Angiotensin-I-converting enzyme (ACE) inhibitors from marine resources: Prospects in the pharmaceutical industry

Marine Drugs

Volumn 8, Issue 4, 2010, Pages 1080-1093

  Wijesekara, Isuru ^a   Kim, Se Kwon ^a  

^a Pukyong National University   (South Korea)

Author keywords

Angiotensin I converting enzyme inhibitors; Antihypertensive activity; Bioactive peptides; Chitooligosaccharides; Hypertension; Phlorotannins

Indexed keywords

AHNFELTIOPSIS FLABELLIFORMIS EXTRACT; AMINOETHYLCHITIN; AMINOETHYLCHITOOLIGOSACCHARIDE; BIOACTIVE PEPTIDE; CAPTOPRIL; CHITIN; CHITIN DERIVATIVE; CHITOSAN; CHITOSAN OLIGOSACCHARIDE; CHITOSE OLIGOSACCHARIDE; DIECKOL; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ECKLONIA CAVA EXTRACT; ECKLONIA STOLONIFERA EXTRACT; ECKOL; GIGARTINA TENELLA EXTRACT; OLIGOSACCHARIDE; PELVETIA SILIQOUSA EXTRACT; PEPTIDE HYDROLASE INHIBITOR; PHLOROFUCOFUROECKOL A; PHLOROTANNIN; PLANT EXTRACT; UNCLASSIFIED DRUG; UNDARIA PINNATIFIDA EXTRACT;

AHNFELTIOPSIS FLABELLIFORMIS; ANTIHYPERTENSIVE ACTIVITY; DRUG INDUSTRY; DRUG MECHANISM; DRUG SYNTHESIS; ECKLONIA CAVA; ECKLONIA STOLONIFERA; ENZYME INHIBITION; GIGARTINA TENELLA; HYPERTENSION; MARINE SPECIES; NONHUMAN; PELVETIA SILIQOUSA; RED ALGA; REVIEW; SEAWEED; UNDARIA PINNATIFIDA;

EID: 77952564007     PISSN: None     EISSN: 16603397     Source Type: Journal    
DOI: 10.3390/md8041080     Document Type: Review

References (93)

1. Harris, T.; Cook, E.F.; Kannel, W.; Schatzkin, A.; Goldman, L. Blood pressure experience and risk of cardiovascular disease in the elderly. Hypertension 1985, 7, 118-124. (Pubitemid 15117149)
2. Kannel, W.B.; Higgins, M. Smoking and hypertension as predictors of cardiovascular risk in population studies. J. Hypertens. 1990, 8, S3-S8.
3. Alper, A.B.; Calhoun, D.A.; Oparil, S. Hypertension. In Encyclopedia of Life Sciences; Nature Publishing Group: London, UK; 2001, pp. 1-8.
4. Skeggs, L.T.; Kahn, J.R.; Shumway, N.P. The preparation and function of the hypertension-converting enzyme. J. Exp. Med. 1956, 103, 295-299.
5. Li, G.H.; Le, G.W.; Shi, Y.H.; Shrestha, S. Angiotensin I - converting enzyme inhibitory peptides derived from food proteins and their physiological and pharmacological effects. Nutr. Res. 2003, 24, 469-486. (Pubitemid 38968489)
6. Ondetti, M.A. Design of specific inhibitors of angiotensin-converting enzyme: New class of orally active antihypertensive agents. Science 1977, 196, 441-444.
7. Atkinson, A.B.; Robertson, J.I.S. Captopril in the treatment of clinical hypertension and cardiac failure. Lancet 1979, 2, 836-839.
8. Goretta, L.A.; Ottaviani, J.I.; Keen, C.L.; Fraga, C.G. Inhibition of angiotensin converting enzyme (ACE) activity by flavan-3-ols and procyanidins. FEBS Lett. 2003, 555, 597-600.
9. Lee, D.H.; Kim, J.H.; Park, J.S.; Choi, Y.J.; Lee, J.S. Isolation and characterization of a novel angiotensin-I-converting enzyme inhibitory peptide derived from the edible mushroom Tricholoma giganteum. Peptides 2004, 25, 621-627.
10. Maruyama, S.; Miyoshi, S.; Tanaka, H. Angiotensin-I-converting enzyme inhibitor derived from Ficus carica. Agric. Biol. Chem. 1989, 53, 2763-2769.
11. Demain, A.L.; Somkuti, G.A.; Hunter-Cevera, J.C.; Rossmoore, H.W. Novel microbial products for medicine and agriculture. Elsevier Science Publishers: Amsterdam, The Netherlands; 1989.
12. Fujita, H.; Yokoyama, K.; Yoshikawa, M. Classification and antihypertensive activity of angiotensin I-converting enzyme inhibitory peptides derived from food proteins. J. Food Sci. 2000, 65, 564-569.
13. Je, J.Y.; Qian, Z.J.; Lee, S.H.; Byun, H.G.; Kim, S.K. Purification and antioxidant properties of bigeye tuna (Thunnus obesus) dark muscle peptide on free radical-mediated oxidation systems. J. Med. Food. 2008, 11, 629-637.
14. Sheih, I.C.; Fang, T.J.; Wu, T.K. Isolation and characterization of a novel angiotensin I-converting enzyme (ACE) inhibitory peptide from the algae protein waste. Food Chem. 2009, 115, 279-284.
15. Slizyte, R.; Mozuraityte, R.; Martinez-Alvarez, O.; Falch, E.; Fouchereau-Peron, M.; Rustad, T. Functional, bioactive and antioxidative properties of hydrolysates obtained from cod (Gadus morhua) backbones. Process Biochem. 2009, 44, 668-677.
16. Suetsuna, K.; Chen, J.R. Identification of antihypertensive peptides from peptic digest of two microalgae, Chlorella vulgaris and Spirulina platensis. Mar. Biotechnol. 2001, 3, 305-309.
17. Zhao, Y.; Li, B.; Liu, Z.; Dong, S.; Zhao, X.; Zeng, M. Antihypertensive effect and purification of an ACE inhibitory peptide from sea cucumber gelatin hydrolysate. Process Biochem. 2007, 42, 1586-1591. (Pubitemid 350101340)
18. Je, J.Y.; Park, J.Y.; Jung, W.K.; Park, P.J.; Kim, S.K. Isolation of angiotensin I converting enzyme (ACE) inhibitor from fermented oyster sauce, Crassostrea gigas. Food Chem. 2005, 90, 809-814.
19. Je, J.Y.; Park, P.J.; Byun, H.K.; Jung, W.K.; Kim, S.K. Angiotensin I converting enzyme (ACE) inhibitory peptide derived from the sauce of fermented blue mussel, Mytilus edulis. Bioresour. Technol. 2005, 96, 1624-1629. (Pubitemid 40840711)
20. Kim, S.K.; Choi, Y.R.; Park, P.J.; Choi, J.H.; Moon, S.H. Screening of biofunctional peptides from cod processing wastes. J. Korean Soc. Agric. Chem. Biotechnol. 2000, 33, 198-204.
21. Kim, S.K.; Kim, Y.T.; Byun, H.G.; Nam, K.S.; Joo, D.S.; Shahidi, F. Isolation and characterization of antioxidative peptides from gelatin hydrolysate of Alaska pollack skin. J. Agric. Food Chem. 2001, 49, 1984-1989. (Pubitemid 32816849)
22. Jun, S.Y.; Park, P.J.; Jung, W.K.; Kim, S.K. Purification and characterization of an antioxidative peptide from enzymatic hydrolysates of yellowfin sole (Limanda aspera) frame protein. Eur. Food Res. Technol. 2004, 219, 20-26.
23. Ravallec, P.R.; Charlot, C.; Pires, C.; Braga, V.; Batista, I.; Wormhoudt, A.V.; Gal, Y.L.; Fouchereau-Peron, M. The presence of bioactive peptides in hydrolysates prepared from processing waste of sardine (Sardina pilchardus). J. Sci. Food Agric. 2001, 81, 1120-1125. (Pubitemid 32773923)
24. Yokoyama, K.H.; Chiba, H.; Yoshikawa, M. Peptide inhibitors for angiotensin-I-converting enzyme from thermolysin digest of dried bonito. Biosci. Biotechnol. Biochem. 1992, 56, 1541-1545.
25. Kim, S.Y.; Je, J.Y.; Kim, S.K. Purification and characterization of antioxidant peptide from hoki (Johnius balengerii) frame protein by gastrointestinal digestion. J. Nutr. Biochem. 2007, 18, 31-38.
26. Mendis, E.; Rajapakse, N.; Kim, S.K. Antioxidant properties of a radical-scavenging peptide purified from enzymatically prepared fish skin gelatin hydrolysate. J. Agric. Food Chem. 2005, 53, 581-587.
27. Jo, H.Y.; Jung, W.K.; Kim, S.K. Purification and characterization of a novel anticoagulant peptide from marine echiuroid worm, Urechis unicinctus. Process Biochem. 2008, 43, 179-184.
28. Rajapakse, N.; Jung, W.K.; Mendis, E.; Moon, S.H.; Kim, S.K. A novel anticoagulant purified from fish protein hydrolysate inhibits factor XIIa and platelet aggregation. Life Sci. 2005, 76, 2607-2619.
29. Liu, Z.; Dong, S.; Xu, J.; Zeng, M.; Song, H.; Zhao, Y. Production of cysteine-rich antimicrobial peptide by digestion of oyster (Crassostrea gigas) with alcalase and bromelin. Food Control. 2008, 19, 231-235.
30. Stensvag, K.; Haug, T.; Sperstad, S.V.; Rekdal, O.; Indrevoll, B.; Styrvold, O.B. Arasin 1, a proline-arginine-rich antimicrobial peptide isolated from the spider crab, Hyas araneus. Dev. Comp. Immuno. 2008, 32, 275-285.
31. Defelice, S.L. The nutritional revolution: Its impact on food industry R&D. Trends Food Sci. Technol. 1995, 6, 59-61.
32. Erdmann, K.; Cheung, B.W.Y.; Schroder, H. The possible roles of food-derived bioactive peptides in reducing the risk of cardiovascular disease. J. Nutr. Biochem. 2008, 19, 643-654.
33. Park, C.H.; Kim, H.J.; Kang, K.T.; Park, J.W.; Kim, J.S. Fractionation and angiotensin I-converting enzyme (ACE) inhibitory activity of gelatin hydrolysates from by-products of Alaska Pollock surimi. Fish. Aqua. Sci. 2009, 12, 79-85.
34. Byun, H.G.; Kim, S.K. Purification and characterization of angiotensin I converting enzyme (ACE) inhibitory peptides from Alaska Pollack (Theragra chalcogramma) skin. Process Biochem. 2001, 36, 1155-1162.
35. Qian, Z.J.; Je, J.Y.; Kim, S.K. Antihypertensive effect of angiotensin I converting enzyme-inhibitory peptide from hydrolysates of bigeye tuna dark muscle, Thunnus obesus. J. Agric. Food Chem. 2007, 55, 8398-8403.
36. Lee, S.H.; Qian, Z.J.; Kim, S.K. A novel angiotensin I converting enzyme inhibitory peptide from tuna frame protein hydrolysate and its antihypertensive effect in spontaneously hypertensive rats. Food Chem. 2010, 118, 96-102.
37. He, H.L.; Chen, X.L.; Sun, C.Y.; Zhang, Y.Z.; Zhou, B.C. Analysis of novel angiotensin-I-converting enzyme inhibitory peptides from protease-hydrolyzed marine shrimp Acetes chinensis. J. Peptide Sci. 2006, 12, 726-733.
38. Wang, Y.K.; He, H.L.; Chen, X.L.; Sun, C.Y.; Zhang, Y.Z.; Zhou, B.C. Production of novel angiotensin I-converting enzyme inhibitory peptides by fermentation of marine shrimp Acetes chinensis with Lactobacillus fermentum SM 605. Appl. Microbiol. Biotechnol. 2008, 79, 785-791.
39. Tsai, J.S.; Chen, J.L.; Pan, B.S. ACE-inhibitory peptides identified from the muscle protein hydrolysate of hard clam (Meretrix lusoria). Process Biochem. 2008, 43, 743-747.
40. Zhao, Y.; Bafang, L.; Dong, S.; Liu, Z.; Zhao, X.; Wang, J.; Zeng, M. A novel ACE inhibitory peptide isolated from Acaudina molpadioidea hydrolysate. Peptides 2009, 30, 1028-1033.
41. Lee, J.K.; Hong, S.; Jeon, J.K.; Kim, S.K.; Byun, H.G. Purification and characterization of angiotensin I converting enzyme inhibitory peptides from the rotifer, Brachionus rotundiformis. Bioresour. Technol. 2009, 100, 5255-5259.
42. Suetsuna, K.; Nakano, T. Identification of an antihypertensive peptide from peptic digest of wakame (Undaria pinnatifida). J. Nutr. Biochem. 2000, 11, 450-454.
43. Sheih, I.C.; Fang, T.J.; Wu, T.K. Isolation and characterization of a novel angiotensin I-converting enzyme (ACE) inhibitory peptide from the algae protein waste. Food Chem. 2009, 115, 279-284.
44. Jung, W.K.; Mendis, E.; Je, J.Y.; Park, P.J.; Son, B.W.; Kim, H.C.; Choi, Y.K.; Kim, S.K. Angiotensin I-converting enzyme inhibitory peptide from yellowfin sole (Limanda aspera) frame protein and its antihypertensive effect in spontaneously hypertensive rats. Food Chem. 2006, 94, 26-32.
45. Fujita, H.; Yoshikawa, M. LKPNM: A prodrug-type ACE-inhibitory peptide derived from fish protein. Immunopharmacology 1999, 44, 123-127.
46. Matsui, T.; Matsufuji, H.; Seki, E.; Osajima, K.; Nakashima, M.; Osajima, Y. Inhibition of angiotensin I-converting enzyme by Bacillus licheniformis alkaline protease hydrolysates derived from sardine muscle. Biosci. Biotech. Biochem. 1993, 57, 922-925.
47. Wang, J.; Hu, J.; Cui, J.; Bai, X.; Du, Y.; Miyaguchi, Y.; Lin, B. Purification and identification of a ACE inhibitory peptide from oyster proteins hydrolysate and the antihypertensive effect of hydrolysate in spontaneously hypertensive rats. Food Chem. 2008, 111, 302-308.
48. Wu, H.; He, H.L.; Chen, X.L.; Sun, C.Y.; Zhang, Y.Z.; Zhou, B.C. Purification and identification of novel angiotensin-I-converting enzyme inhibitory peptides from shark meat hydrolysate. Process Biochem. 2008, 43, 457-461.
49. Ichimura, T.; Hu, J.; Aita, D.Q.; Maruyama, S. Angiotensin I-converting enzyme inhibitory activity and insulin secretion stimulative activity of fermented fish sauce. J. Biosci. Bioeng. 2003, 96, 496-499.
50. Fahmi, A.; Morimura, S.; Guo, H.C.; Shigematsu, T.; Kida, K.; Uemura, Y. Production of angiotensin I converting enzyme inhibitory peptides from sea bream scales. Process Biochem. 2004, 39, 1195-1200.
51. Cheung, H.S.; Chushman, D.W. Spectrophotometric assay and properties of the angiotensin-converting enzyme of rabbit lung. Biochem. Pharmacol. 1971, 20, 1637-1648.
52. Suetsuna, K.; Nakano, T. Identification of an antihypertensive peptide from peptic digest of wakame (Undaria pinnatifida). J. Nutr. Biochem. 2000, 11, 450-454.
53. Rho, S.J.; Lee, J.S.; Chung, Y.I.; Kim, Y.W.; Lee, H.G. Purification and identification of an angiotensin I-converting enzyme inhibitory peptide from fermented soybean extract. Process Biochem. 2009, 44, 490-493.
54. Qian, Z.J.; Jung, W.K.; Lee, S.H.; Byun, H.G.; Kim, S.K. Antihypertensive effect of an angiotensin I-converting enzyme inhibitory peptide from bullfrog (Rana catesbeiana Shaw) muscle protein in spontaneously hypertensive rats. Process Biochem. 2007, 42, 1443-1448.
55. Shahidi, F.; Arachchi, J.K.V.; Jeon, Y.J. Food applications of chitin and chitosans. Trends Food Sci. Technol. 1999, 10, 37-51.
56. Kim, S.K.; Nghiep, N.D.; Rajapakse, N. Therapeutic prospectives of chitin, chitosan and their derivatives. J. Chitin Chitosan 2006, 11, 1-10.
57. Dou, J.L.; Tan, C.Y.; Du, Y.G.; Bai, X.F.; Wang, K.Y.; Ma, X.J. Effects of chitooligosaccharides on rabbit neutrophils in vitro. Carbohydr. Polym. 2007, 69, 209-213.
58. Jeon, Y.J.; Kim, S.K. Continuous production of chitooligosaccharides using a dual reactor system. Process Biochem. 2000, 35, 623-632.
59. Jeon, Y.J.; Kim, S.K. Production of chitooligosaccharides using ultrafiltration membrane reactor and their antibacterial activity. Carbohydr. Polym. 2000, 41, 133-141.
60. Kim, S.K.; Rajapakse, N. Enzymatic production and biological activities of chitosan oligosaccharides (COS): A review. Carbohydr. Polym. 2005, 62, 357-368.
61. Hong, S.P.; Kim, M.H.; Oh, S.W.; Han, C.H.; Kim, Y.H. ACE inhibitory and antihypertensive effect of chitosan oligosaccharides in SHR. Korean J. Food Sci. Technol. 1998, 30, 1476-1479.
62. Park, P.J.; Je, J.Y.; Kim, S.K. Free radical scavenging activity of chitooligosaccharides by electron spin resonance spectrometry. J. Agric. Food Chem. 2003, 51, 4624-4627.
63. Park, P.J.; Lee, H.K.; Kim, S.K. Preparation of hetero- chitooligosaccharides and their antimicrobial activity on Vibrio parahaemolyticus. J. Microbiol. Biotechnol. 2004, 14, 41-47.
64. Shen, K.T.; Chen, M.H.; Chan, H.Y.; Jeng, J.H.; Wang, Y.J. Inhibitory effects of chitooligosaccharides on tumor growth and metastasis. Food Chem. Toxicol. 2009, 47, 1864-1871.
65. Jeon, Y.J.; Kim, S.K. Antitumor activity of chitosan oligosaccharides produced in ultrafiltration membrane reactor system. J. Microbiol. Biotechnol. 2002, 12, 503-507.
66. Jeon, Y.J.; Kim, S.K. Potential immuno-stimulating effect of antitumoral fraction of chitosan oligosaccharides. J. Chitin Chitosan 2001, 6, 163-167.
67. Liu, B.; Liu, W.S.; Han, B.Q.; Sun, Y.Y. Antidibetic effects of chito-oligosaccharides on pancreatic islet cells in streptozotocin-induced diabetic rats. World J. Gastroenterol. 2007, 13, 725-731.
68. Kim, K.N.; Joo, E.S.; Kim, K.I.; Kim, S.K.; Yang, H.P.; Jeon, Y.J. Effect of chitosan oligosaccharides on cholesterol level and antioxidant enzyme activities in hypercholesterolemic rat. J. Korean Soc. Food Sci. Nutr. 2005, 34, 36-41.
69. Miura, T.; Usami, M.; Tsuura, Y.; Ishida, H.; Seino, Y. Hypoglycemic and hypolipidemic effect of chitosan in normal and neonatal streptozotocin-induced diabetic mice. Biol. Pharm. Bull. 1995, 18, 1623-1625.
70. Yoon, N.Y.; Ngo, D.N.; Kim, S.K. Acetylcholinesterase inhibitory activity of novel chitooligosaccharide derivatives. Carbohydr. Polym. 2009, 78, 869-872.
71. Park, P.J.; Je, J.Y.; Jung, W.K.; Kim, S.K. Anticoagulant activity of heterochitosans and their oligosaccharide sulfates. Eur. Food Res. Technol. 2004, 219, 529-533.
72. Cho, E.J.; Rahman, A.; Kim, S.W.; Baek, Y.M.; Hwang, H.J.; Oh, J.Y.; Hwang, H.S.; Lee, S.K.; Yun, J.W. Chitosan oligosaccharides inhibit adipogenesis in 3T3-L1 adipocytes. J. Microbiol. Biotechnol. 2008, 18(1), 80-87.
73. Park, P.J.; Je, J.Y.; Kim, S.K. Angiotensin I converting enzyme (ACE) inhibitory activity of hetero-chitooligosaccharides prepared from partially different deacetylated chitosans. J. Agric. Food Chem. 2003, 51, 4930-4934.
74. Je, J.Y.; Park, P.J.; Kim, B.; Kim, S.K. Antihypertensive activity of chitin derivatives. Biopolymers 2006, 83, 250-254.
75. Ngo, D.N.; Qian, Z.J.; Je, J.Y.; Kim, M.M.; Kim, S.K. Aminoethyl chitooligosaccharides inhibit the activity of angiotensin converting enzyme. Process Biochem. 2008, 43, 119-123.
76. Huang, R.; Mendis, E.; Kim, S.K. Improvement of ACE inhibitory activity of chitooligosaccharides (COS) by carboxyl modifications. Bioorg. Med. Chem. 2005, 13, 3649-3655.
77. Park, P.J.; Ahn, L.B.; Jeon, Y.J.; Je, J.Y. Renin inhibition activity by chitooligosacharides. Bioorg. Med. Chem. Lett. 2008, 18, 2471-2474.
78. Ragan, M.A.; Glombitza, K.W. Handbook of physiological methods. Cambridge University Press: Cambridge, UK, 1986; pp. 129-241.
79. Singh, I.P.; Bharate, S.B. Phloroglucinol compounds of natural origin. Nat. Prod. Rep. 2006, 23, 558-591.
80. Glombitza, K.W.; Li, S.M. Hydroxyphlorethols from the brown alga Carpophyllum maschalocarpum. Phytochemistry 1991, 30, 2741-2745.
81. Heo, S.J.; Park, E.U.; Lee, K.W.; Jeon, Y.J. Antioxidant activities of enzymatic extracts from brown seaweeds. Bioresour. Technol. 2005, 96, 1613-1623.
82. Li, Y.; Qian, Z.J.; Ryu, B.M.; Lee, S.H.; Kim, M.M.; Kim, S.K. Chemical components and its antioxidant properties in vitro: An edible marine brown alga, Ecklonia cava. Bioorg. Med. Chem. 2009, 17, 1963-1973.
83. Artan, M.; Li, Y.; Karadeniz, F.; Lee, S.H.; Kim, M.M.; Kim, S.K. Anti-HIV-1 activity of phloroglucinol derivative, 6,6′-bieckol, from Ecklonia cava. Bioorg. Med. Chem. 2008, 16, 7921-7926.
84. Kong, C.S.; Kim, J.A.; Yoon, N.Y.; Kim, S.K. Induction of apoptosis by phloroglucinol derivative from Ecklonia cava in MCF-7 human breast cancer cells. Food. Chem. Toxicol. 2009, 47, 1653-1658.
85. Jung, W.K.; Ahn, Y.W.; Lee, S.H.; Choi, Y.H.; Kim, S.K.; Yea, S.S.; Choi, I.; Park, S.G.; Seo, S.K.; Lee, S.W.; Choi, I.W. Ecklonia cava ethanolic extracts inhibit lipopolysaccharide-induced cyclooxygenase-2 and inducible nitric oxide synthase expression in BV2 microglia via the MAP kinase and NF-kB pathways. Food Chem. Toxicol. 2009, 47, 410-417.
86. 2-terminal kinase pathway. Eur. J. Pharmacol. 2008, 591, 114-123.
87. Lee, S.H.; Li, Y.; Karadeniz, F.; Kim, M.M.; Kim, S.K. α-Glycosidase and α-amylase inhibitory activities of phloroglucinal derivatives from edible marine brown alga, Ecklonia cava. J. Sci. Food Agric. 2009, doi 10.1002/jsfa.3623.
88. Yoon, N.Y.; Lee, S.H.; Li, Y.; Kim, S.K. Phlorotannins from Ishige okamurae and their acetyl- and butyry-lcholinesterase inhibitory effects. J. Func. Foods. 2009, 1, 331-335.
89. Nagayama, K.; Iwamura, Y.; Shibata, T.; Hirayama, I.; Nakamura, T. Bactericidal activity of phlorotannins from the brown alga Ecklonia kurome. J. Antimicrob. Chemother. 2002, 50, 889-893. (Pubitemid 36032809)
90. Jung, H.A.; Hyun, S.K.; Kim, H.R.; Choi, J.S. Angiotensin-converting enzyme I inhibitory activity of phlorotannins from Ecklonia stolonifera. Fisheries Sci. 2006, 72, 1292-1299.
91. Liu, J.C.; Hsu, F.L.; Tsai, J.C.; Chan, P.; Liu, J.Y.H.; Thomas, G.N.; Tomlinsond, B.; Loe, M.-Y.; Linf, J.-Y. Antihypertensive effects of tannins isolated from traditional Chinese herbs as non-specific inhibitors of angiotensin converting enzyme. Life Sci. 2003, 73, 1543-1555.
92. Athukorala, Y.; Jeon, Y.J. Screening for Angiotensin 1-converting enzyme inhibitory activity of Ecklonia cava. J. Food Sci. Nutr. 2005, 10, 134-139.
93. Cha, S.H.; Lee, K.W.; Jeon, Y.J. Screening of extracts from red algae in Jeju for potentials marine angiotensin-I converting enzyme (ACE) inhibitory activity. Algae 2006, 21, 343-348.