M., Spooner R. J., Bergmeyen H. V., Assay of glutathione reductase Methods of Enzymatic Analysis 1983 Weinheim, Germany Chemie 258 265
72. Habig W. H., Pabst M. J., Jakoby W. B., Glutathione S transferases. The first enzymatic step in mercapturic acid formation The Journal of Biological Chemistry 1974 249 22 7130 7139
73. Bradford M. M., A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein dye binding Analytical Biochemistry 1976 72 1-2 248 254
74. Chattopadhyay S., Sahoo D. K., Subudhi U., Chainy G. B. N., Differential expression profiles of antioxidant enzymes and glutathione redox status in hyperthyroid rats: a temporal analysis Comparative Biochemistry and PhysiologyC 2007 146 3 383 391 (Pubitemid 47127012)
75. Zangen S. W., Ryu S., Ornoy A., Alterations in the expression of antioxidant genes and the levels of transcription factor NF-Kappa B in relation to diabetic embryopathy in the cohen diabetic rat model Birth Defects Research Part AClinical and Molecular Teratology 2006 76 2 107 114 (Pubitemid 43375824)
76. Li G., Xie P., Li H., Hao L., Xiong Q., Qiu T., Liu Y., Acute effects of microcystins on the transcription of 14 glutathione S-transferase isoforms in Wistar rat Environmental Toxicology 2011 26 2 187 194
77. Bauer B., Hartz A. M. S., Lucking J. R., Yang X., Pollack G. M., Miller D. S., Coordinated nuclear receptor regulation of the efflux transporter, Mrp2, and the phase-II metabolizing enzyme, GST, at the blood-brain barrier Journal of Cerebral Blood Flow and Metabolism 2008 28 6 1222 1234 (Pubitemid 351733346)
78. Li H. Y., Wu S. Y., Shi N., Transcription factor Nrf2 activation by deltamethrin in PC12 cells: involvement of ROS Toxicology Letters 2007 171 1-2 87 98 (Pubitemid 46994730)
79. Livak K. J., Schmittgen T. D., Analysis of relative gene expression data using real-time quantitative PCR and the 2-CT method Methods 2001 25 4 402 408 (Pubitemid 34164012)