Marine collagen as a source of bioactive molecules: A review

Natural Products Journal

Volumn 3, Issue 2, 2013, Pages 105-114

  Alemán, Ailén ^a   Martínez Alvarez, Oscar ^a  

^a INSTITUTE OF FOOD SCIENCE   (Spain)

Author keywords

Bioactive peptides; By products; Collagen; Fish; Gelatin; Hydrolysates; Nutraceuticals

Indexed keywords

COLLAGEN; GELATIN; OPIATE;

ANTIHYPERTENSIVE ACTIVITY; ANTIMICROBIAL ACTIVITY; ANTIOXIDANT ACTIVITY; ARTHROPATHY; BACTERIAL STRAIN; BIOLOGICAL ACTIVITY; BONE DISEASE; CARTILAGE; DIGESTION; HYDROLYSIS; MARINE SPECIES; NONHUMAN; OSSIFICATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; REVIEW; SATIETY;

EID: 84893325258     PISSN: 22103155     EISSN: 22103163     Source Type: Journal    
DOI: 10.2174/2210315511303020005     Document Type: Review

References (129)

1. Arnesen, J.A.; Gildberg, A. Extraction and characterisation of gelatin from Atlantic salmon (Salmo salar) skin. Bioresource Technol., 2007, 98, 53-57.
2. Najafian, L.; Babji, A.S. A review of fish-derived antioxidant and antimicrobial peptides: Their production, assessment, and applications. Peptides, 2012, 33, 178-185.
3. Kołodziejska, I.; Skierka, E.; Sadowska, M.; Kołodziejski, W.; Niecikowska, C. Effect of extracting time and temperature on yield of gelatin from different fish offal. Food Chem., 2008, 107, 700-706.
4. Kawaguchi, T.; Nanbu, P.N.; Kurokawa, M. Distribution of prolylhydroxyproline and its metabolites after oral administration in rats. Biol. Pharm. Bull., 2012, 35, 422-427.
5. Moskowitz, R.W. Role of collagen hydrolysate in bone and joint disease. Semin. Arthritis Rheu., 2000, 30, 87-99.
6. Di Bernardini, R.; Harnedy, P.; Bolton, D.; Kerry, J.; O’Neill, E.; Mullen, A.M.; Hayes, M. Antioxidant and antimicrobial peptidic hydrolysates from muscle protein sources and by-products. Food Chem., 2011, 124, 1296-1307.
7. Temple, N.J. Antioxidant and disease: More questions than answers. Nutr. Res., 2000, 20, 449-459.
8. Butterfield, D.A.; Castegna, A.; Pocernich, C.B.; Drake, J.; Scapagnini, G.; Calabrese, V. Nutritional approaches to combat oxidative stress in Alzheimer's disease. J. Nutr. Biochem., 2002, 13, 444-461.
9. Lee, J.; Koo, N.; Min, D.B. Reactive oxygen species, aging, and antioxidative nutraceuticals. Compr. Rev. Food Sci. F., 2004, 3, 21-33.
10. Correa, P.; Fontham, E.; Bravo, L.E.; Mera, R. Antioxidant supplements for prevention of gastrointestinal cancers. Lancet, 2005, 3, 365-470.
11. Hettiarachchy, N.S.; Glenn, K.C.; Gnanasambandan, R.; Johnson, M.G. Natural antioxidant extract from fenugreek (Trigonella foenumgraecum) for ground beef patties. J. Food Sci., 1996, 61, 516-519.
12. Park, P.J.; Jung, W.K.; Nam, K.S.; Shahidi, F.; Kim, S.K. Purification and characterization of antioxidative peptides from protein hydrolysate of lecithin-free egg yolk. J. Am. Oil Chem. Soc., 2001, 78, 651-656.
13. Byun, H.G.; Kim, S.K. Purification and characterization of angiotensin I converting enzyme (ACE) inhibitory peptides from Alaska Pollack (Theragra chalcogramma) skin. Process Biochem., 2001, 36, 1155-1162.
14. Kim, S.K.; Kim, Y.T.; Byun, H.G.; Park, P.J.; Ito, H. Purification and characterization of antioxidative peptides from bovine skin. J. Biochem. Mol. Biol., 2001, 34, 214-219.
15. Mendis, E.; Rajapakse, N.; Kim, S.K. Antioxidant properties of a radical-scavenging peptide purified from enzymatically prepared fish skin gelatin hydrolysate. J. Agric. Food Chem., 2005, 53, 581-587.
16. Kim, S.K; Kim, Y.T; Byun, H.G; Nam, K.S; Joo, D.S; Shahidi, F. Isolation and characterization of antioxidative peptides from gelatin hydrolysate of Alaska. J. Agric. Food Chem., 2001, 49, 1984-1989.
17. Yang, J.I.; Ho, H.Y.; Chu, Y.J.; Chow, C.J. Characteristic and antioxidant activity of retorted gelatin hydrolysates from cobia (Rachycentron canadum) skin. Food Chem., 2008, 110, 128-136.
18. Chow, C.J.; Yang, J.I. The effect of process variables for production of cobia (Rachycentron canadum) skin gelatin hydrolysates with antioxidant properties. J. Food Biochem., 2011, 35, 715-734.
19. Khantaphant, S.; Benjakul, S. Comparative study on the proteases from fish pyloric caeca and the use for production of gelatin hydrolysate with antioxidative activity. Comp. Biochem. Physiol., 2008, 151, 410-419.
20. Je, J.; Qian, Z.; Byun, H.; Kim, S. Purification and characterization of an antioxidant peptide obtained from tuna backbone protein by enzymatic hydrolysis. Process Biochem., 2007, 42, 840-846.
21. Giménez, B.; Alemán, A.; Montero, P.; Gómez-Guillén, M.C. Antioxidant and functional properties of gelatin hydrolysates obtained from skin of sole and squid. Food Chem., 2009, 114, 976-983.
22. Zhuang, Y.L.; Sun, L.P.; Zhao, X.; Hou, H.; Li, B.F. Investigation of gelatin polypeptides of jellyfish (Rhopilema esculentum) for their antioxidant activity in vitro. Food Technol. Biotechnol., 2010, 48, 222-228.
23. Himaya, S.W.A.; Ngo, D.H.; Ryu, B.; Kim, S.K. An active peptide purified from gastrointestinal enzyme hydrolysate of Pacific cod skin gelatin attenuates angiotensin-1 converting enzyme (ACE) activity and cellular oxidative stress. Food Chem., 2012, 132, 1872-1882.
24. Ngo, D.H.; Ryu, B.; Vo, T.S.; Himaya, S.W.A.; Wijesekara, I.; Kim, S.K. Free radical scavenging and angiotensin-I converting enzyme inhibitory peptides from Pacific cod (Gadus macrocephalus) skin gelatin. Int. J. Biol. Macromol., 2011, 49, 1110-1116.
25. Alemán, A.; Giménez, B.; Pérez-Santín, E.; Gómez-Guillén, M.C.; Montero, P. Contribution of Leu and Hyp residues to antioxidant and ACE-inhibitory activities of peptides sequences isolated from squid gelatin hydrolysate. Food Chem., 2011, 125, 334-341.
26. Lin, L.; Li, B. Radical scavenging properties of protein hydrolysates from Jumbo flying squid (Dosidicus eschrichitii Steenstrup) skin gelatin. J. Sci. Food Agric., 2006, 86, 2290-2295.
27. Mendis, E.; Rajapakse, N.; Byun, H.G.; Kim, S.K. Investigation of jumbo squid (Dosidicus gigas) skin gelatin peptides for their in vitro antioxidant effects. Life Sci., 2005, 77, 2166-2178.
28. Erdmann, K.; Cheung, B.W.; Schroder, H. The possible roles of food-derived bioactive peptides in reducing the risk of cardiovascular disease. J. Nutr. Biochem., 2008, 19, 643-654.
29. Sarmadi, B.H.; Ismail, A. Antioxidative peptides from food proteins: A review. Peptides, 2010, 31, 1949-1956.
30. Suetsuna, K.; Ukeda, H.; Ochi, H. Isolation and characterization of free radical scavenging activities peptides derived from casein. J. Nutr. Biochem., 2000, 11, 128-131.
31. Dávalos, A.; Miguel, M.; Bartolomé, B.; López-Fandiño, R. Antioxidant activity of peptides derived from egg white proteins by enzymatic hydrolysis. J. Food Protect., 2004, 67, 1939-1944.
32. Qian, Z.; Jung, W.; Kim, S. Free radical scavenging activity of a novel antioxidative peptide purified from hydrolysate of bullfrog skin, Rana catesbeina Shaw. Bioresource Technol., 2008, 99, 1690-1698.
33. Hernández-Ledesma, B.; Dávalos, A.; Bartolomé, B.; Amigo, L. Preparation of antioxidant enzymatic hydrolysates from α-lactalbumin and β-lactoglobulin. Identification of active peptides by HPLC-MS/MS. J. Agric. Food Chem., 2005, 53, 588-593.
34. Chen, H.M.; Muramoto, K.; Yamauchi, F. Structural analysis of antioxidative peptides from soybean β-conglycinin. J. Agric. Food Chem., 1995, 43, 574-578.
35. Ranathunga, S.; Rajapakse, N.; Kim, S.K., Purification and characterization of antioxidative peptide derived from muscle of conger eel (Conger myriaster). Eur. Food Res. Technol., 2006, 222, 310-315.
36. Alemán, A.; Giménez, B.; Montero, P.; Gómez-Guillén, M.C. Antioxidant activity of several marine skin gelatins. Lebensm.-Wiss Technol., 2011, 44, 407-413.
37. Gómez-Guillén, M.C.; López-Caballero, M.E.; López de Lacey, A.; Alemán, A.; Giménez, B.; Montero, P. In: Sea by-products as a real material: New ways of application; Le Bihan, E., Ed.; Transworld Research Network Signpost: Kerala (India), 2010; Chapter 7, pp. 89-115.
38. Kearney, P.M.; Whelton, M.; Reynolds, K.; Muntner, P.; Whelton, P.K.; He, J. Global burden of hypertension. Lancet, 2005, 365, 217-223.
39. Murray, B.A.; FitzGerald, R.J. Angiotensin converting enzyme inhibitory peptides derived from food proteins: Biochemistry, bioactivity and production. Curr. Pharm. Des., 2007, 13, 773-791.
40. De Leo, F.; Panarese, S.; Gallerani, R.; Ceci, L.R. Angiotensin converting enzyme (ACE) inhibitory peptides: Production and implementation of functional food. Curr. Pharm. Des., 2009, 15, 3622-3643.
41. Wijesekara, I.; Kim, S.-K. Angiotensin-I-Converting Enzyme (ACE) Inhibitors from marine resources: Prospects in the pharmaceutical industry. Mar. Drugs, 2010, 8, 1080-1093.
42. Nagai, T.; Nagashima, T.; Abe, A.; Suzuki, N. Antioxidative activities and angiotensin I-converting enzyme inhibition of extracts prepared from chum salmon (Oncorhynchus keta) cartilage and skin. Int. J. Food Prop., 2006, 9, 813-822.
43. Park, C.H.; Kim, H.J.; Kang, K.T.; Park, J.W.; Kim, J.S. Fractionation and angiotensin I-converting enzyme (ACE) inhibitory activity of gelatin hydrolysates from by-products of Alaska Pollack surimi. J. Fish Aquat. Sci., 2009, 12, 79-85.
44. Fahmi, A.; Morimura, S.; Guo, H. C.; Shigematsu, T.; Kida, K.; Uemura, Y. Production of angiotensin I converting enzyme inhibitory peptides from sea bream scales. Process Biochem., 2004, 39, 1195-1200.
45. Zhao, Y.; Li, B.; Liu, Z.; Dong, S.; Zhao, X.; Zeng, M. Antihypertensive effect and purification of an ACE inhibitory peptide from sea cucumber gelatin hydrolysate. Process Biochem., 2007, 42, 1586-1591.
46. Alemán, A.; Pérez-Santín, E.; Bordenave-Juchereau, S.; Arnaudin, I.; Gómez-Guillén, M. C.; Montero, P. Squid gelatin hydrolysates with antihypertensive, anticancer and antioxidant activity. Food Res. Int., 2011, 44, 1044-1051.
47. Lin, L.; Lv, S.; Li, B. Angiotensin-I-converting enzyme (ACE)-inhibitory and antihypertensive properties of squid skin gelatin hydrolysates. Food Chem., 2012, 131, 225-230
48. Kim, S.K.; Mendis, E. Bioactive compounds from marine processing byproducts-A review. Food Res. Int., 2006, 39, 383-393.
49. Gómez-Guillén, M.C.; Giménez, B.; López-Caballero, M.E.; Montero, M.P. Functional and bioactive properties of collagen and gelatin from alternative sources: A review. Food Hydrocol., 2011, 25, 1813-1827.
50. Balti, R.; Nedjar-Arroume, N.; Bougatef, A.; Guillochon, D.; Nasri, M. Three novel angiotensin I-converting enzyme (ACE) inhibitory peptides from cuttlefish (Sepia officinalis) using digestive proteases. Food Res. Int., 2010, 43, 1136-1143.
51. Balti, R.; Nedjar-Arroume, N.; Adjé, E.Y.; Guillochon, D.; Nasri, M., Analysis of novel angiotensin I-converting enzyme inhibitory peptides from enzymatic hydrolysates of cuttlefish (Sepia officinalis) muscle proteins. J. Agric. Food Chem., 2010, 58, 3840-3846.
52. FitzGerald, R.J.; Meisel, H. Milk protein-derived peptide inhibitors of angiotensin-I-converting enzyme. Brit. J. Nutr., 2000, 84, 33-37.
53. Contreras, M.; Carrón, R.; Montero, M.J.; Ramos, M.; Recio, I. Novel casein-derived peptides with antihypertensive activity. Int. Dairy J., 2009, 19, 566-573.
54. Vermeirssen, V.; Van Camp, J.; Verstraete, W., Bioavailability of angiotensin I converting enzyme inhibitory peptides. Brit. J. Nutr., 2004, 92, 357-366.
55. Meisel, H.; FitzGerald, R.J. Biofunctional peptides from milk proteins: Mineral binding and cytomodulatory effects. Curr. Pharm. Des., 2003, 9, 1289-1295.
56. Ichimura, T.; Yamanaka, A.; Otsuka, T.; Yamashita, E.; Maruyama, S. Antihypertensive effect of enzymatic hydrolysate of collagen and Gly-Pro in spontaneously hypertensive rats. Biosci. Biotech. Bioch., 2009, 73, 2317-2319.
57. Saiga, A.I.; Iwai, K.; Hayakawa, T.; Takahata, Y.; Kitamura, S.; Nishimura, T.; Morimatsu, F. Angiotensin I-Converting Enzyme-Inhibitory Peptides Obtained from Chicken Collagen Hydrolysate. J. Agric. Food Chem., 2008, 56, 9586-9591.
58. Wang, L.; An, X.X.; Yang, F.M.; Xin, Z.H.; Zhao, L.Y.; Hu, Q.H. Isolation and characterisation of collagens from the skin, scale and bone of deep-sea redfish (Sebastes mentella). Food Chem., 2008, 108, 616-623.
59. Zhuang, Y.; Sun, L.; Zhang, Y.; Liu, G. Antihypertensive effect of long-term oral administration of jellyfish (Rhopilema esculentum) collagen peptides on renovascular hypertension. Mar. Drugs, 2012, 10, 417-426.
60. Hou, W.C.; Chen, H.J.; Lin, Y.H. Antioxidant peptides with angiotensin converting enzyme inhibitory activities and applications for angiotensin converting enzyme purification. J. Agric. Food Chem., 2003, 51, 1706-1709.
61. Vo, T.S.; Ngo, D.H.; Kim, J.A.; Ryu, B.; Kim, S.K. An antihypertensive peptide from tilapia gelatin diminishes free radical formation in murine microglial cells. J. Agric. Food Chem., 2011, 59, 12193-12197.
62. Zasloff, M. Antimicrobial peptides of multicellular organisms. Nature, 2002, 415, 389-395.
63. Brogden, K.A.; Ackermann, M.; McCray, P.B.; Tack, B.F. Antimicrobial peptides in animals and their role in host defences. Int. J. Antimicrob. Ag., 2003, 22, 465-478.
64. Sima, P.; Trebichavsky, I.; Sigler, K. Mammalian antibiotic peptides. Folia Microbiol., 2003, 48, 123-137.
65. Finlay, B.B.; Hancock, R.E. Can innate immunity be enhanced to treat microbial infections? Nat. Rev. Microbiol., 2004, 2, 497-504.
66. Boman, H.G. Peptide antibiotics and their role in innate immunity. Annu. Rev. Immunol., 1995, 13, 61-92.
67. McPhee, J.B., Scott, M.G.; Hancock, R.E. Design of host defence peptides for antimicrobial and immunity enhancing activities. Comb. Chem. High T. Scr., 2005, 8, 257-272.
68. Floris, R.; Recio, I.; Berkhout, B.; Visser, S. Antibacterial and antiviral effects of milk proteins and derivatives thereof. Curr. Pharm. Des., 2003, 9, 1257-1275.
69. Ginsburg, I. Cationic peptides from leukocytes might kill bacteria by activating their autolytic enzymes causing bacteriolysis: why are publications proposing this concept never acknowledged (letter). Blood, 2001, 97, 2530-2531.
70. Ginsburg, I. Bactericidal cationic peptides can also function as bacteriolysis-inducing agents mimicking beta-lactam antibiotics? it is enigmatic why this concept is consistently disregarded. Med. Hypotheses, 2004, 62, 367-374.
71. Zhang, L.; Falla, T.J. Cationic antimicrobial peptides–an update. Expert Opin. Inv. Drug, 2004, 13, 97-106.
72. Brogden, K.A. Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria? Nat. Rev. Microbiol., 2005, 3, 238-250.
73. Lohner, K.; Blondelle, S.E. Molecular mechanisms of membrane perturbation by antimicrobial peptides and the use of biophysical studies in the design of novel peptide antibiotics. Comb. Chem. High T. Scr., 2005, 8, 241-256.
74. Kitts, D.D.; Weiler, K. Bioactive proteins and peptides from food sources. Applications of bioprocesses used in isolation and recovery. Curr. Pharm. Des., 2003, 9, 1309-1323.
75. Korhonen, H.; Pihlanto, A. Food-derived bioactive peptides-Opportunities for designing future foods. Curr. Pharm. Des., 2003, 9, 1297-1308.
76. Pellegrini, A. Antimicrobial peptides from food proteins. Curr. Pharm. Des., 2003, 9, 1225-1238.
77. Biziulevicius, G.A. How food-borne peptides may give rise to their immunostimulatory activities: a look through the microbiologist’s window into the immunologist’s garden (hypothesis). Brit. J. Nutr., 2004, 92, 1009-1012.
78. Wieprecht, T.; Dathe, M.; Epand, R.M.; Beyermann, M.; Krause, E.; Maloy, W.L.; McDonald, D.L.; Bienert, M. Influence of the angle subtended by the positively charged helix face on the membrane activity of amphipathic, antibacterial peptides. Biochemistry-US, 1997, 36, 12869-12880.
79. Brief, A.A.; Maurer, S.G.; Di Cesare, P.E. Use of glucosamine and chondroitin sulfate in the management of osteoarthritis. J. Am. Acad. Orthop. Sur., 2001, 9, 71-78.
80. Bello, A.E.; Oesser, S. Collagen hydrolysate for the treatment of osteoarthritis and other joint disorders: A review of the literature. Curr. Med. Res. Opin., 2006, 22, 2221-2232.
81. Oesser, S.; Adam, M.; Babel, W.; Seifert, J., Oral administration of (14)C labeled gelatin hydrolysate leads to an accumulation of radioactivity in cartilage of mice (C57/BL). J. Nutr., 1999, 129, 1891-1895.
82. Kuettner, K.E.; Aydelotte, M.B.; Thonar, E.J. Articular cartilage matrix and structure: a minireview. J. Rheumatol., 1991, 27, 46-48.
83. Oesser, S.; Seifert, J. Stimulation of type II collagen biosynthesis and secretion in bovine chondrocytes cultured with degraded collagen. Cell Tissue Res., 2003, 311, 393-399.
84. Raabe, O.; Reich, C.; Wenisch, S.; Hild, A.; Burg-Roderfeld, M.; Siebert, H.C.; Arnhold, S. Hydrolyzed fish collagen induced chondrogenic differentiation of equine adipose tissue-derived stromal cells. Histochem. Cell Biol., 2010, 134, 545-554.
85. Walrand, S.; Chiotelli, E.; Noirt, F.; Mwewa, S.; Lassel, T. Consumption of a functional fermented milk containing collagen hydrolysate improves the concentration of collagen-specific amino acids in plasma. J. Agric. Food Chem., 2008, 56, 7790-7795.
86. Nakatani, S.; Mano, H.; Sampei, C.; Shimizu, J.; Wada, M. Chondroprotective effect of the bioactive peptide prolylhydroxyproline in mouse articular cartilage in vitro and in vivo. Osteoarthr. Cartilage, 2009, 17, 1620-1627.
87. Koyama, Y.; Hirota, A.; Mori, H.; Takahara, H.; Kuwaba, K.; Kusubata, M.; Matsubara, Y.; Kasugai, S.; Itoh, M.; Irie, S. Ingestion of gelatin has differential effect on bone mineral density and body weight in protein undernutrition. J. Nutr. Sci. Vitaminol., 2001, 47, 84-86.
88. Wu, J. Assessment of effectiveness of oral administration of collagen peptide on bone metabolism in growing and mature rats. J. Bone Miner. Metab., 2004, 22, 547-553.
89. Nomura, Y.; Oohashi, K.; Watanabe, M.; Kasugai, S., Increase in bone mineral density through oral administration of shark gelatin to ovariectomized rats. Nutrition, 2005, 21, 1120-1126.
90. Guillerminet, F.; Beaupied, H.; Fabien-Soulé, V.; Tomé, D.; Benhamou, C.L.; Roux, C.; Blais, A. Hydrolyzed collagen improves bone metabolism and biomechanical parameters in ovariectomized mice: An in vitro and in vivo study. Bone, 2010, 46, 827-834.
91. Han, X.; Xu, Y.; Wang, J.; Pei, X.; Yang, R.; Li, N.; Li, Y. Effects of cod bone gelatin on bone metabolism and bone microarchitecture in ovariectomized rats. Bone, 2009, 44, 942-947.
92. Adam, M.; Spacek, P.; Hulejova, H.; Galianova, A.; Blahos, J.; Postmenopausal osteoporosis. Treatment with calcitonin and a diet rich in cartilage proteins. Cas. Lek. Cesk., 1996, 135, 74-78.
93. Cúneo, F.; Costa-Paiva, L.; Pinto-Neto, A.M.; Morais, S.S.; Amaya-Farfan, J. Effect of dietary supplementation with collagen hydrolysates on bone metabolism of postmenopausal women with low mineral density. Maturitas, 2010, 65, 253-257.
94. Mizuno, M.; Kuboki, Y. Osteoblast-related gene expression of bone marrow cells during the osteoblastic differentiation induced by type I collagen. J. Biochem., 2001, 129, 133-138.
95. Kopylova, G.N.; Bakaeva, Z.V.; Badmaeva, S.E.; Umarova, B.A.; Samonina, G.E.; Guseva, A.A. Therapeutic effects of glyprolines (PGP, GP, and PG) in rats with stress-induced behavioral disorders. Bull. Exp. Biol. Med., 2007, 143, 167-170.
96. Badmaeva, S.E.; Kopylova, G.N.; Abushinova, N.N.; Samonina, G.E.; Umarova, B.A., Effects of glyprolines on stress-induced behavioral disorders in rats. Neurosci. Behav. Physiol., 2006, 36, 409-413.
97. Kopylova, G.N.; Badmaeva, S.E.; Levitskaya, N.G.; Samonina, G.E.; Umarova, B.A.; Guseva, A.A. Effect of Peptide Pro-Gly-Pro on Stress-Induced Behavioral Changes in Rats. Bull. Exp. Biol. Med, 2004, 138, 5-7.
98. Samonina, G.; Lyapina, L.; Kopylova, G.; Pastorova, V.; Bakaeva, Z.; Jeliaznik, N.; Zuykova, S.; Ashmarin, I. Protection of gastric mucosal integrity by gelatin and simple proline-containing peptides. Pathophysiology, 2000, 7, 69-73.
99. Ashmarin, I.P.; Karazeeva, E.P.; Lyapina, L.A.; Samonina, G. E., The simplest proline-containing peptides PG, GP, PGP, and GPGG: Regulatory activity and possible sources of biosynthesis. Biochemistry (Moscow), 1998, 63, 119-124.
100. Ray, A.K.; Dey, P.K. In: Current Status of Centrally Acting Peptides. Dhawan, B.D., Ed.; Pergamon Press: Oxford, New York. 1982, pp. 261-264.
101. Gupta, S.; Mehrotra, S.; Villalon, C. M.; Garrelds, I. M.; de Vries, R.; van Kats, J. P.; Sharma, H. S.; Saxena, P. R.; Maassenvandenbrink, A. Characterisation of CGRP receptors in human and porcine isolated coronary arteries: evidence for CGRP receptor heterogeneity. Eur. J. Pharmacol., 2006, 530, 107-116.
102. Arulmani, U.; MaassenVanDenBrink, A.; Villalon, C.M.; Saxena, P.R. Calcitonin gene-related peptide and its role in migraine pathophysiology. Eur. J. Pharmacol., 2004, 500, 315-330.
103. Yallampalli, C.; Chauhan, M.; Thota, C.S.; Kondapaka, S.; Wimalawansa, S.J. Calcitonin gene-related peptide in pregnancy and its emerging receptor heterogeneity. Trends Endocrin. Met., 2002, 13, 263-269.
104. Martínez-Alvarez, O.; Guimas, L.; Delannoy, C.; Fouchereau-Peron, M. Occurrence of a CGRP-like molecule in siki (Centroscymnus coelolepsis) hydrolysate of industrial origin. J. Agric. Food Chem., 2007, 55, 5469-5475.
105. Martínez-Alvarez, O.; Ravallec, R.; Cudennec, B.; Guimas, L.; Delannoy, C.; Fouchereau-Peron, M. Effects of daily gavage with a collagen hydrolysate containing CGRP-like molecules on plasma CGRP-levels in male Wistar rats. J. Funct. Foods, 2012, 4, 767-775.
106. Slizyte, R.; Mozuraityte, R.; Martínez-Alvarez, O.; Falch, E.; Fouchereau-Peron, M.; Rustad, T. Functional, bioactive and antioxidative properties of hydrolysates obtained from cod (Gadus morhua) backbones. Process Biochem., 2009, 44, 668-677.
107. Picot, L.; Ravallec, R.; Fouchereau Peron, M.; Vandanjon, L.; Jaouen, P.; Chaplain-Derouiniot, M.; Guerard, F.; Chabeaud, A.; Legal, Y.; Martínez-Alvarez, O.; Bergé, J. P.; Piot, J. M.; Batista, I.; Pires, C.; Thorkelsson, G.; Delannoy, C.; Jakobsen, G.; Johansson, I.; Bourseau, P. Impact of ultrafiltration and nanofiltration of an industrial fish protein hydrolysate on its bioactive properties. J. Sci. Food Agric., 2010, 90, 1819-1826.
108. Ravallec-Plé, R.; Charlot, C.; Batista, I.; Van Wormhoudt, A.; Le Gal., Y.; Fouchereau Peron, M., The presence of bioactive peptides in hydrolysates prepared from processing waste of sardine (Sardina pilchardus). J. Sci. Food Agric., 2001, 81, 1120-1125.
109. Rousseau, M.; Batista, I.: Le Gal, Y.; Fouchereau-Peron, M. Purification of a functional competitive antagonist for calcitonin gene related peptide action from sardine hydrolysates. Electron. J. Biotechnol., 2001, 4, 25-32.
110. Dockray, G.J. Clinical endocrinology and metabolism. Gastrin. Best Pract. Res. Cl. En., 2004, 18, 555-568.
111. Rehfeld, J.F. Cholecystokinin. Best Pract. Res. Cl. En., 2004, 18, 569-586.
112. Cancre, I.; Ravallec, R.; Van Wormhoudt, A.; Stenberg, E.; Gildberg, A.; Le Gal, Y. Secretagogues and growth factors in fish and crustacean protein hydrolysates. Mar. Biotechnol., 1999, 1, 489-494.
113. Thorkelsson, G.; Sigurgisladottir, S.; Geirsdottir, M.; Jóhannsson, R.; Guerard, F.; Chabeaud, A.; Bourseau, P.; Vandanjon, L.; Jaouen, P.; Chaplain-Derouiniot, M.; Fouchereau-Peron, M.; Martinez-Alvarez, O.; Le Gal, Y.; Ravallec-Ple, R.; Picot, L.; Berge, J.P.; Delannoy, C.; Jakobsen, G.; Johansson, I.; Batista, I.; Pires, C. In: Improving seafood products for the consumer; Borresen, T. Ed.; Woodhead Publishing Limited: Cambridge, 2008, pp. 363-398
114. Pastorova, V.E.; Lyapina, L.A.; Ashmarin, I.P.; Ostrovskaya, R.U.; Gudasheva, T.A.; Lugovskoi, E.V. Fibrin-depolymerization activity and the antiplatelet effect of small cyclic and linear proline-containing peptides. Biol. Bull., 2001, 28, 504-507.
115. Pastorova, V.E.; Lyapina, L.A.; Smolina, T.; Ashmarin, I.P. Anticoagulant and fibrinolytic effects of certain proline-containing peptides, Biol. Bull., 1998, 3, 1–5.
116. Lyapina, L.A.; Pastorova, V.E.; Obergan, T.Yu.; Samonina, G.E.; Ashmarin, I.P., Myasoedov, N.F. Comparison of anticoagulant effects of regulatory proline-containing oligopeptides. Specificity of glyprolines, semax, and selank and potential for their practical application. Biol. Bull., 2006, 33, 153-161.
117. Zhuikova, S.E.; Badmaeva, K.E.; Bakaeva, Z.V.; Samonina, G.E. Antiulcer Effects of the Tripeptide PGP and Its Possible Metabolites (PG, GP, Glycine, and Proline) in Different Models of Ulcer Induction in Rats. Biol. Bull., 2004, 31, 484-487.
118. Baglikova, K.; Trufanova, A.; Bakaeva, Z.; Samonina, G.; Andreeva, L.; Klimova, P.; Vas’kovsky, B. The influence of hydroxyproline-and proline-containing glyproline on ethanol-induced gastric lesions in rats. Mosc. Univ. Biol. Sci. Bull., 2009, 64, 7-11.
119. Badmaeva, S.E.; Kopylova, G.N.; Abushinova, N.N.; Samonina, G.E.; Umarova, B.A. The effect of glyprolines on stressogenic disorders in the rat behaviour. Russ. J. Physiol., 2005, 91, 543-550.
120. Umarova, B.A.; Kopylova, G.N.; Smirnova, E.A.; Guseva, A.A.; Zhuikova, S.E. Secretory activity of mast cell during stress: Effect of prolyl-glycyl-proline and Semax. Bull. Exp. Biol. Med., 2003, 136, 325-327.
121. Watanabe, Y.; Sagara, Y.; Sugahara, K.; Kodama, H. Iminodipeptides containing proline with C-terminal and N-terminal residues prime the stimulation of human neutrophil superoxide generation by fMLP. Biochem. Bioph. Res. Commun., 1994, 205, 758-764.
122. Ruehl, M.; Somasundaram, R.; Schoenfelder, I., Farndale, R.W.; Knight, C.G.; Schmid, M.; Ackermann, R.; Riecken, E.O.; Zeitz, M.; Schuppan, D. The epithelial mitogen keratinocyte growth factor binds to collagens via the consensus sequence glycine-proline-hydroxyproline. J. Biol. Chem., 2002, 277, 26872-26878.
123. Postlethwaite, A.E.; Seyer J.M.; Kang, A.H. Chemotactic attraction of human fibroblasts to type I, II, and III collagens and collagen-derived peptides. Proc. Natl. Acad. Sci. USA, 1978, 75, 871-875.
124. Zhang, Z.; Wang, J.; Ding, Y.; Dai, X.; Li, Y. Oral administration of marine collagen peptides from Chum Salmon skin enhances cutaneous wound healing and angiogenesis in rats. J. Sci. Food Agric., 2011, 91, 2173-2179.
125. Zhu, C.-F.; Li, G.-Z.; Peng, H.-B.; Zhang, F.; Chen, Y.; Li, Y. Effect of marine collagen peptides on markers of metabolic nuclear receptors in Type 2 diabetic patients with/without hypertension. Biomed. Environ. Sci., 2010, 23, 113-120.
126. Iwai, K.; Hasegawa, T.; Taguchi, Y.; Morimatsu, F.; Sato, K.; Nakamura, Y.; Higashi, A.; Kido, Y.; Nakabo, Y.; Ohtsuki, K. Identification of food-derived collagen peptides in human blood after oral ingestion of gelatin hydrolysate. J. Agric. Food Chem., 2005, 53, 6531-6536.
127. Ohara, H.; Matsumoto, H.; Ito, K.; Iwai, K.; Sato, K. Comparison of quantity and structures of hydroxyproline-containing peptides in human blood after oral ingestion of gelatin hydrolysates from different sources. J. Agric. Food Chem., 2007, 55, 1532-1535.
128. Watanabe-Kamiyama, M.; Shimizu, M.; Kamiyama, S.; Taguchi, Y.; Sone, H.; Morimatsu, F.; Shirakawa, H.; Furukawa, Y.; Koma, M. Absorption and effectiveness of orally administered low molecular weight collagen hydrolysate in rats. J. Agric. Food Chem., 2010, 58, 835-841.
129. Aito-Inoue, M.; Lackeyram, D.; Fan, M.Z.; Sato, K.; Mine, Y. Transport of a tripeptide, Gly-Pro-Hyp, across the porcine intestinal brush-border membrane. J. Pept. Sci., 2007, 13, 468-474.