Protection of gastric mucosal integrity by gelatin and simple proline-containing peptides

Pathophysiology

Volumn 7, Issue 1, 2000, Pages 69-73

  Samonina, G ^a   Lyapina, L ^a   Kopylova, G ^a   Pastorova, V ^a   Bakaeva, Z ^a   Jeliaznik, N ^a   Zuykova, S ^a   Ashmarin, I ^a  

^a MOSCOW STATE UNIVERSITY   (Russian Federation)

Author keywords

Gastric mucosal integrity; Platelet aggregation; Simple proline containing peptides

Indexed keywords

ALCOHOL; GELATIN; GLYCYLPROLINE; PEPTIDE; PROLINE; PROLYLGLYCINE; PROLYLGLYCYLPROLINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIET SUPPLEMENTATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; STOMACH MUCOSA; STOMACH MUCOSA LESION; STOMACH PROTECTION; THROMBOCYTE AGGREGATION;

EID: 0034175945     PISSN: 09284680     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-4680(00)00045-6     Document Type: Article

References (13)

1. Abramova M., Samonina G., Ashmarin I. Prolin and simplest prolin-containing fragments of neuropeptides modulate gastric mucosa state through central and peripheral mechanisms. Neurochimija. 13:1996;209-215.
2. Abramova M., Samonina G., Mamedov C., Kopylova G. Some antiulcer mechanisms of one of simplest proline-containing fragment of regulatory peptides Pro-Gly-Pro Moscow University Biological. Sci. Bull. 2:1997;7-10.
3. Ashmarin I., Karaseeva E., Lyapina L., Samonina G. The simplest proline containing peptides PG, GP, PGP and GPGG as putative bioregulators and possible sources of their synthesis. Biochemistry. (Moscow). 63:1998;119-124.
4. Ashmarin I., Lyapina L., Pastorova V. Modulation of in vitro and in vivo hemostatic reactions by representatives of regulatory peptides families. Vestnik RAMS1996. 6:1996;50-58.
5. Ashmarin I.P., Samonina G.E., Jelyaznik N.J., Bakaeva Z.V. Protective action of PGP peptide on gastric mucosa. Dokl. Akad. Nauk. 368:1999;1-2.
6. Bienkowski R., Cowan M., McDonald J., Crystal R. Degradation of newly synthesized collagen. J. Biol. Chem. 253:1978;4356-4363.
7. Born G. Aggregation of blood platelet by adenosinediphosphate and its reversal. Nature. 194:1962;927-929.
8. Ganapathy V., Mendicino J., Leibach F. Transport of glycyl-L-proline into intestinal and renal brush border vesicles from rabbit. J. Biol. Chem. 256:1981;118-124.
9. 1 in the procoagulant response of single, collagen-adherent platelets. Thromb. Haemost. 81:1999;782-792.
10. Kini R., Evans H. A novel approach to the design of potent bioactive peptides by incorporation of proline brackets: antiplatelet effects of Arg-Gly-Asp peptides. FEBS Lett. 375:1995;15-17.
11. McCarthy D.M. Mechanisms of mucosal injury and healing: the role of non-steroidal anti-inflammatory drugs. Scand. J. Gastroenterol. Suppl. 208:1995;24-29.
12. Prockop D., Keiser H.R., Sjoersma A. Gastrointestinal absorbtion and renal excretion of Hydroxyproline peptides. Lancet. 11:1962;527-528.
13. Ruggeri Z. Mechanisms of shear-induced platelet adhesion and aggregation. Thromb. Haemost. 70:1993;119-123.