Gastrin

Best Practice and Research: Clinical Endocrinology and Metabolism

Volumn 18, Issue 4, 2004, Pages 555-568

  Dockray, Graham J ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

Amidated gastrin; Colorectal cancer; Enterochromaffin like cell carcinoid tumours; G17; G34; Gastrinoma; Gly gastrin; Helicobacter pylori; MEN 1; Pernicious anaemia; Progastrin; Proton pump inhibitors

Indexed keywords

1 (2,3 DIHYDRO 1 METHYL 2 OXO 5 PHENYL 1H 1,4 BENZODIAZEPIN 3 YL) 3 (3 METHYLPHENYL)UREA; 1 [2,3 DIHYDRO 2 OXO 1 PIVALOYLMETHYL 5 (2 PYRIDYL) 1H 1,4 BENZODIAZEPIN 3 YL] 3 [3 (METHYLAMINO)PHENYL]UREA; BENZODIAZEPINE DERIVATIVE; BIOGENIC AMINE; CALCIUM; CHOLECYSTOKININ; CHOLECYSTOKININ B RECEPTOR; CHOLECYSTOKININ B RECEPTOR ANTAGONIST; CYTOTOXIC AGENT; GASTRIMMUNE; GASTRIN; GASTRIN 17; GASTRIN RECEPTOR; GENE PRODUCT; GLYCINE; GROWTH FACTOR; HORMONE ANTIBODY; HORMONE PRECURSOR; INDIUM 111; L 790043; PEPTOID; PROGASTRIN; PROTEINASE; PROTON PUMP INHIBITOR; SECRETIN; SPIROGLUMIDE; STOMACH SECRETION INHIBITOR; UNCLASSIFIED DRUG; UNINDEXED DRUG; UNSPECIFIC MONOOXYGENASE; YTTRIUM 90; AMIDE; HORMONE ANTAGONIST; PROTEIN PRECURSOR;

ARTICLE; ATROPHIC GASTRITIS; CARCINOID; CELL PROLIFERATION; CHRONIC DISEASE; DIAGNOSTIC TEST; DISEASE COURSE; DYSPLASIA; ENTEROCHROMAFFIN CELL; EPITHELIUM CELL; GASTRIN BLOOD LEVEL; GASTRIN CELL; GASTRIN RELEASE; GASTRINOMA; GENE EXPRESSION; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HORMONE ACTION; HUMAN; HYPERGASTRINEMIA; NONHUMAN; PANCREAS ADENOCARCINOMA; PROVOCATION TEST; STOMACH ACID SECRETION; ANIMAL; BIOSYNTHESIS; DRUG ANTAGONISM; GENETICS; PHYSIOLOGY; REVIEW;

AMIDES; ANIMALS; GASTRINS; HORMONE ANTAGONISTS; HUMANS; PROTEIN PRECURSORS; RECEPTOR, CHOLECYSTOKININ B;

EID: 16644396848     PISSN: 1521690X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.beem.2004.07.003     Document Type: Article

References (91)

1. W. Beaumont Gastric Juice and the Physiology of Digestion 1833 FP Allen Plattsburgh
2. W.M. Bayliss & E.H. Starling The mechanism of pancreatic secretion Journal of Physiology 28 1902 325-353
3. J.S. Edkins On the chemical mechanism of gastric secretion Proceedings of the Royal Society Series B 76 1905 376
4. R.A. Gregory & H.J. Tracy The constitution and properties of two gastrins extracted from hog antral mucosa Gut 5 1964 103-114
5. J.S. Morley H.J. Tracy & R.A. Gregory Structure-function relationships in the active C-terminal tetrapeptide sequence of gastrin Nature 207 1965 1356-1359
6. R.A. Gregory & H.J. Tracy Isolation of two 'big gastrins' from Zollinger-Ellison tumour tissue Lancet 2 1972 797-799
7. R.A. Gregory H.J. Tracy K.L. Agarwal et al. Aminoacid constitution of two gastrins isolated from Zollinger-Ellison tumour tissue Gut 10 1969 603-608
8. G.J. Dockray A. Varro R. Dimaline et al. The gastrins: Their production and biological activities Annual Review of Physiology 63 2001 119-139
9. A. Varro & J.E. Ardill Gastrin: An analytical review Annals of Clinical Biochemistry 40 2003 472-480
10. R. Ito K. Sato T. Helmer et al. Structural analysis of the gene encoding human gastrin: The large intron contains an Alu sequence Proceedings of the National Academy of Science USA 81 1984 4662-4666
11. J.H. Walsh In: Gastrin J.H. Walsh G.J. Dockray (Eds.) Gut Peptides 1994 Raven Press New York 75-121
12. A. Varro J. Henry C. Vaillant et al. Discrimination between temperature- and brefeldin A-sensitive steps in the sulfation, phosphorylation, and cleavage of progastrin and its derivatives Journal of Biological Chemistry 269 1994 20764-20770
13. R.S. Jackson J.W. Creemers I.S. Farooqi et al. Small-intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency Journal of Clinical Investigation 112 2003 1550-1560
14. A. Varro S. Voronina & G.J. Dockray Pathways of processing of the gastrin precursor in rat antral mucosa Journal of Clinical Investigation 95 1995 1642-1649
15. J. Nemeth B. Taylor S. Pauwels et al. Identification of progastrin derived peptides in colorectal carcinoma extracts Gut 34 1993 90-95
16. G.D. Ciccotosto A. McLeish K.J. Hardy et al. Expression, processing, and secretion of gastrin in patients with colorectal carcinoma Gastroenterology 109 1995 1142-1153
17. R.K. Siddheshwar J.C. Gray & S.B. Kelly Plasma levels of progastrin but not amidated gastrin or glycine extended gastrin are elevated in patients with colorectal carcinoma Gut 48 2001 47-52
18. L. Bishop R. Dimaline C. Blackmore et al. Modulation of the cleavage of the gastrin precursor by prohormone phosphorylation Gastroenterology 115 1998 1154-1162
19. A.G. Pearse The cytochemistry and ultrastructure of polypeptide hormone-producing cells of the APUD series and the embryologic, physiologic and pathologic implications of the concept Journal of Histochemistry and Cytochemistry 17 1969 303-313
20. C.G. Blackmore A. Varro R. Dimaline et al. Measurement of secretory vesicle pH reveals intravesicular alkalinization by vesicular monoamine transporter type 2 resulting in inhibition of prohormone cleavage Journal of Physiology 531 2001 605-617
21. J.H. Walsh H.T. Debas & M.I. Grossman Pure human big gastrin. Immunochemical properties, disappearance half time, and acid-stimulating action in dogs Journal of Clinical Investigation 54 1974 477-485
22. S.J. Brand & D. Stone Reciprocal regulation of antral gastrin and somatostatin gene expression by omeprazole-induced achlorhydria Journal of Clinical Investigation 82 1988 1059-1066
23. S.V. Wu A. Giraud M. Mogard et al. Effects of inhibition of gastric secretion on antral gastrin and somatostatin gene expression in rats American Journal of Physiology 258 1990 G788-G793
24. G.W. Bate A. Varro R. Dimaline et al. Control of preprogastrin messenger RNA translation by gastric acid in the rat Gastroenterology 111 1996 1224-1229
25. S.F. Moss S. Legon & J. Calam Reciprocal changes in antral gastrin and somatostatin mRNA in pernicious anemia Digestive Diseases and Sciences 39 1994 321-326
26. J.P. Goetze F.C. Nielsen F. Burcharth et al. Closing the gastrin loop in pancreatic carcinoma: Coexpression of gastrin and its receptor in solid human pancreatic adenocarcinoma Cancer 88 2000 2487-2494
27. M.L. Kochman J. Delvalle C.J. Dickinson et al. Post-translational processing of gastrin in neoplastic human colonic tissues Biochemical and Biophysical Research Communications 189 1992 1165-1169
28. T.J. Koh C.J. Bulitta J.V. Fleming et al. Gastrin is a target of the beta-catenin/TCF-4 growth-signaling pathway in a model of intestinal polyposis Journal of Clinical Investigation 106 2000 533-539
29. T.J. Koh J.K. Field A. Varro et al. Glycine-extended gastrin promotes the growth of lung cancer Cancer Research 64 2003 196-201
30. A. Schmassmann & J.C. Reubi Cholecystokinin-B/gastrin receptors enhance wound healing in the rat gastric mucosa Journal of Clinical Investigation 106 2000 1021-1029
31. C. Broberger K. Holmberg T.J. Shi et al. Expression and regulation of cholecystokinin and cholecystokinin receptors in rat nodose and dorsal root ganglia Brain Research 903 2001 128-140
32. C.R. Haigh S.E. Attwood D.G. Thompson et al. Gastrin induces proliferation in Barrett's metaplasia through activation of the CCK2 receptor Gastroenterology 124 2003 615-625
33. J.C. Reubi & B. Waser Unexpected high incidence of cholecystokinin-B/gastrin receptors in human medullary thyroid carcinomas International Journal of Cancer 67 1996 644-647
34. T.M. Behr & M.P. Behe Cholecystokinin-B/gastrin receptor-targeting peptides for staging and therapy of medullary thyroid cancer and other cholecystokinin-B receptor-expressing malignancies Seminars in Nuclear Medicine 32 2002 97-109
35. D.S. Weinberg B. Ruggeri M.T. Barber et al. Cholecystokinin A and B receptors are differentially expressed in normal pancreas and pancreatic adenocarcinoma Journal of Clinical Investigation 100 1997 597-603
36. J.C. Reubi J.C. Schaer & B. Waser Cholecystokinin (CCK)-A and CCK-B/gastrin receptors in human tumors Cancer Research 57 1997 1377-1386
37. J.C. Reubi B. Waser A. Schmassmann et al. Receptor autoradiographic evaluation of cholecystokinin, neurotensin, somatostatin and vasoactive intestinal peptide receptors in gastro-intestinal adenocarcinoma samples: Where are they really located? International Journal of Cancer 81 1999 376-386
38. P. Singh X. Lu S. Cobb et al. Progastrin1-80 stimulates growth of intestinal epithelial cells in vitro via high-affinity binding sites American Journal of Physiology. Gastrointestinal and Liver Physiology 284 2003 G328-G339
39. P.N. Maton Gastrinoma and other hypergastrinemic syndromes In: J.H. Walsh G.J. Dockray (Eds.) Gut Peptides: Biochemistry and Physiology 1994 Raven Press New York
40. A. Varro G.J. Dockray G.W. Bate et al. Gastrin biosynthesis in the antrum of patients with pernicious anemia Gastroenterology 112 1997 733-741
41. L. Bardram & J.F. Rehfeld Processing-independent radioimmunoanalysis: A general analytical principle applied to progastrin and its products Anals of Biochemistry 175 1988 537-543
42. R.T. Jensen Involvement of cholecystokinin/gastrin-related peptides and their receptors in clinical gastrointestinal disorders Pharmacology & Toxicology 91 2002 333-350
43. P.K. Roy D.J. Venzon H. Shojamanesh et al. Zollinger-Ellison syndrome Medicine (Baltimore) 79 2000 379-411
44. F. Gibril M. Schumann A. Pace et al. Multiple endocrine neoplasia type 1 and Zollinger-Ellison syndrome: A prospective study of 107 cases and comparison with 1009 cases from the literature Medicine (Baltimore) 83 2004 43-83
45. P. Jais & M. Mignon Normal serum gastrin concentration in gastrinoma Lancet 346 1995 1421-1422
46. H. Frucht J.M. Howard J.I. Slaff et al. Secretin and calcium provocative tests in the Zollinger-Ellison syndrome. A prospective study Annals of Internal Medicine 111 1989 713-722
47. M. Wada I. Komoto R. Doi et al. Intravenous calcium injection test is a novel complementary procedure in differential diagnosis for gastrinoma World Journal of Surgery 26 2002 1291-1296
48. J.B. Jansen E.C. Klinkenberg-Knol S.G. Meuwissen et al. Effect of long-term treatment with omeprazole on serum gastrin and serum group A and C pepsinogens in patients with reflux esophagitis Gastroenterology 99 1990 621-628
49. R. Lamberts W. Creutzfeldt H.G. Struber et al. Long-term omeprazole therapy in peptic ulcer disease: Gastrin, endocrine cell growth, and gastritis Gastroenterology 104 1993 1356-1370
50. M. Ligumsky J. Lysy G. Siguencia et al. Effect of long-term, continuous versus alternate-day omeprazole therapy on serum gastrin in patients treated for reflux esophagitis Journal of Clinical Gastroenterol 33 2001 32-35
51. S. Levi K. Beardshall G. Haddad et al. Campylobacter pylori and duodenal ulcers: The gastrin link Lancet 1 1989 1167-1168
52. J. Calam A. Gibbons Z.V. Healey et al. How does Helicobacter pylori cause mucosal damage? Its effect on acid and gastrin physiology Gastroenterology 113 1997 S43-S49
53. G.R. van Den Brink F.J. ten Kate C.Y. Ponsioen et al. Expression and activation of NF-kappa B in the antrum of the human stomach Journal of Immunology 164 2000 3353-3359
54. Y. Zavros G. Rieder A. Ferguson et al. Genetic or chemical hypochlorhydria is associated with inflammation that modulates parietal and G-cell populations in mice Gastroenterology 122 2002 119-133
55. R.Y. Wilson B.E. Boyes B.H. Stagg et al. Antral G-cell hyperplasia with hypergastrinaemia producing a Zollinger-Ellison syndrome Gut 13 1972 848-849
56. I.L. Taylor J. Calam J.I. Rotter et al. Family studies of hypergastrinemic, hyperpepsinogenemic I duodenal ulcer Annals of Internal Medicine 95 1981 421-425
57. K.E. McColl D. Gillen & E. El Omar The role of gastrin in ulcer pathogenesis Baillières Best Practice & Research. Clinical Gastroenterology 14 2000 13-26
58. J. Beltinger P. Hildebrand J. Drewe et al. Effects of spiroglumide, a gastrin receptor antagonist, on acid secretion in humans European Journal of Clinical Investigation 29 1999 153-159
59. J.W. Black & N.P. Shankley How does gastrin act to stimulate oxyntic cell secretion? TIPS 8 1987 486-490
60. E. Lindstrom D. Chen P. Norlen et al. Control of gastric acid secretion: the gastrin-ECL cell-parietal cell axis Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology 128 2001 505-514
61. T.J. Koh J.R. Goldenring S. Ito et al. Gastrin deficiency results in altered gastric differentiation and decreased colonic proliferation in mice Gastroenterology 113 1997 1015-1025
62. L. Friis-Hansen F. Sundler Y. Li et al. Impaired gastric acid secretion in gastrin-deficient mice American Journal of Physiology 274 1998 G561-G568
63. Y. Miyazaki Y. Shinomura S. Tsutsui et al. Gastrin induces heparin-binding epidermal growth factor-like growth factor in rat gastric epithelial cells transfected with gastrin receptor Gastroenterology 116 1999 78-89
64. T.C. Wang C.A. Dangler D. Chen et al. Synergistic interaction between hypergastrinemia and Helicobacter infection in a mouse model of gastric cancer Gastroenterology 118 2000 36-47
65. S. Mahr N. Neumayer H.J. Kolb et al. Growth factor effects on apoptosis of rat gastric enterochromaffin-like cells Endocrinology 139 1998 4380-4390
66. C. Bordi T. D'Adda C. Azzoni et al. Hypergastrinemia and gastric enterochromaffin-like cells American Journal of Surgical Pathology 19 supplement 1 1995 S8-19
67. P.L. Peghini B. Annibale C. Azzoni ety al. Effect of chronic hypergastrinemia on human enterochromaffin-like cells: Insights from patients with sporadic gastrinomas Gastroenterology 123 2002 68-85
68. K. Borch H. Renvall & G. Liedberg Gastric endocrine cell hyperplasia and carcinoid tumors in pernicious anemia Gastroenterology 88 1985 638-648
69. S.M. Sjoblom P. Sipponen M. Miettinen et al. Gastroscopic screening for gastric carcinoids and carcinoma in pernicious anemia Endoscopy 20 1988 52-56
70. A.D. Higham L.A. Bishop R. Dimaline et al. Mutations of RegIalpha are associated with enterochromaffin-like cell tumor development in patients with hypergastrinemia Gastroenterology 116 1999 1310-1318
71. G. Rindi C. Azzoni S. La Rosa et al. ECL cell tumor and poorly differentiated endocrine carcinoma of the stomach: Prognostic evaluation by pathological analysis Gastroenterology 116 1999 532-542
72. R.M. Thomas J.H. Baybick A.M. Elsayed et al. Gastric carcinoids. An immunohistochemical and clinicopathologic study of 104 patients Cancer 73 1994 2053-2058
73. B.I. Hirschowitz J. Griffith D. Pellegrin et al. Rapid regression of enterochromaffinlike cell gastric carcinoids in pernicious anemia after antrectomy Gastroenterology 102 1992 1409-1418
74. A.D. Higham R. Dimaline A. Varro et al. Octreotide suppression test predicts beneficial outcome from antrectomy in a patient with gastric carcinoid tumor Gastroenterology 114 1998 817-822
75. Z.E. Khan T.C. Wang G. Cui et al. Transcriptional regulation of the human trefoil factor, TFF1, by gastrin1 Gastroenterology 125 2003 510-521
76. L.E. Wroblewski D.M. Pritchard S. Carter et al. Gastrin-stimulated gastric epithelial cell invasion: The role and mechanism of increased matrix metalloproteinase 9 expression The Biochemical Journal 365 2002 873-879
77. A. Varro E. Hemers D. Archer et al. Identification of plasminogen activator inhibitor-2 as a gastrin-regulated gene: Role of Rho GTPase and menin Gastroenterology 123 2002 271-280
78. C. Seva C.J. Dickinson & T. Yamada Growth-promoting effects of glycine-extended progastrin Science 265 1994 410-412
79. F. Hollande A. Imdahl T. Mantamadiotis et al. Glycine-extended gastrin acts as an autocrine growth factor in a nontransformed colon cell line Gastroenterology 113 1997 1576-1588
80. T.C. Wang T.J. Koh A. Varro et al. Processing and proliferative effects of human progastrin in transgenic mice Journal of Clinical Investigation 98 1996 1918-1929
81. C.M. Thorburn G.D. Friedman C.J. Dickinson et al. Gastrin and colorectal cancer: A prospective study Gastroenterology 115 1998 275-280
82. G.S. Baldwin & A. Shulkes Gastrin, gastrin receptors and colorectal carcinoma Gut 42 1998 581-584
83. T.J. Koh & D. Chen Gastrin as a growth factor in the gastrointestinal tract Regulatory Peptides 93 2000 37-44
84. T.J. Koh G.J. Dockray A. Varro et al. Overexpression of glycine-extended gastrin in transgenic mice results in increased colonic proliferation Journal of Clinical Investigation 103 1999 1119-1126
85. P. Singh M. Velasco R. Given et al. Progastrin expression predisposes mice to colon carcinomas and adenomas in response to a chemical carcinogen Gastroenterology 119 2000 162-171
86. P. Singh M. Velasco R. Given et al. Mice overexpressing progastrin are predisposed for developing aberrant colonic crypt foci in response to AOM American Journal of Physiology 278 2000 G390-G399
87. P.D. Ottewell A.J. Watson T.C. Wang et al. Progastrin stimulates murine colonic epithelial mitosis after DNA damage Gastroenterology 124 2003 1348-1357
88. S.A. Watson & A.D. Gilliam G17DT-a new weapon in the therapeutic armoury for gastrointestinal malignancy Expert Opinion on Biological Therapy 1 2001 309-317
89. J.W. Black & S.B. Kalindjian Gastrin agonists and antagonists Pharmacology & Toxicology 91 2002 275-281
90. F. Lehmann P. Hildebrand & C. Beglinger New molecular targets for treatment of peptic ulcer disease Drugs 63 2003 1785-1797
91. M. Behe W. Becker M. Gotthardt et al. Improved kinetic stability of European Journal of Nuclear Medicine and Molecular Imaging 30 2003 1140-1146