Indigenous New Zealand honeys exhibit multiple anti-inflammatory activities

Innate Immunity

Volumn 18, Issue 3, 2012, Pages 459-466

  Leong, Aidan G ^a   Herst, Patries M ^a,b   Harper, Jacquie L ^a  

^a MALAGHAN INSTITUTE OF MEDICAL RESEARCH   (New Zealand)

^b UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

Acute inflammation; anti inflammatory activity; New Zealand honeys; radical scavenging; respiratory burst

Indexed keywords

PHENOL; SCAVENGER; SUPEROXIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; HONEY; HUMAN; HUMAN CELL; IN VITRO STUDY; MALE; MOUSE; NEUTROPHIL; NEUTROPHIL CHEMOTAXIS; NEW ZEALAND; NONHUMAN; NORMAL HUMAN;

ADMINISTRATION, TOPICAL; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ARACHIDONIC ACID; CELL MOVEMENT; CELLS, CULTURED; EDEMA; HONEY; HUMANS; MALE; MICE; MICE, INBRED C57BL; MONOCYTES; NEUTROPHIL ACTIVATION; NEUTROPHILS; NEW ZEALAND; SUPEROXIDES;

MUS;

EID: 84861558613     PISSN: 17534259     EISSN: 17534267     Source Type: Journal    
DOI: 10.1177/1753425911422263     Document Type: Article

References (34)

1. Zumla A, Lulat A. Honey-a remedy rediscovered. J R Soc Med. 1989 ; 82: 384-385
2. Al Somal N, Coley KE, Molan PC, Hancock BM. Susceptibility of Helicobacter pylori to the antibacterial activity of manuka honey. J R Soc Med. 1994 ; 87: 9-12
3. Cooper R, Molan P. The use of honey as an antiseptic in managing Pseudomonas infection. J Wound Care. 1999 ; 8: 161-164
4. Cooper RA, Molan PC, Harding KG. Antibacterial activity of honey against strains of Staphylococcus aureus from infected wounds. J R Soc Med. 1999 ; 92: 283-285
5. White J, Subers M, Scherpartz A. The identification of inhibine, the antibacterial factor in honey, as hydrogen peroxide and its origin in a honey glucose-oxidase system. Biochim Biophys Acta. 1963 ; 73: 57-70
6. Thornalley PJ. Pharmacology of methylglyoxal: formation, modification of proteins and nucleic acids, and enzymatic detoxification-a role in pathogenesis and antiproliferative chemotherapy. Gen Pharmacol. 1996 ;:
7. Cooper RA, Molan PC, Harding KG. The sensitivity to honey of Gram-positive cocci of clinical significance isolated from wounds. J Appl Microbiol. 2002 ; 93: 857-863
8. Majtan J, Majtan V. Is manuka honey the best type of honey for wound care?. J Hosp Infect. 2010 ; 74: 305-306
9. Molan PC. The evidence supporting the use of honey as a wound dressing. Int J Low Extrem Wounds. 2006 ; 5: 40-54
10. Simon A, Traynor K, Santos K, Blaser G, Bode U, Molan P. Medical honey for wound care-still the 'latest resort'?. Evid Based Complement Alternat Med. 2009 ; 6: 165-173
11. Youngberg DM. Honey-based dressings and wound care. JWound Ostomy Continence Nurs. 2009 ; 36: 588-589
12. Chambers J. Topical manuka honey for MRSA-contaminated skin ulcers. Palliat Med. 2006 ; 20: 557-557
13. Mavric E, Wittmann S, Barth G, Henle T. Identification and quantification of methylglyoxal as the dominant antibacterial constituent of Manuka (Leptospermum scoparium) honeys from New Zealand. Mol Nutr Food Res. 2008 ; 52: 483-489
14. Adams CJ, Boult CH, Deadman BJ, Farr JM, Grainger MNC, Manley-Harris M, et al. Isolation by HPLC and characterisation of the bioactive fraction of New Zealand manuka (Leptospermum scoparium) honey. Carbohyd Res. 2008 ; 343: 651-659
15. Tonks AJ, Cooper RA, Jones KP, Blair S, Parton J, Tonks A. Honey stimulates inflammatory cytokine production from monocytes. Cytokine. 2003 ; 21: 242-247
16. van den Berg AJJ, van den Worm E, van Ufford HCQ, Halkes SBA, Hoekstra MJ, Beukelman CJ. An in vitro examination of the antioxidant and anti-inflammatory properties of buckwheat honey. J Wound Care. 2008 ; 17: 172-174
17. Mesaik MA, Azim MK, Mohiuddin S. Honey modulates oxidative burst of professional phagocytes. Phytother Res. 2008 ; 22: 1404-1408
18. Cuzzocrea S, Riley DP, Caputi AP, Salvemini D. Antioxidant therapy: a new pharmacological approach in shock, inflammation, and ischemia/reperfusion injury. Pharmacol Rev. 2001 ; 53: 135-159
19. Henriques A, Jackson S, Cooper R, Burton N. Free radical production and quenching in honeys with wound healing potential. J Antimicrob Chemother. 2006 ; 58: 773-777
20. Inoue K, Muramaya S, Seshimo F, Takeba K, Yoshimura Y, Nakazawa H. Identification of phenolic compound in manuka honey as specific superoxide anion radical scavenger using electron spin resonance (ESR) and liquid chromatography with coulometric array detection. J Sci Food Agric. 2005 ; 85: 872-878
21. Medhi B, Prakash A, Avti PK, Saikia UN, Pandhi P, Khanduja KL. Effect of Manuka honey and sulfasalazine in combination to promote antioxidant defense system in experimentally induced ulcerative colitis model in rats. Indian J Exp Biol. 2008 ; 46: 583-590
22. Prakash A, Medhi B, Avti PK, Saikia UN, Pandhi P, Khanduja KL. Effect of different doses of Manuka honey in experimentally induced inflammatory bowel disease in rats. Phytother Res. 2008 ; 22: 1511-1519
23. Nasuti C, Gabbianelli R, Falcioni G, Cantalamessa F. Antioxidative and gastroprotective activities of anti-inflammatory formulations derived from chestnut honey in rats. Nutr Res. 2006 ; 26: 130-137
24. Biswal BM, Zakaria A, Ahmad NM. Topical application of honey in the management of radiation mucositis: a preliminary study. Support Care Cancer. 2003 ; 11: 242-248
25. Khanal B, Baliga M, Uppal N. Effect of topical honey on limitation of radiation-induced oral mucositis: an intervention study. Int J Oral Maxillofac Surg. 2010 ; 39: 1181-1185
26. Motallebnejad M, Akram S, Moghadamnia A, Moulana Z, Omidi S. The effect of topical application of pure honey on radiation-induced mucositis: a randomized clinical trial. J Contemp Dent Pract. 2008 ; 9: 40-47
27. Khanal B, Baliga M, Uppal N. Effect of topical honey on limitation of radiation-induced oral mucositis: an intervention study. Int J Oral Maxillofac Surg. 2010 ; 39: 1181-1185
28. Stephens JM, Schlothauer RC, Morris BD, Yang D, Fearnley L, Greenwood DR, et al. Phenolic compounds and methylglyoxal in some New Zealand manuka and kanuka honeys. Food Chem. 2010 ; 120: 78-86
29. Tan AS, Berridge MV. Superoxide produced by activated neutrophils efficiently reduces the tetrazolium salt, WST-1 to produce a soluble formazan: a simple colorimetric assay for measuring respiratory burst activation and for screening anti-inflammatory agents. J Immunol Methods. 2000 ; 238: 59-68
30. McCord JM, Fridovich I. The reduction of cytochrome c by milk xanthine oxidase. J Biol Chem. 1968 ; 243: 5753-5760
31. Daley JM, Thomay AA, Connolly MD, Reichner JS, Albina JE. Use of Ly6G-specific monoclonal antibody to deplete neutrophils in mice. J Leukoc Biol. 2008 ; 83: 64-70
32. Vermes I, Haanen C, Steffens-Nakken H, Reutelingsperger C. A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V. J Immunol Methods. 1995 ; 184: 39-51
33. Young JM, Spires DA, Bedord CJ, Wagner B, Ballaron SJ, De Young LM. The mouse ear inflammatory response to topical arachidonic acid. J Invest Dermatol. 1984 ; 82: 367-371
34. Wilkins A, Lu Y. Extractives from New Zealand Honeys. 5. Aliphatic Dicarboxylic Acids in New Zealand Rewarewa (Knightea excelsa) Honey. J Agric Food Chem. 1995 ; 43: 3021-3025